CN115104674A - Preparation method and application of composite organic acidifier - Google Patents
Preparation method and application of composite organic acidifier Download PDFInfo
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- CN115104674A CN115104674A CN202110294866.8A CN202110294866A CN115104674A CN 115104674 A CN115104674 A CN 115104674A CN 202110294866 A CN202110294866 A CN 202110294866A CN 115104674 A CN115104674 A CN 115104674A
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/105—Aliphatic or alicyclic compounds
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/111—Aromatic compounds
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/26—Compounds containing phosphorus
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/28—Silicates, e.g. perlites, zeolites or bentonites
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/60—Feeding-stuffs specially adapted for particular animals for weanlings
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
- A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
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- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/50—Treatment of water, waste water, or sewage by addition or application of a germicide or by oligodynamic treatment
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Abstract
The invention discloses a preparation method and application of a composite organic acidifier, which comprises the following raw materials in parts by weight: 40-90 parts of organic acid, 0-40 parts of synergist and 0-30 parts of stabilizer. The acidifying agent provided by the invention is added into the livestock and poultry drinking water to improve the growth, metabolism and ingestion of the livestock and poultry to a certain extent, improve the laying rate, feed-egg ratio and eggshell quality of the livestock and poultry, and improve the utilization rate of various nutrient substances. The acidifier provided by the invention is added into the livestock feed and mixed with the feed, so that the mildewing can be prevented, the growth and metabolism of livestock can be improved, the feed intake can be improved, the diarrhea can be improved, the disease resistance of organisms can be enhanced, and the morbidity and mortality of the animals can be reduced.
Description
Technical Field
The invention relates to an acidifier, in particular to a preparation method and application of a composite organic acidifier.
Background
Once we have mistakenly thought that after antibiotics, the disease has ceased to abuse, but then bacterial resistance has been growing worldwide, putting the anti-infective therapy in distress, and in order to avoid the tragedy of no available drugs, it is necessary to reduce the unnecessary abuse of antibiotics. Nowadays, "non-resistance" is a great trend, both in humans and in animal production, with a series of antibiotic banning regulations promulgated by the country.
In the production of livestock and poultry, in order to improve the annual productivity of sows to the maximum and fully utilize expensive house facilities, early weaning is generally adopted in the modern pig raising production, and after the piglets are weaned early, because the digestive function of the piglets is not completely developed, particularly the gastric acid secretion is insufficient, and in addition, the stimulation of the nutrition, environment and psychological changes after weaning, intestinal tract injury and food can not be well digested, so that the large-scale propagation of pathogenic bacteria such as escherichia coli and the like can be caused, the symptoms such as diarrhea and the like can be generated, and the growth of the piglets is seriously influenced. Application studies at home and abroad show that the addition of the acidifier in the feed or drinking water of the piglets can improve the daily gain and feed conversion rate of the piglets, reduce stress and reduce diarrhea rate and death rate. The acidifier serving as a high-efficiency, pollution-free and residue-free feed additive is widely applied to livestock, and is continuously developed in recent years. The acidifying agent can improve the production performance of the laying hens, increase benefits, improve the health condition of the laying hens, especially increase the weight gain and the eggshell thickness of eggs, reduce the egg fouling rate and the deformed egg proportion, improve the appearance and the quality of the eggs, is a good bioactive additive for the laying hens, and can promote the improvement of the production level of the laying hens.
In recent years, the research on the acidifier is gradually deepened, and with the large-scale implementation of the intensive culture, higher requirements are put forward on the development and the use of the compound acidifier, and the acidifier not only can replace antibiotics for use, but also has the disinfection and sterilization effects. Firstly, for an acidulant used for drinking water, pathogenic bacteria in the drinking water need to be effectively killed, and the acidulant after dilution needs small pH change to ensure the bacteriostatic and bactericidal functions in the water. Secondly, the acidifier has higher buffer capacity, and can effectively avoid the excessive fluctuation of the acidity of the gastrointestinal tract of the animal. In view of the above, the present invention is particularly proposed.
Disclosure of Invention
The invention aims to provide a preparation method and application of a compound organic acidifier so as to meet the requirements in the background technology.
In order to achieve the purpose, the invention provides the following technical scheme:
the invention provides a compound organic acidifier which is characterized by mainly comprising the following components: organic acid, synergist and stabilizer.
Further, the composite organic acidifier provided by the invention can also comprise the following components in parts by weight:
40-90 parts of organic acid
0-40 parts of synergist
0-30 parts of stabilizer
The organic acid comprises one or more of citric acid, malic acid, fumaric acid, sorbic acid, tartaric acid and benzoic acid.
