CN114010540A - Dandruff-removing scalp scrub cream of natural essential oil compound microemulsion and preparation process of dandruff-removing scalp scrub cream - Google Patents
Dandruff-removing scalp scrub cream of natural essential oil compound microemulsion and preparation process of dandruff-removing scalp scrub cream Download PDFInfo
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- essential oil
- microemulsion
- scalp
- dandruff
- cinnamaldehyde
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- KJPRLNWUNMBNBZ-QPJJXVBHSA-N (E)-cinnamaldehyde Chemical compound O=C\C=C\C1=CC=CC=C1 KJPRLNWUNMBNBZ-QPJJXVBHSA-N 0.000 claims abstract description 43
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
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- A61Q5/00—Preparations for care of the hair
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
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Abstract
The invention discloses an anti-dandruff scalp scrub cream of natural essential oil compound microemulsion and a preparation process thereof. The raw materials comprise sodium laureth sulfate, sodium cocoyl isethionate, cocamidopropyl betaine, cocamide DEA, glycerol, sodium chloride, polyquaternium-7, citric acid, cinnamaldehyde and carvacrol essential oil microemulsion. Mixing the cinnamaldehyde and carvacrol essential oil microemulsion with polyquaternium-7, adding citric acid, cocamide DEA and cocamidopropyl betaine, and heating; adding sodium chloride, sodium cocoyl isethionate, sodium laureth sulfate and glycerin, heating, keeping the temperature, and cooling to room temperature to obtain the finished product. The invention uses the cinnamaldehyde essential oil and the carvacrol essential oil to compound the microemulsion to replace water to prepare the anti-dandruff scrub cream, delays the volatilization of the essential oil, has better stability, can release the essential oil in the scrub cream in the massage process, deeply cleans scalp and hairline, and has small dosage.
Description
Technical Field
The invention relates to an anti-dandruff scalp scrub cream containing a natural essential oil compound microemulsion of cinnamaldehyde and carvacrol and a preparation process thereof, belonging to the technical field of daily-use chemistry.
Background
The scalp is the most abundant part of the whole body oil secretion, keratinocytes on the scalp continuously carry out metabolism activity, once the metabolism is abnormal, a large amount of fungus which takes oil as food, namely malassezia bacteria, is bred, the balance of the oil secretion of the scalp is damaged, and therefore a large amount of metabolic waste, namely dandruff, is generated, and meanwhile scalp pruritus is caused. Scalp health standards are listed in one of the 10 major health standards of the world health organization. About 50 percent of adults in China have various scalp health problems, such as oil, scurf, itchy head, sensitive scalp, pruritus and the like, and unhealthy scalp directly influences hair growth and even causes alopecia. Therefore, killing breeding bacteria, repairing scalp barrier function, and balancing water and oil are key steps in scalp care, and are also the center of gravity for solving scalp problems.
In order to solve the scalp problems, shampoo is prepared by adding a chemical synthesis anti-dandruff agent (ZPT/OCT/HD) or an antibacterial drug in the market, and has large side effects and easy hair loss; some dandruff-removing shampoo products have the problems of incomplete dandruff removal, easy repeated attack and the like, even aggravate scalp problems and cause a series of scalp inflammations.
Therefore, how to develop a mild and efficient daily chemical product which can really and effectively solve the scalp problem is very important, and is also a technical problem which needs to be solved urgently by technical personnel in the field.
The cinnamaldehyde is also called as cinnamaldehyde, is the main component of cinnamon essential oil extracted from cinnamon, and accounts for 75-90 percent. Cinnamaldehyde is nontoxic, pollution-free, residue-free, low in cost, high in activity, and can be used for preventing and promoting health of cardiovascular disease, cerebrovascular disease, gastrointestinal disease, etc. Meanwhile, the cinnamaldehyde has strong aromatic smell and good bacteriostatic and bactericidal effects, is often used as a seasoning and a fresh-keeping, antiseptic and mildew inhibitor, and is listed as an edible spice and a food additive which are allowed to be used by the nation at present. The cinnamaldehyde serving as a plant source bactericide has the characteristics of strong sterilizing capability, safety, easiness in degradation, ecological friendliness and the like.
