CN114053365A - Traditional Chinese medicine composition for treating infertility and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating infertility and preparation method thereof Download PDFInfo
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- CN114053365A CN114053365A CN202111371961.XA CN202111371961A CN114053365A CN 114053365 A CN114053365 A CN 114053365A CN 202111371961 A CN202111371961 A CN 202111371961A CN 114053365 A CN114053365 A CN 114053365A
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- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The invention provides a traditional Chinese medicine composition for treating infertility and a preparation method thereof, and relates to the technical field of traditional Chinese medicines. A traditional Chinese medicine composition for treating infertility comprises the following raw materials in parts by weight: 5-15 parts of byssus purpurea, 5-15 parts of salvia miltiorrhiza, 3-10 parts of angelica, 5-15 parts of American ginseng, 5-10 parts of deerhorn glue, 5-15 parts of astragalus membranaceus, 3-8 parts of phyllanthus urinaria, 3-8 parts of tiger ginger and 5-15 parts of all-flower honey. The medicine prepared by the invention has the effects of tonifying kidney and qi, promoting blood circulation and enriching blood, warming channels and relieving pain, and tonifying qi and consolidating exterior, has obvious effects on infertility caused by female irregular menstruation, unsmooth qi and blood and deficiency of kidney yin, and has the effects of tonifying liver and kidney, tonifying yang and arresting seminal emission for male, so that the medicine can treat the infertility of male and female, has short treatment period, quick response, small toxic and side effects, high safety and obvious curative effect.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating infertility and a preparation method thereof.
Background
Infertility refers to the situation that couples of childbearing age do not take any contraceptive measures more than one year after marriage, and have normal sexual life without successful pregnancy, and is mainly divided into primary infertility and secondary infertility, wherein the primary infertility is never pregnant; the secondary infertility is infertility after once pregnancy. Infertility is a common problem, affecting approximately at least 10-15% of the fertile couples, and causes infertility that are divided into male infertility and female infertility. From the classification of female etiology, ovulation factors, fallopian tube factors, cervical factors and endometriosis are the main causes of female infertility. From the etiologic classification of andropathy, factors such as reduced spermatogenesis rate, factors of vas deferens, abnormal semen and sexual dysfunction are mainly included.
At present, the infertility is treated by taking western medicines or traditional Chinese medicines to condition body functions, the western medicines are easy to cause side effects such as body fatness, the treatment process is painful, and some traditional Chinese medicine formulas have certain curative effects, but the treatment process is long and the curative effect is not obvious.
Disclosure of Invention
The invention aims to provide the traditional Chinese medicine composition for treating the infertility, and the traditional Chinese medicine composition can effectively treat the infertility and has a remarkable effect.
The invention also aims to provide a preparation method of the traditional Chinese medicine composition for treating infertility, which has simple and convenient process and can fully exert the drug effects of the medicinal materials.
The technical problem to be solved by the invention is realized by adopting the following technical scheme.
On the one hand, the embodiment of the application provides a traditional Chinese medicine composition for treating infertility, which comprises the following raw materials in parts by weight: 5-15 parts of byssus purpurea, 5-15 parts of salvia miltiorrhiza, 3-10 parts of angelica, 5-15 parts of American ginseng, 5-10 parts of deerhorn glue, 5-15 parts of astragalus membranaceus, 3-8 parts of phyllanthus urinaria, 3-8 parts of tiger ginger and 5-15 parts of all-flower honey.
In another aspect, the present application provides a method for preparing a traditional Chinese medicine composition for treating infertility, comprising the following steps:
washing herba Chenopodii Hybridi with wine, pulverizing, and decocting Mel of various flowers with strong fire to viscous;
cleaning herba phyllanthi and rhizoma et radix Saxifragae, steaming with wine for 4-6 hr, soaking the rest raw materials in water, adding herba phyllanthi and rhizoma et radix Saxifragae, extracting with water for 2-4 times, and mixing the medicinal liquids;
adding herba Chenopodii Hybridi and Mel of various flowers into the above medicinal liquid, concentrating, and making into fluid extract;
adding adjuvants into the above fluid extract, drying, and making into general dosage form.
In the above examples, the efficacy of each raw material was as follows:
chengxing: sweet in taste and neutral in nature, has the effects of stopping bleeding and promoting blood circulation, and is mainly used for treating irregular menstruation, metrorrhagia and metrostaxis, hemoptysis, epistaxis, hematuria, sores and carbuncles and pyogenic infections;
red sage root: bitter taste, slightly cold nature, heart and liver meridian entered; has effects of removing blood stasis, relieving pain, promoting blood circulation, dredging channels, clearing heart fire, and relieving restlessness, and can be used for treating menoxenia, amenorrhea, dysmenorrhea, abdominal mass, thoracico-abdominal pain, pyretic arthralgia, pyocutaneous disease, swelling and pain, and vexation insomnia; hepatosplenomegaly, angina pectoris.
