CN114028471A - Compound preparation for preventing inflammation of poultry reproductive system and preparation method and application thereof - Google Patents

Compound preparation for preventing inflammation of poultry reproductive system and preparation method and application thereof Download PDF

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CN114028471A
CN114028471A CN202111497964.8A CN202111497964A CN114028471A CN 114028471 A CN114028471 A CN 114028471A CN 202111497964 A CN202111497964 A CN 202111497964A CN 114028471 A CN114028471 A CN 114028471A
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vitamin
reproductive system
poultry
extract
inflammation
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杨慧芳
程习宏
丁大明
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Henan Bangbang Bioengineering Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/11—Aldehydes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288—Taraxacum (dandelion)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/533—Leonurus (motherwort)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/78—Saururaceae (Lizard's-tail family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

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  • Pharmacology & Pharmacy (AREA)
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Abstract

The invention discloses a compound preparation for preventing inflammation of a poultry reproductive system, which comprises the following components in percentage by weight: 5-6% of monomolecular essential oil, 5-8% of dandelion extract, 3-5% of motherwort extract, 3-5% of houttuynia cordata extract, 1-2 million U/ml of vitamin A and vitamin D31-2 ten thousand U/ml, vitamin E2-3%, Tween-802-3%, span-802-3%, soybean oil 15%, sodium bisulfite 0.05%, and purified water in balance. The immunity of the laying hens can be obviously improved, the disease resistance can be enhanced, various factors causing reproductive system infection can be prevented, and the ovaries and the oviducts of the laying hens are protected; the egg quality is improved, and the laying rate is increased; the emulsion process is adopted, the composite emulsifier is used, and the production process is stable.

