CN106578415A - Feed additive containing organic acid salts and medium-chain fatty acid compounds - Google Patents
Feed additive containing organic acid salts and medium-chain fatty acid compounds Download PDFInfo
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- CN106578415A CN106578415A CN201611009092.5A CN201611009092A CN106578415A CN 106578415 A CN106578415 A CN 106578415A CN 201611009092 A CN201611009092 A CN 201611009092A CN 106578415 A CN106578415 A CN 106578415A
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- chain fatty
- fatty acid
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- feed addictive
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Abstract
The invention discloses a feed additive containing organic acid salts and medium-chain fatty acid compounds. The feed additive comprises the following components in parts by weight: 10 to 30 parts of citrate, 10 to 30 parts of fumarate, 30 to 60 parts of medium-chain fatty acid compounds, and 5 to 20 parts of carriers. The feed additive is added into feeds of animals (pigs and poultry), can reduce the using amount of antibiotics, and promotes the healthy growth of animals.
Description
Technical field
It is more particularly to a kind of containing acylate and medium chain fatty acid compound the present invention relates to a kind of feed addictive
Feed addictive.
Background technology
Feeding antibiotic has reduces the disease incidence that bacterium infection causes, and promotes animal health growth, improves animal
Production performance, become the additive commonly used in pig, fowl feed at present.However, adding antibiotic in feed for a long time
People and drug resistance of the animal to antibiotic can be caused, and antibiotic residue phenomenon is more universal in livestock products.Therefore reduce and raise
Become focus of concern with the use of antibiotic, the suitable antibiotic substitute products of searching.
Medium chain fatty acid (MCFA) is generally referred to containing the saturated fatty acid that carbon chain lengths are 6-12 carbon, including octanoic acid
(C8), capric acid (C10), laurate (C12) etc., during coconut oil, palm-kernel oil are primarily present in nature.Medium chain fatty acid
Have a wide range of applications in Animal husbandry production.In addition to participating in function, medium chain fatty acid also has suppression alimentary canal bacterium
Growth, it is fat-soluble that the antifungal mechanism of medium chain fatty acid is that the Medium chain fatty acid molecule not dissociated has, can be with penetration cell
Wall.After being dissociated into hydrogen ion and Medium chain fatty acid ion in the cell, one side hydrogen ion is accumulated and bacterium is consumed energy in a large number
Exclude hydrogen ion；On the other hand, Medium chain fatty acid group is accumulated in the cell with toxicity as anion, affects the normal work(of cell
Energy.Medium chain fatty acid mainly has significant inhibitory action to gram-positive bacterias such as C.perfringens, and for gram-negative
Property bacterium is without obvious inhibitory action.Therefore be added in feed for the diseases such as the diarrhoea caused by gram negative pathogenic bacteria without
Positive effect so as to which practical effect is restricted.
The content of the invention
It is an object of the invention to provide a kind of feed addictive containing acylate and medium chain fatty acid compound, adds
In being added in animal (pig, fowl) feed, the use of antibiotic is reduced, promote animal health growth.
The technical solution adopted for the present invention to solve the technical problems is：
A kind of feed addictive containing acylate and medium chain fatty acid compound, including the component of following weight portion：
Citrate 10-30 parts, fumarate 10-30 parts, medium chain fatty acid compound 30-60 parts, carrier 5-20 parts.
Feed addictive feature of the present invention is：Citrate, fumarate to Gram-negative bacteria without bacteriostasis, in
Chain fatty acid compound gram-positive bacteria has bacteriostasis, and to Gram-negative bacteria without bacteriostasis, the present invention passes through will
Medium chain fatty acid compound is compounded with acylate (citrate, fumarate), so as to expand medium chain fatty acid compound
Scope of restraining fungi, it is not only inhibited to Gram-positive pathogenic bacterium in alimentary canal, and Gram-negative bacteria is also had
Inhibitory action.In making an addition to pig, fowl feed (premix, concentrate feed and complete diet pellet) as feed addictive, can reduce by
The incidence of various diseases that gram-positive bacteria and gram positive bacterial infection cause.
Preferably, the citrate is one or more in sodium citrate, potassium citrate, calcium citrate.
Preferably, the fumarate is one or more in fumaric acid sodium, Potassium fumarate, calcium fumarate.