Chinese angelica: sweet and pungent in flavor and warm in nature, enters liver, heart and spleen channels, has the functions of replenishing blood and activating blood, regulating menstruation and relieving pain, and relaxing bowel, and is used for treating blood deficiency and chlorosis, dizziness and palpitation, irregular menstruation, amenorrhea and dysmenorrheal, deficiency cold and abdominal pain, intestinal dryness and constipation, rheumatic arthralgia, traumatic injury, carbuncle, cellulitis and pyocutaneous disease.
American ginseng: has sweet and slightly bitter taste and cool property, has the effects of invigorating qi, nourishing yin, clearing heat and promoting fluid production, and can be used for treating deficiency of qi and yin, internal heat, cough, phlegm and blood, asthenic fever, vexation and fatigue, diabetes, and xerostomia and dry throat.
Deer-horn glue: has sweet, salty and warm properties, has the effects of warming and nourishing liver and kidney, replenishing vital essence and nourishing blood, and is used for treating impotence, spermatorrhea, soreness and coldness of waist and knees, asthenia, emaciation, metrorrhagia, metrostaxis, hematochezia, hematuria, yin gangrene, swelling and pain, kidney qi deficiency, female uterus deficiency cold and leukorrhagia.
Astragalus root: sweet taste and warm nature, enters lung and spleen channels, has the efficacies of invigorating qi, consolidating exterior, promoting urination, expelling pus, healing sore and promoting granulation, and is used for qi deficiency and hypodynamia, poor appetite and loose stool, sinking of middle-jiao energy, chronic diarrhea and rectocele, hematochezia and metrorrhagia, exterior deficiency and spontaneous perspiration, qi deficiency and edema, carbuncle, cellulitis and ulceration difficulty, chronic ulceration difficulty, blood deficiency and flaccidity and jaundice, internal heat and thirst quenching.
All-flower honey: has effects of nourishing, clearing away heat and toxic materials, loosening bowel to relieve constipation, regulating functions of five internal organs, and tonifying deficiency.
Leaf bottom bead: sweet and bitter in taste, neutral in nature, and can be used for dispelling pathogenic wind, promoting blood circulation, invigorating kidney, and strengthening tendons. Can be used for treating facial paralysis, poliomyelitis sequelae, vertigo, deafness, neurasthenia, lethargy, and sexual impotence.
The tiger and ginger: sweet and pungent in flavor and neutral in nature, has the effects of tonifying spleen and lung, nourishing yin and tonifying kidney, promoting qi and blood circulation, astringing and stopping bleeding, and reducing swelling and detoxifying, and is used for treating spleen deficiency and poor appetite, lung deficiency cough, dizziness and body pain, spermatorrhea and night sweat, metrorrhagia and leukorrhagia, early stage of sore and furuncle, and scrofula.
Aiming at infertility, female infertility is infertility, male infertility is infertility, the basic conditions of conception are that male and female are vigorous in kidney qi, sex is sufficient, and conception vessels are sufficient, female is full of sperm and overflows when the month is short, and the two sexes are matched at proper time, so that sperm can be absorbed to form pregnancy. Therefore, the treatment of infertility is mainly based on kidney tonifying, the kidney stores essence and qi, and mainly plays roles in growth, development and reproduction, and attention is paid to the vigorous qi and blood and the balance of yin and yang. Therefore, the antler glue is adopted to warm and nourish liver and kidney, benefit essence and nourish blood, and the phyllanthus urinaria and the old ginger are adopted to nourish yin and tonify kidney, promote qi and activate blood; adopts Chenopodium hybridum to stop bleeding and activate blood, and Salvia miltiorrhiza Bunge and Angelica sinensis tonify blood, regulate menstruation and relieve pain; american ginseng and astragalus root are adopted to tonify qi and strengthen superficies, and are used for qi deficiency and yin deficiency, internal heat and thirst quenching; adopts all-flower honey to nourish five internal organs and tonify deficiency. The traditional Chinese medicine composition has the effects of treating both principal and secondary aspects of diseases by combining the medicines, mainly warming and nourishing the kidney, promoting qi and blood circulation and reinforcing deficiency, has the functions of tonifying the kidney and qi, promoting blood circulation and enriching the blood, warming channels and relieving pain, and tonifying qi and consolidating exterior by combining the medicines. The prescription can treat male and female infertility, has short treatment period, quick response, small toxic and side effects and high safety, and has obvious curative effect on the infertility.
On the basis of the prescription, the safflower with pungent taste and warm nature, which enters heart and liver meridians, can be added for activating blood and dredging channels, dissipating blood stasis and relieving pain, and is used for amenorrhea, dysmenorrhea, lochiorrhea, abdominal mass, traumatic injury and sore and ulcer swelling and pain. The safflower is combined with the salvia miltiorrhiza and the angelica, can smooth qi and blood of women, promote blood circulation to remove blood stasis, achieve the effects of nourishing liver and kidney, nourishing blood and regulating menstruation, and have obvious effects on the infertility caused by irregular menstruation, unsmooth qi and blood and deficiency of kidney yin of women.
