CN114097939B - Sustained release tablet matrix and preparation method and application thereof - Google Patents

Sustained release tablet matrix and preparation method and application thereof Download PDF

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CN114097939B
CN114097939B CN202111398452.6A CN202111398452A CN114097939B CN 114097939 B CN114097939 B CN 114097939B CN 202111398452 A CN202111398452 A CN 202111398452A CN 114097939 B CN114097939 B CN 114097939B
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release tablet
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CN114097939A (en
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Shanghai Paige Hospital Management Co ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/163—Sugars; Polysaccharides
    • C—CHEMISTRY; METALLURGY
    • C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F1/00—Treatment of water, waste water, or sewage
    • C02F1/68—Treatment of water, waste water, or sewage by addition of specified substances, e.g. trace elements, for ameliorating potable water

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  • Life Sciences & Earth Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
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  • Animal Husbandry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
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Abstract

The invention provides a sustained-release tablet matrix and a preparation method and application thereof, wherein the preparation raw materials of the sustained-release tablet matrix comprise sodium alginate, an adhesive, a sweetener and water; the binder includes protein and complex cellulose. The matrix of the sustained-release tablet provided by the invention can slowly dissolve the nutrition additive contained in the sustained-release tablet into water while ensuring that the normal operation of a water dispenser and a filter element is not influenced, so that the concentration of the nutrition additive in drinking water of pets is stably maintained within a certain range.

Description

Sustained release tablet matrix and preparation method and application thereof
Technical Field
The invention belongs to the technical field of pet foods, and particularly relates to a sustained-release tablet matrix and a preparation method and application thereof.
Background
With the rise of the pet market, more and more pet health products or medicines are marketed along with the rise of the pet market. Among them, a large number of products are made into forms which are soluble in daily drinking water of pets, such as mouthwash, nutrition drops, etc., for facilitating the main feeding of pets. However, most of the pet drinking water machines in the market are matched with filter elements for purifying and filtering drinking water of pets, but simultaneously, nutrient substances or other effective components added into the drinking water of pets by pets are filtered, so that the products are invalid.
CN112806493a discloses a freeze-dried bone and meat staple food for dogs and cats added with sheep colostrum and selenium and a preparation method thereof. The freeze-dried bone and meat staple food for dogs and cats comprises the following components in parts by weight: 1-3 parts of sheep colostrum and sodium selenite microcapsule powder, 50-70 parts of meat, 10-20 parts of bone-in meat, 5-15 parts of animal liver, 5-8 parts of animal heart, 0.5-2 parts of core premix and 3-4 parts of fruit and vegetable mixture. The microcapsule technology is adopted to embed the sheep colostrum and the sodium selenite, so that the nutritional ingredients of the sheep colostrum and the sodium selenite are protected from being damaged in the processing process, and the aim of slow release is achieved, so that the bioavailability of the nutritional ingredients of the sheep colostrum and the sodium selenite is improved; however, the microcapsule technology adopted by the invention has complex operation and higher cost.
CN102550836a discloses a trace element composite package of animal nutrition additive, its preparation and application, the composite package is mainly composed of composite glycine polymineral, selenite and trace element basic salt, the composite glycine polymineral contains copper glycinate, ferrous glycinate, zinc glycinate, manganese glycinate, etc.; the basic salt of trace element contains at least one of basic chloride, basic carbonate or basic sulfate corresponding to trace element copper, zinc, manganese, etc. However, the animal nutrition additive trace element composite package is not suitable for the pet water dispenser, and the biological utilization rate of the animal nutrition additive trace element composite package in the pet water dispenser is not high.
Therefore, how to provide a sustained-release tablet matrix, which can slowly dissolve the nutrition additive contained in the sustained-release tablet into water while ensuring that the normal operation of a water dispenser and a filter element is not influenced, so that the concentration of the nutrition additive in drinking water of pets is stably maintained within a certain range, and the sustained-release tablet matrix becomes a problem to be solved urgently at present.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide a sustained-release tablet matrix, and a preparation method and application thereof. The matrix of the sustained-release tablet provided by the invention can slowly dissolve the nutrition additive contained in the sustained-release tablet into water while ensuring that the normal operation of a water dispenser and a filter element is not influenced, so that the concentration of the nutrition additive in drinking water of pets is stably maintained within a certain range.
