CN113866127B - Intra-fiber micro-fluidic sensing device based on four-hole microstructure optical fiber integration - Google Patents
Intra-fiber micro-fluidic sensing device based on four-hole microstructure optical fiber integration Download PDFInfo
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- 230000010354 integration Effects 0.000 title claims abstract description 19
- 239000000835 fiber Substances 0.000 title claims description 84
- 239000007788 liquid Substances 0.000 claims abstract description 39
- 239000011148 porous material Substances 0.000 claims abstract description 21
- 239000002699 waste material Substances 0.000 claims abstract description 14
- 238000005520 cutting process Methods 0.000 claims description 25
- 238000003466 welding Methods 0.000 claims description 23
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 10
- 239000011247 coating layer Substances 0.000 claims description 9
- 238000005253 cladding Methods 0.000 claims description 8
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- 238000005259 measurement Methods 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 5
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 3
- 239000001569 carbon dioxide Substances 0.000 claims description 3
- 235000011187 glycerol Nutrition 0.000 claims description 3
- 238000005086 pumping Methods 0.000 claims description 3
- 238000004080 punching Methods 0.000 claims description 3
- 238000005459 micromachining Methods 0.000 claims description 2
- 239000012530 fluid Substances 0.000 abstract description 11
- 238000001514 detection method Methods 0.000 abstract description 10
- 230000035945 sensitivity Effects 0.000 abstract description 6
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- 230000010287 polarization Effects 0.000 description 1
- 238000001448 refractive index detection Methods 0.000 description 1
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- 239000000126 substance Substances 0.000 description 1
- 238000000411 transmission spectrum Methods 0.000 description 1
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- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/41—Refractivity; Phase-affecting properties, e.g. optical path length
- G01N21/4133—Refractometers, e.g. differential
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- G01N21/45—Refractivity; Phase-affecting properties, e.g. optical path length using interferometric methods; using Schlieren methods
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- G01N21/41—Refractivity; Phase-affecting properties, e.g. optical path length
- G01N21/45—Refractivity; Phase-affecting properties, e.g. optical path length using interferometric methods; using Schlieren methods
- G01N2021/458—Refractivity; Phase-affecting properties, e.g. optical path length using interferometric methods; using Schlieren methods using interferential sensor, e.g. sensor fibre, possibly on optical waveguide
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Abstract
The invention discloses an intrafiber microfluidic sensing device based on four-hole microstructure optical fiber integration, which belongs to the technical field of optical fiber sensing and is characterized in that: the micro-flow optical fiber micro-flow sensing unit (2) is formed by an open-pore capillary optical fiber (7) and an open-pore capillary optical fiber (8) respectively to form a liquid inlet and a liquid outlet of a sample to be tested, which are welded on two sides of a micro-structure optical fiber (10), and are respectively connected with the micro-flow pump (4) and the waste liquid tank (5). The sensor utilizes the perforated capillary optical fiber as a liquid inlet and a liquid outlet and combines with the micro-structure optical fiber to realize the detection of micro-fluid in the optical fiber, and integrates a micro-fluid control system and optics into a whole so that the sensor is more miniaturized and the sensitivity is greatly improved. The method has potential application in the fields of environmental monitoring, biochemical detection and the like.
Description
Technical Field
The invention belongs to the technical field of optical fiber sensors, and particularly relates to an in-fiber microfluidic sensing device based on four-hole microstructure optical fiber integration.
Background
Sensor technology is the leading edge technology of modern technology, is one of three major posts of modern information technology, and the level is one of important marks for measuring the state of technology development. The sensor industry is also a high-technology industry with development prospect recognized at home and abroad, and the sensor is attractive by the characteristics of high technical content, good economic benefit, strong permeability, wide market prospect and the like. With the development of modern science and technology, the acquisition of information is becoming more and more important. The sensor is an important technical means for sensing, detecting, monitoring and converting information. The optical fiber sensor is a novel sensor integrated with optics and electronics. Because of the excellent physical, chemical, mechanical and transmission properties of the optical fiber, the optical fiber sensor has the advantages of small volume, light weight, electromagnetic interference resistance, corrosion resistance, high sensitivity, wide measurement bandwidth, long interval between detection electronic equipment and the sensor, and the like. The optical fiber sensing technology is a technology for converting external physical quantity into a signal which can be directly measured by using the sensitive characteristic of optical fiber to certain physical quantity. The optical fiber can be used as a propagation medium of optical waves, and the characteristic parameters (amplitude, phase, polarization state, wavelength and the like) of the optical waves can be directly or indirectly changed due to the action of external factors (such as temperature, pressure, strain, magnetic field, electric field, displacement, rotation and the like) when the optical waves propagate in the optical fiber, so that the optical fiber can be used as a sensing element to detect various physical quantities. Most of the current optical fiber sensors detect external physical quantity, are interfered by external environment, and have limited sensitivity. The micro-fluid detection device utilizes the micro-structure optical fiber to detect the micro-fluid in the optical fiber, so that the light and the micro-fluid fully act, the interference is effectively avoided, the sensitivity is improved, and the consumption of the micro-fluid is reduced, the material waste is reduced and the micro-detection of the micro-fluid is realized due to the structural characteristics of the micro-structure optical fiber.