Meanwhile, the male sex pheromone has the effects of tonifying liver and kidney, and tonifying yang and arresting seminal emission, on the basis of the formula, a male silkworm moth can be added, is salty in taste and warm in nature, has the effects of tonifying liver and kidney, and tonifying yang and arresting seminal emission, and is mainly used for treating impotence, spermatorrhea, whitish and turbid urine, hematuria, wounds, ulcers and scalds. The male Bombycis Mori and colla cornus cervi can be used for invigorating kidney, replenishing vital essence, warming and invigorating liver and kidney, and is suitable for male infertility caused by deficiency of liver and kidney, deficiency of kidney essence, and deficiency of both qi and blood, such as azoospermia, oligospermia, dead sperm, teratospermia, immune infertility, and sperm motility abnormality.
Compared with the prior art, the embodiment of the invention has at least the following advantages or beneficial effects:
the traditional Chinese medicine composition adopts the medicinal materials of chenopodium hybridum, salvia miltiorrhiza, angelica, American ginseng, antler glue, astragalus, phyllanthus urinaria, kadsura longepedunculata and all-flower honey as raw medicinal materials, has synergistic effects, mainly warms and nourishes kidney, promotes qi and blood circulation, and supplements deficiency, so that the traditional Chinese medicine composition treats both symptoms and root causes, has the effects of tonifying kidney and qi, promoting blood circulation and enriching blood, warming channels and relieving pain, invigorating qi and consolidating exterior, has obvious effects on female irregular menstruation, unsmooth qi and blood and infertility caused by deficiency of kidney yin, can nourish liver and kidney, nourish blood and regulate menstruation, has the effects of tonifying liver and tonifying yang and arresting seminal emission, and is suitable for male infertility caused by deficiency of liver and kidney, deficiency of kidney essence and deficiency of both qi and blood, such as azoospermia, oligospermia, necrospermia, teratospermia, immune infertility, abnormal sperm motility and the like. The prescription can treat male and female infertility, has short treatment period, quick response, small toxic and side effects and high safety, and has obvious curative effect on the infertility.
In addition, the preparation method of the invention has simple and convenient flow, can relax the drug property after steaming with wine, enhances the effects of promoting blood circulation and removing meridian obstruction, can fully exert the drug effects of various medicinal materials after repeated water extraction, can extract more beneficial substances in the raw medicinal materials after concentrating into clear paste, improves the proportion of the beneficial substances in the finished product, is convenient to prepare pills, granules, tablets and the like in the follow-up manner after adding auxiliary materials, is convenient to carry and take, and has good treatment effect.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present invention will be described in detail below with reference to specific examples.
The embodiment of the invention provides a traditional Chinese medicine composition for treating infertility, which comprises the following raw materials in parts by weight: 5-15 parts of byssus purpurea, 5-15 parts of salvia miltiorrhiza, 3-10 parts of angelica, 5-15 parts of American ginseng, 5-10 parts of deerhorn glue, 5-15 parts of astragalus membranaceus, 3-8 parts of phyllanthus urinaria, 3-8 parts of tiger ginger and 5-15 parts of all-flower honey.
In the embodiment, the traditional Chinese medicine composition adopts chenopodium hybridum, salvia miltiorrhiza, angelica, American ginseng, antler glue, astragalus, phyllanthus urinaria, kadsura longepedunculata and all-flower honey as raw medicinal materials, has synergistic effects, mainly has the effects of warming and nourishing kidney, promoting qi and blood circulation, and tonifying deficiency, so that the traditional Chinese medicine composition treats both principal and secondary aspects of diseases, has the effects of tonifying kidney and qi, promoting blood circulation and enriching blood, warming channels and relieving pain, and tonifying qi and consolidating exterior, has obvious effects on female irregular menstruation, unsmooth qi and blood and infertility caused by deficiency of kidney yin, can nourish liver and kidney, nourish blood and regulate menstruation, has the effects of tonifying liver and kidney, tonifying yang and arresting seminal emission, and is suitable for male infertility caused by deficiency of liver and kidney, deficiency of kidney essence, deficiency of qi and blood, azoospermia plurality of dead sperms, teratospermia, immune infertility, abnormal sperm motility and the like. The prescription can treat male and female infertility, has short treatment period, quick response, small toxic and side effects and high safety, and has obvious curative effect on the infertility.
In some embodiments of the present invention, the raw materials are used in the following amounts by weight: 8-12 parts of Chenopodium hybridum, 8-12 parts of Salvia miltiorrhiza, 5-8 parts of Angelica sinensis, 8-12 parts of American ginseng, 8-12 parts of antler glue, 8-12 parts of Astragalus membranaceus, 5-6 parts of phyllanthus urinaria, 5-6 parts of rhizoma kadsurae japonicae and 8-12 parts of all-flower honey. In the above examples, the drug effect can be better achieved by further determining the amount of the raw materials to achieve better therapeutic effects.
