CN114098059A - Instant oral composition for relieving alcoholism and protecting liver and preparation method and preparation equipment thereof - Google Patents
Instant oral composition for relieving alcoholism and protecting liver and preparation method and preparation equipment thereof Download PDFInfo
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- CN114098059A CN114098059A CN202111366441.XA CN202111366441A CN114098059A CN 114098059 A CN114098059 A CN 114098059A CN 202111366441 A CN202111366441 A CN 202111366441A CN 114098059 A CN114098059 A CN 114098059A
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- powder
- pipe
- mixing
- air supply
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- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
- A23L29/37—Sugar alcohols
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Abstract
The invention relates to the field of alcohol effect dispelling and liver protecting, in particular to an instant oral composition for alcohol effect dispelling and liver protecting, a preparation method and preparation equipment thereof. The technical problem is as follows: the existing anti-alcohol and liver-protecting product in the prior art has the fresh effects of relieving physical consumptive disease and listlessness after drinking or hangover, and the existing anti-alcohol and liver-protecting product is inconvenient to use. The invention provides an instant composition for relieving alcoholism and protecting liver and a preparation method and preparation equipment thereof, wherein the instant composition for relieving alcoholism and protecting liver comprises kudzu root, hovenia dulcis thunb, turmeric, black ginseng, fruit powder, sugar alcohol, starch, acidity regulator, sweetener, adhesive and essence. According to the invention, the black ginseng powder is added into the oral instant composition for relieving alcoholism and protecting liver, so that the oral instant composition is rich in ginsenoside and ginseng polysaccharide, and the dryness of the black ginseng is removed after nine times of steaming.
Description
Technical Field
The invention relates to the field of alcohol effect dispelling and liver protecting, in particular to an instant oral composition for alcohol effect dispelling and liver protecting, a preparation method and preparation equipment thereof.
Background
Radix Puerariae is a Chinese medicinal preparation used as both medicine and food, is dried root of Pueraria lobata Ohwi of Leguminosae, and has effects of relieving muscles and fever, promoting fluid production to quench thirst, promoting eruption, invigorating yang and relieving diarrhea, dredging meridian passage, and relieving alcoholism. It is used to treat fever, headache, diabetes, measles without adequate eruption, dysentery, diarrhea, vertigo, headache, apoplexy, hemiplegia, thoracic obstruction, cardiodynia, and alcoholic injury. The modern pharmacology also carries out extensive research on the effect of treating alcoholism by the kudzuvine root, and numerous animal experiments prove that the kudzuvine root total flavonoids have the effects of inhibiting the alcohol absorption amount of experimental animals, accelerating alcohol metabolism, improving alcohol tolerance, reducing alcoholism death rate, reducing damage of alcohol to organs and the like.
Semen Hoveniae is a Chinese medicine used as both medicine and food, has effects of quenching thirst, relieving restlessness, clearing away damp-heat, relieving alcoholism, etc., and can be used for treating alcoholism, polydipsia, vomiting, constipation, etc. Researches show that the hovenia dulcis thunb can shorten the drunkenness time and the sleep time caused by drunkenness, accelerate the alcohol metabolism in vivo, inhibit the muscle relaxation caused by ethanol, and activate related enzymes in the alcohol metabolism process, such as Alcohol Dehydrogenase (ADH), acetaldehyde dehydrogenase (ALDH), glutathione catalase (GSH-PX) and the like. Therefore, the hovenia dulcis thunb is also a raw material with the effects of dispelling the effects of alcohol and sobering up.
The curcuma longa belongs to the genus curcuma longa in the family of zingiberaceae, and according to the record of the Ming dynasty Li Shizhen's Ben Cao gang mu, the Tang dynasty's pharmaceutical monograph has the record of the use of curcuma longa as a medicine, and is an important medicine for promoting blood circulation, removing blood stasis and promoting the circulation of qi. According to the record of Chinese pharmacopoeia: turmeric is pungent, bitter and warm in nature. It enters spleen and liver meridians. The turmeric has digestive system diseases, gynecological diseases, respiratory system diseases, hypertension, pain relieving and the like in clinical application, and modern researches find that the turmeric can also treat various diseases such as diabetes, cancer and the like. The turmeric is a food additive prepared by extracting and refining turmeric plant raw materials, and the main components of the turmeric are flavonoid components, wherein the turmeric components comprise: the study shows that the curcumin has the effects of relieving alcoholism, protecting liver, protecting gastrointestinal tract, inhibiting tumor cells, resisting oxidation, regulating immunity and the like, and particularly has obvious effects of relieving alcoholism and protecting the gastrointestinal tract. Indian also uses it as a medicine for treating gastropathy. The Japanese academy of creek and wild company also performed alcohol tolerance test on healthy men of 30-40 years old, and found that the concentration of alcohol and the concentration of alcohol metabolite acetaldehyde in blood of curcumin-ingested group were low, the degree of drunkenness was low, and the balance after drunkenness was significantly improved.
Chinese patent with publication number CN111671026A discloses a turmeric compound sobering-up and protecting gastrointestinal tract and a preparation method thereof, the formula of the turmeric compound sobering-up and protecting gastrointestinal tract comprises kudzuvine root, hovenia dulcis thunb, turmeric and corn oligopeptide, and the mechanism is to reduce alcohol concentration, improve enzyme activity, protect liver and protect gastric mucosa; however, the effects of relieving hangover and supplementing primordial qi are not achieved, the effects are not comprehensive enough, the effects of relieving alcoholism and protecting liver cannot be achieved better, the first-pass effect of liver cannot be avoided due to the liquid beverage, the bioavailability of the effective components is low, and the preparation is not convenient to take on a wine table.