To achieve the purpose, the invention adopts the following technical scheme:
In a first aspect, the present invention provides a sustained-release tablet matrix, wherein the preparation raw materials of the sustained-release tablet matrix comprise sodium alginate, an adhesive, a sweetener and water;
Wherein the binder comprises protein and complex cellulose.
In the invention, the protein and the compound cellulose are matched with each other to synergistically and jointly maintain the constancy of various nutrient substances in the dish of the pet drinking machine.
In the invention, the nutrition additive is loaded into the matrix of the sustained-release tablet and then is placed in a water storage tank of the pet drinking machine (a water tank of the pet drinking machine), so that the slow release of the nutrition substances can be realized; the water flows into the drinking water tray from the holes on the tray through the water pump, and the drunk water flows back into the water storage tank through the filter element and then returns to the tray again through the water pump; circulation of the water is achieved while the nutrient content of the water in the tray is maintained within a certain range.
In the invention, the preparation raw materials of the sustained-release tablet matrix comprise the following components in parts by weight:
Wherein the binder comprises protein and complex cellulose.
In the matrix of the sustained-release tablet of the present invention, the weight portion of sodium alginate is 0.01 to 95 parts, for example, 0.01 part, 0.1 part, 1 part, 5 parts, 10 parts, 15 parts, 20 parts, 25 parts, 30 parts, 35 parts, 40 parts, 45 parts, 50 parts, 55 parts, 60 parts, 65 parts, 70 parts, 75 parts, 80 parts, 85 parts, 90 parts, 95 parts, etc., preferably 20 to 30 parts.
In the matrix of the sustained-release tablet of the present invention, the binder may be 0.01 to 94 parts by weight, for example, 0.01 part, 0.1 part, 1 part, 5 parts, 10 parts, 15 parts, 20 parts, 25 parts, 30 parts, 35 parts, 40 parts, 45 parts, 50 parts, 55 parts, 60 parts, 65 parts, 70 parts, 75 parts, 80 parts, 85 parts, 90 parts, 95 parts, etc., preferably 50 to 70 parts.
In the matrix of the sustained-release tablet of the present invention, the weight part of the sweetener is 0.01 to 45 parts, for example, 0.01 part, 0.1 part, 1 part, 5 parts, 10 parts, 15 parts, 20 parts, 25 parts, 30 parts, 35 parts, 40 parts, 45 parts, etc., preferably 5 to 20 parts.
In the matrix of the sustained-release tablet of the present invention, the water may be 0.01 to 2 parts by weight, for example, 0.01 part, 0.02 part, 0.04 part, 0.06 part, 0.08 part, 0.1 part, 0.2 part, 0.4 part, 0.6 part, 0.8 part, 1 part, 1.2 part, 1.4 part, 1.6 part, 1.8 part, 2 parts, etc., preferably 0.5 to 1.5 parts.
In the present invention, the weight ratio of the protein to the complex cellulose is 1 (1-5), and may be, for example, 1:1, 1:1.5, 1:2, 1:2.5, 1:3, 1:3.5, 1:4, 1:4.5, 1:5, etc.
Preferably, the complex cellulose comprises sodium carboxymethyl cellulose and hydroxypropyl methylcellulose.
In the invention, sodium carboxymethyl cellulose and hydroxypropyl methyl cellulose are selected as composite cellulose, a layer of film can be formed on the surface of the nutrition additive, a certain protection effect is achieved on the nutrition additive, and a low-oxygen and high-carbon dioxide gas environment is formed between the film and the nutrition additive due to the existence of the film, so that the gas exchange rate and the material exchange rate are reduced, and the method is used for prolonging the release time of the nutrition additive.
Preferably, the weight ratio of sodium carboxymethyl cellulose to hydroxypropyl methyl cellulose is (0.5-1.5): 1, and may be, for example, 0.5:1, 0.6:1, 0.7:1, 0.8:1, 0.9:1, 1:1, 1.1:1, 1.2:1, 1.3:1, 1.4:1, 1.5:1, etc.
In the present invention, the protein comprises gelatin and/or sodium caseinate, preferably a combination of gelatin and sodium caseinate.
In the present invention, the combination of gelatin and sodium caseinate is selected as the protein, which has unique amphiphilic properties of both hydrophilicity and lipophilicity.
