CN114040767A - 用于治疗心理、认知、行为和/或情绪障碍的包含5ht受体激动剂的方法和组合物 - Google Patents
用于治疗心理、认知、行为和/或情绪障碍的包含5ht受体激动剂的方法和组合物 Download PDFInfo
- Publication number
- CN114040767A CN114040767A CN202080027002.3A CN202080027002A CN114040767A CN 114040767 A CN114040767 A CN 114040767A CN 202080027002 A CN202080027002 A CN 202080027002A CN 114040767 A CN114040767 A CN 114040767A
- Authority
- CN
- China
- Prior art keywords
- pharmaceutically acceptable
- less
- disorder
- pharmaceutical composition
- receptor agonist
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5123—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
- A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Psychiatry (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Inorganic Chemistry (AREA)
- Physics & Mathematics (AREA)
- Nanotechnology (AREA)
- Optics & Photonics (AREA)
- Biochemistry (AREA)
- Emergency Medicine (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Addiction (AREA)
- Biophysics (AREA)
- Dispersion Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962798998P | 2019-01-30 | 2019-01-30 | |
| US201962799010P | 2019-01-30 | 2019-01-30 | |
| US62/799,010 | 2019-01-30 | ||
| US62/798,998 | 2019-01-30 | ||
| PCT/IB2020/000052 WO2020157569A1 (en) | 2019-01-30 | 2020-01-29 | Methods and compositions comprising a 5ht receptor agonist for the treatment of psychological, cognitive, behavioral, and/or mood disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114040767A true CN114040767A (zh) | 2022-02-11 |
Family
ID=71841404
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202080027002.3A Pending CN114040767A (zh) | 2019-01-30 | 2020-01-29 | 用于治疗心理、认知、行为和/或情绪障碍的包含5ht受体激动剂的方法和组合物 |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US20220096504A1 (https=) |
| EP (1) | EP3917537A4 (https=) |
| JP (2) | JP2022523700A (https=) |
| KR (1) | KR20210134313A (https=) |
| CN (1) | CN114040767A (https=) |
| AU (2) | AU2020215150B8 (https=) |
| BR (1) | BR112021014750A2 (https=) |
| CA (1) | CA3127854A1 (https=) |
| IL (1) | IL285186A (https=) |
| MA (1) | MA54877A (https=) |
| MX (2) | MX2021009037A (https=) |
| WO (1) | WO2020157569A1 (https=) |
Families Citing this family (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102874080B1 (ko) | 2016-07-07 | 2025-10-23 | 하워드 휴즈 메디컬 인스티튜트 | 변형된 리간드-게이팅 이온 채널 및 사용 방법 |
| US12459965B2 (en) | 2017-10-09 | 2025-11-04 | Compass Pathfinder Limited | Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use |
| GB2571696B (en) | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
| JP2021502101A (ja) | 2017-11-10 | 2021-01-28 | ハワード ヒューズ メディカル インスティチュート | 修飾されたリガンド依存性イオンチャネルおよび使用の方法 |
| EP4219498A1 (en) * | 2019-03-07 | 2023-08-02 | Arbormentis LLC | Compositions and methods of use comprising substances with neural plasticity actions administered at non-psychedelic / psychotomimetic dosages and formulations |
| KR20220009954A (ko) | 2019-04-17 | 2022-01-25 | 컴퍼스 패쓰파인더 리미티드 | 신경인지 장애, 만성 통증을 치료하고 염증을 감소시키는 방법 |
| EP4003395A4 (en) * | 2019-07-23 | 2023-07-19 | Caamtech, Inc. | COMPOSITIONS WITH TOAD SECRETION COMPOUNDS |
| CN114787363A (zh) | 2019-10-01 | 2022-07-22 | 恩派瑞安神经科学公司 | 对真菌进行遗传工程化以调节色胺表达 |
