CN113940388A - Additive for improving pet urinary calculus and preparation method and application thereof - Google Patents

Additive for improving pet urinary calculus and preparation method and application thereof Download PDF

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Publication number
CN113940388A
CN113940388A CN202111197710.4A CN202111197710A CN113940388A CN 113940388 A CN113940388 A CN 113940388A CN 202111197710 A CN202111197710 A CN 202111197710A CN 113940388 A CN113940388 A CN 113940388A
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additive
acid
pet
calculus
dog
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Chinese (zh)
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汪迎春
任阳
唐一鸣
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Shanghai Fubei Pet Products Co ltd
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Shanghai Fubei Pet Products Co ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/105—Aliphatic or alicyclic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/158—Fatty acids; Fats; Products containing oils or fats
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/20—Inorganic substances, e.g. oligoelements
    • A23K20/28—Silicates, e.g. perlites, zeolites or bentonites
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/40—Feeding-stuffs specially adapted for particular animals for carnivorous animals, e.g. cats or dogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/04—Drugs for disorders of the urinary system for urolithiasis

Abstract

The invention relates to an additive for improving urinary calculus of pets, and a preparation method and application thereof. According to the invention, the burdock, medium-chain fatty acid, citric acid, lactic acid and other health functional substances in the urinary tract are made into additives, so that the additive is anti-inflammatory and diuretic, the pH value of urine is reduced to promote the dissolution of dog struvite, and the formation of pet struvite and calcium oxalate stones is reduced. The additive can be added into the pet daily ration in the form of a functional bag, and only 1-2% of the additive needs to be added into the pet daily ration, so that the effect of remarkably improving and preventing the problems of struvite and calcium oxalate stones of pets can be achieved.