Chinese patent with publication number CN106858198A discloses a kudzu flower-ginseng compound oral liquid for alleviating hangover and protecting liver and a preparation method thereof, the formula of the oral liquid is kudzu flower, ginseng, ganoderma lucidum, chrysanthemum, scutellaria, astragalus, mulberry and thyme, ginseng is added, and the effect of invigorating primordial qi after wine is introduced; however, the overall formula is biased to accelerate alcohol metabolism and strengthen the detoxifying effect of the liver, the gastric mucosa is not protected, and the ginseng is easy to cause internal heat and can cause stomach discomfort after drinking. The preparation form is oral liquid, the first pass effect of the liver cannot be avoided, the bioavailability of the active ingredients is low, and the oral liquid is inconvenient to take on a wine table.
In conclusion, the existing mechanisms of the anti-alcohol and liver-protecting products mostly focus on inhibiting alcohol absorption, reducing alcohol blood concentration, improving activities of alcohol dehydrogenase and acetaldehyde dehydrogenase, protecting liver and enhancing liver detoxification capacity, but the fresh products have the effects of relieving physical weakness and listlessness after drinking or hangover, and the existing anti-alcohol and liver-protecting products are mostly tablets, solid granules, liquid beverages and the like, are inconvenient to use, such as the liquid beverages cannot protect privacy, the solid granules are inconvenient to take, too many tablet auxiliary materials exist, and the efficacy is poor. Meanwhile, in the prior art, when the powder such as the kudzu root powder, the hovenia dulcis thunb powder, the black ginseng powder and the fruit powder is mixed, the powder is often stacked together in proportion and then mixed by a mechanical means, when the powder is stacked and mixed together, the powder is easy to agglomerate, a large amount of powder is easy to remain in a mixing container, and the powder is easy to float in the air. Therefore, the invention provides an instant composition for relieving alcoholism and protecting liver and an oral cavity, and a preparation method and preparation equipment thereof.
Disclosure of Invention
In order to overcome the defects that the mechanisms of the hangover-alleviating and liver-protecting products in the prior art are mostly focused on inhibiting alcohol absorption, reducing alcohol blood concentration, improving activity of alcohol dehydrogenase and acetaldehyde dehydrogenase, protecting liver and enhancing detoxification capability of liver, but fresh products have the effects of alleviating physical weakness and listlessness after drinking or hangover, and the dosage forms of the existing hangover-alleviating and liver-protecting products are mostly tablets, solid granules, liquid beverages and the like, are inconvenient to use, such as the liquid beverages cannot protect privacy, the solid granules are inconvenient to take, too many tablet auxiliary materials exist, and the effect is poor, in the prior art, when powder such as kudzuvine root powder, hovenia dulcis thunb powder, black ginseng powder, fruit powder and the like are mixed, the powder is often piled together according to a proportion, then the powder is mixed by a mechanical means, when the piled-up and mixed together, the powder is easy to agglomerate, a large amount of powder is easy to remain in a mixing container, and the powder is easy to disperse in the air, the invention provides an instant composition for relieving alcoholism and protecting liver and an oral cavity, and a preparation method and preparation equipment thereof.
The technical implementation scheme of the invention is as follows: an instant oral composition for relieving alcoholism and protecting liver comprises 3-5 parts of kudzu vine root, 5-8 parts of hovenia dulcis thunb, 2-4 parts of turmeric, 2-4 parts of black ginseng, 1-2 parts of fruit powder, 15-20 parts of sugar alcohol, 1-2 parts of starch, 0.5-1 part of acidity regulator, 0.2-1 part of sweetener, 0.2-1 part of adhesive and 0.2-1 part of essence.
More preferably, the sugar alcohol is one or more of xylitol, maltitol, erythritol, sorbitol and mannitol.
More preferably, the starch is one or more of modified starch, potato starch and corn starch.
More preferably, the fruit powder is more than one of strawberry fruit powder, cherry fruit powder, sweet orange fruit powder and banana fruit powder; the acidity regulator is more than one of citric acid, malic acid, tartaric acid and citric acid; the sweetener is more than one of mogroside, stevioside, sucralose, sodium cyclamate, acesulfame potassium and aspartame.
More preferably, the starch is doped with dextrin, and the dextrin is one or more of resistant dextrin and maltodextrin.
In order to prepare the instant composition for relieving alcoholism and protecting liver, the invention also provides a preparation method of the instant composition for relieving alcoholism and protecting liver, which comprises the following steps:
s1: mixing, and mixing radix Puerariae powder, semen Hoveniae powder, radix Ginseng Indici powder, fruit powder, sugar alcohol, starch and sweetener.
S2: and (4) crushing, namely crushing the mixed materials in the S1 uniformly.
S3: and (4) sieving, namely sieving the crushed material in the S2 by a sieve of 65 meshes to 120 meshes.
S4: preparing an adhesive, namely preparing an adhesive solution with the adhesive concentration of 0.5-2%.
S5: boiling and granulating, wherein the material temperature is 30-50 ℃, the frequency of a fan is 15-30 Hz, the liquid supply rotating speed is 8-20 rpm, the atomization pressure is 0.2-0.5Mpa, and the adhesive is dissolved in water.
S6: and (4) drying the materials in the S5, then granulating, granulating to 18-65 meshes, adding turmeric and essence, mixing for 30-60S without gravity, packaging and warehousing.
More preferably, the black ginseng powder is previously subjected to nine-steaming to remove the dry components.
In order to overcome the problem that experimental data is wrong due to the fact that the kudzu root powder, the hovenia dulcis thunb powder, the black ginseng powder, the fruit powder, the sugar alcohol and the starch are not uniform and easy to remain when being mixed, the invention further provides pneumatic type residue-free powder mixing equipment which comprises a mixing cabin, a mixing system and a powder feeding system, wherein the mixing cabin is connected with the mixing system used for mixing the powder through wind, and the upper surface of the mixing cabin is connected with the powder feeding system used for feeding the powder without residue.
