CN113943652B - Multistage magnetic rod module and nucleic acid extraction equipment with same - Google Patents
Multistage magnetic rod module and nucleic acid extraction equipment with same Download PDFInfo
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- CN113943652B CN113943652B CN202010681493.5A CN202010681493A CN113943652B CN 113943652 B CN113943652 B CN 113943652B CN 202010681493 A CN202010681493 A CN 202010681493A CN 113943652 B CN113943652 B CN 113943652B
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- 150000007523 nucleic acids Chemical class 0.000 title claims abstract description 31
- 102000039446 nucleic acids Human genes 0.000 title claims abstract description 31
- 108020004707 nucleic acids Proteins 0.000 title claims abstract description 31
- 238000000605 extraction Methods 0.000 title claims abstract description 27
- 230000004308 accommodation Effects 0.000 claims description 5
- 210000001503 joint Anatomy 0.000 claims description 2
- 230000000149 penetrating effect Effects 0.000 claims description 2
- 239000011324 bead Substances 0.000 description 10
- 238000000034 method Methods 0.000 description 8
- 239000002184 metal Substances 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 238000007886 magnetic bead extraction Methods 0.000 description 5
- 238000004026 adhesive bonding Methods 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000003028 elevating effect Effects 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 238000001821 nucleic acid purification Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
- C12N15/1006—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
- C12N15/1013—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers by using magnetic beads
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Abstract
The invention relates to a multi-section type magnetic rod module and nucleic acid extraction equipment with the same, wherein the nucleic acid extraction equipment mainly comprises a lifting table, a multi-section type magnetic rod module, a fixed base and a magnetic rod sleeve, and the multi-section type magnetic rod module comprises a fixing piece, a built-in magnetic rod and an external magnetic rod; the fixing piece comprises a containing hole, the built-in magnetic rod is fixed in the containing hole, the external magnetic rod is selectively inserted in the containing hole, and the magnetic poles of the end parts of the external magnetic rod and the built-in magnetic rod which are butted with each other are different. Therefore, the external magnetic rod is fixed in a magnetic attraction mode, so that the external magnetic rod can be quickly replaced; in addition, the accommodating hole can form a positioning function, so that the external magnetic rod cannot swing or deviate; and because the external magnetic rod can be directly inserted into the magnetic rod sleeve, the magnetic attraction force can be obviously improved.
Description
Technical Field
The present invention relates to a multi-stage magnetic rod module and a nucleic acid extraction apparatus having the same, and more particularly, to a multi-stage magnetic rod module suitable for a magnetic bead extraction method and a nucleic acid extraction apparatus having the same.
Background
The magnetic bead extraction method for detecting the nucleic acid has extremely high flexibility and practicability, can realize automatic treatment, can save the operation time and the manpower requirement, has high stability of automatic treatment, can avoid the missing or error of manual treatment, and gradually becomes the main stream in the nucleic acid purification technology. Further, the magnetic bead extraction method is a process of extracting nucleic acid at each stage of reaction, washing and extraction by using a magnetic control device (e.g., a magnetic rod) to provide magnetic force or magnetic field to attract and drive the magnetic beads after adsorbing nucleic acid in a mixed solution to be detected in a specific manner by using particles (hereinafter referred to as "magnetic beads") having specific functional groups. However, as described above, the great advantage of using the magnetic bead method for purifying nucleic acid is automation, since the magnetic beads can be aggregated or dispersed under the magnetic field, thereby completely eliminating the manual procedures required for centrifugation and the like.
In addition, magnetic beads are usually adsorbed and extracted by a magnetic rod in the magnetic bead extraction method, and the magnetic rod type which is more common in the prior art is referred to "magnetic rod structure of magnetic bead extraction nucleic acid detection system" in taiwan novel patent publication No. M485907. Referring to fig. 1A, a schematic diagram of a conventional magnetic rod 9 is shown: as shown in the drawing, the conventional magnetic rod 9 includes a hollow rod 91 and a magnetic block 92, wherein the magnetic block 92 is fixed in the hollow rod 91 and cuts Ji Zhongkong the lower end surface of the rod 91. Further, the upper end portion of the hollow rod 91 is directly adhered to the base 94.
