CN113993883A - 一种多肽及其应用 - Google Patents

一种多肽及其应用 Download PDF

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CN113993883A
CN113993883A CN202080042030.2A CN202080042030A CN113993883A CN 113993883 A CN113993883 A CN 113993883A CN 202080042030 A CN202080042030 A CN 202080042030A CN 113993883 A CN113993883 A CN 113993883A
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polypeptide
seq
modification
group
mice
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董服民
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Ottawa Hdl Pharmaceutical Research And Development Co
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Ottawa Hdl Pharmaceutical Research And Development Co
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    • C07ORGANIC CHEMISTRY
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    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542Carboxylic acids, e.g. a fatty acid or an amino acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
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  • Child & Adolescent Psychology (AREA)
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  • Toxicology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

提供了一种多肽及其应用。该多肽包含由SEQ ID NO:1所示的氨基酸序列中16‑23个连续氨基酸所构成的肽段。该多肽可以改善代谢综合征、减肥、治疗非酒精性脂肪肝病和心血管疾病。

Description

PCT国内申请,说明书已公开。

Claims (8)

  1. PCT国内申请,权利要求书已公开。
CN202080042030.2A 2019-08-29 2020-08-28 一种多肽及其应用 Pending CN113993883A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201910807205.3A CN112442114A (zh) 2019-08-29 2019-08-29 一种多肽及其应用
CN2019108072053 2019-08-29
PCT/CN2020/112007 WO2021037187A1 (zh) 2019-08-29 2020-08-28 一种多肽及其应用

Publications (1)

Publication Number Publication Date
CN113993883A true CN113993883A (zh) 2022-01-28

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CN202080042030.2A Pending CN113993883A (zh) 2019-08-29 2020-08-28 一种多肽及其应用

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US (1) US20220298209A1 (zh)
EP (1) EP4023663A4 (zh)
CN (2) CN112442114A (zh)
WO (1) WO2021037187A1 (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112442114A (zh) * 2019-08-29 2021-03-05 渥太华Hdl药物研发公司 一种多肽及其应用

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001057188A2 (en) * 2000-02-03 2001-08-09 Hyseq, Inc. Novel nucleic acids and polypeptides
US20080234192A1 (en) * 2006-12-08 2008-09-25 Washington, University Of Compositions and methods of use for treating cardiovascular disease
CN101721712A (zh) * 2008-10-21 2010-06-09 何明磊 一种双链聚乙二醇-胰岛素复合物及其制备方法
US20120329703A1 (en) * 2002-05-08 2012-12-27 The Regents Of Te University Of California Potent and Selective Mediators of Cholesterol Efflux
US20140336113A1 (en) * 2011-10-06 2014-11-13 Vanderbilt University Compositions and methods for treating and preventing hyperlipidemia, fatty liver, atherosclerosis and other disorders associated with metabolic syndrome
CN105008524A (zh) * 2012-12-12 2015-10-28 东安大略研究所儿童医院有限公司 用于治疗脑癌的组合物和方法
CN107011427A (zh) * 2017-03-16 2017-08-04 深圳先进技术研究院 调节能量代谢的多肽及其用途
CN109200273A (zh) * 2017-07-04 2019-01-15 中国药科大学 一种多肽用于制备预防或治疗脂肪肝病药物的用途
CN109420157A (zh) * 2017-08-21 2019-03-05 华中科技大学 一种药物组合物的应用
AU2018314773A1 (en) * 2017-08-09 2020-03-26 Sanofi GLP-1/glucagon receptor agonists in the treatment of fatty liver disease and steatohepatitis
CN111225680A (zh) * 2017-10-18 2020-06-02 上海贺普药业股份有限公司 非酒精性脂肪性肝病的治疗药物
CN112442114A (zh) * 2019-08-29 2021-03-05 渥太华Hdl药物研发公司 一种多肽及其应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2375771A1 (fr) * 1999-06-17 2000-12-28 Aventis Pharma S.A. Acides nucleiques et proteines correspondant au gene abc1 humain
WO2001032184A2 (en) * 1999-11-01 2001-05-10 Wisconsin Alumni Research Foundation Abc1 modulation for the modulation of cholesterol transport
SG11201609084QA (en) * 2014-05-02 2016-11-29 Cerenis Therapeutics Holding Sa Hdl therapy markers
US10293043B2 (en) * 2014-06-02 2019-05-21 Armo Biosciences, Inc. Methods of lowering serum cholesterol

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001057188A2 (en) * 2000-02-03 2001-08-09 Hyseq, Inc. Novel nucleic acids and polypeptides
US20120329703A1 (en) * 2002-05-08 2012-12-27 The Regents Of Te University Of California Potent and Selective Mediators of Cholesterol Efflux
US20080234192A1 (en) * 2006-12-08 2008-09-25 Washington, University Of Compositions and methods of use for treating cardiovascular disease
CN101721712A (zh) * 2008-10-21 2010-06-09 何明磊 一种双链聚乙二醇-胰岛素复合物及其制备方法
US20140336113A1 (en) * 2011-10-06 2014-11-13 Vanderbilt University Compositions and methods for treating and preventing hyperlipidemia, fatty liver, atherosclerosis and other disorders associated with metabolic syndrome
CN105008524A (zh) * 2012-12-12 2015-10-28 东安大略研究所儿童医院有限公司 用于治疗脑癌的组合物和方法
CN107011427A (zh) * 2017-03-16 2017-08-04 深圳先进技术研究院 调节能量代谢的多肽及其用途
CN109200273A (zh) * 2017-07-04 2019-01-15 中国药科大学 一种多肽用于制备预防或治疗脂肪肝病药物的用途
AU2018314773A1 (en) * 2017-08-09 2020-03-26 Sanofi GLP-1/glucagon receptor agonists in the treatment of fatty liver disease and steatohepatitis
CN109420157A (zh) * 2017-08-21 2019-03-05 华中科技大学 一种药物组合物的应用
CN111225680A (zh) * 2017-10-18 2020-06-02 上海贺普药业股份有限公司 非酒精性脂肪性肝病的治疗药物
CN112442114A (zh) * 2019-08-29 2021-03-05 渥太华Hdl药物研发公司 一种多肽及其应用

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
M. PILAR VALDECANTOS等: "Differential Effects of a Glucagon-Like Peptide 1 Receptor Agonist in Non-Alcoholic Fatty Liver Disease and in Response to Hepatectomy", 《SCIENTIFIC REPORTS》, vol. 8, no. 16461, pages 1 - 15 *
张颖玮,王艳侠,石岩等主编: "《肾脏病学现代基础与临床》", 内蒙古科学技术出版社, pages: 339 - 9 *
梁辰: "16个氨基酸多肽对高脂饮食+CCl4诱导的非酒精性脂肪肝的保护性作用及机制研究", <中国优秀硕士学位论文全文数据库医药卫生科技辑>, pages 064 - 80 *

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Publication number Publication date
EP4023663A1 (en) 2022-07-06
CN112442114A8 (zh) 2021-04-16
EP4023663A4 (en) 2023-01-04
US20220298209A1 (en) 2022-09-22
WO2021037187A1 (zh) 2021-03-04
CN112442114A (zh) 2021-03-05

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