In some embodiments of the present invention, the composition further comprises 5 to 15 parts by weight of male silkworm moth. In the above embodiments, a male silkworm moth with salty taste and warm nature can be added on the basis of the formula, has the functions of tonifying liver and kidney, tonifying yang and arresting seminal emission, and is mainly used for treating impotence, spermatorrhea, whitish and turbid urine, hematuria, wounds, ulcers and scalds. The male Bombycis Mori and colla cornus cervi can be used for invigorating kidney, replenishing vital essence, warming and invigorating liver and kidney, and is suitable for male infertility caused by deficiency of liver and kidney, deficiency of kidney essence, and deficiency of both qi and blood, such as azoospermia, oligospermia, dead sperm, teratospermia, immune infertility, and sperm motility abnormality.
In some embodiments of the present invention, the composition further comprises 3 to 10 parts by weight of safflower. In the above embodiments, on the basis of the prescription, safflower, which is pungent in flavor, warm in nature, enters heart and liver meridians, has the functions of activating blood and dredging meridians, and removing blood stasis and relieving pain, and can be used for treating amenorrhea, dysmenorrhea, lochiorrhea, abdominal mass, traumatic injury, sore and ulcer with swelling and pain. The safflower is combined with the salvia miltiorrhiza and the angelica, can smooth qi and blood of women, promote blood circulation to remove blood stasis, achieve the effects of nourishing liver and kidney, nourishing blood and regulating menstruation, and have obvious effects on the infertility caused by irregular menstruation, unsmooth qi and blood and deficiency of kidney yin of women.
In some embodiments of the present invention, the composition further comprises an auxiliary material, wherein the auxiliary material comprises 40-50 parts by weight of starch and 2.0-2.5 parts by weight of dextrin. In the above embodiments, starch and dextrin are added as auxiliary materials, so that the Chinese medicinal composition can be dried and then prepared into pills, tablets, granules or other dosage forms.
The embodiment of the invention also provides a preparation method of the traditional Chinese medicine composition for treating infertility, which comprises the following steps:
washing herba Chenopodii Hybridi with wine, pulverizing, and decocting Mel of various flowers with strong fire to viscous; cleaning herba phyllanthi and rhizoma et radix Saxifragae, steaming with wine for 4-6 hr, soaking the rest raw materials in water, adding herba phyllanthi and rhizoma et radix Saxifragae, extracting with water for 2-4 times, and mixing the medicinal liquids; adding herba Chenopodii Hybridi and Mel of various flowers into the above medicinal liquid, concentrating, and making into fluid extract; adding adjuvants into the above fluid extract, drying, and making into general dosage form.
In the embodiment, the preparation method is simple and convenient in flow, the medicine property can be relieved after the wine steaming, the effects of promoting blood circulation and removing meridian obstruction are enhanced, the medicine effects of various medicinal materials can be fully exerted after the repeated water extraction, more beneficial substances in the raw medicinal materials can be extracted after the wine steaming is concentrated into clear paste, the proportion of the beneficial substances in the finished product is improved, auxiliary materials are added and then the paste is dried, the paste can be conveniently and subsequently prepared into pills, granules, tablets and the like, the carrying and the taking are convenient, and the prepared medicine has a good treatment effect.
In some embodiments of the present invention, the size of the crushed Chenopodium hybridum is 100-150 mesh. In the above examples, the blood is crushed to this size, which removes excess impurities and facilitates the extraction of more beneficial substances in subsequent steps.
In some embodiments of the invention, the water extraction temperature is 90-100 ℃ and the water extraction time is 2.8-3.2 h each time the water extraction is performed. In the above embodiment, the water extraction time and the water extraction temperature are limited, so that the beneficial substances in the raw medicinal materials can be sufficiently extracted, and the drug effect can be sufficiently exerted.
In some embodiments of the invention, the fluid extract has a relative density of 1.08-1.18 at 48-55 ℃. In the above embodiment, the concentration of the liquid medicine can further increase the concentration of the medicine, enhance the efficacy, and simultaneously facilitate the preparation of other dosage forms.
In some embodiments of the invention, the drying temperature is 55-65 ℃ and the drying time is 40-60 min. In the embodiment, the auxiliary materials are added into the clear paste and then the clear paste is dried at a low temperature, the water is easily lost too fast when the drying temperature is too high, and some volatile beneficial substances are volatilized.
The features and properties of the present invention are described in further detail below with reference to examples.
