CN114007656A - 用于制备标准化充气微泡的冻干组合物 - Google Patents

用于制备标准化充气微泡的冻干组合物 Download PDF

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Publication number
CN114007656A
CN114007656A CN202080046128.5A CN202080046128A CN114007656A CN 114007656 A CN114007656 A CN 114007656A CN 202080046128 A CN202080046128 A CN 202080046128A CN 114007656 A CN114007656 A CN 114007656A
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CN
China
Prior art keywords
gas
suspension
mixture
microvesicles
lyophilized
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202080046128.5A
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English (en)
Chinese (zh)
Inventor
A·拉苏斯
S·沙尔卡维
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco Suisse SA
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Bracco Suisse SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Suisse SA filed Critical Bracco Suisse SA
Publication of CN114007656A publication Critical patent/CN114007656A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Acoustics & Sound (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Confectionery (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN202080046128.5A 2019-06-25 2020-06-24 用于制备标准化充气微泡的冻干组合物 Pending CN114007656A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19182226.1 2019-06-25
EP19182226 2019-06-25
PCT/EP2020/067756 WO2020260423A1 (en) 2019-06-25 2020-06-24 Freeze-dried composition for preparing calibrated gas-filled microvesicles

Publications (1)

Publication Number Publication Date
CN114007656A true CN114007656A (zh) 2022-02-01

Family

ID=67070596

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080046128.5A Pending CN114007656A (zh) 2019-06-25 2020-06-24 用于制备标准化充气微泡的冻干组合物

Country Status (7)

Country Link
US (1) US20220409749A1 (enExample)
EP (1) EP3990033B1 (enExample)
JP (2) JP7712877B2 (enExample)
CN (1) CN114007656A (enExample)
DK (1) DK3990033T3 (enExample)
ES (1) ES2967371T3 (enExample)
WO (1) WO2020260423A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20240035750A (ko) 2021-07-14 2024-03-18 브라코 스위스 에스.에이. 양이온성 보정된 크기의 기체 충전된 미세소포
NL2033467B1 (en) * 2022-11-04 2024-05-24 Demcon Curonix B V System for generating microvesicles having a predefined size and/or size distribution
CN120529925A (zh) 2022-12-21 2025-08-22 博莱科瑞士股份有限公司 含全氟烯烃的充气微泡
WO2025073838A1 (en) * 2023-10-04 2025-04-10 Bracco Suisse Sa Freeze-drying process
WO2025125516A1 (en) 2023-12-13 2025-06-19 Bracco Suisse Sa Calibrated gas-filled microvesicles with ligand
WO2025252942A1 (en) 2024-06-06 2025-12-11 Bracco Suisse Sa Anionic gas-filled microvesicles with calibrated sizes

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100501863B1 (ko) * 1996-02-19 2005-09-27 아머샴 헬스 에이에스 열안정화된조영제
AU2004210221B2 (en) * 2003-02-04 2008-11-20 Bracco Suisse S.A. Ultrasound contrast agents and process for the preparation thereof
US9555136B2 (en) * 2010-06-21 2017-01-31 University Of Washington Through Its Center For Commercialization Coated magnetic nanoparticles
GB201405735D0 (en) 2014-03-31 2014-05-14 Ge Healthcare As Ultrasound precursor preparation method
CN105999314B (zh) * 2016-07-11 2018-12-18 四川省人民医院 一种超声造影剂及其制备方法
DK3506882T3 (da) * 2016-08-30 2022-03-21 Bracco Suisse Sa Fremstilling af størrelseskontrollerede mikropartikler

Also Published As

Publication number Publication date
US20220409749A1 (en) 2022-12-29
JP7712877B2 (ja) 2025-07-24
JP2025118720A (ja) 2025-08-13
EP3990033A1 (en) 2022-05-04
JP2022538769A (ja) 2022-09-06
EP3990033B1 (en) 2023-12-06
DK3990033T3 (da) 2023-12-18
ES2967371T3 (es) 2024-04-30
WO2020260423A1 (en) 2020-12-30

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