Description

Additive for improving pet urinary calculus and preparation method and application thereof
Technical Field
The invention belongs to the field of pet additives, and particularly relates to an additive for improving urinary calculus of pets, and a preparation method and application thereof.
Background
Urolithiasis is a common disease in pets, especially cats and dogs. Urinary calculus can cause dysuria, frequent micturition, odynuria, hematuria, urodriasis and the like, often accompanies inflammation, and seriously affects the health of pets. Urinary calculus is commonly struvite, i.e. struvite calculus and calcium oxalate calculus, which can be dissolved, and calcium oxalate calculus which cannot be dissolved. Pets of different varieties, sexes and ages are susceptible to calculus, and the recurrence rate is high. Therefore, the method is very important for helping crystallization and dissolution and controlling the recurrence of urinary calculus through daily ration nutrition. At present, the compatibility of Chinese herbal medicines for solving the calculus is researched more, but a scheme for solving the calculus in the urinary tract of a pet by controlling the acidity of urine and the urinary tract inflammation at the same time is not reported. The problem of inflammation in dogs and cats solved by using the burdock is not reported.
Patent document CN 103478496 a describes a urinary tract health maintenance nutritional health food for dogs and cats and a preparation method thereof. The health-care grain comprises the following components in percentage by mass: 10-30% of chicken, 10-50% of grain, 5-20% of vegetable protein, 5-20% of chicken fat, 5-15% of egg powder, 0.5-5% of tuckahoe, 0.5-5% of bighead atractylodes rhizome, 0.5-5% of plantain seed, 0.5-5% of rhizoma alismatis, 0.5-5% of akebiaquinata, 0.5-5% of rhizoma atractylodis, 0.5-5% of mangnolia officinalis, 0.5-5% of radix ophiopogonis, 0.5-5% of dried orange peel, 0.5-5% of liquorice, 1-5% of spinach, 1-5% of carrot, 0.5-5% of brewer's yeast, 0.2-0.5% of fructooligosaccharide, 0.5-5% of vitamin and 0.5-5% of mineral substance. Aiming at the induction reasons of the urinary tract diseases of dogs and cats, the invention starts with nutritional diet for maintaining the health of the urinary tract, and selects a full-nutritional special formula prepared from natural feedable plants to maintain the health of the urinary tract of dogs and cats. After feeding, the technology of the invention is effective for maintaining the health of the urinary tract of dogs and cats.
Patent document CN 112715751 a describes a urinary tract protection feed additive for dogs and cats and a preparation method thereof, comprising 10-40 parts by weight of a herba clerodendranthi spicati extract, 20-40 parts by weight of semen plantaginis, 5-10 parts by weight of turmeric powder and 40-60 parts by weight of a dispersant, wherein the dispersant is wheat bran. A preparation method of a urinary tract protection feed additive for dogs and cats comprises a) preparation of a Orthosiphon aristatus extract and b) mixing. When the additive is added at about 1%, the drinking water amount of dogs and cats can be obviously increased, the urine output and the urine output times are increased, and metabolic end products accumulated in serum are discharged, so that the nitrogen content of serum urea is obviously reduced, but the content of serum protein is not obviously changed, and the nitrogen balance of dogs and cats is not influenced.
Patent document CN 112790277a describes a food for preventing urinary calculus of pet dogs and a preparation method thereof. The food for preventing the urinary calculus of the pet dog comprises the following raw materials in parts by weight: 100-300 parts of bovine bone meal, 10-50 parts of fish meal, 20-35 parts of beet fiber, 1-5 parts of celery powder, 10-30 parts of carrot powder, 10-15 parts of soybean meal, 5-10 parts of dandelion powder, 1-5 parts of vitamin C and 1-5 parts of vitamin E. The pet dog food provided by the invention can effectively prevent initial formation of calcium oxalate urolithiasis of a pet dog, and further reduce the risk of the pet dog suffering from urolithiasis.
The composition adopts a Chinese herbal medicine scheme, has the main effect of promoting the urinary dilution of urine of pets, can prevent the generation of calculus by diluting the urine, and has no dissolving effect on the existing calculus or crystal. However, no technology for improving urinary calculus of pets, especially dogs and cats by using an acidifier is available in the existing reports. The invention uses the diuretic Chinese herbal medicines and combines with the acidified urine, not only can prevent the generation of new calculus, but also can dissolve the existing struvite crystals or calculus by continuously feeding.
Disclosure of Invention
The invention aims to solve the problems and provides an additive for improving pet urinary calculus and a preparation method and application thereof.
The purpose of the invention can be realized by the following scheme:
the invention provides an additive for improving urinary calculus of pets, which comprises the following components: citric acid, lactic acid, fructus Arctii, medium-chain fatty acid, and flowing agent.
As an embodiment of the invention, the additive comprises the following components in percentage by weight:
Figure BDA0003303706070000021
in the invention, the addition amount of citric acid and lactic acid is too small, urine acidification is not obvious, and the risk of excessive calcium oxalate calculus is increased. The burdock fruit has little addition amount and no diuretic effect, and can cause discomfort such as abdominal pain, diarrhea and the like when being too much. The addition amount of medium-chain fatty acid is small, the bacteriostatic action is avoided, and gastrointestinal mucosa discomfort can be caused by excessive addition. The addition amount of the flow agent is small, so that the flow agent cannot play a role in lubrication and dispersion, and the mouthfeel of animals is influenced too much.