The synergist comprises one or more of ammonium formate, calcium propionate, sodium diacetate, potassium diformate, choline chloride and oligosaccharide.
The stabilizer comprises one or more of sodium tripolyphosphate, sodium dihydrogen phosphate, calcium phosphate and sodium silicate.
The invention also provides a preparation method of the compound organic acidifier, which comprises the following steps: (1) adding organic acid into the mixer according to the proportion. (2) Adding the stabilizer into the mixer in proportion, and stirring for 5-10 min. (3) Adding synergist into the mixer according to a certain proportion, and stirring for 10-15 min. (4) And (4) after the step (3) is finished, packaging the solid finished product to obtain the composite organic acidifier.
The invention has the beneficial effects that:
(1) the single-type acidifier is combined, so that the synergistic effect is fully exerted, the defects of single function and large addition amount of the single-type acidifier are overcome, the acidifier has obvious effect, no side effect, small addition amount and low cost, and the compound acidifier becomes one of the best products for replacing antibiotics.
(2) The acidifier is a green product for replacing antibiotics, and can effectively promote the growth of livestock and improve the production performance. Effectively acidify the intestinal canal, reduce the pH value, condition the micro-ecological environment of the intestinal canal, inhibit the propagation of harmful bacteria and promote the propagation of intestinal canal probiotics, thereby improving the intestinal health of livestock. The feed is predigested, the burden of glandular muscles and stomachs is relieved, the short-chain fatty acid promotes the regeneration of villi of small intestines, the specific surface area of the small intestines is increased, the digestion and absorption of organisms to nutrient substances are assisted, the feed-meat ratio is reduced, the production performance of laying hens is improved, the eggshell thickness and the egg weight are increased, the proportion of soft preserved eggs, broken eggs and deformed eggs is reduced, and the benefit is increased. In addition, the invention can also relieve stress reaction caused by factors such as human and environment, reduce the morbidity of livestock and reduce diarrhea rate and mortality.
(3) The composite organic acidifier can effectively strip off the biomembrane on the inner wall of the waterline, smoothen the waterline and the nipple, can kill bacteria in drinking water, particularly escherichia coli, salmonella and the like, and reduces the occurrence of diseases.
(4) The acidifier has strong buffering capacity, is dissolved in animal drinking water, can obviously reduce the pH value of the drinking water to 3-4, has small fluctuation change of acidity after dilution, and reduces the dissociation degree of organic acid in the water to ensure the irritation to the gastric mucosa of the animal.
Detailed Description
The invention will now be further illustrated by the following examples, it being understood that any of the following examples is in no way intended to limit the invention thereto.
The inventor conducts formulation tests of hundreds of times of the components of the acidifying agent by weight, and the effect of most formulations is general, so the implementation process of other tests is not repeated, and the test of 6 groups of formulations with better effect is selected, and each test formulation is as follows:
example 1:
according to the parts by weight: 80 parts of citric acid, 6 parts of fumaric acid, 1 part of benzoic acid, 5 parts of calcium propionate, 3 parts of sodium diacetate and 5 parts of sodium tripolyphosphate, and respectively weighing a proper amount of each raw material;
the preparation method of the compound organic acidifier comprises the following steps: (1) sequentially adding citric acid, fumaric acid and benzoic acid into the mixer according to a certain proportion. (2) Adding sodium tripolyphosphate into the mixer according to a certain proportion, and stirring for 5-10 min. (3) Sequentially adding calcium propionate and sodium diacetate into the mixer according to the proportion, and stirring for 10-15 min. (4) And (4) after the step (3) is finished, packaging the solid finished product to obtain the composite organic acidifier.
Example 2:
according to the parts by weight: 70 parts of citric acid, 10 parts of malic acid, 5 parts of tartaric acid, 5 parts of calcium formate, 5 parts of potassium diformate, 2 parts of ammonium formate and 3 parts of sodium dihydrogen phosphate, and respectively weighing appropriate amounts of the raw materials;
the preparation method of the compound organic acidifier comprises the following steps: (1) sequentially adding citric acid, malic acid and tartaric acid into a mixer according to a certain proportion. (2) Adding sodium dihydrogen phosphate into the mixer at a certain proportion, and stirring for 5-10 min. (3) And sequentially adding calcium formate, potassium diformate and ammonium formate into the mixer according to the proportion, and stirring for 10-15 min. (4) And (4) after the step (3) is finished, packaging the solid finished product to obtain the composite organic acidifier.
