CN113952409A - 一种全鹿丸制剂制备工艺及其泛丸包衣装置 - Google Patents

一种全鹿丸制剂制备工艺及其泛丸包衣装置 Download PDF

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CN113952409A
CN113952409A CN202111213751.8A CN202111213751A CN113952409A CN 113952409 A CN113952409 A CN 113952409A CN 202111213751 A CN202111213751 A CN 202111213751A CN 113952409 A CN113952409 A CN 113952409A
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pill
deer
pan
pot
whole
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何炳谕
王福春
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Jilin Huaqiao Pharmaceutical Group Co ltd
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Jilin Huaqiao Pharmaceutical Group Co ltd
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Abstract

本发明公开了一种全鹿丸制剂制备工艺，包括如下步骤：S1、备料，称取一定质量份的主料和辅料；S2、将上述配料称量调剂后，粉碎成细粉，过筛，混匀，加入炼蜜500‑600g合坨处理，每100g粉末加炼蜜40‑55g，干混5分钟，加热温度为100℃，搅拌90分钟；S3、泛丸，在泛丸锅中喷适量水润湿，撒适量药粉，转动泛丸锅，刷下附着粉粒；S4、干燥，温度55±3℃，时间为60‑90分钟，制得全鹿丸，且丸重0.9±0.05g。本发明还公开了一种全鹿丸制剂制备用泛丸包衣装置，包括泛丸锅和工作台架，所述泛丸锅包括上锅体和下锅体，建立全鹿丸制剂工艺规程，规范生产过程，确保持续稳定生产，降低工人劳动强度，完善生产工艺规程，依据流程，保证产品的合格率。