| CN114650809A (zh) | 2019-10-03 | 2022-06-21 | 斯塔顿治疗公司 | 屈大麻酚的透皮递送 |
| US12409131B2 (en) | 2019-10-03 | 2025-09-09 | Pike Therapeutics Usa, Inc. | Transdermal delivery of dronabinol |
| US12016829B2 (en) | 2019-10-11 | 2024-06-25 | Pike Therapeutics Inc. | Pharmaceutical composition and method for treating seizure disorders |
| CA3155176A1 (en) | 2019-10-11 | 2021-04-15 | Pike Therapeutics, Inc., 1219014 B.C. Ltd. | Transdermal compositions comprising cannabidiol (cbd) for use in the treatment of seizure disorders |
| CA3155181A1 (en) | 2019-10-14 | 2021-04-22 | Pike Therapeutics, Inc., 1219014 B.C. Ltd. | Transdermal delivery of cannabidiol |
| US12268699B2 (en) | 2019-10-14 | 2025-04-08 | Pike Therapeutics Inc. | Transdermal delivery of tetrahydrocannabinol |
| US12121617B2 (en) | 2019-10-14 | 2024-10-22 | Pike Therapeutics Inc. | Transdermal delivery of cannabidiol |
| WO2021072530A1 (en) * | 2019-10-15 | 2021-04-22 | Tassili Life Sciences, Corp. | Controlled release formulations of psilocybe-derived agents and method for their use, and methods and compositions for threating mild traumatic brain injury with post traumatic stress disorder. |
| CA3160793A1 (en) * | 2019-12-04 | 2021-06-10 | Neonmind Biosciences Inc. | Use of psilocin, psilocybin or analogs thereof in weight loss, treatment of obesity and compulsive eating disorder |
| US20210220336A1 (en) * | 2020-01-22 | 2021-07-22 | Clexio Biosciences Ltd. | Topical detomidine formulations |
| PH12022551981A1 (en) | 2020-02-04 | 2023-10-16 | Mindset Pharma Inc | Psilocin derivatives as serotonergic psychedelic agents for the treatment of cns disorders |
| MX2022009528A (es) | 2020-02-04 | 2022-11-14 | Mindset Pharma Inc | Derivados de 3-pirrolidina-indol como agentes psicodélicos serotoninérgicos para el tratamiento de trastornos del snc. |
| WO2021207824A1 (en) * | 2020-04-17 | 2021-10-21 | Revive Therapeutics Ltd. | Use of psilocybin in the treatment of neurological brain injury and migraines |
| IL297912A (en) | 2020-05-05 | 2023-01-01 | Univ Basel | Mdma treatment to enhance acute emotional effects profile of lsd, psilocybin or other psychedelics |
| AU2021268204A1 (en) | 2020-05-08 | 2022-12-08 | Psilera Inc. | Novel compositions of matter and pharmaceutical compositions |
| KR20240096817A (ko) | 2020-05-19 | 2024-06-26 | 사이빈 아이알엘 리미티드 | 중수소화된 트립타민 유도체 및 사용 방법 |
| WO2021243460A1 (en) * | 2020-06-03 | 2021-12-09 | Neonmind Biosciences Inc. | Method for weight loss with therapy |
| CA3186958A1 (en) * | 2020-07-29 | 2022-02-03 | Judith BLUMSTOCK | Extended release 5-ht receptor agonists for neurological conditions |
| WO2022051578A1 (en) * | 2020-09-03 | 2022-03-10 | Yale University | Psilocybin in patients with obsessive-compulsive disorder |
| US20230364115A1 (en) * | 2020-10-01 | 2023-11-16 | Mydecine Innovations Group Inc. | Novel psychedelic compositions, delivery systems and therapeutic uses thereof |
| CA3197488A1 (en) * | 2020-10-12 | 2022-04-21 | Goodcap Pharmaceuticals Ltd. | Compositions for reducing inflammation to improve or maintain mental or physical health |
| US20230398234A1 (en) * | 2020-10-28 | 2023-12-14 | Mydecine Innovations Group Inc. | Novel fungal compoind formulations and their therapeutic methods of use |