Example 3:
according to the parts by weight: 80 parts of citric acid, 6 parts of tartaric acid, 1 part of benzoic acid, 5 parts of ammonium formate, 5 parts of choline chloride and 3 parts of sodium dihydrogen phosphate, and respectively weighing a proper amount of raw materials;
the preparation method of the compound organic acidifier comprises the following steps: (1) sequentially adding citric acid, tartaric acid and benzoic acid into the mixer according to the proportion. (2) Adding sodium dihydrogen phosphate into the mixer according to a certain proportion, and stirring for 5-10 min. (3) And sequentially adding ammonium formate and choline chloride into the mixer according to the proportion, and stirring for 10-15 min. (4) And (4) after the step (3) is finished, packaging the solid finished product to obtain the composite organic acidifier.
Example 4:
according to the parts by weight: 40 parts of malic acid, 40 parts of tartaric acid, 4 parts of calcium propionate, 4 parts of potassium diformate, 4 parts of oligosaccharide and 8 parts of sodium tripolyphosphate, and respectively weighing appropriate amounts of the raw materials;
the preparation method of the compound organic acidifier comprises the following steps: (1) malic acid and tartaric acid are added into the mixer in sequence according to the proportion. (2) Adding sodium tripolyphosphate into the mixer according to a certain proportion, and stirring for 5-10 min. (3) Sequentially adding calcium propionate, potassium diformate and oligosaccharide into the mixer according to the proportion, and stirring for 10-15 min. (4) And (4) after the step (3) is finished, packaging the solid finished product to obtain the compound organic acidifier.
Example 5:
according to the parts by weight: 73 parts of citric acid, 6 parts of tartaric acid, 1 part of sorbic acid, 4 parts of ammonium formate, 4 parts of sodium diacetate, 4 parts of oligosaccharide and 8 parts of sodium silicate, and respectively weighing appropriate raw materials;
the preparation method of the compound organic acidifier comprises the following steps: (1) sequentially adding citric acid, tartaric acid and sorbic acid into the mixer according to the proportion. (2) Adding sodium silicate into the mixer according to the proportion, and stirring for 5-10 min. (3) Sequentially adding ammonium formate, sodium diacetate and oligosaccharide into the mixer according to the proportion, and stirring for 10-15 min. (4) And (4) after the step (3) is finished, packaging the solid finished product to obtain the composite organic acidifier.
Example 6:
according to the parts by weight: 73 parts of citric acid, 7 parts of tartaric acid, 4 parts of calcium formate, 4 parts of potassium diformate, 4 parts of choline chloride and 8 parts of calcium phosphate, and respectively weighing a proper amount of each raw material;
the preparation method of the compound organic acidifier comprises the following steps: (1) sequentially adding citric acid and tartaric acid into the mixer according to the proportion. (2) Adding calcium phosphate into the mixer according to the proportion, and stirring for 5-10 min. (3) Sequentially adding calcium formate, potassium diformate and choline chloride into the mixer according to the proportion, and stirring for 10-15 min. (4) And (4) after the step (3) is finished, packaging the solid finished product to obtain the compound organic acidifier.
In order to prove that the composite organic acidifiers prepared by the invention have stronger pH buffering capacity, corresponding times of dilution are carried out in a laboratory to determine the pH values of different times, and the determination results are shown in Table 1.
TABLE 1 test of pH buffer Capacity
| 500 times of | 1000 times of | 2000 times of | 3000 times of | |
| Example 1 | 2.53 | 2.90 | 3.15 | 3.36 |
| Example 2 | 2.26 | 2.74 | 2.78 | 2.85 |
| Example 3 | 2.40 | 2.82 | 2.97 | 3.09 |
| Example 4 | 2.38 | 2.72 | 2.75 | 2.90 |
| Example 5 | 3.23 | 3.66 | 3.89 | 4.17 |
| Example 6 | 3.10 | 3.58 | 3.84 | 4.05 |
The determination results in table 1 show that the pH change of the composite organic acidifying agent of the invention in diluted solutions with different dilution times is relatively stable, and the 6 composite organic acidifying agents of the invention are proved to have good buffering capacity, can effectively balance the intestinal flora of animals and keep the health of organisms.