Disclosure of Invention
The invention aims to solve the problems in the background technology, and provides an in-fiber microfluidic sensing device based on four-hole microstructure optical fiber integration, which realizes high-sensitivity optical fiber internal microfluidic detection. An intra-fiber microfluidic sensing device based on four-hole microstructure optical fiber integration comprises a supercontinuum light source (1), a four-hole microstructure optical fiber microfluidic sensing unit (2), a spectrum analyzer (3), a microfluidic pump (4) and a waste liquid tank (5), wherein the four-hole microstructure optical fiber microfluidic sensing unit (2) is formed by an open-pore capillary optical fiber I (7) and an open-pore capillary optical fiber II (8) which respectively form a liquid inlet and a liquid outlet of a sample to be detected, which are welded on two sides of the four-hole microstructure optical fiber (10), and the liquid inlet and the liquid outlet are respectively connected with the microfluidic pump (4) and the waste liquid tank (5).
The technical scheme adopted for realizing the technical purposes is as follows:
further, the preparation method of the four-hole microstructure optical fiber micro-flow sensor comprises the following steps:
1) Removing coating layers of a section of single-mode fiber and capillary fiber respectively, wiping with alcohol, cutting the end face flat with a cutter, and utilizing an on-line micro-processing platform of the fiber to pair the single-mode fiber and capillary fiber Ji Rongjie;
2) Punching the capillary fiber wall on the single-mode fiber-capillary fiber obtained in the step 1) at the positions 20 microns and 50 microns away from the welding point by using a carbon dioxide laser, wherein the aperture is controlled to be 10 microns;
3) Cutting the capillary optical fiber of the structure obtained in the step 2) at a position 30 micrometers away from the welding point by using an optical fiber online micro-processing platform;
4) Removing a coating layer from another section of single-mode fiber, wiping the single-mode fiber clean by alcohol, cutting the end face flat by a cutting knife, aligning and welding the single-mode fiber with the rest open-pore capillary fiber in the step 3) by using an optical fiber online micro-processing platform, and cutting the capillary fiber at a position 30 microns away from a welding point by using the optical fiber online micro-processing platform after welding;
5) Removing a coating layer from a section of the four-hole micro-structure optical fiber, wiping the four-hole micro-structure optical fiber with alcohol, cutting the end face flat by a cutting knife, and then cutting the four-hole micro-structure optical fiber with the single-mode-perforated capillary optical fiber pair Ji Rongjie obtained in the step 3) by using an optical fiber online micro-processing platform, wherein after welding, the four-hole optical fiber is cut at a position 2 cm away from a welding point by using the optical fiber online micro-processing platform;
6) And (3) aligning and welding the structure processed in the step (5) with the single-mode-open-pore capillary optical fiber obtained in the step (4) by using an optical fiber on-line micro-processing platform. The micro-fluidic sensing device in the fiber based on the four-hole microstructure fiber integration is connected with the micro-fluidic pump (4) and the waste liquid tank (5), and the micro-fluidic pump (4) is used for pumping the refractive index matching liquid into the sensor at a constant speed through the perforated capillary fiber, so that the sensing measurement of the refractive index of the micro-fluid in the fiber can be realized.
Further, the capillary fiber in step 1) has an outer diameter of 125 microns and an inner diameter of 50 microns, the single-mode fiber cladding has a diameter of 125 microns, the fiber core has a diameter of 8.2 microns, the four-hole microstructured fiber in step 5) has a cladding diameter of 125 microns, the fiber core has a diameter of 8 microns, the air hole has a diameter of 25 microns, and the refractive index matching fluid in step 6) is prepared from glycerin with different solubilities and has a refractive index ranging from 1.333 to 1.340.