Preferably, the medium chain fatty acid compound is by weight percentage by medium chain fatty acid 20-50%, middle chain fat
Fat acid monoglyceride 50-80%.Medium chain fatty acid monoglyceride, middle chain fat are especially added with medium chain fatty acid compound of the present invention
Fat acid monoglyceride is more notable compared with medium chain fatty acid to the bacteriostasis of gram-positive bacteria, however, medium chain fatty acid two
Ester, MCT Oil do not have obvious bacteriostasis to gram-positive bacteria.
Preferably, the medium chain fatty acid is one or more in octanoic acid, capric acid, laurate.
Preferably, the medium chain fatty acid monoglyceride is that Capmul MCM C8, Capmul MCM C10, laurate list are sweet
One or more in grease.
Preferably, the carrier is silica.
Preferably, the carrier is biological absorption-type carrier, the bio-absorbable type carrier is by maltodextrin, carragheen
It is mixed with agar, preparation method is as follows：By the agar of 3-5 weight portions, the carragheen of 1-2 weight portions and 100-150 weight
The water mixing of part, side agitating heating is until be completely dissolved, the maltodextrin for being subsequently adding 6-10 weight portions is uniformly mixed, cold
But after, freeze and crush.The conventional carrier of feed addictive is silica, but silica will not be digested by animal,
Only possesses the function of carrier.The present invention, to the further improvement of carrier, develops a kind of bio-absorbable type carrier through research, with
It is good by the compatibility of loading, make product prevented from caking, improve the nutrition rate of exchange, absorption easy to digest.The bio-absorbable type of the present invention is carried
Body is the feed addictive particular design of the present invention, and the feed addictive main component of the present invention is medium chain fatty acid compound,
The close oiliness of property, and it is inorganic carrier that conventional carrier is silica, it is bad with the compatibility of medium chain fatty acid compound, this
The bio-absorbable type carrier of invention is selected as organic matter carrier, good with the compatibility of medium chain fatty acid compound.
The invention has the beneficial effects as follows：By the compounding addition acylate in medium chain fatty acid compound (without antibacterial work
With), the scope of restraining fungi of medium chain fatty acid compound is expanded, not only Gram-positive pathogenic bacterium in alimentary canal is had and suppresses to make
With, and also have certain inhibitory action to Gram-negative bacteria.As feed addictive make an addition to pig, fowl feed (premix,
Concentrate feed and complete diet pellet) in, the various diseases that can reduce being caused by gram-positive bacteria and gram positive bacterial infection
Incidence.
Specific embodiment
Below by specific embodiment, technical scheme is described in further detail.
In the present invention, if not refering in particular to, the raw material for being adopted and equipment etc. are commercially available or commonly used in the art.
Method in following embodiments, if no special instructions, is the conventional method of this area.
Embodiment 1：
A kind of feed addictive containing acylate and medium chain fatty acid compound, is mixed by the raw material of following weight portion
Make：10 parts of sodium citrate, 10 parts of fumaric acid sodium, 30 parts of medium chain fatty acid compound, 5 parts of silica.The Medium chain fatty
Sour compound is by weight percentage by octanoic acid 20%, Capmul MCM C8 80%.
Embodiment 2：
A kind of feed addictive containing acylate and medium chain fatty acid compound, is mixed by the raw material of following weight portion
Make：30 parts of potassium citrate, 30 parts of Potassium fumarate, 60 parts of medium chain fatty acid compound, 20 parts of silica.The Medium chain fatty
Sour compound is by weight percentage by capric acid 30%, Capmul MCM C10 70%.
Embodiment 3：
A kind of feed addictive containing acylate and medium chain fatty acid compound, is mixed by the raw material of following weight portion
Make：20 parts of calcium citrate, 15 parts of calcium fumarate, 50 parts of medium chain fatty acid compound, 15 parts of bio-absorbable type carrier.In described
Chain fatty acid compound is by weight percentage by laurate 30%, lauric monoglyceride 70%.
The bio-absorbable type carrier is mixed by maltodextrin, carragheen and agar, and preparation method is as follows：By 3 weights
The agar of amount part, the carragheen of 1 weight portion mix with the water of 100 weight portions, and side agitating heating is subsequently adding up to being completely dissolved
The maltodextrin of 6 weight portions is uniformly mixed, and after cooling, freezes and crushes.