Description

一种全鹿丸制剂制备工艺及其泛丸包衣装置
技术领域
本发明涉及中药保健制品技术领域，具体涉及一种全鹿丸制剂制备工艺，本发明还涉及一种全鹿丸制剂制备用泛丸包衣装置。
背景技术
全鹿丸是以鹿肉为主要材料的中药制剂，具有补气养血，调经散寒，补肾益精，滋阴养颜等功效，常以鹿胎为主要原料制备成鹿胎膏，作为直接服用的中药制品，鹿胎膏在中国已有几百年的服用历史，清代时也被皇宫列为大补珍品。
现有的全鹿丸制剂生产大都采用一种半自动手工制丸方法，被称为泛丸法。这种泛丸法是将母丸放入转动的荸荠式泛丸锅内，药丸在锅内滚动摩擦，然后间歇手动喷水，间歇手动撒粉，使母丸渐渐长大。长大的药丸人工从泛丸锅内舀出，倒进筛分机筛分分级，成品丸装桶，小丸返回泛丸锅继续长大，大丸粉碎重新制成母丸。这种半自动手工制丸方法的缺点是药品产量低，质量严重依赖工人的经验，而且工人劳动强度大，生产工艺规程不完善，无法保证产品的合格率，造成一定的浪费。
发明内容
本发明的目的在于提供一种全鹿丸制剂制备工艺及其泛丸包衣装置，建立全鹿丸制剂工艺规程，规范生产过程，确保持续稳定生产，降低工人劳动强度，完善生产工艺规程，依据流程，保证产品的合格率，以解决上述背景技术中提出的问题。
为实现上述目的，本发明提供如下技术方案：
一种全鹿丸制剂制备工艺，包括如下步骤：
S1、备料，称取一定质量份的主料和辅料，其中主料包括鹿干70-90g，辅料包括党参30-50g、地黄30-50g、牛膝30-50g、熟地黄30-50g、楮实子30-50g、菟丝子30-50g、山药30-50g、盐补骨脂30-50g、枸杞子30-50g、川芎30-50g、肉苁蓉30-50g、酒当归30-50g、巴戟天30-50g、炙甘草30-50g、天冬30-50g、五味子30-50g、麦冬30-50g、炒白术30-50g、覆盆子30-50g、盐杜仲30-50g、芡实30-50g、花椒10-30g、茯苓30-50g、陈皮30-50g、炙黄芪30-50g、小茴香10-30g、盐续断30-50g、青盐10-30g、胡芦巴30-50g、沉香10-30g；
S2、将上述配料称量调剂后，粉碎成细粉，过筛，混匀，加入炼蜜500-600g合坨处理，每100g粉末加炼蜜40-55g，干混5分钟，加热温度为100℃，搅拌90分钟；
S3、泛丸，在泛丸锅中喷适量水润湿，撒适量药粉，转动泛丸锅，刷下附着粉粒，再喷水、撒粉，反复循环，粉粒渐大；
S4、干燥，温度55±3℃，时间为60-90分钟，制得全鹿丸，且丸重0.9±0.05g。
作为优选的技术方案，步骤S1中所述的锁阳、川芎、小茴香和胡芦巴均采用酒炒的处理方式。
作为优选的技术方案，步骤S1中所述的枸杞子采用盐水炒的处理方式，所述五味子蒸熟。
作为优选的技术方案，所述干燥后的全鹿丸成丸需要进行打光处理6-8分钟，装入内包装袋后，在进行外包装，完成入库。
一种全鹿丸制剂制备用泛丸包衣装置，包括泛丸锅和工作台架，所述泛丸锅包括上锅体和下锅体，所述下锅体转动安装于工作台架上，所述工作台架上表面设置有龙门支架，所述龙门支架顶部居中位置固定安装有电动推杆，且龙门支架顶部一侧固定安装有水泵，所述电动推杆的活塞杆端延伸至龙门支架下方，所述上锅体顶部固定安装有水箱，所述水泵和水箱固定连通，所述水箱底部设置有喷淋头，所述水箱固定连接于电动推杆的活塞杆端和上锅体之间，所述泛丸锅两侧对称设置有烘干风管，所述烘干风管滑动安装于龙门支架内。
作为优选的技术方案，所述电动推杆内壁对称安装有两组支撑板，所述支撑板底面固定安装有电动滑台，所述电动滑台的移动块上固定安装有夹持杆，所述烘干风管一端固定安装于夹持杆内。
作为优选的技术方案，所述工作台架内固定安装有风机，所述风机的出风口固定联通有加热器，所述加热器的出风口和烘干风管一端固定连通。
作为优选的技术方案，所述上锅体内壁对称设置有带有凸起的第一卡块，所述下锅体内壁对称设置有带有凹槽的第二卡块，所述第一卡块和第二卡块间隙配合。
作为优选的技术方案，所述喷淋头设置有四组，四组所述喷淋头通过弯管环形等距阵列于水箱下表面。
作为优选的技术方案，所述下锅体底部环形等距阵列有万向球轮，所述工作台架上表面开设有环形凹槽，所述万向球轮和环形凹槽间隙配合。
综上所述，由于采用了上述技术，本发明的有益效果是：