Example 1
A traditional Chinese medicine composition for treating infertility is prepared by the following steps:
washing 10g of Hyunda procumbens with wine, and pulverizing into 120-mesh powder, decocting 10g of honey of various flowers with strong fire to obtain viscous powder;
cleaning 5g of phyllanthus urinaria and 5g of kadsura longepedunculata and steaming with wine for 5h, adding water into 10g of salvia miltiorrhiza, 7g of angelica, 10g of American ginseng, 7g of deerhorn glue and 10g of astragalus root for soaking, adding the phyllanthus urinaria and the kadsura longepedunculata steamed with wine, carrying out water extraction for 3 times, wherein the water extraction temperature is 100 ℃ and the water extraction time is 3.0h when water extraction is carried out for each time, and combining liquid medicines after the water extraction for 3 times;
adding herba Chenopodii Hybridi and Mel of various flowers into the above medicinal liquid, concentrating to obtain fluid extract with relative density of 1.10 at 50 deg.C;
adding starch 45g and dextrin 2.2g into the above fluid extract, drying, and making into granule, wherein the drying temperature is 60 deg.C, and the drying time is 50 min.
Example 2
A traditional Chinese medicine composition for treating infertility is prepared by the following steps:
washing 10g of Hyunda procumbens with wine, and pulverizing into 120-mesh powder, decocting 10g of honey of various flowers with strong fire to obtain viscous powder;
cleaning 5g of phyllanthus urinaria and 5g of saxifrage japonica and steaming with wine for 5h, adding 10g of salvia miltiorrhiza, 7g of angelica, 10g of American ginseng, 7g of deerhorn glue, 10g of astragalus and 10g of male silkworm moth into water for soaking, adding the phyllanthus urinaria and the saxifrage japonica steamed with wine, carrying out water extraction for 3 times, wherein the water extraction temperature is 100 ℃ and the water extraction time is 3.0h when water extraction is carried out for each time, and combining liquid medicines obtained after the water extraction for 3 times;
adding herba Chenopodii Hybridi and Mel of various flowers into the above medicinal liquid, concentrating to obtain fluid extract with relative density of 1.10 at 50 deg.C;
adding starch 45g and dextrin 2.2g into the above fluid extract, drying, and making into pill at 60 deg.C for 50 min.
The medicine prepared in the embodiment is mainly used for treating male infertility.
Example 3
A traditional Chinese medicine composition for treating infertility is prepared by the following steps:
washing 10g of Hyunda procumbens with wine, and pulverizing into 120-mesh powder, decocting 10g of honey of various flowers with strong fire to obtain viscous powder;
cleaning 5g of phyllanthus urinaria and 5g of saxifrage ginger, steaming the cleaned phyllanthus urinaria and 5g of saxifrage ginger for 5 hours, adding 10g of salvia miltiorrhiza, 7g of angelica, 10g of American ginseng, 7g of deerhorn glue, 10g of astragalus and 7g of safflower into water, soaking the soaked phyllanthus urinaria and saxifrage ginger, carrying out water extraction for 3 times, wherein the water extraction temperature is 100 ℃ and the water extraction time is 3.0 hours each time, and combining liquid medicines obtained after the 3 times of water extraction;
adding herba Chenopodii Hybridi and Mel of various flowers into the above medicinal liquid, concentrating to obtain fluid extract with relative density of 1.10 at 50 deg.C;
adding starch 45g and dextrin 2.2g into the above fluid extract, drying, and making into pill at 60 deg.C for 50 min.
The medicine prepared by the embodiment is mainly used for treating female infertility.
Example 4
A traditional Chinese medicine composition for treating infertility is prepared by the following steps:
washing 5g of Hyunda procumbens with wine, pulverizing into powder with a particle size of 100 meshes, and decocting 5g of honey of various flowers with strong fire to be viscous for later use;
cleaning 3g of phyllanthus urinaria and 3g of saxifrage japonica thumb, steaming with wine for 4h, soaking 5g of salvia miltiorrhiza, 3g of angelica sinensis, 5g of American ginseng, 5g of deerhorn glue, 5g of astragalus mongholicus and 3g of safflower carthamus in water, adding the phyllanthus urinaria and the saxifrage thumb steamed with wine, performing water extraction for 2 times, wherein the water extraction temperature is 90 ℃ and the water extraction time is 3.2h when water extraction is performed for each time, and combining liquid medicines after the water extraction for 2 times;
adding herba Chenopodii Hybridi and Mel of various flowers into the above medicinal liquid, concentrating to obtain fluid extract with relative density of 1.18 at 48 deg.C;
adding starch 40g and dextrin 2.0g into the above fluid extract, drying, and making into pill at 55 deg.C for 60 min.
The medicine prepared by the embodiment is mainly used for treating female infertility.