Description

Compound preparation for preventing inflammation of poultry reproductive system and preparation method and application thereof
Technical Field
The invention belongs to the field of compound preparations, and mainly relates to a compound preparation for preventing inflammation of a poultry reproductive system, and a preparation method and application thereof.
Background
Inflammation of ovary and oviduct is a common disease of the reproductive system of laying hens, and is characterized by inflammation of the peritoneum of the ovary and the oviduct, wherein the follicle of a serious patient is deformed, hyperemia and hemorrhage, is grayish brown and even is broken; yolk liquid ruptured in abdominal cavity forms vitelline peritonitis; sometimes the follicles shrink, dull; the bleeding of the fallopian tube is a yellow-white cheese sample, so the inflammation of the ovary and the fallopian tube of the laying hen should be highly regarded.
Salpingitis is mainly caused by the lack of vitamin A, D, E in feed or viral diseases, parasitic diseases, and secondary infection of Escherichia coli. The health care of the reproductive system of laying hens is mainly focused on the ovaries and the oviducts. Infection of the reproductive system of the laying hens poses certain threat to the healthy development of the laying hen breeding industry, and a key problem is how to control the cause of secondary infection of the ovary and the oviduct and well protect the ovary and the oviduct.
Disclosure of Invention
The invention aims to provide a compound preparation for preventing inflammation of a poultry reproductive system.
The invention also aims to provide a preparation method of the compound preparation.
The third purpose of the invention is to provide the application of the compound preparation in preventing the inflammation of the reproductive system of poultry.
In order to achieve the purpose, the invention adopts the following technical scheme:
the compound preparation for preventing the inflammation of the reproductive system of the poultry comprises the following components in percentage by weight: 5-6% of monomolecular essential oil, 5-8% of dandelion extract, 3-5% of motherwort extract, 3-5% of houttuynia cordata extract, 1-2 million U/ml of vitamin A and vitamin D31-2 ten thousand U/ml, vitamin E2-3%, Tween-802-3%, span-802-3%, soybean oil 15%, sodium bisulfite 0.05%, and the balance of purified water.
Preferably, the Tween-80 is an O/W type emulsifier, and the span-80 is a W/O type emulsifier.
The preparation method of the compound preparation for preventing the inflammation of the reproductive system of the poultry comprises the following steps:
(1) sequentially adding vitamin A, vitamin D3 and vitamin E into soybean oil, respectively dissolving, and adding span-80 for dissolving;
(2) sequentially adding monomolecular essential oil, dandelion extract, motherwort extract and houttuynia cordata extract into purified water, respectively dissolving, and adding tween-80 for dissolving for later use;
(3) adding sodium bisulfite into purified water, and stirring to dissolve;
(4) and (3) slowly adding the solution obtained in the step (1) into the solution obtained in the step (2), rapidly stirring to form an emulsion, slowly adding the solution obtained in the step (3) into the solution, and fixing the volume by using purified water.
Preferably, in the step (4), after constant volume is determined, the mixture is poured into a colloid mill to be milled into fine emulsion, and then the mixture is encapsulated and sterilized.
The application of the compound preparation for preventing the inflammation of the reproductive system of poultry.
Preferably, the amount is 2.5ml per 1L poultry.
The invention has the advantages and beneficial effects that:
(1) the invention can obviously improve the immunity of the laying hens and enhance the disease resistance, (2) the invention can prevent various factors causing reproductive system infection and protect the ovaries and the oviducts of the chickens; the egg quality is improved, and the laying rate is increased; (3) the process adopts an emulsion process, uses a compound emulsifier, and has stable production process; (4) the preparation is easy to absorb after entering the body, is convenient for clinical administration, is suitable for group administration, and saves manpower and material resources; (5) the invention has definite medicine content, accurate medicine administration and controllable quality.
In particular, the monomolecular essential oil is composed of thymol, carvacrol and cinnamaldehyde raw materials, the plant essential oil in the nanometer molecular type is completely dissolved in water, can quickly inhibit anaerobic bacteria, escherichia coli, salmonella, clostridium perfringens, fungi and staphylococcus aureus in intestinal tracts, can penetrate barriers of reproductive systems, can inhibit germs in the reproductive systems, and has the effect of resisting coccidian.
The herba Taraxaci extract has antibacterial and antiviral effects, and can inhibit Staphylococcus aureus, hemolytic streptococcus, Diplococcus pneumoniae, Pseudomonas aeruginosa, Bacillus proteus, Catacococcus, Mycobacterium tuberculosis, influenza virus and various dermatophytes. Has the function of improving the immunologic function, and the dandelion extract can obviously improve the peripheral blood lymphocyte transformation function in vitro.
The extract of motherwort has the function of estrogen, has good health care function on ovaries, and has good promotion function on the growth and development of laying hens and egg laying indexes.
The houttuynia cordata extract can improve the immunity of the livestock and poultry and has obvious effect on the newcastle disease of the chicken.
Vitamin A, vitamin D, and vitamin E can supplement reproductive system infection caused by vitamin deficiency.
The combined application of the medicines can improve the immunity of the laying hens, enhance the disease resistance, prevent various factors causing reproductive system infection and protect the ovaries and the oviducts of the chickens, and meanwhile, the used raw materials are all safe, effective and residue-free green products, so that the compound feed is a good product for preventing the inflammation of the reproductive system of the poultry for farmers.
Detailed Description
The present invention will be further described below by way of examples, but the scope of the present invention is not limited thereto.
Example 1 Compound preparation for preventing inflammation of poultry reproductive System
The emulsion contains the following components per 100 ml: single molecule essential oil (Yaoxifei Biotech, Zhejiang) 5%, herba Taraxaci extract (Hengretta Biotech, Sichuan) 8%, herba Leonuri extract (Hengretta Biotech, Sichuan) 3%, and herba Houttuyniae extract (Hengretta, Sichuan)Dabiotech Co., Ltd.), 5 percent of vitamin A1 ten thousand U/ml and vitamin D32 ten thousand U/ml, vitamin E2%, tween-802%, span-803%, soybean oil 15%, sodium bisulfite 0.05% and the balance of purified water.
Preparing liquid: (1) adding the formulated amount of vitamin A and vitamin D into soybean oil in sequence3Respectively dissolving vitamin E, adding span-80, and dissolving for later use;
(2) sequentially adding monomolecular essential oil, dandelion extract, motherwort extract and houttuynia cordata extract into purified water, respectively dissolving, and adding tween-80 for dissolving for later use;
(3) adding sodium bisulfite into purified water, and stirring to dissolve;
