CN113906139A - Angptl2反义寡核苷酸及其用途 - Google Patents

Angptl2反义寡核苷酸及其用途 Download PDF

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Publication number
CN113906139A
CN113906139A CN202080039696.2A CN202080039696A CN113906139A CN 113906139 A CN113906139 A CN 113906139A CN 202080039696 A CN202080039696 A CN 202080039696A CN 113906139 A CN113906139 A CN 113906139A
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Prior art keywords
aso
seq
angptl2
nucleotides
dna
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Chinese (zh)
Inventor
B·R·安德森
R.E.奥尔森
I·M·麦克唐纳
S·E·默瑟
P·哈格多恩
M·L·詹森
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Roche Innovation Center Copenhagen AS
Bristol Myers Squibb Co
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Roche Innovation Center Copenhagen AS
Bristol Myers Squibb Co
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CN202080039696.2A 2019-04-03 2020-04-02 Angptl2反义寡核苷酸及其用途 Pending CN113906139A (zh)

Applications Claiming Priority (3)

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US201962828864P 2019-04-03 2019-04-03
US62/828,864 2019-04-03
PCT/US2020/026379 WO2020206115A2 (en) 2019-04-03 2020-04-02 Angptl2 antisense oligonucleotides and uses thereof

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CN113906139A true CN113906139A (zh) 2022-01-07

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US (1) US20220213484A1 (https=)
EP (1) EP3947680A2 (https=)
JP (2) JP7725370B2 (https=)
KR (1) KR20210149107A (https=)
CN (1) CN113906139A (https=)
AU (1) AU2020252374A1 (https=)
BR (1) BR112021019182A2 (https=)
CA (1) CA3135794A1 (https=)
EA (1) EA202192733A1 (https=)
IL (1) IL286826A (https=)
MX (1) MX2021012098A (https=)
SG (1) SG11202110745VA (https=)
WO (1) WO2020206115A2 (https=)

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FR3131970B1 (fr) 2022-01-14 2024-02-23 Univ D’Aix Marseille Amu Dispositif pour la simulation en chirurgie abdominale

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6287769B1 (en) * 1998-03-31 2001-09-11 Sanyo Electric Co., Ltd. Method of amplifying DNA fragment, apparatus for amplifying DNA fragment, method of assaying microorganisms, method of analyzing microorganisms and method of assaying contaminant
US20110319317A1 (en) * 2009-03-04 2011-12-29 Opko Curna, Llc Treatment of sirtuin 1 (sirt1) related diseases by inhibition of natural antisense transcript to sirt1
WO2014167529A1 (en) * 2013-04-10 2014-10-16 Institut De Cardiologie De Montreal Methods and compositions for preventing and treating atherosclerosis
US20160237427A1 (en) * 2015-02-04 2016-08-18 Bristol-Myers Squibb Company Tau Antisense Oligomers and Uses Thereof