Embodiment 4：
The present embodiment is with the difference of embodiment 3：The bio-absorbable type carrier is by maltodextrin, carragheen and agar
It is mixed, preparation method is as follows：The agar of 5 weight portions, the carragheen of 2 weight portions are mixed with the water of 150 weight portions, while stirring
Heating is mixed until being completely dissolved, the maltodextrin for being subsequently adding 10 weight portions is uniformly mixed, after cooling, freeze and crush.
The other the same as in Example 3.
Embodiment 5：
The present embodiment is with the difference of embodiment 3：The bio-absorbable type carrier is by maltodextrin, carragheen and agar
It is mixed, preparation method is as follows：The agar of 4 weight portions, the carragheen of 1 weight portion are mixed with the water of 120 weight portions, while stirring
Heating is mixed until being completely dissolved, the maltodextrin for being subsequently adding 8 weight portions is uniformly mixed, after cooling, freeze and crush.
The other the same as in Example 3.
Test：
Test one
1. test material
Gram-negative bacteria (Escherichia coli, salmonella)
Gram-positive bacteria (C.perfringens, streptococcus)
Tryptose soy broth bouillon (TSB).
2. test method
By medium chain fatty acid compound (medium chain fatty acid compound by weight percentage by medium chain fatty acid 30%, in
Chain fatty acid monoglyceride 70%), (citrate and fumarate are according to 1 for acylate:1 weight forms organic acid than proportioning
Salt), the feed addictive of the present invention be dissolved in respectively in TSB, two times of gradient dilutions take each gradient dilution liquid 0.1mL injection aseptic
96 well culture plates in.Then 1 × 10 is added in each hole5CFU/mL Gram-negative bacterias (Escherichia coli, salmonella) with
Gram-positive bacteria (C.perfringens, streptococcus) is used as indicator bacteria.Acylate group only adds Gram-negative bacteria (large intestine
Bacillus, salmonella).
One group is taken in addition does not connect the gradient liquid of indicator bacteria as negative control.96 orifice plates are covered into sterile film and is put in 37 DEG C of trainings
Foster 24h, determines light absorption value.The A of sample well indicator bacteria600Value has concentration during notable difference to be considered as minimum suppression with negative control group
Bacteria concentration.
3. result of the test
Medium chain fatty acid compound group
Note：+ representative growth ,-representative do not grow.
Acylate group
Note：+ representative growth ,-representative do not grow.
The feed addictive group of the present invention
Note：+ representative growth ,-representative do not grow.
4. conclusion
Medium chain fatty acid compound has bacteriostasis to gram-positive bacteria, to Gram-negative bacteria without bacteriostasis；Have
Machine hydrochlorate is to gram-positive bacteria, negative bacterium without obvious bacteriostasis；The feed addictive of the present invention is to animal-breeding process
In common Gram-negative bacteria have good bacteriostasis with gram-positive bacteria.
Test two
1. experimental animal
The white plumage Broiler chicks of AA 360 of 1 age in days or so are selected, 3 groups are randomly divided into, per group of each 12 repetition, each repetition
10.
2. test period
42 days experimental periods, it is divided into two stages：Early stage 0～21 day, 22～42 days later stages.
3. experimental design
3 groups are respectively I groups (blank control group, basal diet), (test group, basal diet+2kg/t is of the invention for II groups
Feed addictive), III groups (antibiotic positive controls, basal diet+20g/t Bacitracin Zinc+10g/t sulfuric acid Bacillus adhaerens
Element).Free choice feeding, drinking-water.Routine disinfection and immunity and preservation and controlling.
4. test index
Claim just starting weight during on-test, at the end of claim to terminate weight, record feeding daily.Calculate early stage, the average day in later stage
The average daily gain of weightening, average feed intake and feedstuff-meat ratio, and full period, average feed intake, feedstuff-meat ratio and the death rate.
5. result of the test
Impact of the feed addictive of the addition present invention to broiler chicken early stage and later stage production performance
Impact of the feed addictive of the addition present invention to broiler chicken full period production performance
6. conclusion
Add the feed addictive (addition is 0.2%) of the present invention in feed with feedstuff-meat ratio and the death rate is reduced, promote
Enter the effect of broiler health growth, reach the effect of addition doses antibiotic.
Embodiment described above is one kind preferably scheme of the present invention, not makees any pro forma to the present invention
Limit, also have other variants and remodeling on the premise of without departing from the technical scheme described in claim.