Example 5
A traditional Chinese medicine composition for treating infertility is prepared by the following steps:
washing 5g of Hyunda procumbens with wine, pulverizing into powder with a particle size of 100 meshes, and decocting 5g of honey of various flowers with strong fire to be viscous for later use;
cleaning 3g of phyllanthus urinaria and 3g of saxifrage japonica, steaming with wine for 4h, adding 5g of salvia miltiorrhiza, 3g of angelica, 5g of American ginseng, 5g of deerhorn glue, 5g of astragalus and 5g of male silkworm moth into water for soaking, adding the phyllanthus urinaria and the saxifrage japonica steamed with wine, carrying out water extraction for 2 times, wherein the water extraction temperature is 90 ℃ and the water extraction time is 3.2h when water extraction is carried out for each time, and combining liquid medicines obtained after 2 times of water extraction;
adding herba Chenopodii Hybridi and Mel of various flowers into the above medicinal liquid, concentrating to obtain fluid extract with relative density of 1.18 at 48 deg.C;
adding starch 40g and dextrin 2.0g into the above fluid extract, drying, and making into pill at 55 deg.C for 60 min.
The medicine prepared in the embodiment is mainly used for treating male infertility.
Example 6
A traditional Chinese medicine composition for treating infertility is prepared by the following steps:
washing 15g of Hyunda procumbens with wine, and pulverizing into 150-mesh powder, decocting 15g of honey of various flowers with strong fire to be viscous for later use;
cleaning 8g of phyllanthus urinaria and 8g of saxifrage japonica and steaming with wine for 6h, soaking 15g of salvia miltiorrhiza, 10g of angelica, 15g of American ginseng, 10g of deerhorn glue, 15g of astragalus and 10g of safflower in water, adding the phyllanthus urinaria and the saxifrage japonica which are steamed with wine, carrying out water extraction for 4 times, wherein the water extraction temperature is 100 ℃ and the water extraction time is 2.8h when water extraction is carried out for each time, and combining liquid medicines obtained after the water extraction for 4 times;
adding herba Chenopodii Hybridi and Mel of various flowers into the above medicinal liquid, concentrating to obtain fluid extract with relative density of 1.08 at 55 deg.C;
adding starch 50g and dextrin 2.5g into the above fluid extract, drying, and making into tablet, wherein the drying temperature is 65 deg.C, and the drying time is 40 min.
The medicine prepared by the embodiment is mainly used for treating female infertility.
Example 7
A traditional Chinese medicine composition for treating infertility is prepared by the following steps:
washing 15g of Hyunda procumbens with wine, and pulverizing into 150-mesh powder, decocting 15g of honey of various flowers with strong fire to be viscous for later use;
cleaning 8g of phyllanthus urinaria and 8g of saxifrage japonica, steaming with wine for 6h, adding 15g of salvia miltiorrhiza, 10g of angelica, 15g of American ginseng, 10g of deerhorn glue, 15g of astragalus and 15g of male silkworm moth, soaking in water, adding the phyllanthus urinaria and the saxifrage japonica steamed with wine, carrying out water extraction for 4 times, wherein the water extraction temperature is 100 ℃ and the water extraction time is 2.8h when water extraction is carried out for each time, and combining liquid medicines obtained after 4 times of water extraction;
adding herba Chenopodii Hybridi and Mel of various flowers into the above medicinal liquid, concentrating to obtain fluid extract with relative density of 1.08 at 55 deg.C;
adding starch 50g and dextrin 2.5g into the above fluid extract, drying, and making into tablet, wherein the drying temperature is 65 deg.C, and the drying time is 40 min.
The medicine prepared in the embodiment is mainly used for treating male infertility.
Examples of the experiments
200 cases of infertility patients are selected, wherein 100 cases of male patients and 100 cases of female patients are selected, the male patients are aged 22-60 years and the female patients are aged 19-45 years, and the patients all accord with the diagnosis standard of infertility, namely, couples live for 2 years and have normal sexual life and are not contraceptive but are never pregnant; or one who had been pregnant and then not contraceptive for 2 consecutive years. Male patients and female patients were divided into 5 groups of 20 patients each, and the grouping and medication were as follows:
control group 1: administering 3g of radix et rhizoma Rhei and Eupolyphaga Seu Steleophaga pill (prepared from Peking Cochinotang) and 10g of FU HUNG GONG pill (prepared from Tianjin Chinese medicinal materials) 1 time per day;
female group 1: 2.5g of the medicine prepared in the embodiment 1 of the invention is taken for 3 times in 1 day;
female 2 groups: 2.5g of the medicine prepared in the embodiment 3 of the invention is taken for 3 times in 1 day;
female 3 groups: 2.5g of the medicine prepared in the embodiment 4 of the invention is taken for 3 times in 1 day;
women 4 groups: 2.5g of the medicine prepared in the embodiment 6 of the invention is taken for 3 times in 1 day;
control group 2: administering Zanyudan (manufactured by Bozhou Huasheng Biotech Co., Ltd.) 3g each time for 2 times 1 day;
male 1 group: 2.5g of the medicine prepared in the embodiment 1 of the invention is taken for 3 times in 1 day;
male 2 groups: 2.5g of the medicine prepared in the embodiment 2 of the invention is taken for 3 times in 1 day;
male 3 groups: 2.5g of the medicine prepared in the embodiment 5 of the invention is taken for 3 times in 1 day;
male 4 groups: 2.5g of the medicine prepared in the embodiment 7 of the invention is taken for 3 times in 1 day;
each group takes 3 months as 1 course of treatment, the administration is stopped after 2 courses of continuous administration, and the conception condition and the concurrent symptom improvement condition of the tested patient within two years are recorded. The clinical curative effect adopts three-level evaluation of recovery, effectiveness and ineffectiveness.