More preferably, the mixing system comprises a slide bar, a push plate, a first air supply pipe, a second air supply pipe, an exhaust pipe, a plug, a first support, a first main air pipe and a branch pipe, the slide bar is fixedly connected inside the mixing cabin, the first air supply pipe is fixedly connected to the left part of the mixing cabin and is connected with an external air supply device, the second air supply pipe is fixedly connected to the right part of the mixing cabin and is connected with an external air supply device, the first air supply pipe and the second air supply pipe are respectively provided with a sieving component, the push plate is slidably connected to the slide bar and is used for pushing powder and accelerating the mixing of the powder, the exhaust pipe is connected to the right top part of the mixing cabin, the exhaust pipe is internally provided with an electric valve and a sieving component, the plug is inserted into the right bottom part of the mixing cabin, the first support is fixedly connected to the middle part of the rear side surface of the mixing cabin, the first main air pipe is connected to the external air supply device, be connected with the branch pipe on the first main tuber pipe to branch pipe and mixing cabin slope are connected, and the branch pipe air outlet is equipped with the subassembly that sieves.
More preferably, the powder feeding system comprises a second support, a second main air pipe, a circular tube and a powder feeding assembly, the second support is fixedly connected to the upper portion of the rear side face of the mixing chamber, the second support is connected with the second main air pipe, the left portion of the second main air pipe is connected with an external air supply device, the circular tube is connected to the second main air pipe, an electric valve and a sieving assembly are arranged in the circular tube, the upper surface of the mixing chamber is connected with a plurality of powder feeding assemblies, and the powder feeding assemblies are connected with the circular tube; the powder feeding assembly comprises a support frame, a powder feeding tank, a guide rail, a sliding block, a support plate, a rotating sleeve, an air feed pipe, a first gear, a motor, a second gear, a push disc, a first scraping strip, a second scraping strip and a scraping ring; the upper surface of the mixing chamber is fixedly connected with a support frame, the support frame is provided with a powder feeding tank, the powder feeding tank is connected with a circular tube, a discharge pipe of an electric valve arranged at the bottom of the powder feeding tank is communicated with the mixing chamber, the upper surface of the mixing chamber is fixedly connected with a guide rail positioned in front of the powder feeding tank, the guide rail is slidably connected with a slide block, the slide block is fixedly connected with a support plate, the rear part of the support plate is rotatably connected with a rotating sleeve, an air supply pipe is fixedly connected in the rotating sleeve, the upper part of the outer surface of the rotating sleeve is fixedly connected with a first gear, a motor is arranged on the support plate and positioned in front of the air supply pipe, an output shaft of the motor is fixedly connected with a second gear, the second gear is mutually meshed with the first gear, the bottom of the air supply pipe is fixedly connected with a push disc, the air supply pipe is connected with an external air supply device, the outer ring of the push disc is fixedly connected with a first scraping strip, the lower surface of the push disc is fixedly connected with a second scraping strip, the upper part of the outer ring is fixedly connected with a scraping ring, the first scraping strip, the second scraping strip and the scraping ring are used for scraping the residual crushing in the powder feeding tank, the push disc is provided with a vent hole, and the vent hole corresponds to the first scraping strip.
Compared with the prior art, the invention has the following advantages:
the invention adds the black ginseng powder, which is rich in ginsenoside and ginseng polysaccharide, into the oral instant composition for relieving alcoholism and protecting liver, removes the dryness of the black ginseng after nine times of steaming and nine times of processing in the preparation process, greatly supplements primordial qi without causing internal heat, simultaneously prepares the oral instant composition for relieving alcoholism and protecting liver into the dosage form of oral instant granules, avoids the first pass effect of liver through oral absorption, improves the bioavailability, is dissolved in the mouth immediately, is taken 1.5-2g each time, has small packaging volume, convenient taking and relatively more drug-loading rate, overcomes the inconvenience in use brought by tablets, solid granules and liquid beverages in the prior art, improves the bioavailability by preparing turmeric into micro-capsule powder through an embedding technology, plays a certain role in protecting stomach, adopts gravity-free mixed whole granules and adds a mixture of turmeric and essence, has short time, only 30-60 s, solving the problems that the traditional mixing process is long in time, some substances are easy to oxidize, and even some microcapsule powder is easy to extrude and crush;
the invention takes food raw materials of kudzu root, raisin tree seed, turmeric and black ginseng as an efficacy formula, takes at least one or a plurality of combinations of xylitol, erythritol, sorbitol, maltitol, mannitol and the like and at least one or a plurality of combinations of maltodextrin, corn starch, potato starch, resistant dextrin, modified starch and the like as formulation auxiliary materials, combines two methods of evaluating single materials and crowd taste test mixed materials by simulating scenes to screen the most appropriate auxiliary material system, and verifies that the formula has obvious hangover alleviating effect through zebra fish animal experiments;
the invention designs a pneumatic residue-free powder mixing device for mixing kudzu root powder, hovenia dulcis thunb powder, black ginseng powder, fruit powder, sugar alcohol and starch, which scrapes the powder remained on the inner wall of a powder feeding tank through four first scraping strips, and the scraping ring is in close contact with the inner wall of the powder feeding tank, so that the powder in the powder feeding tank can be fully transferred downwards to a mixing cabin and prevented from caking, meanwhile, the powder stuck on the first scraping strips and the second scraping strips can be subjected to self-cleaning treatment, the powder transferred into the mixing cabin can be expanded and dispersed under the action of wind, thereby improving the mixing effect, meanwhile, a branch pipe obliquely upwards acts on the powder transferred from a discharge pipe at the bottom of the powder feeding tank, so that the powder can be fully and uniformly mixed, and a push plate can reciprocate left and right under the action of air pressure, thereby generating air flow and acting on the powder, and fully mixing various powders, when the push plate transfers the powder out of the mixing cabin, the push plate is in contact with the inner wall of the mixing cabin, so that the powder can be prevented from remaining in the mixing cabin.