| US12029718B2 (en) | 2021-11-09 | 2024-07-09 | Cct Sciences, Llc | Process for production of essentially pure delta-9-tetrahydrocannabinol |
| EP4251139A2 (en) * | 2020-11-30 | 2023-10-04 | Wesana Health Inc. | Compositions and methods for treating migraine |
| US20240050454A1 (en) * | 2020-11-30 | 2024-02-15 | Jeffrey Jewell | Compositions and Methods For Treating Neurological Conditions |
| US12343328B2 (en) | 2020-12-09 | 2025-07-01 | Caamtech, Inc. | Dialkyl tryptamines and their therapeutic uses |
| CA3113240C (en) | 2020-12-28 | 2023-09-05 | Psilo Scientific Ltd. | Transmucosal psychoactive alkaloid composition and preparation thereof |
| EP4126857A1 (en) | 2021-01-15 | 2023-02-08 | Beckley Psytech Limited | Ergoline analogues |
| US12534441B2 (en) | 2021-01-15 | 2026-01-27 | Beckley Psytech Limited | Tryptamine analogues |
| US11312684B1 (en) | 2021-02-10 | 2022-04-26 | Eleusis Therapeutics Us, Inc. | Pharmaceutically acceptable salts of psilocin and uses thereof |
| US20220265601A1 (en) * | 2021-02-10 | 2022-08-25 | David Alan Heldreth, JR. | Methods of use and formulations of allosteric modulators of the serotonin, dopamine and other receptor systems for medical, recreational, religious, research and other uses. |
| US20220273628A1 (en) * | 2021-02-19 | 2022-09-01 | Universitätsspital Basel | Effects of lysergic acid diethylamide (lsd) and of lsd analogs to assist psychotherapy for generalized anxiety disorder or other anxiety not related to life-threatening illness |
| US20220370413A1 (en) * | 2021-03-06 | 2022-11-24 | Mind Medicine, Inc. | Formulations of psilocin that have enhanced stability |
| WO2022189855A1 (en) * | 2021-03-08 | 2022-09-15 | Diamond Therapeutics Inc. | 5-ht receptor agonist titration |
| WO2022204323A1 (en) * | 2021-03-24 | 2022-09-29 | The Trustees Of Columbia University In The City Of New York | Non-hallucinogenic ariadne analogs for treatment of neurological and psychiatric disorders |
| EP4312995A1 (en) * | 2021-03-30 | 2024-02-07 | COMPASS Pathfinder Limited | Psilocybin compositions, methods of making and methods of using the same |
| US20230026731A1 (en) * | 2021-03-31 | 2023-01-26 | Mycrodose Therapeutics Inc. | Transdermal system, formulation, and method for the therapeutic administration of a psychedelic agent |
| WO2022221554A2 (en) * | 2021-04-16 | 2022-10-20 | Callitas Health Inc. | Compositions and methods for delivery of psilocin and prodrugs thereof |
| WO2022221942A1 (en) * | 2021-04-19 | 2022-10-27 | Betterlife Pharma Inc. | Prevention of drug diversion |
| CN117355302A (zh) * | 2021-04-30 | 2024-01-05 | 思维医学股份有限公司 | Lsd盐晶体形式 |
| EP4333979A4 (en) * | 2021-05-03 | 2025-01-15 | Mind Medicine, Inc. | Method of titrating dose of psychedelics |
| US20220354862A1 (en) * | 2021-05-04 | 2022-11-10 | Mind Medicine, Inc. | Liposome delivery of psychedelics |
| EP4351539B1 (en) * | 2021-06-07 | 2026-04-22 | University of Mississippi | Methods for the pulsed delivery of bioactive agents |
| US11801256B2 (en) | 2021-06-08 | 2023-10-31 | Universitätsspital Basel | Antidepressant-psilocybin co-treatment to assist psychotherapy |