Preferably, the weight ratio of gelatin to sodium caseinate is (0.5-1.5): 1, which may be, for example, 0.5:1, 0.6:1, 0.7:1, 0.8:1, 0.9:1, 1:1, 1.1:1, 1.2:1, 1.3:1, 1.4:1, 1.5:1, etc.
In the present invention, the binder further comprises a polysaccharide.
Preferably, the polysaccharide comprises any one or a combination of at least two of modified starch, agar or heteropolysaccharide.
Preferably, the modified starch comprises any one or a combination of at least two of sodium starch phosphate, sodium carboxymethyl starch, hydroxypropyl starch, maltodextrin or beta-cyclodextrin.
Preferably, the heteropolysaccharide comprises any one or a combination of at least two of arabinogelatin, xanthan gum, pectin, tamarind gum, sesbania gum or carrageenan.
Preferably, the polysaccharide comprises 0.01-90% of the total weight of the binder, for example, 0.01%, 0.1%, 1%, 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, etc.
In the present invention, the sweetener includes any one or a combination of at least two of sugar, glycoside or sugar alcohol.
Preferably, the sugar comprises any one or a combination of at least two of monosaccharides, oligosaccharides or polysaccharides.
Preferably, the monosaccharide includes any one or a combination of at least two of glucose, fructose or xylose.
Preferably, the oligosaccharide comprises any one or a combination of at least two of sucrose, maltose, lactose, isomaltooligosaccharide, soybean oligosaccharide, fructooligosaccharide or high fructose syrup.
Preferably, the polysaccharide comprises one or a combination of at least two of inulin, glycogen, aloe polysaccharide or astragalus polysaccharide.
Preferably, the glycoside comprises any one or a combination of at least two of glycyrrhizin, stevioside or mogroside.
Preferably, the sugar alcohol comprises any one or a combination of at least two of sorbitol, maltitol or lactitol.
In a second aspect, the present invention provides a method for preparing a sustained-release tablet matrix according to the first aspect, the method comprising the steps of: mixing sodium alginate, adhesive, sweetener and water, and stirring to obtain the matrix of the sustained-release tablet.
In the present invention, the temperature of the stirring is 10 to 35 ℃, for example 10℃、11℃、12℃、13℃、14℃、15℃、16℃、17℃、18℃、19℃、20℃、21℃、22℃、23℃、24℃、25℃、26℃、27℃、28℃、29℃、30℃、31℃、32℃、33℃、34℃、35℃, etc.; the stirring speed is 100-400rpm, and may be 100rpm、120rpm、140rpm、160rpm、180rpm、200rpm、220rpm、240rpm、260rpm、280rpm、300rpm、320rpm、340rpm、360rpm、380rpm、400rpm, for example.
In the present invention, after the stirring, tabletting is also required.
In a third aspect, the present invention provides a use of a slow release matrix according to the first aspect for preparing a pet drinking fountain adapted product.
Compared with the prior art, the invention has the following beneficial effects:
(1) The matrix of the sustained-release tablet provided by the invention can be compatible with all pet water fountain filter elements in the market, and the normal operation of the water fountain and the filter elements is not affected;
(2) The sustained-release tablet matrix provided by the invention can slowly dissolve the nutrition additive contained in the sustained-release tablet matrix in water while providing safe and sanitary drinking water for pets, so as to ensure that the nutrition additive in the drinking water of the pets is maintained in a certain range before the sustained-release tablet is completely dissolved.
Detailed Description
The technical scheme of the invention is further described by the following specific embodiments. It will be apparent to those skilled in the art that the examples are merely to aid in understanding the invention and are not to be construed as a specific limitation thereof.