Drawings
FIG. 1 is a first schematic structural view of one embodiment of a pneumatic residue-free powder mixing apparatus of the present invention;
FIG. 2 is a second schematic structural view of an embodiment of the pneumatic residue-free powder mixing apparatus of the present invention;
FIG. 3 is a third schematic diagram of an embodiment of a pneumatic residue-free powder mixing apparatus according to the invention;
FIG. 4 is a first partial schematic view of a pneumatic residue-free powder mixing apparatus according to an embodiment of the present invention;
FIG. 5 is a second partial schematic structural view of an embodiment of a pneumatic residue-free powder mixing apparatus according to the present invention;
FIG. 6 is a schematic diagram of a powder feeding system of an embodiment of the pneumatic residue-free powder mixing apparatus of the present invention;
FIG. 7 is a schematic view of a first partial configuration of a powder feed system of an exemplary embodiment of a pneumatic residue-free powder mixing apparatus of the present invention;
FIG. 8 is a schematic diagram of a second partial configuration of a powder feed system according to one embodiment of the pneumatic residue-free powder mixing apparatus of the present invention;
FIG. 9 is a schematic diagram of a third configuration of a powder feed system according to an embodiment of the present invention;
FIG. 10 is an enlarged view of the powder feed system at A of one embodiment of the pneumatic residue-free powder mixing apparatus of the present invention;
FIG. 11 is a schematic illustration of a three-stage monitoring of the present invention;
FIG. 12 is a diagram illustrating the results of a taste test performed on a population according to the present invention;
FIG. 13 is a behavior trace diagram of zebra fish treated by the anti-hangover and hepatoprotective solid beverage of the present invention;
FIG. 14 is a schematic diagram showing the comparison between the total moving distance of zebra fish treated by the anti-hangover and hepatoprotective solid beverage of the present invention and a model control group;
fig. 15 is a schematic diagram comparing the anti-inebriation effect of zebra fish after the anti-inebriation and liver protection solid beverage is treated with a model control group.
Wherein the figures include the following reference numerals: 1-mixing cabin, 2-support leg, 201-sliding rod, 202-push plate, 203-first air supply pipe, 204-second air supply pipe, 205-exhaust pipe, 206-plug, 207-first bracket, 208-first main air pipe, 209-branch pipe, 301-second bracket, 302-second main air pipe, 303-circular pipe, 304-supporting frame, 305-powder feeding tank, 306-guide rail, 307-sliding block, 308-supporting plate, 309-rotating sleeve, 310-air supply pipe, 311-first gear, 312-motor, 313-second gear, 314-push disc, 315-first scraping strip, 316-second scraping strip, 317-scraping ring and 314 a-vent hole.
Detailed Description
The invention is further described below with reference to the figures and examples.
Examples
The preparation method comprises the following steps of:
taking 4 parts of kudzuvine root, 6 parts of hovenia dulcis thumb, 3 parts of turmeric, 3 parts of black ginseng, 1.5 parts of fruit powder, 17 parts of sugar alcohol, 1.5 parts of starch, 0.75 part of acidity regulator, 0.6 part of sweetener, 0.6 part of adhesive and 0.6 part of essence, firstly, uniformly mixing the kudzuvine root powder, the hovenia dulcis thumb powder, the black ginseng powder, the fruit powder, the sugar alcohol, the starch and the sweetener by using pneumatic type residue-free powder mixing equipment, then carrying out crushing treatment, sieving by a 90-mesh sieve, simultaneously preparing adhesive solution with the concentration of 1.5%, then dissolving the adhesive in water and carrying out boiling granulation, controlling the temperature to be 40 ℃, the frequency of a fan to be 25Hz, the liquid supply rotation speed to be 16rpm and the atomization pressure to be 0.3Mpa, then drying, carrying out granulation to be 45 meshes, then adding the turmeric and the essence, mixing for 40s without gravity, packaging and warehousing, thus obtaining the instant composition for sobering and protecting the liver. Wherein the sugar alcohol is xylitol, the starch is potato starch doped with resistant dextrin, the fruit powder is strawberry fruit powder, and the sweetener is mogroside.
Mixing radix Puerariae powder, semen Hoveniae powder, radix Ginseng Indici powder, fruit powder, sugar alcohol, starch and sweetener with pneumatic residue-free powder mixing equipment.
In the embodiment of the present invention, the number of the powder feeding tanks 305 is 7, and those skilled in the art will appreciate that the number of the powder feeding tanks 305 may be more or less, the guide rails 306 and the sliding blocks 307 may be electrically driven or hydraulically driven or activated, and the sieving assembly is used to separate the powder.
A pneumatic residue-free powder mixing device is shown in figures 1-10 and comprises a mixing cabin 1, support legs 2, a mixing system and a powder feeding system, wherein the bottom of the mixing cabin 1 is supported and fixed on the ground through the support legs 2, the mixing system is connected to the mixing cabin 1, and the powder feeding system is connected to the upper surface of the mixing cabin 1.