A detection method of an intra-fiber microfluidic sensing device based on four-hole microstructure optical fiber integration sequentially connects a supercontinuum light source (1), a four-hole microstructure optical fiber microfluidic sensing unit (2) and a spectrum analyzer (3) in series, and connects a microfluidic pump (4) and a waste liquid pool with a sensor through an open pore quartz capillary optical fiber I (7), an open pore quartz capillary optical fiber II (8) respectively.
Compared with the prior art, the invention has the following advantages:
the invention uses the perforated capillary fiber as the liquid inlet and the liquid outlet, the four-hole microstructure fiber is used as the microfluidic detection channel, the microfluidic material and the microstructure fiber are integrated in one optical system, and the sensor integrates the optical unit and the microfluidic system, so that the high sensitivity characteristic of the optical sensor is maintained, the advantage of low sample consumption of the microfluidic system is combined, and compared with the common optical sensor, the sensor has more compact structure and stronger practicability, and provides a new solution for microminiaturizing the integrated microfluidic system and the functionalization of the optical structure. Meets the development trend of miniaturization of instruments; the anti-interference device has the advantages of strong anti-interference performance, novel structure, simple manufacture and wide application prospect in the fields of disease detection, medicine development, environment monitoring, food safety and the like.
Drawings
Fig. 1 is a diagram of a refractive index detection device of an in-fiber microfluidic sensing device based on four-hole microstructure fiber integration.
Fig. 2 is a schematic structural diagram of an in-fiber microfluidic sensing device based on four-hole microstructure fiber integration.
Fig. 3 is a flow chart of manufacturing an in-fiber micro-fluidic sensor device based on four-hole micro-structure optical fiber integration.
Detailed Description
The invention will be further described with reference to the drawings and detailed description.
Example 1
The example is to measure the refractive index of liquid by using an in-fiber micro-fluidic sensor based on four-hole micro-structure optical fiber integration. When light of the supercontinuum light source enters the left open pore capillary optical fiber through the input single mode optical fiber, a higher-order mode is excited, the higher-order mode and the fiber core mode are transmitted in the fiber core and the cladding of the four-hole microstructure optical fiber at the same time, and due to the fact that refractive indexes of the fiber core and the cladding of the four-hole microstructure optical fiber are different, propagation constants of the higher-order mode and the fiber core fundamental mode in the optical fiber are different, light of different modes has different optical paths, and therefore light transmitted between the fiber core and the cladding of the four-hole microstructure optical fiber also has optical path difference, and phase difference can be generated between the higher-order mode and the fiber core fundamental mode. When light of different modes propagates to the fusion point of the right open-pore capillary optical fiber and the output single-mode optical fiber, the light is re-coupled into the fiber core of the output single-mode optical fiber, and the existence of the phase difference enables the light of different modes to interfere, so that an interference spectrum is obtained. When the measured physical quantity in the micro-flow cavity is changed, the phase difference is also changed, so that the interference spectrum is changed.
The working principle of the invention is as follows: when light emitted from the supercontinuum light source enters the left open-pore capillary optical fiber through an input single mode, a high-order mode can be excited, and a basic mode and the high-order mode are respectively used as two beams of light participating in interference. Let the light intensities of the fundamental mode and the high-order mode participating in interference be I 1 And I 2 The transmitted spectrum intensity is:
wherein,as the phase difference between the core mode and the higher order mode, it can be expressed as:
wherein Δn eff L is the sensor microfluidic cavity length, and lambda is the wavelength of incident light, for the effective index difference between the fundamental and higher order modes. When the phase difference satisfiesWhen the intensity of the transmission spectrum reaches a valley point, the wavelength of the corresponding valley point can be expressed as:
as can be seen from the above equation, the interference wavelength will change with the change of the length and the effective refractive index difference of the sensor, and in general, the length of the sensor will not change, and when the refractive index of the liquid in the microfluidic cavity changes, the effective refractive index of the four-hole microstructured optical fiber cladding will change, but the refractive index of the fiber core will not be affected by the environment, so that the change of the effective refractive index difference can cause the interference spectrum to drift, thereby realizing refractive index measurement.
