CN113876745A - Bee venom bone penetrating therapy - Google Patents

Bee venom bone penetrating therapy Download PDF

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Publication number
CN113876745A
CN113876745A CN202111385003.8A CN202111385003A CN113876745A CN 113876745 A CN113876745 A CN 113876745A CN 202111385003 A CN202111385003 A CN 202111385003A CN 113876745 A CN113876745 A CN 113876745A
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CN
China
Prior art keywords
parts
bee venom
bone penetrating
plaster
pepper
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202111385003.8A
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Chinese (zh)
Inventor
邱凯
李德清
张娟娟
沈晶晶
韩强
申海龙
吕方
戴国平
费中华
郑鹏华
褚玲娜
杨健
汪海平
蒋晓莉
朱世杰
张显富
李宁
邱汝民
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Changxing Yifeng Bee Industry Technology Co ltd
Original Assignee
Changxing Yifeng Bee Industry Technology Co ltd
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Application filed by Changxing Yifeng Bee Industry Technology Co ltd filed Critical Changxing Yifeng Bee Industry Technology Co ltd
Priority to CN202111385003.8A priority Critical patent/CN113876745A/en
Publication of CN113876745A publication Critical patent/CN113876745A/en
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A61K31/125—Camphor; Nuclear substituted derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/64—Insects, e.g. bees, wasps or fleas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/64—Insects, e.g. bees, wasps or fleas
    • A61K35/644—Beeswax; Propolis; Royal jelly; Honey
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11—Pteridophyta or Filicophyta (ferns)
    • A61K36/12—Filicopsida or Pteridopsida
    • A61K36/126—Drynaria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/486—Millettia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/716—Clematis (leather flower)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9062—Alpinia, e.g. red ginger or galangal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis

Abstract

The invention relates to a bee venom bone penetrating therapy, which comprises a bee venom bone penetrating plaster, wherein the bee venom bone penetrating plaster is applied to a patient and is replaced every 3 to 5 days; the bee venom bone penetrating plaster is prepared from the following raw materials in parts by weight: garden balsam stem, drynaria rhizome, suberect spatholobus stem, clematis root, Chinese angelica, cassia bark, Szechuan lovage rhizome, dahurian angelica root, eucommia bark, black pepper, galangal, hot pepper, bee venom, honey, beewax, xanthan gum, edible gelatin, glyceryl monostearate and camphor. By adopting the scheme, the bee venom bone penetrating plaster is applied to the affected part, so that the discomfort of joints of the neck, the shoulder, the waist, the legs and the like of a human body can be relieved, and the health is promoted.