(4) slowly adding the solution (1) into the solution (2), rapidly stirring to form an emulsion, slowly adding the solution (3) into the solution, adding purified water to a constant volume, pouring into a colloid mill, milling to obtain a fine emulsion, filling and sealing, and sterilizing to obtain the compound preparation for preventing the inflammation of the reproductive system of the poultry.
Quality inspection: the emulsion obtained is a brownish yellow milky liquid; the emulsion has an effective period of 2 years.
The using method comprises the following steps: the mixed liquid is taken 2.5ml per 1L chicken.
Example 2 Compound preparation for preventing inflammation of poultry reproductive System
The emulsion contains the following components per 100 ml: 6% of monomolecular essential oil, 5% of dandelion extract, 5% of motherwort extract, 3% of houttuynia cordata extract, 2 ten thousand U/ml of vitamin A, and D31 ten thousand U/ml, vitamin E3%, tween-803%, span-802%, soybean oil 15%, sodium bisulfite 0.05% and the balance of purified water.
Preparing liquid: (1) adding the formulated amount of vitamin A and vitamin D into soybean oil in sequence3Respectively dissolving vitamin E, adding span-80, and dissolving for later use;
(2) sequentially adding monomolecular essential oil, dandelion extract, motherwort extract and houttuynia cordata extract into purified water, respectively dissolving, and adding tween-80 for dissolving for later use;
(3) adding sodium bisulfite into purified water, and stirring to dissolve;
(4) slowly adding the solution (1) into the solution (2), rapidly stirring to form an emulsion, slowly adding the solution (3) into the solution, adding purified water to a constant volume, pouring into a colloid mill, milling to obtain a fine emulsion, filling and sterilizing to obtain the compound preparation for preventing the inflammation of the reproductive system of the poultry.
Quality inspection: the obtained emulsion is a brownish yellow milky liquid, and the validity period of the emulsion is 2 years.
The using method comprises the following steps: the mixed liquid is taken 2.5ml per 1L chicken.
Example 3 Compound preparation for preventing inflammation of poultry reproductive System
The emulsion contains the following components per 100 ml: 6% of monomolecular essential oil, 6% of dandelion extract, 4% of motherwort extract, 4% of houttuynia cordata extract, 2 ten thousand U/ml of vitamin A, and D32 ten thousand U/ml, vitamin E2%, tween-802.5%, span-802.5%, soybean oil 15%, sodium bisulfite 0.05%, and the balance of purified water.
Preparing liquid: (1) adding the formulated amount of vitamin A and vitamin D into soybean oil in sequence3Respectively dissolving vitamin E, adding span-80, and dissolving for later use;
(2) sequentially adding monomolecular essential oil, dandelion extract, motherwort extract and houttuynia cordata extract into purified water, respectively dissolving, and adding tween-80 for dissolving for later use;
(3) adding sodium bisulfite into purified water, and stirring to dissolve;
(4) slowly adding the solution (1) into the solution (2), rapidly stirring to form an emulsion, slowly adding the solution (3) into the solution, adding purified water to a constant volume, pouring into a colloid mill, milling to obtain a fine emulsion, filling and sterilizing to obtain the compound preparation for preventing the inflammation of the reproductive system of the poultry.
Quality inspection: the obtained emulsion is a brownish yellow milky liquid, and the validity period of the emulsion is 2 years.
The using method comprises the following steps: the mixed liquid is taken 2.5ml per 1L chicken.
Example 4 Compound preparation for preventing inflammation of poultry reproductive System
The preparation method comprises the following steps: taking 6% of monomolecular essential oil, 8% of dandelion extract, 5% of motherwort extract, 5% of houttuynia extract, 2 ten thousand U/ml of vitamin A and D32 million U/ml, vitamin E3 percent and the balance of purified water are sequentially added into a mixer and mixed for 30 minutes to obtain the compound preparation of the embodiment 4.
Example 5 comparative test of the therapeutic Effect of the Compound preparation of the present invention on inflammation of the reproductive System of laying hens and poultry
(one) test drugs
Test groups 1, 2, 3: the compound preparations prepared in examples 1, 2 and 3;
control group 1: the combination prepared in example 4;
control group 2: egg chang 500 (Henan Zhongji alliance Biotechnology Co., Ltd.)
(II) test method
(1) And (3) experimental design: laying hens with the following symptoms were selected for 500 feathers and randomly divided into 5 groups. The laying rates of 5 groups after grouping were not significantly different (P > 0.05) by the biometric analysis.
Symptoms are: the sick chicken is painful and uneasy, and the eggshell of the produced egg has blood stain. Yellow and white purulent secretion is often discharged from the fallopian tube to pollute the feathers around and under the anus, and the egg laying is difficult. Dull standing, drooping of the two wings, loose feathers. The laying rate is obviously reduced, the egg distortion rate and the egg breaking rate are increased, and the feed intake is reduced.
The test group daily ration is basic daily ration, and the using methods of the embodiments 1, 2 and 3 are as follows: the mixed liquid is taken 2.5ml per 1L chicken. (2.5 ml is the amount of finished compound preparation)
Control 1 is basal diet +0.1% of example 4
Control group 2 was basal diet +0.1% oozing 500
Figure 825604DEST_PATH_IMAGE001
And (3) test period: 7 days
The basic ration formula and the nutritional ingredients thereof are shown in table 1. The feeding management adopts 3 layers of cage rearing, and other management is carried out according to a large-scale laying hen production management system.
(2) Measurement indexes are as follows: laying rate, number of dead chickens, treatment effect (inefficiency, effective rate and cure rate) and feed-egg ratio.
And (4) invalidation: the symptoms of sick chickens were not reduced.
The method has the following advantages: the laying rate is improved, the egg distortion rate and the egg breakage rate are reduced, the feed intake is increased, the mental condition is improved, and the amount of feather and mucus adhered to the surface of the eggshell is obviously reduced.
And (3) curing: the laying rate is recovered to be normal, the egg distortion rate and the egg breaking rate are lower than 2%, the feed intake is obviously increased, the mental condition is good, and the surface of the eggshell is free from adhering feather and mucus and blood spots.
(3) Test results
Figure DEST_PATH_IMAGE002
As can be seen from table 2, the average laying rate of the test group is 91.03%, which is 12.7% and 13.23% higher than those of the control group 1 and the control group 2, respectively, and the difference is significant; the average feed-egg ratio of the test group is 2.43, and the feed-egg ratio of the test group is respectively reduced by 0.18 and 0.16 compared with the control group 1 and the control group 2, and the difference is obvious; the total effective rate of the test group is averagely 91.3 percent and is respectively improved by 23.3 percent and 31.3 percent compared with the control group 1 and the control group 2; the number of dead chickens in the test group was 5 feathers on average, and 10 feathers and 13 feathers were reduced compared with those in control group 1 and control group 2, respectively.