The criteria for efficacy assessment are as follows:
and (3) healing: conception within 2 years, normal physical signs, symptoms and test indexes;
the method has the following advantages: the symptoms, signs and test indexes related to the disease are improved although the disease is not pregnant;
and (4) invalidation: the symptoms, physical signs and test indexes are not improved.
The total effective rate (cure + effective)/total number of people x 100%, and the therapeutic effect is shown in table 1.
TABLE 1
| Group of | Recovery (human) | Effective (human) | Invalid (human) | Total effective rate (%) |
| Control group 1 | 13 | 3 | 4 | 80％ |
| Female 1 group | 15 | 2 | 3 | 85％ |
| Female 2 groups | 18 | 1 | 1 | 95％ |
| Female 3 groups | 16 | 2 | 2 | 90％ |
| Female 4 groups | 17 | 1 | 2 | 90％ |
| Control group 2 | 11 | 4 | 5 | 75％ |
| Male 1 group | 14 | 3 | 3 | 85％ |
| Male 2 groups | 17 | 2 | 1 | 95％ |
| Male 3 groups | 15 | 2 | 3 | 85％ |
| Male 4 groups | 14 | 2 | 4 | 80％ |
As can be seen from Table 1, after the medicine is continuously taken for 2 courses of treatment, the total effective rate of the medicine prepared by the invention for treating female patients can reach more than 85%, and the total effective rate of male patients can reach more than 80%, and compared with the treatment of the traditional Chinese medicine prescription, the effective rate is higher, which shows that the medicine prepared by the invention has better curative effect on male and female infertility patients.
The following are some typical cases:
jinzhi, male, 34 years old, no son after 11 years of marriage, the sperm motility rate detected by hospital is 22.58%, 60% lower than the normal value, the sperm density is 3.52 million/ml, 20 million/ml lower than the normal value, the sperm motility rate is increased to 75.13% after half a year of medicine taking, the sperm density is increased to 22.47 million/ml, and a boy is obtained after 1 and half years of medicine stopping.
Rong and certain, female, 28 years old, infertility, premenstrual hypogastric pain, severe pain, tenderness, obesity, dizziness, heavy sensation in the chest, nausea, vomiting, excessive phlegm, leukorrhagia, and sticky white matter. After taking the medicine prepared by the invention for 3 weeks, the bellyache in menstrual period is relieved, the menstruation is recovered to be normal, the medicine is stopped after taking the medicine for 1 treatment course, the medicine is pregnant after three months of medicine stopping, and the hind paw is born as a baby girl.
Girl is a certain woman, 30 years old, infertility 5 years after marriage, no history of obvious dysmenorrhea, soreness and weakness of waist and knees, dizziness and hypodynamia, pale red tongue, thin and white fur, and deep and weak pulse. After taking the medicine prepared by the invention for 1 course of treatment, various symptoms are obviously improved, and the medicine is stopped after taking the medicine for 2 courses of treatment, and the pregnant woman and the baby are born after half a year of medicine stopping.
In conclusion, the invention provides a traditional Chinese medicine composition for treating infertility, which adopts chenopodium hybridum, salvia miltiorrhiza, angelica, American ginseng, deerhorn glue, astragalus, phyllanthus urinaria, ginger of tiger and all-flower honey as raw medicinal materials, the raw medicinal materials have synergistic interaction, the deerhorn glue warms and tonifies liver and kidney, benefits essence and nourishes blood, the phyllanthus urinaria and the ginger of tiger nourish yin and tonify kidney, promote qi and activate blood; the blood is stopped and is activated, and the salvia miltiorrhiza and the angelica enrich the blood, regulate menstruation and relieve pain; american ginseng and astragalus root are used for tonifying qi and strengthening superficies to treat deficiency of qi and yin, internal heat and diabetes; baihua honey is used for regulating five internal organs and tonifying deficiency. The traditional Chinese medicine composition has the effects of tonifying kidney and qi, promoting blood circulation and enriching blood, warming meridians and relieving pain, and tonifying qi and consolidating exterior, has obvious effects on infertility caused by irregular menstruation, unsmooth qi and blood and deficiency of kidney-yin of women, can nourish liver and kidney, nourish blood and regulate menstruation, has the effects of tonifying liver and kidney and tonifying yang and astringing sperm, and is suitable for male infertility caused by deficiency of liver and kidney, deficiency of kidney-essence and deficiency of both qi and blood, such as azoospermia, oligospermia, necrospermia, teratospermia, immune infertility, sperm motility abnormality and the like. The prescription can treat male and female infertility, has short treatment period, quick response, small toxic and side effects and high safety, and has obvious curative effect on the infertility.