However, the existing magnetic rod 9 must take a considerable amount of time to replace once deformed or broken. Similarly, when the magnetic rod 9 must be replaced according to the change of the magnetic force required or the change of the size of the test tube, the reagent tank or the magnetic rod sleeve, it takes a considerable time to remove the glue again, disassemble the magnetic rod 9 and disassemble the hollow rod 91 and the magnetic block 92.
In addition, referring to fig. 1B together, fig. 1B is a partially schematic cross-sectional view of a conventional magnetic rod 9 inserted into a magnetic rod sleeve 95; as shown in the figure, since the magnet 92 is built in the hollow rod 91, the magnetic force is slightly impaired by the magnetic resistance of the hollow rod 91. In addition, the magnetic rod sleeve 95 must be sleeved outside the magnetic rod 9, so the magnetic rod sleeve is limited by the specification of the magnetic rod sleeve 95, and the thickness of the hollow rod 91 will cause the size of the magnetic block 92 to be more limited, thereby affecting the magnetic force.
Disclosure of Invention
The invention mainly aims to provide a multi-section type magnetic rod module and nucleic acid extraction equipment with the same, which can quickly replace magnetic rods according to different requirements or conditions, and the generated magnetic force is large and is not disturbed.
In order to achieve the above-mentioned purpose, the present invention provides a multi-section magnetic bar module, which mainly includes a fixing member, a built-in magnetic bar and an external magnetic bar; wherein, the fixing piece comprises a containing hole, and the containing hole penetrates at least one end face of the fixing piece; the built-in magnetic rod is fixed in the accommodating hole of the fixing piece; the external magnetic rod is selectively inserted into the accommodating hole of the fixing piece, and the magnetic poles of the end parts of the external magnetic rod and the built-in magnetic rod which are in butt joint are different.
As described above, the external magnetic rod is fixed by the multi-stage magnetic attraction mode, namely the built-in magnetic rod is magnetically attracted, so that the external magnetic rod can be quickly replaced no matter the hard equipment is damaged or the size of the test tube, the reagent tank or the magnetic rod sleeve is changed. In addition, the external magnetic rod is fixed through magnetic attraction, and one end of the external magnetic rod is directly inserted into the accommodating hole, so that the accommodating hole can form a positioning function, and the external magnetic rod cannot swing or deviate. In addition, the external magnetic rod can be directly inserted into the magnetic rod sleeve, so that the problem of weakening of magnetic attraction caused by coating the magnetic rod by the metal outer tube of the traditional magnetic rod is solved, and the magnetic attraction can be obviously improved.
Preferably, the accommodating hole of the multi-section magnetic rod module can penetrate through two corresponding side end surfaces of the fixing piece, and the length of the built-in magnetic rod can be smaller than that of the fixing piece; when the built-in magnetic rod is fixed in the accommodating hole, the accommodating hole comprises a reserved section for the external magnetic rod to be inserted; on the other hand, the length of the built-in magnetic rod can be equal to the length of the fixing piece, and the fixing piece can comprise an upper end face and a lower end face; when the built-in magnetic rod is fixed in the accommodating hole, one end of the built-in magnetic rod can be protruded out of the upper end face of the fixing piece, and a reserved section is arranged between the other end of the built-in magnetic rod and the lower end face of the fixing piece so as to allow the external magnetic rod to be inserted.
In addition, the accommodating hole of the multi-section magnetic rod module can only penetrate through one end face of the fixing piece, and the depth of the accommodating hole can be larger than the length of the built-in magnetic rod; accordingly, when the built-in magnetic rod is fixed in the accommodating hole, the accommodating hole comprises a reserved section for the external magnetic rod to be inserted. In addition, the built-in magnetic rod can be fixed in the accommodating hole of the fixing piece in a gluing mode, but the invention is not limited to the method, and other fixing modes can be applied to the invention, such as screwing, clamping or matching with other fixing pieces such as screws and the like.