Referring to fig. 1, an in-fiber microfluidic sensing device based on four-hole microstructure optical fiber integration comprises a supercontinuum light source (1), a four-hole microstructure optical fiber microfluidic sensing unit (2), a spectrum analyzer (3), a microfluidic pump (4) and a waste liquid tank (5), wherein the four-hole microstructure optical fiber microfluidic sensing unit (2) is formed by an open-pore capillary optical fiber I (7) and an open-pore capillary optical fiber II (8) to form a liquid inlet and a liquid outlet of a sample to be detected respectively, and the liquid inlet and the liquid outlet are connected with the microfluidic pump (4) and the waste liquid tank (5) respectively.
Referring to fig. 2, a four-hole micro-structure optical fiber micro-flow sensing unit (2) of an in-fiber micro-flow sensing device based on four-hole micro-structure optical fiber integration is composed of an open pore capillary optical fiber I (7), an open pore capillary optical fiber II (8) and a four-hole micro-structure optical fiber (10).
Referring to fig. 3, a preparation method of a four-hole microstructure optical fiber micro-flow sensing unit (2) in an in-fiber micro-flow sensing device based on four-hole microstructure optical fiber integration comprises the following steps:
step one: respectively removing coating layers of a section of single-mode fiber (6) and a section of capillary fiber I (7), wiping by alcohol, cutting the end face flat by a cutter, and utilizing an optical fiber on-line micro-processing platform to carry out a pair Ji Rongjie on the single-mode fiber and the capillary fiber;
step two: punching the capillary fiber wall by using a carbon dioxide laser at the positions 20 microns and 50 microns away from the fusion point on the single mode fiber-capillary fiber obtained in the step one, wherein the aperture is controlled to be 10 microns;
step three: cutting the capillary fiber I (7) of the structure obtained in the second step, which is 30 microns away from the welding point, by using an optical fiber online micro-processing platform;
step four: removing a coating layer from another section of single-mode fiber (9), wiping by alcohol, cutting the end face flat by a cutting knife, then carrying out alignment welding on the single-mode fiber and the rest open-pore capillary fiber II (8) in the step three by using an optical fiber online micro-processing platform, and cutting the capillary fiber II (8) at a position 30 micrometers away from the welding point by using the optical fiber online micro-processing platform after welding;
step five: removing a coating layer from a section of the four-hole micro-structure optical fiber (10), wiping the four-hole micro-structure optical fiber with alcohol, cutting the end face flat by a cutting knife, then cutting the four-hole micro-structure optical fiber with the single-mode-perforated capillary optical fiber pair Ji Rongjie obtained in the step three by using an optical fiber online micro-processing platform, and cutting the four-hole optical fiber at a position 2 cm away from a welding point by using the optical fiber online micro-processing platform after welding;
step six: and F, aligning and welding the structure processed in the fifth step with the single-mode-open-pore capillary optical fiber obtained in the fourth step by using an optical fiber online micromachining platform. The micro-fluidic sensing device in the fiber based on the four-hole microstructure fiber integration is connected with the micro-fluidic pump (4) and the waste liquid tank (5), and the micro-fluidic pump (4) is used for pumping the refractive index matching liquid into the sensor at a constant speed through the perforated capillary fiber, so that the sensing measurement of the refractive index of the micro-fluid in the fiber can be realized.
The refractive index performance of the intrafiber microfluidic sensing device based on the four-hole microstructure optical fiber integration is characterized. The four-hole microstructure optical fiber micro-flow sensing unit (2) is respectively connected with the supercontinuum light source (1) and the spectrum analyzer (3). Refractive index matching solutions having refractive indices of 1.333, 1.334, 1.335, 1.336, 1.337, 1.338, 1.339, and 1.340, respectively, were prepared using glycerin of different concentrations. The microfluidic pump (4) and the waste liquid pool (5) are respectively connected with the first perforated capillary optical fiber (7) and the second perforated capillary optical fiber (8), and the refractive index matching liquid is injected into the sensor at a constant speed through liquid inlet and outlet ports formed by the first perforated capillary optical fiber (7) and the second perforated capillary optical fiber (8) to observe the spectral change of the sensor. The sensor was cleaned with alcohol before each change of the different index matching fluid until the sensor interference spectrum was restored to the original spectrum and the next measurement was started. The experiment was performed at room temperature throughout.
In conclusion, the optical fiber micro-flow sensor has novel structure and higher sensitivity, and has wide application prospects in the fields of disease detection, drug development, environment monitoring, food safety and the like.