As an embodiment of the invention, the medium-chain fatty acid is a fatty acid having 6 to 12 carbon atoms.
As an embodiment of the invention, the medium-chain fatty acid is one or more of lauric acid, caprylic acid, capric acid and caproic acid.
As an embodiment of the invention, the dispersant is silica. The flow agent is used as a carrier to fully mix the components, so that the components can be uniformly dispersed in the compound feed.
The invention also provides a preparation method of the additive, which comprises the following steps:
s1, weighing the components of the additive according to the proportion;
s2, mixing the components to obtain the additive for improving the urinary calculus of the pet.
As an embodiment of the invention, the mixing time is 15-30 min.
The invention also provides a pet food which contains the additive.
As one embodiment of the invention, the additive is used in an amount of 1-2% by weight of the pet food.
As an embodiment of the invention, the pet is a cat or a dog.
Compared with the prior art, the invention has the following beneficial effects:
1. the burdock is mainly used for promoting urination, diluting urine and reducing the probability of urine crystal formation. The medium-chain fatty acid is a substance with a strong bacteriostatic effect at present, is stable due to the selection of a glyceride form, is less influenced by PH, and has an effect superior to that of Chinese herbal medicine or plant extract products. The plant extract anti-inflammatory substance is easy to volatilize and lose in the processing process.
2. The acid of the invention can acidify urine, the PH value in the urinary tract is in a partial acid state, on one hand, struvite is dissolved, on the other hand, the invention can inhibit bacterial proliferation, and the acid and medium-chain fatty acid can play a role in synergistic bacteriostasis and anti-inflammation. Acidification of urine and inflammation control are not sufficient in urinary stone control, and inflammation aggravates calculus formation.
3. The additive of the invention relates to the problem of digestive absorption of animals, and needs the matching of two acidifiers, namely lactic acid and citric acid, to play a synergistic effect and release the acidifier to play a role in different parts of gastrointestinal tracts. Citric acid is more acidic than lactic acid, releases acid quickly, but has short duration, and mainly acts on stomach. The acidity of the lactic acid is released slower than that of the citric acid, the lactic acid and the citric acid mainly play a role in the intestinal tract, and the lactic acid and the citric acid are used cooperatively to achieve a good acidification effect in the whole digestion process. Other organic acids are used, the acidity is not suitable and can not be well released, the palatability of inorganic acids with strong acidity is poor, and pets can refuse to eat the pet food. The invention exerts the synergistic effect through the combination of lactic acid and citric acid, and achieves the same effect of acidification without influencing the palatability.
4. The functional substances with healthy urinary tracts such as burdock, medium-chain fatty acid, citric acid, lactic acid and the like are made into an additive functional bag and added into a full-value pet food formula according to 1% for feeding pets, so that the problems of urine acidification and urethritis of the pets are solved, and the remarkable effect of preventing struvite and calcium oxalate stones is achieved.
Drawings
Other features, objects and advantages of the invention will become more apparent upon reading of the detailed description of non-limiting embodiments with reference to the following drawings:
FIG. 1 is a comparison of the results of B-mode ultrasonography before and after the test in test No. 1 dog in test No. 2;
FIG. 2 is a graph showing a comparison of the conditions of the B-mode ultrasound before and after the test in dog No. 2 in test No. 2.
Detailed Description
The invention is described in detail below with reference to the figures and specific embodiments. The following examples, which are set forth to provide a detailed description of the invention and a detailed description of the operation, will help those skilled in the art to further understand the present invention. It should be noted that the scope of the present invention is not limited to the following embodiments, and that several modifications and improvements made on the premise of the idea of the present invention belong to the scope of the present invention.
And (3) burdock: is selected from dry mature fruit of Arctium lappa L of Compositae, and is rich in arctiin, arctigenin and arctinol. Researches show that the arctigenin has good bacteriostatic activity on staphylococcus aureus, escherichia coli, pseudomonas aeruginosa and candida albicans, and can effectively inhibit or block the release of inflammatory factors so as to play an anti-inflammatory role. Modern pharmacological research shows that the burdock has good effects of resisting inflammation, relieving fever and promoting urination.
Medium chain fatty acids: the lauric acid is selected from glycerol laurate, belongs to medium-chain fatty acid, and researches show that the lauric acid has good inhibitory effect on gram-positive bacteria and fungi.
Example 1
The embodiment provides an additive for improving canine urinary tract stones, which comprises the following components in parts by weight:
20% of citric acid;
20% of lactic acid;
10% of burdock;
20% of lauric acid;
30 percent of flow agent.
And (3) mixing the components of the additive weighed according to the proportion for 20min by a mixing machine to obtain the additive for improving the urinary calculus of the dog.
Example 2
The embodiment provides an additive for improving canine urinary tract stones, which comprises the following components in parts by weight:
30% of citric acid;
30% of lactic acid;
10% of burdock;
10% of lauric acid;
20 percent of flow agent.