In order to achieve the above object, the nucleic acid extraction apparatus of the present invention mainly comprises a lifting platform, a multi-stage magnetic rod module, a fixed base and at least one magnetic rod sleeve; wherein the lifting platform is driven to vertically lift; the multi-section magnetic rod module is arranged on the lifting platform; at least one through hole is formed in the fixed base, and at least one of the fixing piece of the multi-section magnetic rod module and the external magnetic rod penetrates through the at least one through hole; the at least one magnetic rod sleeve comprises an open slot, the open slot corresponds to the at least one through hole, and the at least one magnetic rod sleeve is fixed on the fixed base through the open slot. When the lifting table is driven to drive the multi-section type magnetic rod module to descend, the external magnetic rod of the multi-section type magnetic rod module penetrates into the open slot of at least one magnetic rod sleeve.
Accordingly, in the nucleic acid extraction apparatus of the present invention, the external magnetic rod in the multi-stage magnetic rod module is provided, so that the nucleic acid extraction apparatus can be replaced rapidly; in the equipment, the external magnetic rod is directly inserted into the open slot of the magnetic rod sleeve; that is, the external magnetic rod is isolated from the magnetic beads for nucleic acid extraction only by the magnetic rod sleeve, and is not covered by a metal tube like the conventional magnetic rod, so that the magnetic attraction is greatly increased, and the adsorption and extraction effects of the magnetic beads are excellent.
Furthermore, the external magnetic rod of the nucleic acid extraction device of the present invention may include a first end portion and a second end portion, wherein the first end portion may be configured to be inserted into the receiving hole of the fixing member, and a cross-sectional area of the second end portion may be equal to a cross-sectional area of the bottom of the open slot of the at least one magnetic rod sleeve. In other words, the external magnetic rod can be enlarged as much as possible to meet the size of the magnetic rod sleeve, and the magnetic attraction force is greatly increased along with the enlargement of the size of the external magnetic rod.
Drawings
Fig. 1A is a schematic diagram of a conventional magnetic rod.
Fig. 1B is a partially schematic cross-sectional view of a conventional magnetic rod inserted into a magnetic rod sleeve.
FIG. 2 is a perspective view of the nucleic acid extracting apparatus of the present invention.
Fig. 3A is a cross-sectional view of a first embodiment of a multi-segment magnetic bar module of the present invention.
Fig. 3B is an enlarged partial sectional view of the multi-segment magnetic rod module of the present invention inserted into the magnetic rod sleeve.
Fig. 4A is an exploded perspective view of a second embodiment of a multi-segment magnetic bar module according to the present invention.
Fig. 4B is a cross-sectional view of a second embodiment of the multi-segment magnetic bar module of the present invention.
Fig. 5A is an exploded perspective view of a third embodiment of a multi-segment magnetic bar module according to the present invention.
Fig. 5B is a cross-sectional view of a third embodiment of a multi-segment magnetic bar module of the present invention.
Detailed Description
Before the multi-stage magnetic rod module and the nucleic acid extraction apparatus having the same according to the present invention are described in detail in this embodiment, it should be noted that similar components will be denoted by the same reference numerals in the following description. Moreover, the drawings of the present invention are by way of illustration only, and are not necessarily drawn to scale, nor are all details necessarily presented in the drawings.
Referring first to FIG. 2, a perspective view of the nucleic acid extraction apparatus of the present invention is shown. As shown in fig. 2, the nucleic acid extraction apparatus of the present embodiment mainly includes a lifting table 5, a fixed base 6, a motor 8, and 16 sets of multi-segment magnetic rod modules 1. First, although not shown in the drawings, the nucleic acid extracting apparatus of the present invention should further include a lifting device and a rack, wherein the lifting device is assembled on the rack and connected to the lifting platform 5 to drive the lifting platform 5 to rise or fall; in addition, the fixed base 6 may be connected to the frame. In other words, the elevating table 5 can be moved up and down with respect to the fixed base 6. Furthermore, 16 groups of multi-section magnetic rod modules 1 are equidistantly arranged on the lifting platform 5, and the motor 8 is also arranged on the fixed base 6.
Furthermore, as shown in the figure, the fixed base 6 of the present embodiment is provided with 16 through holes 61, and the lower end surface of the fixed base 6 is provided with 16 protruding columns 62, and each through hole 61 penetrates through the upper and lower surfaces of the fixed base 6 and is also connected to a corresponding protruding column 62. Accordingly, when the lifting platform 5 is driven to drive the multi-section magnetic rod modules 1 to descend, each multi-section magnetic rod module 1 can penetrate into the corresponding through hole 61 or directly lift and move in the corresponding through hole 61.