The mixing system comprises slide bars 201, a push plate 202, a first blast pipe 203, a second blast pipe 204, an exhaust pipe 205, a plug 206, a first bracket 207, a first main air pipe 208 and a branch pipe 209, wherein the inside of the mixing cabin 1 is fixedly connected with four slide bars 201, the left part of the mixing cabin 1 is fixedly connected with the first blast pipe 203, the first blast pipe 203 is connected with an external air supply device, the right part of the mixing cabin 1 is fixedly connected with the second blast pipe 204, the second blast pipe 204 is connected with the external air supply device, the first blast pipe 203 and the second blast pipe 204 are both provided with a sieving component, the four slide bars 201 are slidably connected with the push plate 202, the push plate 202 is used for pushing powder and accelerating the powder mixing, the right top of the mixing cabin 1 is connected with the two exhaust pipes 205, the exhaust pipe 205 is internally provided with an electric valve and a sieving component, the right bottom of the mixing cabin 1 is inserted with the plug 206, the plug 206 is provided with a handle, the middle part of the rear side surface of the mixing cabin 1 is fixedly connected with the two first brackets 207, the two first supports 207 are connected with a first main air duct 208, the left part of the first main air duct 208 is connected with an external air supply device, the first main air duct 208 is connected with seven branch pipes 209, the seven branch pipes 209 are obliquely connected with the mixing cabin 1, and air outlets of the branch pipes 209 are provided with sieving assemblies.
The powder feeding system comprises second supports 301, a second main air pipe 302, circular tubes 303 and powder feeding assemblies, wherein the two second supports 301 are fixedly connected to the upper portion of the rear side face of the mixing cabin 1, the two second supports 301 are connected with the second main air pipe 302, the left portion of the second main air pipe 302 is connected with an external air supply device, the seven circular tubes 303 are connected to the second main air pipe 302, an electric valve and a sieving assembly are arranged in the circular tubes 303, the seven powder feeding assemblies are connected to the upper surface of the mixing cabin 1, and the powder feeding assemblies are connected with the circular tubes 303; the powder feeding assembly comprises a supporting frame 304, a powder feeding tank 305, a guide rail 306, a sliding block 307, a support plate 308, a rotating sleeve 309, an air feed pipe 310, a first gear 311, a motor 312, a second gear 313, a push disc 314, a first scraping strip 315, a second scraping strip 316 and a scraping ring 317; a support frame 304 is fixedly connected to the upper surface of the mixing chamber 1, a powder feeding tank 305 is mounted on the support frame 304, the powder feeding tank 305 is connected with a circular tube 303, a discharge pipe of an electric valve arranged at the bottom of the powder feeding tank 305 is communicated with the mixing chamber 1, a guide rail 306 is fixedly connected to the upper surface of the mixing chamber 1 and positioned in front of the powder feeding tank 305, a slide block 307 is slidably connected to the guide rail 306, a support plate 308 is connected to the slide block 307 through bolts, a rotating sleeve 309 is rotatably connected to the rear portion of the support plate 308, an air feeding pipe 310 is fixedly connected to the inside of the rotating sleeve 309, a first gear 311 is fixedly connected to the upper portion of the outer surface of the rotating sleeve 309, a motor 312 is mounted on the support plate 308 and positioned in front of the air feeding pipe 310, a second gear 313 is fixedly connected to an output shaft of the motor 312, the second gear 313 is mutually engaged with the first gear 311, a push disc 314 is fixedly connected to the bottom of the air feeding pipe 310, the air feeding pipe 310 is connected with an external device, four first external ring scraping strips 315 are fixedly connected to the push disc 314, four second scraping strips 316 are fixedly connected to the lower surface of the pushing disc 314, a scraping ring 317 is fixedly connected to the upper portion of the outer annular surface of the pushing disc 314, the first scraping strips 315, the second scraping strips 316 and the scraping ring 317 are used for scraping residual powder in the powder feeding tank 305, four vent holes 314a are formed in the pushing disc 314, and the vent holes 314a correspond to the first scraping strips 315 one by one.
When the anti-alcohol and liver-protecting oral instant composition, the preparation method and the preparation equipment thereof work, powder is firstly added into a powder feeding tank 305, then a slide block 307 on a guide rail 306 is controlled to move downwards, so that a support plate 308, a rotating sleeve 309, an air feeding pipe 310, a first gear 311, a motor 312, a second gear 313, a push disc 314, a first scraping strip 315, a second scraping strip 316 and a scraping ring 317 are driven to move downwards together, so that the push disc 314 is inserted into the powder feeding tank 305, the powder in the powder feeding tank 305 is pressed downwards, so that the powder is transferred into a mixing chamber 1 through a discharge pipe at the bottom of the powder feeding tank, during the downward movement of the push disc 314, the motor 312 drives the second gear 313 to rotate in a reciprocating manner, the second gear 313 drives the rotating sleeve 309 to rotate in a reciprocating manner through the first gear 311, further the rotating sleeve 309 drives the push disc 314 to rotate in a reciprocating manner, during the reciprocating manner, the process, the powder remained on the inner wall of the powder feeding tank 305 is scraped through the four first scraping strips 315, during the downward movement of the push plate 314, the powder remained on the inner wall of the powder feeding tank 305 is scraped again by the scraping ring 317, and the scraping ring 317 is in close contact with the inner wall of the powder feeding tank 305, so that the powder in the powder feeding tank 305 is sufficiently transferred downwards to the mixing chamber 1 and prevented from caking, then when the push plate 314 moves downwards to the bottommost part of the powder feeding tank 305, at this time, four second scraping strips 316 are in contact with the inner bottom surface of the powder feeding tank 305, then the motor 312 is controlled to continue to drive the push plate 314 to rotate in a reciprocating manner, so as to scrape the powder remained on the bottom of the powder feeding tank 305, simultaneously, air is fed into the air pipe 310 and fed into the second main air pipe 302, the air in the air pipe 310 acts on the four first scraping strips 315 through the four vent holes 314a, the air in the second main air pipe 302 is transferred into the circular pipe 303 and then transferred to the bottom of the powder feeding tank 305, so that the powder adhered on the first scraping strips 315 is separated from the powder adhered on the second scraping strips 316, the powder can be sent into the mixing cabin 1 through wind, so that the powder can be spread, and the mixing effect is improved;
