CN114072413A - 一种c-Myc蛋白抑制剂及其制备方法和用途 - Google Patents
一种c-Myc蛋白抑制剂及其制备方法和用途 Download PDFInfo
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Abstract
涉及一类c‑Myc蛋白抑制剂及其制备方法和用途，所述c‑Myc蛋白抑制剂可选择性的抑制c‑Myc蛋白，因此，可用于c‑Myc蛋白失调的相关疾病，如癌症、心脑血管疾病、病毒感染相关疾病等的预防和治疗。
Description
PCT国内申请，说明书已公开。
Claims (14)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2019106105851 | 2019-07-08 | ||
| CN201910610585 | 2019-07-08 | ||
| PCT/CN2020/100103 WO2021004391A1 (zh) | 2019-07-08 | 2020-07-03 | 一种c-Myc蛋白抑制剂及其制备方法和用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US20090099132A1 (en) * | 2007-10-16 | 2009-04-16 | Millennium Pharmaceuticals, Inc. | Proteasome inhibitors |
| US20140296307A1 (en) * | 2013-03-27 | 2014-10-02 | University Of Maryland, Baltimore | Potent analogues of the c-myc inhibitor 10074-g5 with improved cell permeability |
| CN107522700A (zh) * | 2017-08-03 | 2017-12-29 | 中山大学 | 一种喹唑啉酮与α，β‑不饱和酮轭合衍生物及其制备方法和应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090099132A1 (en) * | 2007-10-16 | 2009-04-16 | Millennium Pharmaceuticals, Inc. | Proteasome inhibitors |
| US20140296307A1 (en) * | 2013-03-27 | 2014-10-02 | University Of Maryland, Baltimore | Potent analogues of the c-myc inhibitor 10074-g5 with improved cell permeability |
| CN107522700A (zh) * | 2017-08-03 | 2017-12-29 | 中山大学 | 一种喹唑啉酮与α，β‑不饱和酮轭合衍生物及其制备方法和应用 |
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| JOANNE TAN ET AL.: "De Novo Design of Boron-Based Peptidomimetics as Potent Inhibitors of Human ClpP in the Presence of Human ClpX" * |
| MENG LEI ET AL.: "3D-QSAR-aided design, synthesis, in vitro and in vivo evaluation of dipeptidyl boronic acid proteasome inhibitors and mechanism studies" * |
| STANLEY C. XIE ET AL.: "Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome" * |
| YONGQIANG ZHU ET AL.: "Design, Synthesis, Biological Evaluation, and Structure-Activity Relationship (SAR) Discussion of Dipeptidyl Boronate Proteasome Inhibitors, Part I:Comprehensive Understanding of the SAR of r-Amino Acid Boronates" * |
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