Claims (8)
1. a kind of feed addictive containing acylate and medium chain fatty acid compound, it is characterised in that including following weight
The component of part：Citrate 10-30 parts, fumarate 10-30 parts, medium chain fatty acid compound 30-60 parts, carrier 5-20 parts.
2. feed addictive according to claim 1, it is characterised in that the citrate is sodium citrate, citric acid
One or more in potassium, calcium citrate.
3. feed addictive according to claim 1, it is characterised in that the fumarate is fumaric acid sodium, fumaric acid
One or more in potassium, calcium fumarate.
4. the feed addictive according to claim 1 or 2 or 3, it is characterised in that the medium chain fatty acid compound is by weight
Amount percentages are by medium chain fatty acid 20-50%, medium chain fatty acid monoglyceride 50-80%.
5. feed addictive according to claim 4, it is characterised in that the medium chain fatty acid is octanoic acid, capric acid, bay
One or more in acid.
6. feed addictive according to claim 4, it is characterised in that the medium chain fatty acid monoglyceride is single octanoic acid
One or more in glyceride, Capmul MCM C10, lauric monoglyceride.
7. the feed addictive according to claim 1 or 2 or 3, it is characterised in that the carrier is silica.
8. the feed addictive according to claim 1 or 2 or 3, it is characterised in that the carrier is carried for biological absorption-type
Body, the bio-absorbable type carrier is mixed by maltodextrin, carragheen and agar, and preparation method is as follows：By 3-5 weight portions
Agar, the carragheen of 1-2 weight portions mix with the water of 100-150 weight portions, side agitating heating until be completely dissolved, Ran Houjia
The maltodextrin for entering 6-10 weight portions is uniformly mixed, and after cooling, freezes and crushes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611009092.5A CN106578415A (en) | 2016-11-16 | 2016-11-16 | Feed additive containing organic acid salts and medium-chain fatty acid compounds |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611009092.5A CN106578415A (en) | 2016-11-16 | 2016-11-16 | Feed additive containing organic acid salts and medium-chain fatty acid compounds |
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| CN106578415A true CN106578415A (en) | 2017-04-26 |
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| CN201611009092.5A Pending CN106578415A (en) | 2016-11-16 | 2016-11-16 | Feed additive containing organic acid salts and medium-chain fatty acid compounds |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110506864A (en) * | 2019-09-12 | 2019-11-29 | 华南农业大学 | One boar food replaces anti-additive and its application in pannage |
| CN113940388A (en) * | 2021-10-14 | 2022-01-18 | 上海福贝宠物用品股份有限公司 | Additive for improving pet urinary calculus and preparation method and application thereof |
| CN114642240A (en) * | 2022-03-31 | 2022-06-21 | 湖南纽格润生物科技有限公司 | Functional lipid for improving animal production performance under low-protein daily ration and preparation method thereof |
| CN115349577A (en) * | 2022-08-22 | 2022-11-18 | 华中农业大学 | Feed additive containing organic acid and medium-chain fatty acid and application thereof |
| CN115736108A (en) * | 2022-11-02 | 2023-03-07 | 江苏奥迈生物科技有限公司 | Composite medium-chain fatty acid feed additive and preparation method and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105611840A (en) * | 2013-10-09 | 2016-05-25 | 营养科学股份有限公司 | Composition of medium-chain fatty acids and feed supplemented with composition |
-
2016
- 2016-11-16 CN CN201611009092.5A patent/CN106578415A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105611840A (en) * | 2013-10-09 | 2016-05-25 | 营养科学股份有限公司 | Composition of medium-chain fatty acids and feed supplemented with composition |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110506864A (en) * | 2019-09-12 | 2019-11-29 | 华南农业大学 | One boar food replaces anti-additive and its application in pannage |
| CN113940388A (en) * | 2021-10-14 | 2022-01-18 | 上海福贝宠物用品股份有限公司 | Additive for improving pet urinary calculus and preparation method and application thereof |
| CN114642240A (en) * | 2022-03-31 | 2022-06-21 | 湖南纽格润生物科技有限公司 | Functional lipid for improving animal production performance under low-protein daily ration and preparation method thereof |
| CN115349577A (en) * | 2022-08-22 | 2022-11-18 | 华中农业大学 | Feed additive containing organic acid and medium-chain fatty acid and application thereof |
| CN115736108A (en) * | 2022-11-02 | 2023-03-07 | 江苏奥迈生物科技有限公司 | Composite medium-chain fatty acid feed additive and preparation method and application thereof |
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