The following is a brief description of the operation of the nucleic acid extraction apparatus according to the present embodiment: firstly, the lifting platform 5 descends to drive the multi-section magnetic rod module 1 to descend in the through hole 61 and the convex column 62 of the fixed base 6 and penetrate into the open slot 71 of the magnetic rod sleeve 7, and the open slot 71 is shown in fig. 2 or 3B; wherein, the magnetic rod sleeve 7 is sleeved on the convex column 62 in advance, and the stirring operation is also performed first. However, when the multi-stage magnetic rod module 1 penetrates the magnetic rod sleeve 7, the magnetic beads can be adsorbed.
Please refer to fig. 3A, which is a cross-sectional view of a first embodiment of the multi-sectional magnetic bar module of the present invention. As shown in the figure, the multi-section magnetic rod module of the present embodiment mainly includes a fixing member 2, a built-in magnetic rod 3, and an external magnetic rod 4, wherein the fixing member 2 includes a receiving hole 21 penetrating through an upper end surface 201 and a lower end surface 202 of the fixing member 2. Furthermore, the built-in magnetic rod 3 is fixed in the accommodating hole 21 of the fixing piece 2 in a gluing manner, the external magnetic rod 4 is optionally inserted into the accommodating hole 21 of the fixing piece 2, and the magnetic poles of the end parts of the external magnetic rod 4 and the built-in magnetic rod 3 which are butted with each other are different.
As shown in fig. 3A, the length of the built-in magnetic rod 3 in the embodiment is equal to the length of the fixing member 2, and when the built-in magnetic rod 3 is fixed in the accommodating hole 21, one end of the built-in magnetic rod 3 protrudes out of the upper end face 201 of the fixing member 2, and a reserved section 211 is included between the other end of the built-in magnetic rod 3 and the lower end face 202 of the fixing member 2 for inserting the external magnetic rod 4. However, the reserved section 211 of the accommodating hole 21 can just form a positioning function, so that the external magnetic rod 4 does not swing or deviate. Furthermore, since the adjacent magnetic bars are easily attracted by the magnetic attraction force, the longer the reserved section 211 is, the better the anti-deflection effect is.
In other words, when the external magnetic rod 4 is to be mounted, the external magnetic rod 4 can be easily abutted and fixed in the accommodating hole 21 by the magnetic attraction between the internal magnetic rod 3 and the external magnetic rod 4 only by aligning one end of the external magnetic rod 4 with the accommodating hole 21 and slightly inserting the external magnetic rod into the accommodating hole 21. In addition, when the external magnetic rod 4 is to be removed or replaced, the external magnetic rod 4 is pulled down to release the magnetic attraction between the built-in magnetic rod 3 and the external magnetic rod 4, so that the external magnetic rod 4 can be easily removed.
Referring to fig. 2, fig. 3A and fig. 3B, fig. 3B is an enlarged partial sectional view of the multi-section magnetic rod module of the present invention after being inserted into a magnetic rod sleeve; as shown in the figure, the external magnetic rod 4 of the present embodiment includes a first end 41 and a second end 42, where the first end 41 is configured to be inserted into the accommodating hole 21 of the fixing element 2 and magnetically contact with the built-in magnetic rod 3. On the other hand, the second end portion 42 is for insertion into the open groove 71 of the bar cover 7, and the sectional area of the second end portion 42 is equal to the sectional area of the bottom of the open groove 71. That is, the external magnetic rod 4 is isolated from the magnetic beads (not shown) for nucleic acid extraction only by the magnetic rod sleeve 7, and the metal tube (see fig. 1B) of the conventional magnetic rod is omitted, so that the external magnetic rod 4 has no metal magnetic shielding effect, the size of the whole external magnetic rod 4 can be enlarged, the magnetic attraction force is naturally increased, and the adsorption and extraction effects of the magnetic beads are excellent.