The sources of the components in the following examples are shown below:
Name of the name Manufacturer' s Number plate
Sodium alginate Microphone forest S817374
Gelatin Merck (Merck) 1288485
Casein acid sodium salt Merck (Merck) C8654
Sodium carboxymethyl cellulose Pigeon get BD120067
Hydroxypropyl methylcellulose Pigeon get BD46720
Xanthan gum Merck (Merck) 43708
Glucose Merck (Merck) Y0001745
Liquiritigenin Liquiritigenin BD136401
Sorbitol Merck (Merck) S1876
Cellulose Merck (Merck) 435236
Collagen Merck (Merck) C4243
Example 1
The embodiment provides a sustained-release tablet matrix, which is prepared from the following raw materials in parts by weight:
The preparation method of the sustained-release tablet matrix comprises the following steps:
(1) Adding sodium alginate, gelatin, sodium caseinate, sodium carboxymethylcellulose, hydroxypropyl methylcellulose, xanthan gum and glucose into a stirrer according to the formula amount, and uniformly mixing at 25 ℃ under 200rmp to obtain a mixture 1;
(2) Uniformly mixing the mixture 1 obtained in the step (1) with water at the temperature of 25 ℃ and 200rmp to obtain a mixture 2;
(3) And (3) loading the mixture 2 obtained in the step (2) into a tablet making machine, and tabletting to obtain the sustained-release tablet matrix.
Example 2
The embodiment provides a sustained-release tablet matrix, which is prepared from the following raw materials in parts by weight:
The preparation method of the sustained-release tablet matrix comprises the following steps:
(1) Adding sodium alginate, gelatin, sodium caseinate, sodium carboxymethylcellulose, hydroxypropyl methylcellulose, xanthan gum and glycyrrhizin into a stirrer according to the formula amount, and uniformly mixing at 25deg.C under 200rmp to obtain a mixture 1;
(2) Uniformly mixing the mixture 1 obtained in the step (1) with water at the temperature of 25 ℃ and 200rmp to obtain a mixture 2;
(3) And (3) loading the mixture 2 obtained in the step (2) into a tablet making machine, and tabletting to obtain the sustained-release tablet matrix.
Example 3
The embodiment provides a sustained-release tablet matrix, which is prepared from the following raw materials in parts by weight:
The preparation method of the sustained-release tablet matrix comprises the following steps:
(1) Adding sodium alginate, gelatin, sodium caseinate, sodium carboxymethylcellulose, hydroxypropyl methylcellulose, xanthan gum and sorbitol into a stirrer according to the formula amount, and uniformly mixing at 25deg.C and 200rmp to obtain a mixture 1;
(2) Uniformly mixing the mixture 1 obtained in the step (1) with water at the temperature of 25 ℃ and 200rmp to obtain a mixture 2;
(3) And (3) loading the mixture 2 obtained in the step (2) into a tablet making machine, and tabletting to obtain the sustained-release tablet matrix.
Examples 4 to 5
Examples 4-5 provide 2 sustained-release tablet matrices differing from example 1 only in that examples lacking sodium carboxymethylcellulose or hydroxypropyl methylcellulose are provided, respectively, and the preparation method is the same as that of example 1, and the sustained-release tablet matrices are prepared from the following raw materials in parts by weight:
Examples 6 to 7
Examples 6-7 provide 2 sustained-release tablet matrices differing from example 1 only in that examples lacking gelatin or sodium caseinate are provided, respectively, and the preparation method is the same as that of example 1, and the preparation raw materials of the sustained-release tablet matrices include the following components in parts by weight:
Examples 8 to 9
Examples 8-9 provide 2 sustained-release tablet matrices, which differ from example 1 only in that examples are provided in which the weight ratio of protein to complex cellulose in the binder is larger or smaller, respectively, the preparation method is the same as that of example 1, and the preparation raw materials of the sustained-release tablet matrices comprise the following components in parts by weight:
example 10
This example 1 provides a sustained-release tablet matrix differing from example 1 only in that the composite cellulose (sodium carboxymethyl cellulose and hydroxypropyl methylcellulose) was replaced with an equivalent weight fraction of cellulose (47.8 weight parts), and other preparation materials and preparation methods were the same as in example 1.
Example 11
This example provides a sustained-release tablet matrix which differs from example 1 only in that gelatin is replaced with an equivalent weight fraction of collagen, and other preparation materials and preparation methods are the same as in example 1.
Comparative example 1
This comparative example provides a matrix for sustained-release tablets which differs from example 1 only in that sodium alginate is not contained, and other preparation materials and preparation methods are the same as in example 1.