And (3) mixing the components of the additive weighed according to the proportion for 20min by a mixing machine to obtain the additive for improving the urinary calculus of the dog.
Example 3
The embodiment provides an additive for improving canine urinary tract stones, which comprises the following components in parts by weight:
30% of citric acid;
10% of lactic acid;
20% of burdock;
10% of lauric acid;
30 percent of flow agent.
And (3) mixing the components of the additive weighed according to the proportion for 20min by a mixing machine to obtain the additive for improving the urinary calculus of the dog.
Example 4
The embodiment provides an additive for improving canine urinary tract stones, which comprises the following components in parts by weight:
30% of citric acid;
20% of lactic acid;
20% of burdock;
20% of lauric acid;
10% of a flow agent.
And (3) mixing the components of the additive weighed according to the proportion for 20min by a mixing machine to obtain the additive for improving the urinary calculus of the dog.
Example 5
The embodiment provides an additive for improving canine urinary tract stones, which comprises the following components in parts by weight:
30% of citric acid;
20% of lactic acid;
5% of burdock;
15% of lauric acid;
30 percent of flow agent.
And (3) mixing the components of the additive weighed according to the proportion for 20min by a mixing machine to obtain the additive for improving the urinary calculus of the dog.
Example 6
The embodiment provides an additive for improving canine urinary tract stones, which comprises the following components in parts by weight:
30% of citric acid;
20% of lactic acid;
15% of burdock;
5% of lauric acid;
30 percent of flow agent.
Comparative example 1
The comparative example provides an additive for improving canine urinary tract calculus, which comprises the following components in parts by weight:
5% of citric acid;
5% of lactic acid;
30% of burdock;
20% of lauric acid;
40% of a flow agent.
And (3) mixing the components of the additive weighed according to the proportion for 20min by a mixing machine to obtain the additive for improving the urinary calculus of the dog.
And (3) effect testing:
test 112 normal dogs were selected and fed the diets prescribed for the urinary tract of dogs of comparative example 1 and example 2 at intervals for 2 weeks. Urine was collected at the beginning and end of the test, and the change in pH and urine specific gravity before and after the test was compared. Aims to test the urine acidification effect. The interval feeding comprises feeding control daily ration without adding such functional bag, has no urine acidification effect, feeding comparative example 1 after feeding blank for 2 weeks, and feeding example 2 to reduce individual difference of animals in the same batch, wherein the blank feeding prevents the comparative example and the example from influencing each other
Test 1: the test conditions were as follows
TABLE 1 Canine basic information for trial 1
Figure BDA0003303706070000061
TABLE 2 dog urine pH comparison after feeding of two dog foods in test 1
Figure BDA0003303706070000062
Figure BDA0003303706070000071
Note: the difference of the lower case letters on the shoulders indicates that P is less than 0.05, and the difference is obvious; capital letters indicate P <0.01, and the difference is extremely significant
TABLE 3 dog urine specific gravity comparison after test 1 feeding of two diets
Figure BDA0003303706070000072
Note: the difference of the lower case letters on the shoulders indicates that P is less than 0.05, and the difference is obvious; capital letters indicate P <0.01, and the difference is extremely significant
The test 1 results are shown in tables 2 and 3, after the dog fed the prescription food for urinary tract of the dog in the comparative example 1 (negative control) for 2 weeks, the pH value of urine of the dog is not obviously reduced, and the expected preferable pH value of the urine which does not reach the prescription food for urinary tract calculus is 6.1-6.4; after the dog fed the prescription food for urinary tract of the dog in example 2 for 2 weeks, the pH value of urine of the dog is remarkably reduced, and the expected effect is achieved. The urine specific gravity of the dogs is not obviously different before and after the test, which indicates that the kidney function of the dogs is normal.
Experiment 2 dogs with 5 urinary tract crystals/stones were selected and fed with the urinary tract formula of the dogs of example 2 for 1 month, and bladder B-ultrasonic examination was performed at the beginning and end of the experiment, respectively. The pH value of the urine is acidic, which is beneficial to the crystallization and dissolution of magnesium ammonium phosphate and can prevent the recurrence of magnesium ammonium phosphate and calcium oxalate calculus. The pet hospital test conditions are as shown in fig. 1 and 2, and the entrusted test hospital: shanghai agricultural animal Hospital.
The test 2 dogs were examined and compared for cystocrystallization/calculi. The B ultrasonic condition is shown in figure 1 and figure 2, when the test is started, a B ultrasonic image in the light of No. 1 dog has a visible obvious bright spot which is calculus; the intravesical B-mode ultrasound image of dog No. 2 was seen as a continuous concentrated bright spot, which was crystalline. After removing the calculus, the No. 1 dog is fed with the prescription grain for urinary tract of the dog (example 2) for 1 month, and then bladder B ultrasonic detection is carried out again, and the shadow in the bladder is clean; no. 2 dog had no operation, and after 1 month of feeding the same grain, the bright spots in the bladder disappeared, the shade was clean, and the urine crystals had been dissolved.
The foregoing description of specific embodiments of the present invention has been presented. It is to be understood that the present invention is not limited to the specific embodiments described above, and that various changes and modifications may be made by one skilled in the art within the scope of the appended claims without departing from the spirit of the invention.