| GB202109023D0 (en) * | 2021-06-23 | 2021-08-04 | Ldn Pharma Ltd | Compositions comprising an agonist of 5-hydroxytryptamine (5-ht) receptor subtype 3 |
| WO2022272176A1 (en) * | 2021-06-25 | 2022-12-29 | Synaptive Therapeutics, Llc | Psilocybin analogs for treating psychological disorders |
| JP2024529727A (ja) | 2021-08-19 | 2024-08-08 | マインド メディシン, インコーポレイテッド | 治療適用のためのd-リゼルグ酸ジエチルアミドの凍結乾燥された口腔内崩壊錠製剤 |
| US12492178B2 (en) | 2021-09-01 | 2025-12-09 | Empathbio, Inc. | Stable polymorph of R-MDMA HCl |
| IL326048A (en) * | 2021-09-03 | 2026-03-01 | Alexander Shulgin Res Institute Inc | Asymmetric allyl tryptamines |
| EP4408412A4 (en) * | 2021-09-30 | 2025-07-16 | ATAI Life Sciences AG | COMPOSITIONS AND METHODS FOR TREATING HEADACHES |
| EP4429672A4 (en) * | 2021-11-12 | 2025-04-30 | Terran Biosciences Inc. | PSILOCYBIN AND O-ACETYLPSILOCIN, SALTS AND SOLID FORMS THEREOF |
| WO2023086962A1 (en) * | 2021-11-12 | 2023-05-19 | Terran Biosciences Inc. | Psilocybin and o-acetylpsilocin, salts and solid state forms thereof |
| US11912680B2 (en) | 2021-12-28 | 2024-02-27 | Empathbio, Inc. | Nitric oxide releasing prodrugs of MDA and MDMA |
| JP2024545787A (ja) | 2021-12-30 | 2024-12-11 | アタイ セラピューティクス, インコーポレイテッド | 一酸化窒素送達剤としてのジメチルトリプタミン類似体 |
| EP4457336A4 (en) | 2021-12-31 | 2026-01-14 | Empyrean Neuroscience Inc | ORGANISMS GENETICALLY MODIFIED TO PRODUCE PSYCHOTROPIC ALKALOIDS |
| WO2023137094A1 (en) * | 2022-01-12 | 2023-07-20 | Eleusis Therapeutics Us, Inc. | Psilocin benzoate formulation for intravenous infusion |
| WO2023168023A1 (en) | 2022-03-04 | 2023-09-07 | Reset Pharmaceuticals, Inc. | Co-crystals or salts comprising psilocin |
| WO2023183618A1 (en) * | 2022-03-25 | 2023-09-28 | Ojai Energetics Pbc | Psychedelic compositions and methods for forming the same |
| US20240002463A1 (en) * | 2022-04-27 | 2024-01-04 | Howard Hughes Medical Institute | Chemogenetic receptors and methods of making and using |
| EP4522164A1 (en) * | 2022-05-13 | 2025-03-19 | Reset Pharmaceuticals, Inc. | Administration of a psychedelic compound by intramuscular injection |
| CA3247344A1 (en) | 2022-06-09 | 2023-12-14 | Diamond Therapeutics Inc. | AMORPHIC PSILOCYBIN (A-POLYMORPHIC) |
| WO2023248222A1 (en) * | 2022-06-21 | 2023-12-28 | Technion Research & Development Foundation Limited | 5-ht2c receptor modulating agents for the treatment of neurodegenerative, mental, cognitive and autoimmune cns disorders |
| US20240000795A1 (en) * | 2022-06-30 | 2024-01-04 | Terran Biosciences Inc. | Methods and compositions relating to controlling psychedelic effects with serotonin receptor modulators |
| US12344583B2 (en) | 2022-07-12 | 2025-07-01 | Lobe Sciences Ltd. | Solid psilocin salts |
| CA3261867A1 (en) * | 2022-07-12 | 2024-01-18 | Cynaptec Pharmaceuticals, Inc. | PREPARATION OF STABLE PSILOCIN SALTS, ESTERS AND CONJUGATES AND THEIR USES |
| US20260000693A1 (en) * | 2022-07-19 | 2026-01-01 | Lobe Sciences Ltd. | Serotonergic psychedelic agent for treating selective mutism |
| US12264131B2 (en) | 2022-08-19 | 2025-04-01 | Beckley Psytech Limited | Pharmaceutically acceptable salts and compositions thereof |
| WO2024079648A1 (en) * | 2022-10-11 | 2024-04-18 | Sintalica S.R.L. | Delivery system for the controlled release of psychedelic compound, pharmaceutical composition and uses thereof |