Claims (6)

1. Compound preparation for preventing inflammation of poultry reproductive system, characterized in that: comprises the following components in percentage by weight: 5-6% of monomolecular essential oil, 5-8% of dandelion extract, 3-5% of motherwort extract, 3-5% of houttuynia cordata extract, 1-2 million U/ml of vitamin A and vitamin D31-2 ten thousand U/ml, vitamin E2-3%, Tween-802-3%, span-802-3%, soybean oil 15%, sodium bisulfite 0.05%, and purified water in balance.
2. The compound preparation for preventing inflammation of the reproductive system of poultry according to claim 1, wherein: tween-80 is O/W type emulsifier, and span-80 is W/O type emulsifier.
3. The preparation method of the compound preparation for preventing the inflammation of the reproductive system of the poultry is characterized in that: the method comprises the following steps:
(1) sequentially adding vitamin A, vitamin D3 and vitamin E into soybean oil, respectively dissolving, and adding span-80 for dissolving;
(2) sequentially adding monomolecular essential oil, dandelion extract, motherwort extract and houttuynia cordata extract into purified water, respectively dissolving, and adding tween-80 for dissolving for later use;
(3) adding sodium bisulfite into purified water, and stirring to dissolve;
(4) and (3) slowly adding the solution obtained in the step (1) into the solution obtained in the step (2), rapidly stirring to form an emulsion, slowly adding the solution obtained in the step (3) into the solution, and fixing the volume by using purified water.
4. A method for preparing a compound preparation for preventing inflammation of the reproductive system of poultry according to claim 3, wherein the compound preparation comprises: and (4) after the volume is constant, pouring the mixture into a colloid mill, grinding the mixture into fine emulsion, filling and sealing the emulsion and sterilizing the emulsion.
5. Use of a combination according to any one of claims 1 to 4 for the prevention of inflammation of the reproductive system of poultry.
6. Use of a combination preparation according to claim 5 for the prevention of inflammation of the reproductive system of poultry, characterized in that: the dosage of the feed is 2.5ml per 1L poultry.
CN202111497964.8A 2021-12-09 2021-12-09 Compound preparation for preventing inflammation of poultry reproductive system and preparation method and application thereof Pending CN114028471A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112755066A (en) * 2021-03-12 2021-05-07 中农翎翔河北生物科技有限公司 Chinese medicinal composition for treating salpingitis and oophoritis of laying fowl and preparation method thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112755066A (en) * 2021-03-12 2021-05-07 中农翎翔河北生物科技有限公司 Chinese medicinal composition for treating salpingitis and oophoritis of laying fowl and preparation method thereof

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Application publication date: 20220211