本发明中，通过依次组合三十二种药材清洗粉碎后，利用泛丸锅进行泛丸处理，建立全鹿丸制剂工艺规程，规范生产过程，确保持续稳定生产，降低工人劳动强度，完善生产工艺规程，依据流程，保证产品的合格率；
本发明设置自动喷淋系统，将泛丸锅的上盖设置为水箱结构，直接连通水箱底部环形等距阵列的喷淋管和喷淋头，自动对泛丸锅内的粉料进行喷淋，节省人工；
本发明将泛丸锅设置为上锅体和下锅体分离式结构，不管是投粉还是出丸，都提供了便捷的方式，配合龙门架两侧的烘干风管，成丸后，利用电动推杆打开上锅体，再利用电动滑台将两组烘干风管的出风口推入泛丸锅内，直接对全鹿丸进行烘干处理，节省流程，无需完全依赖工人的经验，保证产品合格率，避免不合格品的浪费。
附图说明
图1为本发明一种全鹿丸制剂制备的工艺流程图；
图2为本发明泛丸包衣装置的主视剖视结构示意图；
图3为本发明图1中的A处结构局部剖视图；
图4为本发明的俯视剖视结构示意图；
图5为本发明的水箱仰视结构示意图。
图中：1、上锅体；101、第一卡块；2、下锅体；201、第二卡块；3、工作台架；4、龙门支架；5、电动推杆；6、水箱；601、喷淋头；602、弯管；7、烘干风管；8、支撑板；9、电动滑台；10、夹持杆；11、风机；12、加热器；13、万向球轮；14、环形凹槽；15、水泵。
具体实施方式
为使本发明实施方式的目的、技术方案和优点更加清楚，下面将结合本发明实施方式中的附图，对本发明实施方式中的技术方案进行清楚、完整地描述，显然，所描述的实施方式是本发明一部分实施方式，而不是全部的实施方式。基于本发明中的实施方式，本领域普通技术人员在没有作出创造性劳动前提下所获得的所有其他实施方式，都属于本发明保护的范围。因此，以下对在附图中提供的本发明的实施方式的详细描述并非旨在限制要求保护的本发明的范围，而是仅仅表示本发明的选定实施方式。基于本发明中的实施方式，本领域普通技术人员在没有作出创造性劳动前提下所获得的所有其他实施方式，都属于本发明保护的范围。
在本发明的描述中，需要理解的是，指示方位或位置关系的术语为基于附图所示的方位或位置关系，仅是为了便于描述本发明和简化描述，而不是指示或暗示所指的设备或元件必须具有特定的方位、以特定的方位构造和操作，因此不能理解为对本发明的限制。
在本发明中，除非另有明确的规定和限定，术语“安装”、“相连”、“连接”、“固定”等术语应做广义理解，例如，可以是固定连接，也可以是可拆卸连接，或成一体；可以是机械连接，也可以是电连接；可以是直接相连，也可以通过中间媒介间接相连，可以是两个元件内部的连通或两个元件的相互作用关系。对于本领域的普通技术人员而言，可以根据说明书具体情况理解上述术语在本发明中的具体含义。
实施例1
本发明提供了如图1所示的一种全鹿丸制剂制备工艺，包括如下步骤：
S1、备料，称取一定质量份的主料和辅料，其中主料包括鹿干80g，辅料包括党参40g、地黄40g、牛膝40g、熟地黄40g、楮实子40g、菟丝子40g、山药40g、盐补骨脂40g、枸杞子40g、川芎40g、肉苁蓉40g、酒当归40g、巴戟天40g、炙甘草40g、天冬40g、五味子40g、麦冬40g、炒白术40g、覆盆子40g、盐杜仲40g、芡实40g、花椒20g、茯苓40g、陈皮40g、炙黄芪40g、小茴香20g、盐续断40g、青盐20g、胡芦巴40g、沉香20g；
S2、将上述配料称量调剂后，粉碎成细粉，过筛，混匀，加入炼蜜550g合坨处理，每100g粉末加炼蜜45g，干混5分钟，加热温度为100℃，搅拌90分钟；
S3、泛丸，在泛丸锅中喷适量水润湿，撒适量药粉，转动泛丸锅，刷下附着粉粒，再喷水、撒粉，反复循环，粉粒渐大；
S4、干燥，温度55±3℃，时间为60-90分钟，制得全鹿丸，且丸重0.9±0.05g。
其中，步骤S1中所述的锁阳、川芎、小茴香和胡芦巴均采用酒炒的处理方式。
其中，步骤S1中所述的枸杞子采用盐水炒的处理方式，所述五味子蒸熟。
所述干燥后的全鹿丸成丸需要进行打光处理6-8分钟，装入内包装袋后，在进行外包装，完成入库。