| WO2024151625A1 (en) * | 2023-01-10 | 2024-07-18 | Georgetown University | Non-toxic plga compositions and methods of making and using same |
| CN121358470A (zh) * | 2023-02-23 | 2026-01-16 | 布莱特西德公司 | 用于调节g蛋白偶联受体的组合物和方法 |
| US12246005B2 (en) | 2023-06-13 | 2025-03-11 | Beckley Psytech Limited | 5-methoxy-n,n-dimethyltryptamine (5-MeO-DMT) formulations |
| WO2025010308A2 (en) * | 2023-07-03 | 2025-01-09 | Empathbio, Inc. | Mdma enantiomer compositions and methods for modulating aggression response |
| WO2025024400A2 (en) * | 2023-07-21 | 2025-01-30 | 2A Biosciences, Inc. | Substituted tryptamines and uses thereof |
| WO2025040932A1 (en) * | 2023-08-21 | 2025-02-27 | Nechama Golan | Fully curing all mental diseases with the use of d-lysergic acid amide in different doses and time of treatment |
| WO2026068690A1 (en) * | 2024-09-27 | 2026-04-02 | Medichem, S.A. | Quetiapine long-acting injection |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108619214A (zh) * | 2017-03-15 | 2018-10-09 | 王慎君 | 一种治疗肿瘤的药物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4641942B2 (ja) * | 2003-10-03 | 2011-03-02 | フェーイレン・ナムローゼ・フェンノートシャップ | ヒトおよび動物におけるigf−1血清レベルの低下と関連した種々の疾患状態の治療用の治療用組成物の製造のための血清中igf−1レベルを増加できる化合物の使用 |
| US20180021326A1 (en) * | 2016-07-23 | 2018-01-25 | Paul Edward Stamets | Compositions and methods for enhancing neuroregeneration and cognition by combining mushroom extracts containing active ingredients psilocin or psilocybin with erinacines or hericenones enhanced with niacin |
| GB2571696B (en) * | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
| EP4219498A1 (en) * | 2019-03-07 | 2023-08-02 | Arbormentis LLC | Compositions and methods of use comprising substances with neural plasticity actions administered at non-psychedelic / psychotomimetic dosages and formulations |
-
2020
- 2020-01-29 AU AU2020215150A patent/AU2020215150B8/en active Active
- 2020-01-29 JP JP2021543489A patent/JP2022523700A/ja active Pending
- 2020-01-29 KR KR1020217026762A patent/KR20210134313A/ko not_active Ceased
- 2020-01-29 CA CA3127854A patent/CA3127854A1/en active Pending
- 2020-01-29 WO PCT/IB2020/000052 patent/WO2020157569A1/en not_active Ceased
- 2020-01-29 CN CN202080027002.3A patent/CN114040767A/zh active Pending
- 2020-01-29 US US17/427,037 patent/US20220096504A1/en not_active Abandoned
- 2020-01-29 EP EP20748736.4A patent/EP3917537A4/en active Pending
- 2020-01-29 MA MA054877A patent/MA54877A/fr unknown
- 2020-01-29 BR BR112021014750-0A patent/BR112021014750A2/pt unknown
- 2020-01-29 MX MX2021009037A patent/MX2021009037A/es unknown
-
2021
- 2021-07-27 MX MX2025007468A patent/MX2025007468A/es unknown
- 2021-07-28 IL IL285186A patent/IL285186A/en unknown
-
2022
- 2022-11-08 US US18/053,648 patent/US20230113351A1/en not_active Abandoned
-
2024
- 2024-08-22 US US18/812,847 patent/US20260053829A1/en active Pending
- 2024-08-23 US US18/814,163 patent/US20260053831A1/en active Pending
-
2025
- 2025-04-30 AU AU2025203049A patent/AU2025203049A1/en active Pending
- 2025-08-14 JP JP2025135216A patent/JP2025186241A/ja active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108619214A (zh) * | 2017-03-15 | 2018-10-09 | 王慎君 | 一种治疗肿瘤的药物 |