Referring to fig. 4A and 4B, fig. 4A is an exploded perspective view of a second embodiment of the multi-segment magnetic rod module according to the present invention, and fig. 4B is a cross-sectional view of the second embodiment of the multi-segment magnetic rod module according to the present invention. The main difference between the second embodiment and the previous embodiment is that the length of the built-in magnetic rod 3 is smaller than the length of the fixing member 2; in other words, when the built-in magnetic rod 3 is fixed in the accommodating hole 21, the built-in magnetic rod 3 is not protruded out of the upper end surface 201 of the fixing member 2, but is flush with the upper end surface 201, so that the accommodating hole 21 naturally forms a reserved section 211 for inserting the external magnetic rod 4.
Referring to fig. 5A and 5B, fig. 5A is an exploded perspective view of a third embodiment of the multi-segment magnetic rod module according to the present invention, and fig. 5B is a cross-sectional view of the third embodiment of the multi-segment magnetic rod module according to the present invention. The main difference between the third embodiment and the first and second embodiments is that in the present embodiment, the accommodating hole 21 only penetrates the lower end face 202 of the fixing member 2, and the depth of the accommodating hole 21 is greater than the length of the built-in magnetic rod 3; when the built-in magnetic rod 3 is fixed in the accommodating hole 21, the accommodating hole 21 naturally forms a reserved section 211 for inserting the external magnetic rod 4.
In summary, compared with the prior art, the external magnetic rod 4 can be replaced according to actual requirements, and the external magnetic rod 4 is easy to install and replace because the external magnetic rod 4 is fixed by magnetic attraction. Furthermore, the present invention designs the reserved section 211 in the accommodating hole 21, so that the external magnetic rod 4 is stable and will not shift or deflect when inserted into the accommodating hole 21. More importantly, the external magnetic rod 4 is directly inserted into the magnetic rod sleeve 7, namely, the metal outer tube in the prior art is subtracted, the magnetic shielding effect generated by the metal sleeve is completely eliminated, and the size of the external magnetic rod 4 can be enlarged, so that the magnetic attraction force can be greatly improved.
The above embodiments are merely illustrative, and the scope of the invention is defined by the claims and not limited to the above embodiments.
Symbol description
1: multi-section type magnetic bar module
2: fixing piece
3: built-in magnetic rod
4: external magnetic bar
5: lifting table
6: fixed base
7: magnetic rod sleeve
8: motor with a motor housing
21: accommodation hole
41: first end portion
42: second end portion
61: through hole
62: convex column
71: open groove
72: disturbance bar
201: upper end surface
202: lower end face
211: the segment is reserved.
Claims (7)
1. A nucleic acid extraction apparatus, comprising:
a lifting table driven to vertically lift;
at least one multi-section magnetic bar module which is assembled on the lifting platform; the at least one multi-segment magnetic bar module comprises: a fixing member including a receiving hole penetrating at least one end surface of the fixing member; the built-in magnetic rod is fixed in the accommodating hole of the fixing piece; the external magnetic rod is selectively inserted into the accommodating hole of the fixing piece, and the magnetic poles of the end parts of the external magnetic rod and the built-in magnetic rod which are in butt joint are different;
the fixed base is provided with at least one through hole, and at least one of the fixing piece of the at least one multi-section magnetic rod module and the external magnetic rod penetrates through the at least one through hole; and
at least one bar magnet sleeve, which comprises an open slot corresponding to the at least one through hole, and is fixed on the fixed base through the open slot;
when the lifting table is driven to drive the at least one multi-section magnetic rod module to descend, the external magnetic rod of the at least one multi-section magnetic rod module penetrates into the open slot of the at least one magnetic rod sleeve.
2. The nucleic acid extraction apparatus according to claim 1, wherein the external magnetic rod includes a first end portion for being inserted into the receiving hole of the fixing member and a second end portion having a cross-sectional area equal to a cross-sectional area of the open groove bottom of the at least one magnetic rod sleeve.
3. The nucleic acid extraction apparatus according to claim 1, wherein the lower end surface of the stationary base is provided with at least one protrusion, the at least one through-hole penetrates the at least one protrusion, and the at least one magnetic rod sleeve is sleeved on the at least one protrusion through the open slot.