Carvacrol (2-methyl-5-isopropylphenol), also known as carvacrol, is a liquid monoterpene phenolic substance that is mainly present in essential oils extracted from aromatic plants (such as oregano, thyme, etc.). The carvacrol and the thymol are isomers, and the molecular formula is C10H14O, the chemical structural formula is shown in figure 1. The carvacrol is colorless to light yellow thick oily liquid in a pure state, has special fragrance, is easily soluble in alcohol and ether at normal temperature, and is almost insoluble in water. In daily life, it can be used for preparing perfume, food additive, insect repellent, sanitary bactericide, antiseptic, etc.
However, the water insolubility and volatility of carvacrol and cinnamaldehyde greatly limit the practical application of carvacrol and cinnamaldehyde. The microemulsion has the advantages that the particle size of liquid drops is 1-100 nm, the microemulsion has good fluidity, the solubility of the plant essential oil in a solvent can be obviously improved under the action of the emulsifier, a stable and uniform solution is formed, the stability and the solubilization of the plant essential oil are improved, the plant essential oil can easily permeate into gaps or pores of objects, and the bacteriostatic effect of the plant essential oil is improved. The natural cinnamaldehyde and carvacrol essential oil and the scalp scrub cream are combined together through a micro-emulsification technology, and the scalp scrub cream has great application potential in the field of daily chemical products.
Disclosure of Invention
The technical problem to be solved by the invention is as follows: how to compound the cinnamaldehyde and the carvacrol natural essential oil into microemulsion to improve the effect of the plant essential oil.
In order to solve the technical problems, the invention provides an anti-dandruff scalp scrub cream of natural essential oil compound microemulsion, which comprises the following raw materials in percentage by mass:
preferably, the raw materials of the cinnamaldehyde and carvacrol essential oil microemulsion comprise, by mass, 0.05% -0.1% of cinnamaldehyde essential oil, 0.2% -0.4% of carvacrol essential oil, 0.2% -0.6% of propylene glycol, 802.5% -5% of tween and the balance of deionized water.
Preferably, the preparation process of the cinnamaldehyde and carvacrol essential oil microemulsion comprises the following steps: mixing cinnamaldehyde essential oil and carvacrol essential oil, adding propylene glycol and tween 80, mixing, dripping distilled water at intervals, and oscillating to obtain microemulsion when the product is clear and transparent. The microemulsion compounded by the cinnamic aldehyde and the carvacrol natural essential oil delays the volatilization of the essential oil, and has better stability and solubilization property.
Preferably, the mass ratio of the sodium laureth sulfate, the cocamidopropyl betaine, the sodium cocoyl isethionate and the cocamide DEA is 5-9: 5-9: 1.5-3: 1.5-3.
The invention also provides a preparation process of the scurf-removing scalp scrub cream of the natural essential oil compound microemulsion, which comprises the following steps:
step 1): mixing the cinnamaldehyde and carvacrol essential oil microemulsion with the polyquaternium-7, uniformly stirring, and completely swelling to obtain a transparent solution;
step 2): adding citric acid, cocamide DEA and cocamidopropyl betaine into the transparent solution obtained in the step 1), uniformly stirring and heating;
step 3): adding sodium chloride, sodium cocoyl isethionate, sodium laureth sulfate and glycerol into the mixture obtained in the step 2), continuously stirring and heating, preserving heat, uniformly stirring, and then cooling to room temperature to obtain a finished product.
Preferably, the heating in step 2) is carried out to a temperature of 45 ℃.
Preferably, the heating in the step 3) is carried out to the temperature of 80-85 ℃, and the heat preservation is carried out for 10 minutes.
The invention uses the cinnamaldehyde essential oil and the carvacrol essential oil to compound the microemulsion to replace water to prepare the anti-dandruff scrub cream, delays the volatilization of the essential oil, has better stability, can release the essential oil in the scrub cream in the massage process, deeply cleans scalp and hair, and has the anti-allergic effect, can relieve skin and inhibit scalp itch caused by dryness, effectively removes dandruff and relieves itching, and has small dosage.
Compared with the prior art, the invention has the advantages that:
(1) the invention takes cinnamaldehyde essential oil and carvacrol essential oil as oil raw materials, combines tween 80 and co-emulsifier propylene glycol to obtain an oil phase, uses distilled water as a water phase to obtain compound essential oil microemulsion, and uses the microemulsion to replace water to prepare the scalp scrub cream.