Comparative examples 2 to 4
Comparative examples 2-4 provide 3 sustained-release tablet matrices differing from example 1 only in that examples containing no protein, no complex cellulose or both protein and complex cellulose are provided, respectively, the preparation method is the same as that of example 1, and the preparation raw materials of the sustained-release tablet matrices include the following components in parts by weight:
Test case
Sustained release effect test
Test sample: examples 1-11 and comparative examples 1-4 provide sustained release tablet matrices
The testing method comprises the following steps: uniformly mixing 0.5g of concentrated vitamin complex powder for cats and 1.5g of sustained release tablet matrix, and then pressing into tablets to obtain the sustained release tablet for cats; a filter element is arranged in the pet water dispenser, and a circulating filtration system is started; adding the concentrated vitamin complex tablet for cats into a water storage tank (a water tank of the pet water dispenser) of the pet water dispenser; after 2 hours, 6 hours, 12 hours and 24 hours, detecting the content of various nutrient substances in the drinking water tray by adopting liquid chromatography;
Every 0.5g of concentrated composite vitamin powder for cats contains 6 mg of vitamin B, 9 mg of vitamin B, 12 mug of vitamin B and 1000mg of taurine; the water quantity in the water storage tank of the pet water fountain is maintained at 2L.
The results of the content test of various nutrients in the drinking water tray after 2 hours and 6 hours are shown in Table 1:
TABLE 1
As can be seen from the data in Table 1, the content of vitamin B 6 in 2 hours is 2-3.5mg/L by adopting the sustained-release tablet matrix provided by the invention (examples 1-11); the content of vitamin B 9 is 0.1-0.7mg/L; the content of vitamin B 12 is 0-0.01mg/L; the content of the taurine is 143-289mg/L; the content of vitamin B 6 in 6h is 2.6-4.5mg/L; the content of vitamin B 9 is 0.15-0.9mg/L; the content of vitamin B 12 is 0.01-0.02mg/L; the content of the taurine is 228-389mg/L; the sustained release tablet matrix provided by the preferred technical scheme (examples 1-3) is adopted, and the content of vitamin B 6 in 2 hours is 2-2.6mg/L; the content of vitamin B 9 is 0.1-0.15mg/L; the content of vitamin B 12 is 0.01mg/L; the content of the taurine is 143-180mg/L; the content of vitamin B 6 in 6h is 2.6-2.9mg/L; the content of vitamin B 9 is 0.15-0.2mg/L; the content of vitamin B 12 is 0.01mg/L; the content of taurine is 228-285mg/L.
The results of the content test of various nutrients in the drinking water tray after 12 hours and 24 hours are shown in Table 2:
TABLE 2
As can be seen from the data in Table 2, the content of vitamin B 6 in 12 hours is 1.5-3.2mg/L by adopting the sustained-release tablet matrix provided by the invention (examples 1-11); the content of vitamin B 9 is 0.18-0.6mg/L; the content of vitamin B 12 is 0.01-0.03mg/L; the content of the taurine is 176-298mg/L; the content of vitamin B 6 in 24h is 0.8-3.2mg/L; the content of vitamin B 9 is 1.3-3.1mg/L; the content of vitamin B 12 is 0-0.01mg/L; the content of the taurine is 112-295mg/L; the sustained release tablet matrix provided by the preferred technical scheme (examples 1-3) is adopted, and the content of vitamin B 6 in 12 hours is 3-3.2mg/L; the content of vitamin B 9 is 0.18-0.22mg/L; the content of vitamin B 12 is 0.01mg/L; the content of the taurine is 258-265mg/L; the content of vitamin B 6 in 24h is 2.9-3.2mg/L; the content of vitamin B 9 is 3-3.1mg/L; the content of vitamin B 12 is 0.01mg/L; the content of taurine is 264-295mg/L.
As can be seen from the comparison of examples 1-3 with other examples, the sustained release precipitation rates of examples 1-3 were most stable, and the nutrient content in the water was maintained at a relatively average level before the sustained release tablets were completely dissolved.
As is clear from the comparative examples of example 1 and examples 4 to 5, sodium carboxymethyl cellulose or hydroxypropyl methylcellulose are matched with each other to synergistically improve the slow release effect of the slow release tablet matrix.
As is evident from the comparison of examples 1 and examples 6-7, gelatin and sodium caseinate are matched with each other to synergistically improve the slow release effect of the slow release tablet matrix.
As is evident from the comparison of examples 1 and examples 8 to 9, the sustained-release tablet matrix exhibited excellent sustained-release effects only when the weight ratio of the protein to the complex cellulose was kept at 1 (1-5).