Description

Bee venom bone penetrating therapy
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a bee venom bone penetrating therapy.
Background
Bee venom therapy, also called bee venom bone penetrating therapy, has been used for a long time in our country, and has 3 functions of acupuncture, medicine and moxibustion, namely 'acupuncture': polypeptide substances contained in bee venom permeate to have stinging feeling, act on acupuncture points, channels and collaterals and skin parts of a human body, can regulate yin and yang, dredge channels and collaterals, strengthen body resistance and eliminate pathogenic factors; the "medicine": the bee venom permeates into human body, so that the effects of regulating immunity, resisting infection, cancer, bacteria, radiation and bacteria are achieved; the method comprises the following steps of (1) moxibustion: after the finger is permeated, the moxibustion has the functions of warming moxibustion, activating local tissues and increasing skin temperature, and has the functions of warming meridians, dredging collaterals, expelling wind and removing cold, relieving swelling and pain, dissipating stagnation and removing blood stasis.
For better treatment, it is necessary to develop external plasters which are applied to the affected part to achieve better prevention or treatment effects.
Disclosure of Invention
The bee venom bone penetrating therapy is pasted on a patient, so that discomfort of joints of the neck, the shoulder, the waist, the legs and the like of a human body can be relieved, and health is promoted.
In order to achieve the purpose, the invention adopts the technical scheme that: a bee venom bone penetrating therapy comprises bee venom bone penetrating patch, which is applied to affected part and replaced every 3-5 days;
the bee venom bone penetrating plaster is prepared from the following raw materials in parts by weight: the bee venom bone penetrating plaster is prepared from the following raw materials in parts by weight: 10-20 parts of garden balsam stem, 4-8 parts of drynaria rhizome, 5-10 parts of suberect spatholobus stem, 5-8 parts of clematis root, 5-10 parts of Chinese angelica, 4-8 parts of cinnamon, 4-8 parts of ligusticum wallichii, 10-15 parts of angelica dahurica, 4-7 parts of eucommia ulmoides, 1-3 parts of black pepper, 1-3 parts of galangal, 1-3 parts of pepper, 5-10 parts of bee venom, 6-10 parts of honey, 4-8 parts of beeswax, 4-8 parts of xanthan gum, 2-4 parts of edible gelatin, 1-3 parts of glyceryl monostearate and 1-3 parts of camphor;
the preparation method of the bee venom bone penetrating plaster comprises the following steps:
firstly, crushing a proper amount of garden balsam stem, rhizoma drynariae, suberect spatholobus stem, clematis root, Chinese angelica, cinnamon, szechuan lovage rhizome, dahurian angelica root, eucommia bark, black pepper, galangal and hot pepper;
step two, putting a proper amount of bee venom, honey, beeswax, xanthan gum, edible gelatin and glyceryl monostearate into a container, fully mixing, and decocting with slow fire for 20-30 minutes;
step three, adding the powdery raw materials in the step one into a container, mixing and stirring, and decocting with slow fire for 40-50 minutes;
step four, adding a proper amount of camphor into the container, and fully stirring for 5-8 minutes to prepare a viscous plaster substrate;
and step five, coating the plaster substrate on cloth, and performing slitting operation to form the bee venom bone penetrating plaster.
By adopting the scheme, the pharmacological effects of the raw materials are as follows:
garden balsam stem: has pungent taste and warm nature, and has effects of dispelling pathogenic wind, removing dampness, relieving rigidity of muscles, promoting blood circulation, removing blood stasis, relieving swelling, removing toxic substance and relieving pain;
rhizoma drynariae: bitter taste and warm nature, and has the effects of tonifying kidney, strengthening bone, healing wound and relieving pain;
caulis spatholobi: bitter and sweet in taste and warm in nature, and has the effects of promoting blood circulation, tonifying blood, regulating menstruation, relieving pain, relaxing muscles and tendons and activating collaterals;
clematis root: pungent, salty and warm in nature, and has the effects of expelling wind-damp and dredging meridians;
chinese angelica: sweet and pungent in flavor and warm in nature, and has the effects of enriching blood, promoting blood circulation, regulating menstruation, relieving pain, moistening intestines and relaxing bowels;
cinnamon: the medicine is pungent and sweet in taste and strong in property and heat, and has the effects of tonifying fire, supporting yang, guiding fire to return to original, dispelling cold, relieving pain and warming and dredging channels and collaterals;
ligusticum wallichii: pungent taste and warm nature, and has effects of promoting blood circulation, activating qi-flowing, dispelling pathogenic wind and relieving pain;
radix angelicae: has pungent taste and warm nature, and has effects of relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, relieving pain, dredging nasal orifice, eliminating dampness, stopping leukorrhagia, relieving swelling, expelling pus, dispelling pathogenic wind, and relieving itching;
eucommia ulmoides: sweet taste and warm nature, and has the effects of nourishing liver and kidney, and strengthening tendons and bones;
black pepper: pungent taste and hot nature, and has the effects of descending qi, eliminating phlegm and removing toxic substances;
galangal: pungent and warm in flavor, and has the effects of dispelling cold, promoting qi circulation and relieving pain;
hot pepper: pungent taste and warm nature, and has the effects of dispelling cold and descending qi;
bee venom: has pungent, bitter and neutral taste, and has effects of dispelling pathogenic wind, removing dampness, and relieving pain;
honey: sweet taste, mild nature, and has effects of invigorating middle warmer, moistening dryness, relieving pain, and removing toxic substance;
beeswax: sweet in taste and slightly warm in nature, and has the effects of detoxifying, healing sore, promoting granulation and relieving pain;
xanthan gum: in the invention, the function of a thickening agent is realized;
edible gelatin: in the invention, the function of a thickening agent is realized;
glyceryl monostearate: the antibacterial activity is strong;
camphor: has pungent taste and warm nature, and has effects of dredging orifices, benefiting qi stagnation, removing filth, killing parasites, relieving itching, and relieving swelling and pain;
the bee venom bone penetrating plaster can relieve the discomfort of joints of neck, shoulder, waist, legs and the like of a human body and promote health.
Detailed Description
A bee venom bone penetrating therapy comprises bee venom bone penetrating patch, which is applied to affected part and replaced every 3-5 days;
the bee venom bone penetrating plaster is prepared from the following raw materials in parts by weight: the bee venom bone penetrating plaster is prepared from the following raw materials in parts by weight: 10-20 parts of garden balsam stem, 4-8 parts of drynaria rhizome, 5-10 parts of suberect spatholobus stem, 5-8 parts of clematis root, 5-10 parts of Chinese angelica, 4-8 parts of cinnamon, 4-8 parts of ligusticum wallichii, 10-15 parts of angelica dahurica, 4-7 parts of eucommia ulmoides, 1-3 parts of black pepper, 1-3 parts of galangal, 1-3 parts of pepper, 5-10 parts of bee venom, 6-10 parts of honey, 4-8 parts of beeswax, 4-8 parts of xanthan gum, 2-4 parts of edible gelatin, 1-3 parts of glyceryl monostearate and 1-3 parts of camphor;
the preparation method of the bee venom bone penetrating plaster comprises the following steps:
firstly, crushing a proper amount of garden balsam stem, rhizoma drynariae, suberect spatholobus stem, clematis root, Chinese angelica, cinnamon, szechuan lovage rhizome, dahurian angelica root, eucommia bark, black pepper, galangal and hot pepper;
step two, putting a proper amount of bee venom, honey, beeswax, xanthan gum, edible gelatin and glyceryl monostearate into a container, fully mixing, and decocting with slow fire for 20-30 minutes;
step three, adding the powdery raw materials in the step one into a container, mixing and stirring, and decocting with slow fire for 40-50 minutes;
step four, adding a proper amount of camphor into the container, and fully stirring for 5-8 minutes to prepare a viscous plaster substrate;
and step five, coating the plaster substrate on cloth, and performing slitting operation to form the bee venom bone penetrating plaster.
When in use, the joint is locally applied externally, 3-5 patches are applied each time, and the joint is replaced every 3-5 days.
Unsuitable for people:
1. the skin allergy or ulceration patients and the skin patients are forbidden;
2. it is forbidden for pregnant women, lactating women and minors;
3. severe liver, kidney, blood diseases and allergy to the product are forbidden.
The above embodiments are merely preferred embodiments of the present invention, and general changes and substitutions by those skilled in the art within the technical scope of the present invention are included in the protection scope of the present invention.