Claims (4)
1. An intrafiber microfluidic sensing device based on four-hole microstructure optical fiber integration belongs to the technical field of optical fiber sensing, and is characterized in that: the preparation method of the four-hole micro-structure optical fiber micro-flow sensing unit (2) comprises a super-continuum spectrum light source (1), a four-hole micro-structure optical fiber micro-flow sensing unit (2), a spectrum analyzer (3), a micro-flow pump (4) and a waste liquid pool (5), wherein the four-hole micro-structure optical fiber micro-flow sensing unit (2) comprises a liquid inlet and a liquid outlet of a sample to be detected, which are respectively formed by an open-pore capillary fiber I (7) and an open-pore capillary fiber II (8), the liquid inlet and the liquid outlet are respectively connected with the micro-flow pump (4) and the waste liquid pool (5), and the preparation method of the four-hole micro-structure optical fiber micro-flow sensing unit (2) comprises the following steps:
1) Removing coating layers of a section of single-mode fiber and capillary fiber respectively, wiping with alcohol, cutting the end face flat with a cutter, and utilizing an on-line micro-processing platform of the fiber to pair the single-mode fiber and capillary fiber Ji Rongjie;
2) Punching the capillary fiber wall on the single-mode fiber-capillary fiber obtained in the step 1) at the positions 20 microns and 50 microns away from the welding point by using a carbon dioxide laser, wherein the aperture is controlled to be 10 microns;
3) Cutting the capillary optical fiber of the structure obtained in the step 2) at a position 30 micrometers away from the welding point by using an optical fiber online micro-processing platform;
4) Removing a coating layer from another section of single-mode fiber, wiping the single-mode fiber clean by alcohol, cutting the end face flat by a cutting knife, aligning and welding the single-mode fiber with the rest open-pore capillary fiber in the step 3) by using an optical fiber online micro-processing platform, and cutting the capillary fiber at a position 30 microns away from a welding point by using the optical fiber online micro-processing platform after welding;
5) Removing a coating layer from a section of the four-hole micro-structure optical fiber, wiping the four-hole micro-structure optical fiber with alcohol, cutting the end face flat by a cutting knife, and then cutting the four-hole micro-structure optical fiber with the single-mode-open-pore capillary optical fiber pair Ji Rongjie obtained in the step 3) by using an optical fiber online micro-processing platform, wherein after welding, the four-hole micro-structure optical fiber is cut at a position 2 cm away from a welding point by using the optical fiber online micro-processing platform;
6) And (3) aligning and welding the structure processed in the step (5) with the single-mode-perforated capillary optical fiber obtained in the step (4) by utilizing an optical fiber on-line micromachining platform, connecting an intra-fiber microfluidic sensing device integrated based on the four-hole microstructure optical fiber with a microfluidic pump (4) and a waste liquid tank (5), and pumping an index matching liquid into the sensor at a constant speed through the perforated capillary optical fiber by using the microfluidic pump (4), so that the sensing measurement of the refractive index of the microfluid in the optical fiber can be realized.
2. The four-hole microstructure fiber integrated intrafiber microfluidic sensor device according to claim 1, wherein the single-mode fiber cladding diameter is 125 microns, the fiber core diameter is 8.2 microns, the four-hole microstructure fiber cladding diameter is 125 microns, the fiber core diameter is 8 microns, the air hole diameter is 25 microns, the capillary fiber outer diameter is 125 microns, and the inner diameter is 50 microns.
3. The four-hole microstructure optical fiber integrated-based intrafiber microfluidic sensing device according to claim 1, wherein the refractive index matching liquid in the step 6) is prepared by glycerin with different concentrations, and the refractive index ranges from 1.333 to 1.340.
4. The preparation method of the micro-fluidic sensing device in the fiber based on the four-hole microstructure optical fiber integration, which is disclosed in claim 1, is characterized in that a super-continuous spectrum light source (1), a four-hole microstructure optical fiber micro-flow sensing unit (2) and a spectrum analyzer (3) are sequentially connected in series, and a micro-flow pump (4) and a waste liquid pool (5) are connected with a sensor through an open-hole capillary optical fiber I (7) and an open-hole capillary optical fiber II (8), wherein the four-hole microstructure optical fiber micro-flow sensing unit (2) consists of the open-hole capillary optical fiber I (7), the open-hole capillary optical fiber II (8) and the four-hole microstructure optical fiber (10).
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