Non-Patent Citations (3)
| Title |
|---|
| FRANCISCO A. MORENO等: "Safety, Tolerability, and Efficacy of Psilocybin in 9 Patients With Obsessive-Compulsive Disorder", J CLIN PSYCHIATRY, vol. 67, no. 11, pages 1735 - 1740 * |
| ROBIN L CARHART-HARRIS等: "Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study", LANCET PSYCHIATRY, vol. 3, pages 619, XP055708476, DOI: 10.1016/S2215-0366(16)30065-7 * |
| 李秀婷等: "致幻蘑菇:从神灵的使者到人类的良药", 南方日报, pages 2 * |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2020215150B8 (en) | 2025-07-03 |
| US20260053831A1 (en) | 2026-02-26 |
| EP3917537A4 (en) | 2022-09-07 |
| JP2022523700A (ja) | 2022-04-26 |
| AU2020215150B2 (en) | 2025-02-06 |
| JP2025186241A (ja) | 2025-12-23 |
| MX2021009037A (es) | 2021-10-13 |
| AU2025203049A1 (en) | 2025-05-22 |
| AU2020215150A1 (en) | 2021-09-09 |
| CA3127854A1 (en) | 2020-08-06 |
| US20260053829A1 (en) | 2026-02-26 |
| KR20210134313A (ko) | 2021-11-09 |
| US20220096504A1 (en) | 2022-03-31 |
| EP3917537A1 (en) | 2021-12-08 |
| MX2025007468A (es) | 2025-07-01 |
| WO2020157569A1 (en) | 2020-08-06 |
| US20230113351A1 (en) | 2023-04-13 |
| BR112021014750A2 (pt) | 2021-09-28 |
| IL285186A (en) | 2021-09-30 |
| AU2020215150A8 (en) | 2025-07-03 |
| MA54877A (fr) | 2021-12-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN114040767A (zh) | 用于治疗心理、认知、行为和/或情绪障碍的包含5ht受体激动剂的方法和组合物 | |
| US20230233584A1 (en) | Extended release 5-ht receptor agonists for neurological conditions | |
| EP3372229B1 (en) | Methods of increasing tonic inhibition and treating angelman syndrome | |
| CN103547260A (zh) | 用于治疗中枢系统疾病的包含Brexpiprazole或其盐和第二种药物的组合 | |
| JP2024533291A (ja) | 併用薬物療法 | |
| JP2025505745A (ja) | フェネチルアミン誘導体、組成物、及び使用方法 | |
| AU2017379247A1 (en) | Pharmaceutical dosage forms containing TASK-1 and TASK-3 channel inhibitors, and the use of same in breathing disorder therapy | |
| JP2025510942A (ja) | 亜酸化窒素及び5-ht2a受容体作動薬の組み合わせ | |
| US20250236589A1 (en) | Therapeutic phenethylamine compositions and methods of use | |
| AU2017379245A1 (en) | Pharmaceutical dosage forms containing TASK-1 and TASK-3 channel inhibitors, and the use of same in breathing disorder therapy | |
| JP2025502208A (ja) | トリプタミン組成物および方法 | |
| WO2025111482A1 (en) | Complexing agent salt formulations of pharmaceutical compounds at low stoichiometric ratios | |
| CN120112511A (zh) | 苯乙胺化合物、组合物和使用方法 | |
| US20260053830A1 (en) | Compositions and methods for improving cognitive function | |
| US20260053832A1 (en) | Compositions and methods for improving cognitive function | |
| JP2026513655A (ja) | フェネチルアミン化合物、組成物、及び使用方法 | |
| JP2016518406A (ja) | 嗜癖障害およびアルコール関連障害を治療するための(+)−1−(3,4−ジクロロフェニル)−3−アザビシクロ[3.1.0]へキサンの使用 | |
| HK1260775A1 (en) | Methods of increasing tonic inhibition and treating angelman syndrome | |
| HK1260775B (en) | Methods of increasing tonic inhibition and treating angelman syndrome | |
| HK40016673A (en) | Pharmaceutical formulation | |
| HK40016673B (en) | Pharmaceutical formulation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20220211 |
|
| WD01 | Invention patent application deemed withdrawn after publication |