further, when the powder is transferred into the mixing chamber 1, air is fed into the first main air pipe 208, the air acts on the powder transferred from the discharging pipe at the bottom of the powder feeding tank 305 obliquely upwards through the branch pipe 209 to fully expand the powder, so that the powder is fully and uniformly mixed, further, in the process of mixing the powder in a plurality of powder feeding tanks 305, air is fed into or exhausted from the first air pipe 203, the push plate 202 reciprocates left and right through the air pressure action to generate air flow and acts on the powder, so that a plurality of kinds of powder are fully mixed, the air pressure balance in the mixing chamber 1 is adjusted through the two exhaust pipes 205, then after the powder is fully mixed, the electric valves in the two exhaust pipes 205 are controlled to be closed, the electric valves in the discharging pipes at the bottom of the powder feeding tanks 305 are controlled to be closed, then air is fed into the first air pipe 203, the push plate 202 is forced to move rightwards through the four sliding rods 201 to push the mixing chamber 1, therefore, the powder is transferred to the right part of the mixing cabin 1 through the push plate 202, the push plate 202 is in contact with the inner wall of the mixing cabin 1, the powder can be prevented from remaining in the mixing cabin 1, then the plug 206 is manually drawn out, and the powder sent out from the mixing cabin 1 is filled in a container, so that the powder mixing process is completed, and the powder cannot remain in the mixing cabin 1, so that the powder residue is avoided, and the error of test data is avoided;
further, air is fed into the second air supply pipe 204 to drive the push plate 202 to move leftwards and reset, and the powder feeding speed of the powder feeding tank 305 can be controlled by matching the electric valve arranged in the discharge pipe at the bottom of the powder feeding tank 305, the downward moving speed of the push disk 314 and the wind speed of the wind fed into the second main air pipe 302 and the air supply pipe 310.
Sensory evaluation
Weighing 96-99% of water-soluble carbohydrate, putting the mixture into a high-speed shearing machine, mixing and powdering, passing through a 65-120 mesh screen, putting the sieved powder at the bottom of a boiling granulator, and spraying an aqueous solution containing sodium carboxymethyl cellulose and a natural colorant, wherein the sodium carboxymethyl cellulose accounts for 0.5-2% of the total weight of a matrix, and the natural colorant accounts for 0.5-2% of the total weight of the matrix, so that the powder is finally coagulated into granules. Wherein the material temperature of the boiling granulation is 30-50 ℃, and the atomization pressure is 0.2-0.5 MPa. The particles are screened for suitable direct drinking type materials through sensory evaluation:
purpose of the experiment: and selecting an oral instant material system suitable for direct drinking.
The experimental method comprises the following steps: the method comprises the following steps: evaluating the single material by simulating the scene; the method 2 comprises the following steps: the crowd taste tests the mixed material.
First, simulating scene evaluation list material
1.1 Experimental model: a round cover glass, acting as the lingual surface and palate, was used to simulate the situation of buccal particles in the mouth.
1.2 Experimental procedures: the three-stage monitoring is divided as shown in fig. 11.
1.2.1 material inlet.
1.2.2 simulated secretion of saliva.
1.2.35 s.
1.3 Experimental evaluation criteria: the dispersibility, agglomeration and wall adhesion of the materials on the glass slide are used as the dominant indexes for judging the material body feeling. The following table shows the simulation scenario evaluation single material case.
| Name (R) | Dispersibility | Agglomeration of the particles | Wall sticking phenomenon |
| Maltodextrin | Is poor | A large number of | Severe severity of disease |
| Resistant dextrins | In general | Small amount of | Light and slight |
| Pregelatinized starch | In general | Small amount of | Light and slight |
| Corn starch | Is preferably used | Small amount of | Light and slight |
| Potato starch | Is preferably used | Is free of | Light and slight |
| Modified starch | In general | Small amount of | Severe severity of disease |
| Sorbitol | Good taste | Is free of | Is free of |
| Erythritol and its preparation method | Good taste | Is free of | Is free of |
| Maltitol | Good taste | Is free of | Is free of |
| Xylitol, its preparation method and use | Good taste | Is free of | Is free of |
The sugar alcohol and the starch material can be known through simulation evaluation, and the comprehensive performance is slightly good; resistant dextrin, pregelatinized starch, corn starch, potato starch, sorbitol, erythritol, maltitol and xylitol are preferably selected as base materials according to comprehensive consideration and are comprehensively proportioned.
Secondly, testing the taste of the crowd to obtain a mixed material
Please 15 sensory evaluation personnel, evaluate 8 single material compositions in the single material experiment for taste evaluation according to the simulation situation, wherein the evaluation indexes are sticky feeling, instant feeling and taste after the entrance and the comprehensive evaluation of the materials. The sticky wall feeling accounts for 15 percent, the score is 0-5 points, the weak sticky wall feeling is 5 points, and the strong sticky wall feeling is 0 point; the instant feeling accounts for 70 percent, the score is 0-5, the instant feeling is weak 0, and the instant feeling is strong 5; the mouthfeel accounts for 15%, the score is 0-5 points, the mouthfeel is good for 5 points, the mouthfeel difference is 0 point; the total score is 15% sticky feeling + 70% instant feeling + 15% mouthfeel, and the score is 0-5. The following table is a taste test rating table of the mixed materials.
The results of the crowd taste tests are shown in fig. 12, and it can be known from the above test results that after the sticky wall feeling, the instant feeling and the taste are combined, resistant dextrin, potato starch, corn starch, erythritol and xylitol are used as base materials, and a composition with or without sorbitol or xylitol is added, preferably in a proper proportion, so as to achieve a multi-level taste of oral instant granules from soft, fine, greasy, sweet, slightly cool and instant.