In addition, the invention also provides a preparation method of the traditional Chinese medicine composition for treating infertility, the preparation method has simple flow, the efficacy of each medicinal material can be fully exerted after three times of repeated water extraction, more beneficial substances in the raw medicinal materials can be extracted after the raw medicinal materials are concentrated into clear paste, the proportion of the beneficial substances in the finished product is improved, auxiliary materials are added for drying, the preparation method is convenient for subsequent preparation of pills, granules, tablets and the like, the carrying and the taking are convenient, and the prepared medicine has good treatment effect.
The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Claims (10)
1. The traditional Chinese medicine composition for treating infertility is characterized by comprising the following raw materials in parts by weight: 5-15 parts of byssus purpurea, 5-15 parts of salvia miltiorrhiza, 3-10 parts of angelica, 5-15 parts of American ginseng, 5-10 parts of deerhorn glue, 5-15 parts of astragalus membranaceus, 3-8 parts of phyllanthus urinaria, 3-8 parts of tiger ginger and 5-15 parts of all-flower honey.
2. The traditional Chinese medicine composition for treating infertility according to claim 1, wherein the raw materials are used in the following amounts by weight: 8-12 parts of Chenopodium hybridum, 8-12 parts of Salvia miltiorrhiza, 5-8 parts of Angelica sinensis, 8-12 parts of American ginseng, 8-12 parts of antler glue, 8-12 parts of Astragalus membranaceus, 5-6 parts of phyllanthus urinaria, 5-6 parts of rhizoma kadsurae japonicae and 8-12 parts of all-flower honey.
3. The traditional Chinese medicine composition for treating infertility according to claim 2, further comprising 5-15 parts by weight of male silkworm moth.
4. The traditional Chinese medicine composition for treating infertility according to claim 2, further comprising 3 to 10 parts by weight of safflower.
5. The Chinese medicinal composition for treating infertility according to any one of claims 2 to 4, further comprising an adjuvant, wherein the adjuvant comprises 40 to 50 parts by weight of starch and 2.0 to 2.5 parts by weight of dextrin.
6. A method for preparing the Chinese medicinal composition for treating infertility according to any of claims 1 to 5, comprising the steps of:
washing herba Chenopodii Hybridi with wine, pulverizing, and decocting Mel of various flowers with strong fire to viscous;
cleaning herba phyllanthi and rhizoma et radix Saxifragae, steaming with wine for 4-6 hr, soaking the rest raw materials in water, adding herba phyllanthi and rhizoma et radix Saxifragae, extracting with water for 2-4 times, and mixing the medicinal liquids;
adding herba Chenopodii Hybridi and Mel of various flowers into the medicinal liquid, concentrating, and making into fluid extract;
adding adjuvants into the fluid extract, drying, and making into general dosage form.
7. The method for preparing a Chinese medicinal composition for the treatment of infertility according to claim 6, wherein the particle size of the crushed Chenopodium hybridum is 100-150 mesh.
8. The method for preparing a Chinese medicinal composition for the treatment of infertility according to claim 6, wherein the water extraction temperature is 90-100 ℃ and the water extraction time is 2.8-3.2 h each time the water extraction is performed.
9. The preparation method of the Chinese medicinal composition for treating infertility according to claim 6, wherein the fluid extract has a relative density of 1.08-1.18 at 48-55 ℃.
10. The method for preparing a Chinese medicinal composition for the treatment of infertility according to claim 9, wherein the drying temperature is 55-65 ℃ and the drying time is 40-60 min.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104544112A (en) * | 2014-12-05 | 2015-04-29 | 广州至信中药饮片有限公司 | Ginseng, American ginseng, Danshen roots and carp-based medicinal diet for tonifying kidney and preparation method thereof |
| CN113769004A (en) * | 2021-10-30 | 2021-12-10 | 浙江养和健康管理科技有限公司 | Traditional Chinese medicine composition for treating endometriosis and preparation method thereof |
-
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104544112A (en) * | 2014-12-05 | 2015-04-29 | 广州至信中药饮片有限公司 | Ginseng, American ginseng, Danshen roots and carp-based medicinal diet for tonifying kidney and preparation method thereof |
| CN113769004A (en) * | 2021-10-30 | 2021-12-10 | 浙江养和健康管理科技有限公司 | Traditional Chinese medicine composition for treating endometriosis and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 黄冬梅，等: "补肾益气和血方对胚泡着床障碍小鼠子宫内膜腺体凋亡的影响", 《中国中西医结合杂志》 * |
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