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
WO1993007883A1 (en) 1991-10-24 1993-04-29 Isis Pharmaceuticals, Inc. Derivatized oligonucleotides having improved uptake and other properties
JP3756313B2 (ja) 1997-03-07 2006-03-15 武 今西 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体
AU9063398A (en) 1997-09-12 1999-04-05 Exiqon A/S Oligonucleotide analogues
CZ296576B6 (cs) 1999-02-12 2006-04-12 Sankyo Company Limited Nukleosidový analog a oligonukleotidový analog a farmaceutický prostredek, sonda a primer s jeho obsahem
WO2000059938A1 (en) * 1999-04-01 2000-10-12 Genetics Institute, Inc. Angiopoietin-like proteins, crisp proteins and polynucleotides encoding same
EP1178999B1 (en) 1999-05-04 2007-03-14 Santaris Pharma A/S L-ribo-lna analogues
US6617442B1 (en) 1999-09-30 2003-09-09 Isis Pharmaceuticals, Inc. Human Rnase H1 and oligonucleotide compositions thereof
US9045518B2 (en) 2002-11-18 2015-06-02 Santaris Pharma A/S Amino-LNA, thio-LNA and alpha-L-oxy-LN
CA2519860C (en) 2003-03-21 2018-01-16 Santaris Pharma A/S Short interfering rna (sirna) analogues
US20070072209A1 (en) * 2005-07-07 2007-03-29 Ashlee Moses Methods of treatment and diagnosis of Kaposi's sarcoma (KS) and KS related diseases
WO2007031091A2 (en) 2005-09-15 2007-03-22 Santaris Pharma A/S Rna antagonist compounds for the modulation of p21 ras expression
JP5342881B2 (ja) 2006-01-27 2013-11-13 アイシス ファーマシューティカルズ, インコーポレーテッド 6−修飾された二環式核酸類似体
DK1984382T3 (da) 2006-01-27 2012-09-03 Santaris Pharma As LNA modificerede fosforthiolerede oligonukleotider
WO2007107162A2 (en) 2006-03-23 2007-09-27 Santaris Pharma A/S Small internally segmented interfering rna
US7666854B2 (en) 2006-05-11 2010-02-23 Isis Pharmaceuticals, Inc. Bis-modified bicyclic nucleic acid analogs
AU2007249349B2 (en) 2006-05-11 2012-03-08 Isis Pharmaceuticals, Inc. 5'-Modified bicyclic nucleic acid analogs
EP2170917B1 (en) 2007-05-30 2012-06-27 Isis Pharmaceuticals, Inc. N-substituted-aminomethylene bridged bicyclic nucleic acid analogs
EP2173760B2 (en) 2007-06-08 2015-11-04 Isis Pharmaceuticals, Inc. Carbocyclic bicyclic nucleic acid analogs
CA2692579C (en) 2007-07-05 2016-05-03 Isis Pharmaceuticals, Inc. 6-disubstituted bicyclic nucleic acid analogs
US8546556B2 (en) 2007-11-21 2013-10-01 Isis Pharmaceuticals, Inc Carbocyclic alpha-L-bicyclic nucleic acid analogs
WO2010036698A1 (en) 2008-09-24 2010-04-01 Isis Pharmaceuticals, Inc. Substituted alpha-l-bicyclic nucleosides
EP2462153B1 (en) 2009-08-06 2015-07-29 Isis Pharmaceuticals, Inc. Bicyclic cyclohexose nucleic acid analogs
JP2011093896A (ja) * 2009-09-30 2011-05-12 Kumamoto Univ 癌治療剤
EP2490699A1 (en) 2009-10-20 2012-08-29 Santaris Pharma A/S Oral delivery of therapeutically effective lna oligonucleotides
EP2580228B1 (en) 2010-06-08 2016-03-23 Ionis Pharmaceuticals, Inc. Substituted 2'-amino and 2'-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
PH12019502377A1 (en) * 2011-04-21 2022-11-14 Isis Pharmaceuticals Inc Modulation of hepatitis b virus (hbv) expression
EP3453761A1 (en) 2011-08-29 2019-03-13 Ionis Pharmaceuticals, Inc. Oligomer-conjugate complexes and their use
JP2015502365A (ja) * 2011-12-12 2015-01-22 オンコイミューニン,インコーポレイティド オリゴヌクレオチドのイン−ビボ送達
EP2850092B1 (en) 2012-04-09 2017-03-01 Ionis Pharmaceuticals, Inc. Tricyclic nucleic acid analogs
US10077443B2 (en) 2012-11-15 2018-09-18 Roche Innovation Center Copenhagen A/S Oligonucleotide conjugates
DK2991656T3 (da) 2013-05-01 2020-03-23 Ionis Pharmaceuticals Inc Sammensætninger og fremgangsmåder til modulering af apolipoprotein c-iii-ekspression
CA2951816A1 (en) * 2013-06-12 2014-12-18 Oncoimmunin, Inc. Systemic in vivo delivery of oligonucleotides
ES2770667T3 (es) 2013-06-27 2020-07-02 Roche Innovation Ct Copenhagen As Oligómeros antisentido y conjugados que se dirigen a PCSK9
HK1244843A1 (zh) * 2014-11-17 2018-08-17 Alnylam Pharmaceuticals, Inc. 载脂蛋白c3(apoc3)irna组合物及其使用方法
US20190022250A1 (en) * 2015-11-06 2019-01-24 National University Corporation Kumamoto University Pharmaceutical composition for preventing or treating heart failure
KR102645243B1 (ko) 2016-11-23 2024-03-11 알닐람 파마슈티칼스 인코포레이티드 표적외 효과가 감소된 변형 rna 작용제
UY38562A (es) * 2019-01-29 2020-08-31 Ionis Pharmaceuticals Inc Compuestos y métodos para reducir la expresión de app

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6287769B1 (en) * 1998-03-31 2001-09-11 Sanyo Electric Co., Ltd. Method of amplifying DNA fragment, apparatus for amplifying DNA fragment, method of assaying microorganisms, method of analyzing microorganisms and method of assaying contaminant
US20110319317A1 (en) * 2009-03-04 2011-12-29 Opko Curna, Llc Treatment of sirtuin 1 (sirt1) related diseases by inhibition of natural antisense transcript to sirt1
WO2014167529A1 (en) * 2013-04-10 2014-10-16 Institut De Cardiologie De Montreal Methods and compositions for preventing and treating atherosclerosis
US20160237427A1 (en) * 2015-02-04 2016-08-18 Bristol-Myers Squibb Company Tau Antisense Oligomers and Uses Thereof
CN107922946A (zh) * 2015-02-04 2018-04-17 霍夫曼-拉罗奇有限公司 Tau反义低聚物及其用途

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
LI-KUN YANG ET AL.: "Knockdown of Angiopoietin-Like Protein 2 Inhibits Proliferation and Invasion in Glioma Cells via Suppressing the ERK MAPK Signaling Pathway", ONCOLOGY RESEARCH, vol. 25, pages 1349 *
梁越等: "血管生成素样蛋白2在下肢动脉粥样硬化闭塞症血浆中的变化及其意义", 中国医学科学院学报, no. 02, pages 32 - 39 *
龚守良主编: "肿瘤基因放射治疗学基础", 北京:人民军医出版社, pages: 392 - 393 *

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AU2020252374A1 (en) 2021-11-11
IL286826A (en) 2021-10-31
JP2026002846A (ja) 2026-01-08
MX2021012098A (es) 2021-11-03
KR20210149107A (ko) 2021-12-08
JP2022524218A (ja) 2022-04-28
EP3947680A2 (en) 2022-02-09
SG11202110745VA (en) 2021-10-28
WO2020206115A3 (en) 2020-11-12
CA3135794A1 (en) 2020-10-08
BR112021019182A2 (pt) 2022-05-31
WO2020206115A2 (en) 2020-10-08
EA202192733A1 (ru) 2022-03-14
JP7725370B2 (ja) 2025-08-19
US20220213484A1 (en) 2022-07-07

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