本发明提供了如图2-4所示的一种全鹿丸制剂制备用泛丸包衣装置，包括泛丸锅和工作台架3，所述泛丸锅包括上锅体1和下锅体2，所述上锅体1内壁对称设置有带有凸起的第一卡块101，所述下锅体2内壁对称设置有带有凹槽的第二卡块201，所述第一卡块101和第二卡块201间隙配合，所述下锅体2转动安装于工作台架3上，所述下锅体2底部环形等距阵列有万向球轮13，所述工作台架3上表面开设有环形凹槽14，所述万向球轮13和环形凹槽14间隙配合，通过设置万向球轮13和环形凹槽14间隙配合，保证了泛丸锅在转动时的稳定性，高速成丸效果更佳；将泛丸锅设置为上锅体1和下锅体2分离式结构，不管是投粉还是出丸，都提供了便捷的方式，使用时，下锅体2底部传动连接有驱动电机，保证泛丸锅的常规转动运行。
所述工作台架3上表面设置有龙门支架4，所述龙门支架4顶部居中位置固定安装有电动推杆5，且龙门支架4顶部一侧固定安装有水泵15，所述电动推杆5的活塞杆端延伸至龙门支架4下方，所述上锅体1顶部固定安装有水箱6，所述水泵15和水箱6固定连通，所述水箱6底部设置有喷淋头601，所述水箱6固定连接于电动推杆5的活塞杆端和上锅体1之间，所述喷淋头601设置有四组，四组所述喷淋头601通过弯管602环形等距阵列于水箱6下表面，将泛丸锅的上锅体1上盖设置为水箱6的结构，直接连通水箱6底部环形等距阵列的喷淋管-弯管602和喷淋头601，自动对泛丸锅内的粉料进行喷淋，节省人工。
所述泛丸锅两侧对称设置有烘干风管7，所述烘干风管7滑动安装于龙门支架4内，所述工作台架3内固定安装有风机11，所述风机11的出风口固定联通有加热器12，所述加热器12的出风口和烘干风管7一端固定连通，连通的管路内设置一段钢丝软管，既能保证通风效果，电动滑台9工作时，不会对烘干风管7移动产生干涉；所述电动推杆5内壁对称安装有两组支撑板8，所述支撑板8底面固定安装有电动滑台9，所述电动滑台9的移动块上固定安装有夹持杆10，夹持杆10包括连接杆和连接杆一段的夹子，适配于烘干风管7的外径夹持范围即可，所述烘干风管7一端固定安装于夹持杆10内，烘干时，利用电动推杆5提升打开上锅体1，再利用电动滑台9将两组烘干风管7的出风口推入泛丸锅内，直接对下锅体2内成型的全鹿丸进行烘干处理，节省流程，无需完全依赖工人的经验，保证产品合格率，避免不合格品的浪费。
实施例2
与实施例1不同的是：
一种全鹿丸制剂制备工艺，包括如下步骤：
S1、备料，称取一定质量份的主料和辅料，其中主料包括鹿干70g，辅料包括党参30g、地黄30g、牛膝30g、熟地黄30g、楮实子30g、菟丝子30g、山药30g、盐补骨脂30g、枸杞子30g、川芎30g、肉苁蓉30g、酒当归30g、巴戟天30g、炙甘草30g、天冬30g、五味子30g、麦冬30g、炒白术30g、覆盆子30g、盐杜仲30g、芡实30g、花椒10g、茯苓30g、陈皮30g、炙黄芪30g、小茴香10g、盐续断30g、青盐10g、胡芦巴30g、沉香10g。
实施例3
与实施例1不同的是：
一种全鹿丸制剂制备工艺，包括如下步骤：
S1、备料，称取一定质量份的主料和辅料，其中主料包括鹿干90g，辅料包括党参50g、地黄50g、牛膝50g、熟地黄50g、楮实子50g、菟丝子50g、山药50g、盐补骨脂50g、枸杞子50g、川芎50g、肉苁蓉50g、酒当归50g、巴戟天50g、炙甘草50g、天冬50g、五味子50g、麦冬50g、炒白术50g、覆盆子50g、盐杜仲50g、芡实50g、花椒30g、茯苓50g、陈皮50g、炙黄芪50g、小茴香30g、盐续断50g、青盐30g、胡芦巴50g、沉香30g。
Figure BDA0003309887300000091
Figure BDA0003309887300000101
Figure BDA0003309887300000111
以上所述，仅为本发明较佳的具体实施方式，但本发明的保护范围并不局限于此，任何熟悉本技术领域的技术人员在本发明揭露的技术范围内，根据本发明的技术方案及其发明构思加以等同替换或改变，都应涵盖在本发明的保护范围之内。
需要说明的是，在本文中，诸如第一和第二等之类的关系术语仅仅用来将一个实体或者操作与另一个实体或操作区分开来，而不一定要求或者暗示这些实体或操作之间存在任何这种实际的关系或者顺序。而且，术语“包括”、“包含”或者其任何其他变体意在涵盖非排他性的包含，从而使得包括一系列要素的过程、方法、物品或者设备不仅包括那些要素，而且还包括没有明确列出的其他要素，或者是还包括为这种过程、方法、物品或者设备所固有的要素。