Claims (10)

1. An additive for improving urinary calculus of pets, which is characterized by comprising the following components: citric acid, lactic acid, fructus Arctii, medium-chain fatty acid, and flowing agent.
2. The additive according to claim 1, wherein the additive comprises the following components in percentage by weight:
Figure FDA0003303706060000011
3. additive according to claim 1, wherein the medium-chain fatty acid is a fatty acid with 6 to 12 carbon atoms.
4. The additive according to claim 1, wherein the medium-chain fatty acid is one or more of lauric acid, caprylic acid, capric acid and caproic acid.
5. Additive according to claim 1, wherein said dispersing agent is silica.
6. A method for preparing the additive of claim 1, comprising the steps of:
s1, weighing the components of the additive according to the proportion;
s2, mixing the components to obtain the additive for improving the urinary calculus of the pet.
7. The method for preparing the additive according to claim 6, wherein the mixing time is 15 to 30 min.
8. A pet food comprising the additive of claim 1.
9. The pet food of claim 8, wherein the additive is present in an amount of 1-2% by weight of the pet food.
10. The pet food of claim 8, wherein the pet is a cat or a dog.
CN202111197710.4A 2021-10-14 2021-10-14 Additive for improving pet urinary calculus and preparation method and application thereof Pending CN113940388A (en)

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CN101653379A (en) * 2008-08-22 2010-02-24 天津生机集团股份有限公司 Method for predicting type of formed calculi of canine cat daily rations
CN101664439A (en) * 2008-09-02 2010-03-10 天津生机集团股份有限公司 Medicinal health agent for preventing and treating canine urinary calculi
CN101721642A (en) * 2008-11-03 2010-06-09 颜奎峰 Medicine for treating calculus of urinary system and preparation method thereof
CN104146185A (en) * 2014-08-28 2014-11-19 甘肃农业大学 Lamb concentrate supplement feed capable of preventing urinary calculus and preparation method thereof
CN106578415A (en) * 2016-11-16 2017-04-26 浙江日出生物科技有限公司 Feed additive containing organic acid salts and medium-chain fatty acid compounds
CN108783003A (en) * 2018-06-29 2018-11-13 佛山市南海东方澳龙制药有限公司 With the composition and preparation method thereof for adjusting animal functions of intestines and stomach
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CN101653379A (en) * 2008-08-22 2010-02-24 天津生机集团股份有限公司 Method for predicting type of formed calculi of canine cat daily rations
CN101664439A (en) * 2008-09-02 2010-03-10 天津生机集团股份有限公司 Medicinal health agent for preventing and treating canine urinary calculi
CN101721642A (en) * 2008-11-03 2010-06-09 颜奎峰 Medicine for treating calculus of urinary system and preparation method thereof
CN104146185A (en) * 2014-08-28 2014-11-19 甘肃农业大学 Lamb concentrate supplement feed capable of preventing urinary calculus and preparation method thereof
CN106578415A (en) * 2016-11-16 2017-04-26 浙江日出生物科技有限公司 Feed additive containing organic acid salts and medium-chain fatty acid compounds
CN108783003A (en) * 2018-06-29 2018-11-13 佛山市南海东方澳龙制药有限公司 With the composition and preparation method thereof for adjusting animal functions of intestines and stomach
CN112189755A (en) * 2020-10-10 2021-01-08 上海福贝宠物用品股份有限公司 Prescription grain nutrition scheme for improving urinary calculus of cat

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娄红军等: "58例犬鸟粪石尿结石的诊疗", 《畜牧与兽医》 *

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