CN113891747A - 诱导免疫细胞活性的组合物及使用该组合物治疗疾病的方法 - Google Patents

诱导免疫细胞活性的组合物及使用该组合物治疗疾病的方法 Download PDF

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Publication number
CN113891747A
CN113891747A CN202080036171.3A CN202080036171A CN113891747A CN 113891747 A CN113891747 A CN 113891747A CN 202080036171 A CN202080036171 A CN 202080036171A CN 113891747 A CN113891747 A CN 113891747A
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cancer
tumor
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cells
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韩志强
李文
邢风云
万娜
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Zhengzhou Virige Biotech Co ltd
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Zhengzhou Virige Biotech Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/76Viruses; Subviral particles; Bacteriophages
    • A61K35/763Herpes virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Abstract

一种在有需要的受试者中诱导免疫细胞活性的组合物,其包含与所述受试者自体同源的肿瘤细胞裂解物、OX40激动剂和TLR激动剂。使用所述组合物用于治疗受试者病症的方法。

Description

PCT国内申请,说明书已公开。

Claims (35)

  1. PCT国内申请,权利要求书已公开。
CN202080036171.3A 2019-05-15 2020-05-15 诱导免疫细胞活性的组合物及使用该组合物治疗疾病的方法 Pending CN113891747A (zh)

Applications Claiming Priority (3)

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CN2019087096 2019-05-15
CNPCT/CN2019/087096 2019-05-15
PCT/CN2020/090631 WO2020228828A1 (zh) 2019-05-15 2020-05-15 诱导免疫细胞活性的组合物及使用该组合物治疗疾病的方法

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CN113891747A true CN113891747A (zh) 2022-01-04

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WO (1) WO2020228828A1 (zh)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107001478A (zh) * 2014-10-14 2017-08-01 诺华股份有限公司 针对pd‑l1的抗体分子及其用途
CN108135934A (zh) * 2015-10-19 2018-06-08 永恒生物科技股份有限公司 通过组合疗法治疗实体或淋巴肿瘤的方法
WO2018127713A1 (en) * 2017-01-09 2018-07-12 Replimune Limited Altered virus
CN108289858A (zh) * 2015-06-30 2018-07-17 宾夕法尼亚州立大学托管会 用于治疗肿瘤性皮肤疾病的瑞喹莫特局部可注射组合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014022138A2 (en) * 2012-07-30 2014-02-06 Alex Wah Hin Yeung Live and in-vivo tumor specific cancer vaccine system developed by co-administration of either at least two or all three of the following components such as tumor cells, an oncolytic virus vector with transgenic expression of gm-csf and an immune checkpoint modulator
TW201716084A (zh) * 2015-08-06 2017-05-16 葛蘭素史克智慧財產發展有限公司 組合物及其用途與治療
JP7410472B2 (ja) * 2015-09-25 2024-01-10 リリース セラピューティクス エスアー 免疫調節物質を産生する免疫隔離細胞とのワクチン接種

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107001478A (zh) * 2014-10-14 2017-08-01 诺华股份有限公司 针对pd‑l1的抗体分子及其用途
CN108289858A (zh) * 2015-06-30 2018-07-17 宾夕法尼亚州立大学托管会 用于治疗肿瘤性皮肤疾病的瑞喹莫特局部可注射组合物
CN108135934A (zh) * 2015-10-19 2018-06-08 永恒生物科技股份有限公司 通过组合疗法治疗实体或淋巴肿瘤的方法
WO2018127713A1 (en) * 2017-01-09 2018-07-12 Replimune Limited Altered virus

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
IDIT SAGIV-BARFI 等: "Eradication of spontaneous malignancy by local immunotherapy", SCIENCE TRANSLATIONAL MEDICINE, vol. 10, 31 January 2018 (2018-01-31), pages 3 *
KASIEWICZ, M.J. 等: "Toll-like receptor ligands in conjunction with agonist anti-OX40 mAb immunotherapy possess differential capacity to revive anergic self-reactive CD8 T cells", THE JOURNAL OF IMMUNOLOGY, vol. 196, no. 1 *
VOO, K.S. 等: "Selective targeting of Toll‐like receptors and OX40 inhibit regulatory T–cell function in follicular lymphoma", INTERNATIONAL JOURNAL OF CANCER, vol. 135, pages 2834 - 2846, XP055739918, DOI: 10.1002/ijc.28937 *

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