JP7712877B2 - 校正されたガス充填微小胞を調製するための凍結乾燥組成物 - Google Patents

校正されたガス充填微小胞を調製するための凍結乾燥組成物

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Publication number
JP7712877B2
JP7712877B2 JP2021573452A JP2021573452A JP7712877B2 JP 7712877 B2 JP7712877 B2 JP 7712877B2 JP 2021573452 A JP2021573452 A JP 2021573452A JP 2021573452 A JP2021573452 A JP 2021573452A JP 7712877 B2 JP7712877 B2 JP 7712877B2
Authority
JP
Japan
Prior art keywords
microvesicles
gas
calibrated
suspension
peg
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2021573452A
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English (en)
Japanese (ja)
Other versions
JP2022538769A (ja
Inventor
アン ラッサス
サミール シェルカウイ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco Suisse SA
Original Assignee
Bracco Suisse SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Suisse SA filed Critical Bracco Suisse SA
Publication of JP2022538769A publication Critical patent/JP2022538769A/ja
Priority to JP2025074157A priority Critical patent/JP2025118720A/ja
Application granted granted Critical
Publication of JP7712877B2 publication Critical patent/JP7712877B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Acoustics & Sound (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Confectionery (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2021573452A 2019-06-25 2020-06-24 校正されたガス充填微小胞を調製するための凍結乾燥組成物 Active JP7712877B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025074157A JP2025118720A (ja) 2019-06-25 2025-04-28 校正されたガス充填微小胞を調製するための凍結乾燥組成物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19182226.1 2019-06-25
EP19182226 2019-06-25
PCT/EP2020/067756 WO2020260423A1 (en) 2019-06-25 2020-06-24 Freeze-dried composition for preparing calibrated gas-filled microvesicles

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025074157A Division JP2025118720A (ja) 2019-06-25 2025-04-28 校正されたガス充填微小胞を調製するための凍結乾燥組成物

Publications (2)

Publication Number Publication Date
JP2022538769A JP2022538769A (ja) 2022-09-06
JP7712877B2 true JP7712877B2 (ja) 2025-07-24

Family

ID=67070596

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2021573452A Active JP7712877B2 (ja) 2019-06-25 2020-06-24 校正されたガス充填微小胞を調製するための凍結乾燥組成物
JP2025074157A Pending JP2025118720A (ja) 2019-06-25 2025-04-28 校正されたガス充填微小胞を調製するための凍結乾燥組成物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2025074157A Pending JP2025118720A (ja) 2019-06-25 2025-04-28 校正されたガス充填微小胞を調製するための凍結乾燥組成物

Country Status (7)

Country Link
US (1) US20220409749A1 (enExample)
EP (1) EP3990033B1 (enExample)
JP (2) JP7712877B2 (enExample)
CN (1) CN114007656A (enExample)
DK (1) DK3990033T3 (enExample)
ES (1) ES2967371T3 (enExample)
WO (1) WO2020260423A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20240035750A (ko) 2021-07-14 2024-03-18 브라코 스위스 에스.에이. 양이온성 보정된 크기의 기체 충전된 미세소포
NL2033467B1 (en) * 2022-11-04 2024-05-24 Demcon Curonix B V System for generating microvesicles having a predefined size and/or size distribution
CN120529925A (zh) 2022-12-21 2025-08-22 博莱科瑞士股份有限公司 含全氟烯烃的充气微泡
WO2025073838A1 (en) * 2023-10-04 2025-04-10 Bracco Suisse Sa Freeze-drying process
WO2025125516A1 (en) 2023-12-13 2025-06-19 Bracco Suisse Sa Calibrated gas-filled microvesicles with ligand
WO2025252942A1 (en) 2024-06-06 2025-12-11 Bracco Suisse Sa Anionic gas-filled microvesicles with calibrated sizes

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000506122A (ja) 1996-02-19 2000-05-23 ニユコメド・イメージング・アクシエセルカペト 熱安定化された造影剤
CN105999314A (zh) 2016-07-11 2016-10-12 四川省人民医院 一种超声造影剂及其制备方法
WO2018041906A1 (en) 2016-08-30 2018-03-08 Bracco Suisse Sa Preparation of size-controlled microparticles

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004210221B2 (en) * 2003-02-04 2008-11-20 Bracco Suisse S.A. Ultrasound contrast agents and process for the preparation thereof
US9555136B2 (en) * 2010-06-21 2017-01-31 University Of Washington Through Its Center For Commercialization Coated magnetic nanoparticles
GB201405735D0 (en) 2014-03-31 2014-05-14 Ge Healthcare As Ultrasound precursor preparation method

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000506122A (ja) 1996-02-19 2000-05-23 ニユコメド・イメージング・アクシエセルカペト 熱安定化された造影剤
CN105999314A (zh) 2016-07-11 2016-10-12 四川省人民医院 一种超声造影剂及其制备方法
WO2018041906A1 (en) 2016-08-30 2018-03-08 Bracco Suisse Sa Preparation of size-controlled microparticles

Also Published As

Publication number Publication date
US20220409749A1 (en) 2022-12-29
JP2025118720A (ja) 2025-08-13
EP3990033A1 (en) 2022-05-04
JP2022538769A (ja) 2022-09-06
EP3990033B1 (en) 2023-12-06
DK3990033T3 (da) 2023-12-18
ES2967371T3 (es) 2024-04-30
CN114007656A (zh) 2022-02-01
WO2020260423A1 (en) 2020-12-30

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