It is evident from a comparison of example 1 and examples 10 to 11 that the substitution of cellulose for complex cellulose or gelatin for collagen affects the slow release effect.
As is clear from the comparison of example 1 and comparative example 1, sodium alginate is an important factor affecting the sustained release effect.
As is evident from the comparison of example 1 and comparative examples 2 to 4, the protein and the complex cellulose are coordinated with each other, and synergistically enhanced, thereby improving the sustained-release effect.
The applicant states that the present invention is illustrated by the above examples as a matrix for sustained release tablets and a method for preparing the same and application thereof, but the present invention is not limited to the above examples, i.e. it is not meant that the present invention must be practiced by relying on the above examples. It should be apparent to those skilled in the art that any modification of the present invention, equivalent substitution of raw materials for the product of the present invention, addition of auxiliary components, selection of specific modes, etc., falls within the scope of the present invention and the scope of disclosure.

Claims (17)

1. The application of the sustained-release tablet matrix in preparing the pet drinking machine-adapted product is characterized in that the preparation raw materials of the sustained-release tablet matrix consist of sodium alginate, an adhesive, a sweetener and water;
Wherein the binder comprises protein and complex cellulose;
the weight ratio of the protein to the composite cellulose is 1 (2-5);
the protein consists of gelatin and sodium caseinate;
the weight ratio of the gelatin to the sodium caseinate is (0.5-1.5): 1;
the composite cellulose comprises sodium carboxymethyl cellulose and hydroxypropyl methyl cellulose;
The weight ratio of the sodium carboxymethyl cellulose to the hydroxypropyl methyl cellulose is (0.5-1.5): 1;
the nutrition additive is loaded into the slow release tablet matrix and then placed into a water storage tank of the pet drinking machine, so that the slow release of the nutrition substances is realized.
2. The use according to claim 1, wherein the slow release tablet matrix is prepared from the following components in parts by weight:
Sodium alginate 0.01-95 parts
0.01-95 Parts of adhesive
Sweetener 0.01-45 parts
0.01-2 Parts of water;
Wherein the binder comprises protein and complex cellulose.
3. The use according to claim 1, wherein the binder further comprises a polysaccharide.
4. The use according to claim 3, wherein the polysaccharide comprises any one or a combination of at least two of modified starch, agar or heteropolysaccharide.
5. The use according to claim 4, wherein the modified starch comprises any one or a combination of at least two of sodium starch phosphate, sodium carboxymethyl starch, hydroxypropyl starch, maltodextrin or beta-cyclodextrin.
6. The use according to claim 4, wherein the heteropolysaccharide comprises any one or a combination of at least two of arabinogelatin, xanthan gum, pectin, tamarind gum, sesbania gum or carrageenan.
7. Use according to claim 3, characterized in that the polysaccharide represents 0.01-90% of the total weight of the binder.
8. The use of claim 1, wherein the sweetener comprises any one or a combination of at least two of a sugar, a glycoside, or a sugar alcohol.
9. The use of claim 8, wherein the sugar comprises any one or a combination of at least two of a monosaccharide, an oligosaccharide, or a polysaccharide.
10. The use of claim 9, wherein the monosaccharide comprises any one or a combination of at least two of glucose, fructose, or xylose.
11. The use according to claim 9, wherein the oligosaccharide comprises any one or a combination of at least two of sucrose, maltose, lactose, isomaltooligosaccharide, soy oligosaccharide or fructooligosaccharide.
12. The use according to claim 9, wherein the polysaccharide comprises inulin.
13. The use of claim 8, wherein the glycoside comprises any one or a combination of at least two of glycyrrhizin, stevioside, or mogroside.
14. The use according to claim 8, wherein the sugar alcohol comprises any one or a combination of at least two of sorbitol, maltitol or lactitol.
15. The use according to claim 1, wherein the method of preparing the sustained release tablet matrix comprises the steps of: mixing sodium alginate, adhesive, sweetener and water, and stirring to obtain the matrix of the sustained-release tablet.
16. The use according to claim 15, wherein the stirring temperature is 10-35 ℃ and the stirring speed is 100-400 rpm.
17. The use according to claim 15, wherein after said stirring, tabletting is also required.
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