(2) The compound essential oil microemulsion obtained by the invention is spontaneously generated by adopting a microemulsion technology, so that the stability is excellent, and the preparation method is simple and convenient. In the form of microemulsion, the light stability, the thermal stability and the compatibility of the oil phase raw material are improved, and the obtained oil-in-water type essential oil microemulsion has clear and transparent appearance and strong stability.
(3) The bacteriostatic component is the microemulsion which is prepared by compounding cinnamaldehyde and carvacrol, the microemulsion is applied to the scalp scrub cream, the stability is better, hair follicle dirt is thoroughly cleaned through massage, complex subsequent cleaning is not needed, no additional stimulation is caused to skin, not only can a comfortable hair washing effect be experienced, but also bacteriostatic substances can be released, malassezia can be effectively inhibited, the scalp microbial environment is improved, water and oil are balanced, and the scalp scrub is relieved and relieved, the requirement on equipment is low, and the preparation process is simple.
(4) The invention adopts sodium laureth sulfate as a main surfactant, combines mild auxiliary surfactants such as cocamidopropyl betaine, sodium cocoyl isethionate and cocamide DEA, selects mild and low-irritation surfactants to achieve the aim of mild cleaning, and adopts glycerin as a humectant to keep the scalp and hair from drying.
Compared with the prior art, the invention has remarkable technical progress. The invention solves the technical problems of poor treatment effect and poor safety of the scurf-removing scalp scrub cream in the prior art, and the product is more green and safe. The invention better applies the cinnamaldehyde essential oil and the carvacrol essential oil to the dandruff removing scalp scrub cream, can inhibit bacteria synergistically, can reduce stimulation to scalp, effectively remove dandruff and relieve itching, has small dosage, reduces environmental pollution caused by chemical bacteriostats, and reduces harm to human bodies.
Drawings
FIG. 1 is a chemical structural formula of carvacrol;
FIG. 2 shows the inhibitory effect of scrub on malassezia.
Detailed Description
In order to make the invention more comprehensible, preferred embodiments are described in detail below with reference to the accompanying drawings.
Each of the raw materials used in each example was a commercially available product (see Table 1).
TABLE 1
The model number of some instruments and equipment used in the present invention and information of the manufacturer are shown in table 2.
TABLE 2
| Name of instrument | Model number | Manufacturer of the product |
| Electronic balance | PL403 | Mettler-Tollido instruments Ltd |
| Constant temperature magnetic stirring | 524G | Shanghai Meiglupu Instrument and Meter manufacturing Co., Ltd |
| Vertical pressure steam sterilizing pot | LS-B50L | Shanghai Medical Nuclear Instrument Factory |
| Precision constant temperature incubator | BPH-9082 | SHANGHAI YIHENG INSTR Co.,Ltd. |
Example 1
An anti-dandruff scalp scrub cream of a cinnamic aldehyde and carvacrol natural essential oil compound microemulsion is prepared from the following raw materials in percentage by mass:
the raw materials of the 59.48% compound essential oil microemulsion comprise, by mass, 0.05% of cinnamaldehyde essential oil, 0.2% of carvacrol essential oil, 0.25% of propylene glycol, 802.5% of tween and 56.48% of deionized water.
The preparation process of the compound essential oil microemulsion comprises the following steps: mixing cinnamaldehyde essential oil and carvacrol essential oil, adding propylene glycol and tween 80, mixing, dripping distilled water at intervals, oscillating, and making into compound microemulsion when it is clear and transparent.
The preparation process of the scurf-removing scalp scrub cream of the cinnamic aldehyde and carvacrol natural essential oil compound microemulsion comprises the following steps:
1) mixing microemulsion prepared by compounding cinnamaldehyde and carvacrol essential oil with polyquaternium-7, uniformly stirring, and completely swelling to obtain a transparent solution;
2) adding citric acid, cocamide DEA and cocamidopropyl betaine into the transparent solution obtained in the step 1), uniformly stirring, heating to 45 ℃;
3) adding sodium chloride granules, sodium cocoyl isethionate, sodium laureth sulfate and glycerol, and continuously stirring and heating to 80-85 ℃; preserving the temperature for 10 minutes, stirring uniformly, and then cooling to room temperature to obtain a finished product.