Sensory evaluation
The preparation method of the instant composition for relieving alcoholism and protecting liver is used for preparing the instant composition for relieving alcoholism and protecting liver, wherein sugar alcohol, starch and dextrin are mixed according to the result of sensory evaluation, 15 sensory evaluators use 5 indexes of taste, smell, instant effect, novelty and comprehensive preference degree as evaluation bases, the score of each index is 0-5 minutes, the final evaluation result is the average sum score of each index, the score range is 0-17.5 is not ideal, the score range is 17.5-21.25 is general, and the score range is 21.25-25 is satisfactory. The following table shows the sensory evaluation results.
According to the results, the comprehensive sensory evaluation of the prepared oral instant granules for improving sleep is satisfactory, so that the dosage form has high public acceptance and good instant taste, improves the overall taking experience and comfort, and is one of good popularization dosage forms.
Evaluation of stability test
The prepared anti-alcohol liver-protecting oral instant composition is subjected to an accelerated stability test for 3 months.
The experimental conditions are as follows: a stabilizing box with the temperature of 37 ℃ plus or minus 2 ℃ and the humidity of RH75 percent plus or minus 5 percent
The experimental results are as follows: after 3 months of accelerated stability experiments, the result is qualified, which shows that the instant granules prepared by the method have good stability.
Efficacy verification experiment
Evaluation of test sample for sobering up and protecting liver
Randomly selecting 180 wild AB strain zebra fishes fertilized for 6 days into a six-hole plate, treating 30 zebra fishes in each hole, inducing the zebra fishes with 3.5% of ethanol for 1 hour to form an intoxication model, removing the ethanol, cleaning the zebra fishes with fish culture water once, dissolving the zebra fishes with water respectively, and giving the solid drinks with the concentration of 300, 600 and 1200 mu g/mL for sobering and protecting the liver, and the positive control medicine RU21 with the concentration of 100 mu g/mL, and simultaneously setting a normal control group and a model control group, wherein the zebra fishes in the control group are treated with the fish culture water, and the volume of each hole is 3 mL. And randomly selecting 10 zebra fishes in each group, placing the zebra fishes in a 96-well plate with 1 tail per well and 200 mu L per well, and recording the zebra fish movement condition within 1h by using a movement behavior analyzer. Analyzing and counting the total movement distance of the zebra fish, and evaluating the hangover alleviating effect of the plant beverage on the ethanol-free induced drunk model zebra fish according to the statistical analysis result of the total movement distance.
The results show that:
the comparison of the total movement distance of the zebra fish in the model control group of 3882mm with the normal control group of 6005mm shows that P is less than 0.001, which indicates that the model is successfully established. The total movement distance of the zebra fish with the positive control drug RU21 of 100 mug/mL is 5256mm, compared with the model control group, P is less than 0.001, and the anti-inebriation effect is 65%, which indicates that RU21 has the anti-inebriation effect on the alcoholic intoxication model zebra fish induced by absolute ethyl alcohol. The total movement distances of zebra fish in the anti-alcohol and liver-protecting solid beverage groups with the concentration of 300 mug/mL, 600 mug/mL and 1200 mug/mL are 5791 mm, 5915 mm and 5388mm respectively, compared with a model control group, P is less than 0.001 and P is less than 0.01, and the anti-alcohol effect is 90%, 96% and 71% respectively. The solid beverage for relieving alcoholism and protecting liver has an obvious function of relieving alcoholism on an alcoholic intoxication model zebra fish induced by absolute ethyl alcohol under the condition of the experimental concentration. The table below shows the anti-hangover effect of zebra fish after the treatment of the plant beverage.
P <0.01, P <0.001, compared to model control group
Wherein, figure 13 is a behavior trace diagram of the zebra fish after the solid beverage for relieving or neutralizing the effect of alcohol and protecting the liver is treated, figure 14 is a comparison of the total movement distance of the zebra fish after the solid beverage for relieving or neutralizing the effect of alcohol and protecting the liver and a model control group, wherein P is 0.01, P is 0.001, figure 15 is a comparison of the effect of relieving or neutralizing the effect of alcohol and protecting the liver and the model control group, wherein P is 0.01, P is 0.001
The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and all the changes or substitutions should be covered within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.
Claims (10)
1. An instant oral composition for relieving alcoholism and protecting liver is characterized by comprising 3-5 parts of kudzu root, 5-8 parts of hovenia dulcis thunb, 2-4 parts of turmeric, 2-4 parts of black ginseng, 1-2 parts of fruit powder, 15-20 parts of sugar alcohol, 1-2 parts of starch, 0.5-1 part of acidity regulator, 0.2-1 part of sweetener, 0.2-1 part of adhesive and 0.2-1 part of essence.
2. The instant oral composition for alleviating hangover and protecting liver according to claim 1, wherein the sugar alcohol is one or more of xylitol, maltitol, erythritol, sorbitol and mannitol.
3. The instant composition for relieving alcoholism and protecting liver in oral cavity according to claim 1, wherein the starch is one or more of modified starch, potato starch and corn starch.
4. The oral instant composition for alleviating hangover and protecting liver according to claim 1, wherein the fruit powder is one or more of strawberry fruit powder, cherry fruit powder, sweet orange fruit powder and banana fruit powder; the acidity regulator is more than one of citric acid, malic acid, tartaric acid and citric acid; the sweetener is more than one of mogroside, stevioside, sucralose, sodium cyclamate, acesulfame potassium and aspartame.
5. The instant oral composition for alleviating hangover and protecting liver as claimed in claim 1, wherein the starch is doped with dextrin, and the dextrin is one or more of resistant dextrin and maltodextrin.