Claims (10)

1.一种全鹿丸制剂制备工艺，其特征在于，包括如下步骤：
S1、备料，称取一定质量份的主料和辅料，其中主料包括鹿干70-90g，辅料包括党参30-50g、地黄30-50g、牛膝30-50g、熟地黄30-50g、楮实子30-50g、菟丝子30-50g、山药30-50g、盐补骨脂30-50g、枸杞子30-50g、川芎30-50g、肉苁蓉30-50g、酒当归30-50g、巴戟天30-50g、炙甘草30-50g、天冬30-50g、五味子30-50g、麦冬30-50g、炒白术30-50g、覆盆子30-50g、盐杜仲30-50g、芡实30-50g、花椒10-30g、茯苓30-50g、陈皮30-50g、炙黄芪30-50g、小茴香10-30g、盐续断30-50g、青盐10-30g、胡芦巴30-50g、沉香10-30g；
S2、将上述配料称量调剂后，粉碎成细粉，过筛，混匀，加入炼蜜500-600g合坨处理，每100g粉末加炼蜜40-55g，干混5分钟，加热温度为100℃，搅拌90分钟；
S3、泛丸，在泛丸锅中喷适量水润湿，撒适量药粉，转动泛丸锅，刷下附着粉粒，再喷水、撒粉，反复循环，粉粒渐大；
S4、干燥，温度55±3℃，时间为60-90分钟，制得全鹿丸，且丸重0.9±0.05g。
2.根据权利要求1所述的一种全鹿丸制剂制备工艺，其特征在于：步骤S1中所述的锁阳、川芎、小茴香和胡芦巴均采用酒炒的处理方式。
3.根据权利要求1所述的一种全鹿丸制剂制备工艺，其特征在于：步骤S1中所述的枸杞子采用盐水炒的处理方式，所述五味子蒸熟。
4.根据权利要求1所述的一种全鹿丸制剂制备工艺，其特征在于：所述干燥后的全鹿丸成丸需要进行打光处理6-8分钟，装入内包装袋后，在进行外包装，完成入库。
5.一种根据权利要求1所述的全鹿丸制剂制备用泛丸包衣装置，包括泛丸锅和工作台架(3)，其特征在于：所述泛丸锅包括上锅体(1)和下锅体(2)，所述下锅体(2)转动安装于工作台架(3)上，所述工作台架(3)上表面设置有龙门支架(4)，所述龙门支架(4)顶部居中位置固定安装有电动推杆(5)，且龙门支架(4)顶部一侧固定安装有水泵(15)，所述电动推杆(5)的活塞杆端延伸至龙门支架(4)下方，所述上锅体(1)顶部固定安装有水箱(6)，所述水泵(15)和水箱(6)固定连通，所述水箱(6)底部设置有喷淋头(601)，所述水箱(6)固定连接于电动推杆(5)的活塞杆端和上锅体(1)之间，所述泛丸锅两侧对称设置有烘干风管(7)，所述烘干风管(7)滑动安装于龙门支架(4)内。
6.根据权利要求5所述的全鹿丸制剂制备用泛丸包衣装置，其特征在于：所述电动推杆(5)内壁对称安装有两组支撑板(8)，所述支撑板(8)底面固定安装有电动滑台(9)，所述电动滑台(9)的移动块上固定安装有夹持杆(10)，所述烘干风管(7)一端固定安装于夹持杆(10)内。
7.根据权利要求5所述的全鹿丸制剂制备用泛丸包衣装置，其特征在于：所述工作台架(3)内固定安装有风机(11)，所述风机(11)的出风口固定联通有加热器(12)，所述加热器(12)的出风口和烘干风管(7)一端固定连通。
8.根据权利要求5所述的全鹿丸制剂制备用泛丸包衣装置，其特征在于：所述上锅体(1)内壁对称设置有带有凸起的第一卡块(101)，所述下锅体(2)内壁对称设置有带有凹槽的第二卡块(201)，所述第一卡块(101)和第二卡块(201)间隙配合。
9.根据权利要求5所述的全鹿丸制剂制备用泛丸包衣装置，其特征在于：所述喷淋头(601)设置有四组，四组所述喷淋头(601)通过弯管(602)环形等距阵列于水箱(6)下表面。
10.根据权利要求5所述的全鹿丸制剂制备用泛丸包衣装置，其特征在于：所述下锅体(2)底部环形等距阵列有万向球轮(13)，所述工作台架(3)上表面开设有环形凹槽(14)，所述万向球轮(13)和环形凹槽(14)间隙配合。
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116549558A (zh) * 2023-05-06 2023-08-08 江西大自然制药有限公司 一种全鹿丸及其制备方法

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* Cited by examiner, † Cited by third party
Title
国家药典委员会: "《中华人民共和国药典：2020年版.一部》", 31 May 2020 *

Cited By (1)

* Cited by examiner, † Cited by third party
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CN116549558A (zh) * 2023-05-06 2023-08-08 江西大自然制药有限公司 一种全鹿丸及其制备方法

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