CN114007690B - 治疗哮喘的方法 - Google Patents
治疗哮喘的方法 Download PDFInfo
- Publication number
- CN114007690B CN114007690B CN202080044814.9A CN202080044814A CN114007690B CN 114007690 B CN114007690 B CN 114007690B CN 202080044814 A CN202080044814 A CN 202080044814A CN 114007690 B CN114007690 B CN 114007690B
- Authority
- CN
- China
- Prior art keywords
- asthma
- airway
- mice
- dapam
- shu jing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
Landscapes
- Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962862434P | 2019-06-17 | 2019-06-17 | |
| US62/862,434 | 2019-06-17 | ||
| PCT/US2020/037696 WO2020257093A1 (en) | 2019-06-17 | 2020-06-15 | Method for treating asthma |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN114007690A CN114007690A (zh) | 2022-02-01 |
| CN114007690B true CN114007690B (zh) | 2024-03-01 |
Family
ID=74040873
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202080044814.9A Active CN114007690B (zh) | 2019-06-17 | 2020-06-15 | 治疗哮喘的方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20220087969A1 (https=) |
| EP (1) | EP3983070B1 (https=) |
| JP (1) | JP7607939B2 (https=) |
| CN (1) | CN114007690B (https=) |
| AU (1) | AU2020296829B2 (https=) |
| CA (1) | CA3141407A1 (https=) |
| MX (1) | MX2021015561A (https=) |
| WO (1) | WO2020257093A1 (https=) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2651407B1 (en) * | 2010-12-15 | 2016-12-21 | Olatec Industries LLC | 3-methanesulfonylpropionitrile for treating inflammation and pain |
| FR3046933B1 (fr) * | 2016-01-25 | 2018-03-02 | Galderma Research & Development | Inhibiteurs nlrp3 pour le traitement des pathologies cutanees inflammatoires |
| US11597706B2 (en) * | 2016-04-18 | 2023-03-07 | Novartis Ag | Compounds and compositions for treating conditions associated with NLRP activity |
-
2020
- 2020-06-15 AU AU2020296829A patent/AU2020296829B2/en active Active
- 2020-06-15 CA CA3141407A patent/CA3141407A1/en active Pending
- 2020-06-15 CN CN202080044814.9A patent/CN114007690B/zh active Active
- 2020-06-15 MX MX2021015561A patent/MX2021015561A/es unknown
- 2020-06-15 JP JP2021574818A patent/JP7607939B2/ja active Active
- 2020-06-15 WO PCT/US2020/037696 patent/WO2020257093A1/en not_active Ceased
- 2020-06-15 EP EP20826406.9A patent/EP3983070B1/en active Active
-
2021
- 2021-12-02 US US17/457,420 patent/US20220087969A1/en not_active Abandoned
Non-Patent Citations (4)
| Title |
|---|
| Blockade of the NLRP3/Caspase-1 Axis Ameliorates Airway Neutrophilic Inflammation in a Toluene Disocyanate-Induced Murine Asthma Model;CHEN SHUYU ET AL;TOXICOLOGICAL SCIENCES;第170卷(第2期);462-475 * |
| OLT1177, a beta-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation;MARCHETTI et al;PNAS;第115卷(第7期);E1530-E1539 * |
| Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors;YANG YANG ET AL;CELL DEATH & DISEASE;第10卷(第2期);128 * |
| Role for NLRP3 Inflammasome-mediated, IL -Ib-Dependent Responses in Severe, Steroid -Resistant Asthma;KIM RICHARD Y ET AL;AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE;第196卷(第3期);283-297 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN114007690A (zh) | 2022-02-01 |
| JP7607939B2 (ja) | 2025-01-06 |
| JP2022536932A (ja) | 2022-08-22 |
| US20220087969A1 (en) | 2022-03-24 |
| AU2020296829B2 (en) | 2026-01-15 |
| CA3141407A1 (en) | 2020-12-24 |
| WO2020257093A1 (en) | 2020-12-24 |
| MX2021015561A (es) | 2022-01-24 |
| EP3983070B1 (en) | 2024-09-11 |
| AU2020296829A1 (en) | 2022-02-10 |
| EP3983070A4 (en) | 2023-04-26 |
| EP3983070A1 (en) | 2022-04-20 |
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