CN114025772A - 用于治疗ras突变体癌症的组合物和方法 - Google Patents

用于治疗ras突变体癌症的组合物和方法 Download PDF

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CN114025772A
CN114025772A CN202080045296.2A CN202080045296A CN114025772A CN 114025772 A CN114025772 A CN 114025772A CN 202080045296 A CN202080045296 A CN 202080045296A CN 114025772 A CN114025772 A CN 114025772A
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txnrd1
subject
inhibitor
cancer
kras
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Chinese (zh)
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C-H·黄
S·C·奈特
S·罗威
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Argen Biotechnology Co ltd
Memorial Sloan Kettering Cancer Center
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Argen Biotechnology Co ltd
Memorial Sloan Kettering Cancer Center
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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    • C07D303/02—Compounds containing oxirane rings
    • C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D303/46—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals by amide or nitrile radicals
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    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
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    • C12Y108/01—Oxidoreductases acting on sulfur groups as donors (1.8) with NAD+ or NADP+ as acceptor (1.8.1)
    • C12Y108/01009—Thioredoxin-disulfide reductase (1.8.1.9), i.e. thioredoxin-reductase
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CN202080045296.2A 2019-04-24 2020-04-23 用于治疗ras突变体癌症的组合物和方法 Pending CN114025772A (zh)

Applications Claiming Priority (3)

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US201962838065P 2019-04-24 2019-04-24
US62/838,065 2019-04-24
PCT/US2020/029513 WO2020219668A1 (en) 2019-04-24 2020-04-23 Compositions and methods for treating ras-mutant cancers

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CN114025772A true CN114025772A (zh) 2022-02-08

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US (1) US20220193109A1 (https=)
EP (1) EP3959199A4 (https=)
JP (2) JP7770924B2 (https=)
CN (1) CN114025772A (https=)
WO (1) WO2020219668A1 (https=)

Families Citing this family (3)

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Publication number Priority date Publication date Assignee Title
EP4149941B1 (en) 2020-05-15 2025-09-03 Algen Biotechnologies, Inc. Certain chemical compositions and methods of use thereof
CN113952359A (zh) * 2021-11-19 2022-01-21 大连理工大学盘锦产业技术研究院 顺铂与Tri-1的联合抗肺癌药物组合物及其应用
EP4551214A1 (fr) * 2022-07-05 2025-05-14 Association Française contre les Myopathies Utilisation de l'ebselen ou l'un de ses derives pour traiter des pathologies ou dysfonctionnements des mitochondries

Citations (5)

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US20070050146A1 (en) * 2004-05-14 2007-03-01 Itzhak Bentwich Micrornas and uses thereof
WO2014122599A1 (en) * 2013-02-05 2014-08-14 Nestec S.A. Drug selection for colorectal cancer therapy using receptor tyrosine kinase profiling
WO2017027359A1 (en) * 2015-08-07 2017-02-16 The Usa, As Represented By The Secretary, Department Of Health And Human Services Pyridines and their use in the treatment of cancer
WO2018145090A1 (en) * 2017-02-06 2018-08-09 New York University Methods of treating cancers having a deregulated nrf2/keap1 pathway
WO2018218087A1 (en) * 2017-05-24 2018-11-29 K-Gen, Inc. Methods of cancer treatment

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CA2718400A1 (en) * 2008-03-11 2009-09-17 The General Hospital Corporation Piperlongumine and piperlongumine analogs for use in the treatment of cancer
CN105263523A (zh) * 2013-03-15 2016-01-20 米尔纳疗法公司 使用微rna和egfr-tki抑制剂的联合癌症治疗
CA2958683A1 (en) * 2014-09-10 2016-03-17 The Regents Of The University Of California Targeting k-ras-mediated signaling pathways and malignancy by prostratin
CN106687134A (zh) * 2014-09-10 2017-05-17 加利福尼亚大学董事会 通过抗hLIF抗体靶向K‑RAS介导的信号转导通路和恶性肿瘤
EA201992781A1 (ru) * 2017-05-22 2020-04-01 Эмджен Инк. Ингибиторы g12c kras и способы их применения
JP7377679B2 (ja) * 2018-11-19 2023-11-10 アムジエン・インコーポレーテツド がん治療のためのｋｒａｓｇ１２ｃ阻害剤及び１種以上の薬学的に活性な追加の薬剤を含む併用療法

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US20070050146A1 (en) * 2004-05-14 2007-03-01 Itzhak Bentwich Micrornas and uses thereof
WO2014122599A1 (en) * 2013-02-05 2014-08-14 Nestec S.A. Drug selection for colorectal cancer therapy using receptor tyrosine kinase profiling
WO2017027359A1 (en) * 2015-08-07 2017-02-16 The Usa, As Represented By The Secretary, Department Of Health And Human Services Pyridines and their use in the treatment of cancer
WO2018145090A1 (en) * 2017-02-06 2018-08-09 New York University Methods of treating cancers having a deregulated nrf2/keap1 pathway
WO2018218087A1 (en) * 2017-05-24 2018-11-29 K-Gen, Inc. Methods of cancer treatment

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EP3959199A4 (en) 2023-06-28
JP7770924B2 (ja) 2025-11-17
US20220193109A1 (en) 2022-06-23
EP3959199A1 (en) 2022-03-02
WO2020219668A1 (en) 2020-10-29
JP2025127483A (ja) 2025-09-01

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