4. The nucleic acid extraction apparatus according to claim 1, wherein the accommodation hole penetrates through both corresponding side end surfaces of the fixing member, and a length of the built-in magnetic rod is smaller than a length of the fixing member; when the built-in magnetic rod is fixed in the accommodating hole, the accommodating hole comprises a reserved section for the external magnetic rod to be inserted.
5. The nucleic acid extraction apparatus according to claim 1, wherein the accommodation hole penetrates through both corresponding side end surfaces of the fixing member, and a length of the built-in magnetic rod is equal to a length of the fixing member; the fixing piece comprises an upper end face and a lower end face; when the built-in magnetic rod is fixed in the containing hole, one end of the built-in magnetic rod protrudes out of the upper end face of the fixing piece, and a reserved section is arranged between the other end of the built-in magnetic rod and the lower end face of the fixing piece so as to allow the external magnetic rod to be inserted.
6. The nucleic acid extraction apparatus according to claim 1, wherein the accommodation hole penetrates one end face of the fixing member, and a depth of the accommodation hole is larger than a length of the built-in magnetic rod; when the built-in magnetic rod is fixed in the accommodating hole, the accommodating hole comprises a reserved section for the external magnetic rod to be inserted.
7. The nucleic acid extraction apparatus according to claim 1, wherein the built-in magnetic rod is fixed in the receiving hole of the fixing member in a glued manner.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010681493.5A CN113943652B (en) | 2020-07-15 | 2020-07-15 | Multistage magnetic rod module and nucleic acid extraction equipment with same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010681493.5A CN113943652B (en) | 2020-07-15 | 2020-07-15 | Multistage magnetic rod module and nucleic acid extraction equipment with same |
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| Publication Number | Publication Date |
|---|---|
| CN113943652A CN113943652A (en) | 2022-01-18 |
| CN113943652B true CN113943652B (en) | 2024-03-19 |
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| CN202010681493.5A Active CN113943652B (en) | 2020-07-15 | 2020-07-15 | Multistage magnetic rod module and nucleic acid extraction equipment with same |
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| CN (1) | CN113943652B (en) |
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| CN203855573U (en) * | 2014-05-28 | 2014-10-01 | 立圜仪器有限公司 | Magnetic rod structure of magnetic bead extraction nucleic acid detection system |
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| CN208200968U (en) * | 2018-04-20 | 2018-12-07 | 洛阳吉恩特生物科技有限公司 | A kind of magnetic bar type nucleic acid extraction and detection integrated apparatus |
| KR20200012291A (en) * | 2018-07-26 | 2020-02-05 | (주)바이오니아 | Target Material Extraction Apparatus with exchangeable Magnetic-Rod-Block |
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| CN111068911A (en) * | 2019-12-20 | 2020-04-28 | 上海颜钛实业有限公司 | Strong magnetic iron attracting device and using method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN203866297U (en) * | 2013-11-01 | 2014-10-08 | 艾康生物技术(杭州)有限公司 | Clamp for nucleic acid extraction instrument |
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2020
- 2020-07-15 CN CN202010681493.5A patent/CN113943652B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN203855573U (en) * | 2014-05-28 | 2014-10-01 | 立圜仪器有限公司 | Magnetic rod structure of magnetic bead extraction nucleic acid detection system |
| CN105543089A (en) * | 2016-03-08 | 2016-05-04 | 湖南圣湘生物科技有限公司 | Magnetic bead based nucleic acid extraction device and method |
| CN208200968U (en) * | 2018-04-20 | 2018-12-07 | 洛阳吉恩特生物科技有限公司 | A kind of magnetic bar type nucleic acid extraction and detection integrated apparatus |
| KR20200012291A (en) * | 2018-07-26 | 2020-02-05 | (주)바이오니아 | Target Material Extraction Apparatus with exchangeable Magnetic-Rod-Block |
| CN210215361U (en) * | 2019-06-12 | 2020-03-31 | 杭州丰盈生物科技有限公司 | Special eight-linkage magnetic rod sleeve for nucleic acid extraction |
| CN210169273U (en) * | 2019-06-17 | 2020-03-24 | 嘉兴嘉飞贸易有限公司 | Electric hair drier capable of quickly replacing air nozzle |
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| Publication number | Publication date |
|---|---|
| CN113943652A (en) | 2022-01-18 |
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