6. A method for preparing the instant composition for relieving alcoholism and protecting liver in oral cavity, which is used for preparing the instant composition for relieving alcoholism and protecting liver in oral cavity of any one of claims 1 to 5, and is characterized by comprising the following steps:
s1: mixing, and mixing radix Puerariae powder, semen Hoveniae powder, radix Ginseng Indici powder, fruit powder, sugar alcohol, starch and sweetener.
S2: and (4) crushing, namely crushing the mixed materials in the S1 uniformly.
S3: and (4) sieving, namely sieving the crushed material in the S2 by a sieve of 65 meshes to 120 meshes.
S4: preparing an adhesive, namely preparing an adhesive solution with the adhesive concentration of 0.5-2%.
S5: boiling and granulating, wherein the material temperature is 30-50 ℃, the frequency of a fan is 15-30 Hz, the liquid supply rotating speed is 8-20 rpm, the atomization pressure is 0.2-0.5Mpa, and the adhesive is dissolved in water.
S6: and (4) drying the materials in the S5, then granulating, granulating to 18-65 meshes, adding turmeric and essence, mixing for 30-60S without gravity, packaging and warehousing.
7. The method for preparing the oral instant composition for alleviating hangover and protecting liver according to claim 1, wherein the black ginseng powder is previously subjected to nine-steaming to remove dry components.
8. A pneumatic residue-free powder mixing device for mixing the kudzu root powder, hovenia dulcis thunb powder, black ginseng powder, fruit powder, sugar alcohol and starch in any one of claims 6 to 7, which is characterized by comprising a mixing cabin (1), a mixing system and a powder feeding system, wherein the mixing cabin (1) is connected with the mixing system for mixing the powder by wind, and the upper surface of the mixing cabin (1) is connected with the powder feeding system for feeding the powder without residue.
9. An air-operated residue-free powder mixing device as claimed in claim 8, wherein the mixing system comprises a slide bar (201), a push plate (202), a first air supply pipe (203), a second air supply pipe (204), an exhaust pipe (205), a plug (206), a first support (207), a first main air pipe (208) and a branch pipe (209), the slide bar (201) is fixedly connected inside the mixing chamber (1), the first air supply pipe (203) is fixedly connected to the left part of the mixing chamber (1), the first air supply pipe (203) is connected with an external air supply device, the second air supply pipe (204) is fixedly connected to the right part of the mixing chamber (1), the second air supply pipe (204) is connected with the external air supply device, the first air supply pipe (203) and the second air supply pipe (204) are respectively provided with a sieving component, the push plate (202) is slidably connected to the slide bar (201), the push plate (202) is used for pushing powder and accelerating the powder mixing, mix cabin (1) right side top and be connected with exhaust pipe (205), be equipped with the motorised valve in exhaust pipe (205) and sieve the subassembly, it has end cap (206) to peg graft in mixed cabin (1) right side bottom, the trailing flank middle part rigid coupling of mixed cabin (1) has first support (207), first support (207) are connected with first main tuber pipe (208), the left part and the external air supply equipment of first main tuber pipe (208) are connected, be connected with branch pipe (209) on first main tuber pipe (208), and branch pipe (209) and mixed cabin (1) slope are connected, branch pipe (209) air outlet is equipped with the subassembly that sieves.
10. The pneumatic residue-free powder mixing device as claimed in claim 8, wherein the powder feeding system comprises a second support (301), a second main air pipe (302), a circular pipe (303) and powder feeding components, the second support (301) is fixedly connected to the upper portion of the rear side surface of the mixing chamber (1), the second support (301) is connected with the second main air pipe (302), the left portion of the second main air pipe (302) is connected with an external air supply device, the circular pipe (303) is connected to the second main air pipe (302), an electric valve and a sieving component are arranged in the circular pipe (303), the upper surface of the mixing chamber (1) is connected with a plurality of powder feeding components, and the powder feeding components are connected with the circular pipe (303); the powder feeding assembly comprises a supporting frame (304), a powder feeding tank (305), a guide rail (306), a sliding block (307), a support plate (308), a rotating sleeve (309), an air feed pipe (310), a first gear (311), a motor (312), a second gear (313), a push disc (314), a first scraping strip (315), a second scraping strip (316) and a scraping ring (317); the upper surface of the mixing cabin (1) is fixedly connected with a support frame (304), the support frame (304) is provided with a powder feeding tank (305), the powder feeding tank (305) is connected with a circular ring pipe (303), a discharge pipe of an electric valve is arranged at the bottom of the powder feeding tank (305) and is communicated with the mixing cabin (1), the upper surface of the mixing cabin (1) is fixedly connected with a guide rail (306) in front of the powder feeding tank (305), the guide rail (306) is slidably connected with a slide block (307), the slide block (307) is fixedly connected with a support plate (308), the rear part of the support plate (308) is rotatably connected with a rotating sleeve (309), a gas feeding pipe (310) is fixedly connected in the rotating sleeve (309), the upper part of the outer surface of the rotating sleeve (309) is fixedly connected with a first gear (311), the support plate (308) is provided with a motor (312) in front of the gas feeding pipe (310), an output shaft of the motor (312) is fixedly connected with a second gear (313), and the second gear (313) is meshed with the first gear (311), the bottom of the air supply pipe (310) is fixedly connected with a push disc (314), the air supply pipe (310) is connected with an external air supply device, a first scraping strip (315) is fixedly connected to the outer annular surface of the push disc (314), a second scraping strip (316) is fixedly connected to the lower surface of the push disc (314), a scraping ring (317) is fixedly connected to the upper portion of the outer annular surface of the push disc (314), the first scraping strip (315), the second scraping strip (316) and the scraping ring (317) are used for scraping and smashing residues in the powder feeding tank (305), a vent hole (314a) is formed in the push disc (314), and the vent hole (314a) corresponds to the first scraping strip (315).
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