Example 2
An anti-dandruff scalp scrub cream of a cinnamic aldehyde and carvacrol natural essential oil compound microemulsion is prepared from the following raw materials in percentage by mass:
42.95% of the preparation raw materials of the compound essential oil microemulsion comprise 0.1% of cinnamaldehyde essential oil, 0.15% of carvacrol essential oil, 0.25% of propylene glycol, 802.5% of tween and 39.95% of deionized water in percentage by mass.
The preparation process of the compound essential oil microemulsion comprises the following steps: mixing cinnamaldehyde essential oil and carvacrol essential oil, adding propylene glycol and tween 80, mixing, dripping distilled water at intervals, oscillating, and making into compound microemulsion when it is clear and transparent.
The preparation process of the scurf-removing scalp scrub cream of the cinnamic aldehyde and carvacrol natural essential oil compound microemulsion comprises the following steps:
1) mixing microemulsion prepared by compounding cinnamaldehyde and carvacrol essential oil with polyquaternium-7, uniformly stirring, and completely swelling to obtain a transparent solution;
2) adding citric acid, cocamide DEA and cocamidopropyl betaine into the transparent solution obtained in the step 1), uniformly stirring, heating to 45 ℃;
3) adding sodium chloride granules, sodium cocoyl isethionate, sodium laureth sulfate and glycerol, and continuously stirring and heating to 80-85 ℃; preserving the temperature for 10 minutes, stirring uniformly, and then cooling to room temperature to obtain a finished product.
Example 3
An anti-dandruff scalp scrub cream of a cinnamic aldehyde and carvacrol natural essential oil compound microemulsion is prepared from the following raw materials in percentage by mass:
the preparation raw materials of the 48.8% compound essential oil microemulsion comprise, by mass, 0.2% of cinnamaldehyde essential oil, 0.05% of carvacrol essential oil, 0.25% of propylene glycol, 802.5% of tween and 45.8% of deionized water.
The preparation process of the scurf-removing scalp scrub cream of the cinnamic aldehyde and carvacrol natural essential oil compound microemulsion comprises the following steps:
1) mixing microemulsion prepared by compounding cinnamaldehyde and carvacrol essential oil with polyquaternium-7, uniformly stirring, and completely swelling to obtain a transparent solution;
2) adding citric acid, cocamide DEA and cocamidopropyl betaine into the transparent solution obtained in the step 1), uniformly stirring, heating to 45 ℃;
3) adding sodium chloride granules, sodium cocoyl isethionate, sodium laureth sulfate and glycerol, and continuously stirring and heating to 80-85 ℃; preserving the temperature for 10 minutes, stirring uniformly, and then cooling to room temperature to obtain a finished product.
The preparation process of the compound essential oil microemulsion comprises the following steps: mixing cinnamaldehyde essential oil and carvacrol essential oil, adding propylene glycol and tween 80, mixing, dripping distilled water at intervals, oscillating, and making into compound microemulsion when it is clear and transparent.
And (4) related tests:
first, efficacy test
According to technical standards on cosmetic safety, the scalp scrub cream obtained by the invention is provided with a negative comparison sample (essential oil is not added in the formula of the scalp scrub cream, and other components and conditions are consistent) to carry out a use effect test. 60 volunteers aged 20-50 were selected for this trial, and the volunteers were randomly divided into 45 treatment groups (15 in each example) and 15 control groups.
The using method comprises the following steps: wetting scalp with towel, separating hair seam, applying the product close to scalp, applying the scalp massage cream of the invention to the treatment group, applying the negative control sample to the control group, rubbing scalp with finger abdomen for 3-4min, washing with clear water for 5 times (3 days) and tracking the use condition. The evaluation results of the scalp and hair condition improving effect are recorded in the following table 3:
table 3 scrub cream efficacy test recording table
Among the good criteria are: after the scalp cream is used, the scalp is not easy to itch, and dandruff, scalp grease and dead skin are obviously improved compared with the prior scalp cream; the general criteria are: after the scalp shampoo is used, the itching of the scalp, dandruff, scalp grease and dead skin are slightly improved compared with the prior scalp shampoo; the criteria for no sensation were: the properties of the scalp before and after use have no difference in their own feelings.
The results show that: the scalp scrub cream obtained by the invention has the advantages that the improvement effect of the dandruff and scalp states of all the embodiments is 80% or more; the negative control group had an improvement effect on the dandruff and scalp condition of only 9%.