In order to prove that the prepared composite organic acidifier has stronger bactericidal performance, experiments are carried out in a large chicken farm in a certain place in the north, and 7 hencoop waterlines are randomly selected, wherein the 1 st to 6 th groups are experimental groups, and the 7 th group is a blank control group; adding a compound mineral substance and vitamin solution to the water line of the 1 st to 6 th groups of chicken coops according to the proportion of 1:100, and enabling the concentration of the compound mineral substance and the vitamin in the water to reach 0.1 mg/L; the 7 th group of coop waterlines are not processed; the compound organic acidifier prepared in the examples 1-6 is added into the chicken coop water line of the groups 1-6 respectively and completely dissolved, and the concentration of the compound organic acidifier in the water line is 0.1 g/L.
After the preparation work is finished, the water valves of all groups of coop waterlines are closed and placed still, water bodies in all groups of coop waterlines are sampled according to time nodes, the concentration of bacteria in the waterlines is detected, and the results are shown in table 2.
TABLE 2 Sterilization Properties test
From the experimental results, the compound organic acidifier disclosed by the embodiments 1-6 can effectively inhibit the proliferation of bacteria under the condition of eutrophic environment, and the water body added with the compound organic acidifier can reach the national drinking water quality sanitary standard after being treated, so that the compound organic acidifier is suitable for daily drinking by livestock and poultry.
In order to confirm the influence of the composite organic acidifier prepared by the invention on the production performance of the laying hens, tests are carried out, and the measurement results are shown in table 3.
TABLE 3 laying hen production Performance test
In the laying performance test of the laying hens, the diarrhea rate of the initial laying hens of a control group is 23.6 percent, the laying rate is 88.6 percent, the average egg weight is 59.3g, the feed-egg ratio in the laying period is 2.75, the eggshell strength is 378.2kpa, and the eggshell thickness is 0.364 mm; in 6 groups of laying hens added with the 6 acidulants, the diarrhea rate of the laying hens in the initial period is 10.6-13.9%, the laying rate is 90.8-93.1%, the average egg weight is 61.1-63.9 g, the feed-egg ratio in the laying period is 2.37-2.59, the eggshell strength is 368.4-394.2 kpa, and the eggshell thickness is 0.360-0.379 mm; the 6 acidifying agents disclosed by the invention can reduce the diarrhea rate and the feed-weight ratio in the egg producing period, improve the egg producing rate, the average egg weight, the eggshell strength and the eggshell thickness, and can obviously improve the production performance of the laying hens.
While particular examples have been illustrated and described, it will be appreciated that many other changes and modifications may be made without departing from the spirit and scope of the invention. It is therefore intended to cover in the appended claims all such changes and modifications that are within the scope of this invention.
Claims (5)
1. The compound organic acidifier is characterized by being mainly prepared from the following components: organic acid, synergist and stabilizer.
2. The compound organic acidifier according to claim 1, comprising the following raw materials in parts by weight:
40-90 parts of organic acid
0-40 parts of synergist
0-30 parts of stabilizer
The compound organic acidulant of claim 1 wherein the organic acid comprises one or more of citric acid, malic acid, fumaric acid, sorbic acid, tartaric acid, and benzoic acid.
3. The compounded organic acidifier according to claim 1, wherein the synergist comprises one or more of ammonium formate, calcium propionate, sodium diacetate, potassium diformate, choline chloride, and oligosaccharides.
4. The compound organic acidifier according to claim 1, wherein the stabilizer comprises one or more of sodium tripolyphosphate, sodium dihydrogen phosphate, calcium phosphate, and sodium silicate.
5. Process for the preparation of a complex organic acidulant as claimed in any one of claims 1 to 5 which comprises the steps of: (1) adding organic acid into the mixer according to the proportion; (2) adding stabilizer into the mixer according to a certain proportion, and stirring for 5-10 min; (3) adding the synergist into the mixer in proportion, and stirring for 10-15 min; (4) and (4) after the step (3) is finished, packaging the solid finished product to obtain the composite organic acidifier.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202110294866.8A CN115104674A (en) | 2021-03-19 | 2021-03-19 | Preparation method and application of composite organic acidifier |
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| CN202110294866.8A CN115104674A (en) | 2021-03-19 | 2021-03-19 | Preparation method and application of composite organic acidifier |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115736106A (en) * | 2022-12-01 | 2023-03-07 | 石家庄石牧药业有限公司 | Compound choline chloride acidifier solution and preparation method thereof |
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2021
- 2021-03-19 CN CN202110294866.8A patent/CN115104674A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115736106A (en) * | 2022-12-01 | 2023-03-07 | 石家庄石牧药业有限公司 | Compound choline chloride acidifier solution and preparation method thereof |
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