Claims (1)

1. A bee venom bone penetrating therapy is characterized in that: comprises a bee venom bone penetrating plaster which is applied to the affected part and is replaced every 3 to 5 days;
the bee venom bone penetrating plaster is prepared from the following raw materials in parts by weight: 10-20 parts of garden balsam stem, 4-8 parts of drynaria rhizome, 5-10 parts of suberect spatholobus stem, 5-8 parts of clematis root, 5-10 parts of Chinese angelica, 4-8 parts of cinnamon, 4-8 parts of ligusticum wallichii, 10-15 parts of angelica dahurica, 4-7 parts of eucommia ulmoides, 1-3 parts of black pepper, 1-3 parts of galangal, 1-3 parts of pepper, 5-10 parts of bee venom, 6-10 parts of honey, 4-8 parts of beeswax, 4-8 parts of xanthan gum, 2-4 parts of edible gelatin, 1-3 parts of glyceryl monostearate and 1-3 parts of camphor;
the preparation method of the bee venom bone penetrating plaster comprises the following steps:
firstly, crushing a proper amount of garden balsam stem, rhizoma drynariae, suberect spatholobus stem, clematis root, Chinese angelica, cinnamon, szechuan lovage rhizome, dahurian angelica root, eucommia bark, black pepper, galangal and hot pepper;
step two, putting a proper amount of bee venom, honey, beeswax, xanthan gum, edible gelatin and glyceryl monostearate into a container, fully mixing, and decocting with slow fire for 20-30 minutes;
step three, adding the powdery raw materials in the step one into a container, mixing and stirring, and decocting with slow fire for 40-50 minutes;
step four, adding a proper amount of camphor into the container, and fully stirring for 5-8 minutes to prepare a viscous plaster substrate;
and step five, coating the plaster substrate on cloth, and performing slitting operation to form the bee venom bone penetrating plaster.
CN202111385003.8A 2021-11-22 2021-11-22 Bee venom bone penetrating therapy Pending CN113876745A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202111385003.8A CN113876745A (en) 2021-11-22 2021-11-22 Bee venom bone penetrating therapy

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Application Number Priority Date Filing Date Title
CN202111385003.8A CN113876745A (en) 2021-11-22 2021-11-22 Bee venom bone penetrating therapy

Publications (1)

Publication Number Publication Date
CN113876745A true CN113876745A (en) 2022-01-04

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102266398A (en) * 2011-07-07 2011-12-07 夏军秀 Composition for mud moxibustion of rheumatic diseases
CN104225534A (en) * 2014-09-10 2014-12-24 吕赛林 Ointment for treating waist, shoulder and foot rheumatism and preparation method of ointment
CN105596608A (en) * 2014-10-17 2016-05-25 北京久颐蜂科技有限公司 Bee venom essence
CN112870283A (en) * 2020-04-16 2021-06-01 林军庭 A Chinese medicinal patch and its preparation method

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102266398A (en) * 2011-07-07 2011-12-07 夏军秀 Composition for mud moxibustion of rheumatic diseases
CN104225534A (en) * 2014-09-10 2014-12-24 吕赛林 Ointment for treating waist, shoulder and foot rheumatism and preparation method of ointment
CN105596608A (en) * 2014-10-17 2016-05-25 北京久颐蜂科技有限公司 Bee venom essence
CN112870283A (en) * 2020-04-16 2021-06-01 林军庭 A Chinese medicinal patch and its preparation method

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