Second, bacteriostatic experiment
The scalp scrub obtained in each embodiment of the invention is used, and a negative comparison sample (no essential oil is added in the formula of the invention, and other components and conditions are consistent) is set for carrying out a bacteriostatic effect test.
The method comprises the following steps: by inoculating Malassezia furfur toEvaluation was performed on in vitro skin treated with scrub cream in an XRF cup, a method to measure surface bacteriostatic activity after washing and rinsing procedures that simulate typical shampoo treatment. Malassezia furfur ATCC14521 was selected as a test strain and formulated at 26 ℃ to 3.8X 106CFU/m L. The treated artificial skin was dried overnight and placed in a jar containing modified Dixon agar. 200uL malassezia furfur suspension is inoculated on the surface of a substrate, after 24 hours of culture at 32 ℃, cells are collected by using a buffer solution, after 10-fold serial dilution, 100uL of the malassezia furfur suspension is coated on an improved Dixon agar plate, the malassezia furfur suspension is cultured for 3 to 4 days, data analysis is carried out by using one-factor analysis of variance, and if the P value of an F test is less than 0.05, the malassezia furfur suspension is considered to have statistical significance.
FIG. 2 shows the inhibitory effect of scrub on malassezia. As can be seen from figure 2, the experimental results of all the examples are that the number of Malassezia is logarithmically reduced, which shows that the invention has obvious inhibition effect on the growth of Malassezia furfur, and the P value is less than 0.05.
Claims (7)
1. The scurf-removing scalp scrub cream containing natural essential oil compounded microemulsion is characterized by comprising the following raw materials in percentage by mass:
2. the anti-dandruff scalp scrub cream of natural essential oil compound microemulsion according to claim 1, wherein the raw materials of the cinnamaldehyde and carvacrol essential oil microemulsion comprise, by mass, 0.05% -0.1% of cinnamaldehyde essential oil, 0.2% -0.4% of carvacrol essential oil, 0.2% -0.6% of propylene glycol, 802.5% -5% of tween and the balance of deionized water.
3. The dandruff-removing scalp scrub of natural essential oil compounded microemulsion according to claim 1, wherein the preparation process of the cinnamaldehyde and carvacrol essential oil microemulsion is as follows: mixing cinnamaldehyde essential oil and carvacrol essential oil, adding propylene glycol and tween 80, mixing, dripping distilled water at intervals, and oscillating to obtain microemulsion when the product is clear and transparent.
4. The anti-dandruff scalp scrub of natural essential oil complex microemulsion according to claim 1, wherein the mass ratio of sodium laureth sulfate, cocamidopropyl betaine, sodium cocoyl isethionate and cocamide DEA is 5-9: 5-9: 1.5-3: 1.5-3.
5. The preparation process of the anti-dandruff scalp scrub cream of the natural essential oil compound microemulsion according to any one of the claims 1 to 4, which is characterized by comprising the following steps:
step 1): mixing the cinnamaldehyde and carvacrol essential oil microemulsion with the polyquaternium-7, uniformly stirring, and completely swelling to obtain a transparent solution;
step 2): adding citric acid, cocamide DEA and cocamidopropyl betaine into the transparent solution obtained in the step 1), uniformly stirring and heating;
step 3): adding sodium chloride, sodium cocoyl isethionate, sodium laureth sulfate and glycerol into the mixture obtained in the step 2), continuously stirring and heating, preserving heat, uniformly stirring, and then cooling to room temperature to obtain a finished product.
6. The process for preparing the dandruff-removing scalp scrub cream of natural essential oil compounded microemulsion according to claim 5, wherein the heating in the step 2) is carried out to a temperature of 45 ℃.
7. The preparation process of the dandruff removing scalp scrub cream of the natural essential oil compound microemulsion as claimed in claim 5, wherein the heating in the step 3) is carried out to a temperature of 80-85 ℃, and the temperature is kept for 10 minutes.
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| US20110288165A1 (en) * | 2008-12-11 | 2011-11-24 | Olini Ltd | Novel lipid composition for the treatment of skin problems in companion animals |
| CN107897870A (en) * | 2017-11-23 | 2018-04-13 | 广东工业大学 | A kind of plants essential oil microemulsion and preparation method thereof |
| CN110538313A (en) * | 2019-09-27 | 2019-12-06 | 杭州玄盾科技有限公司 | Broad-spectrum malassezia-resistant natural product composition and application |
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Application publication date: 20220208 |