AU2020100688A4 - A photothermal micropump based on capillary optical fiber - Google Patents

A photothermal micropump based on capillary optical fiber Download PDF

Info

Publication number
AU2020100688A4
AU2020100688A4 AU2020100688A AU2020100688A AU2020100688A4 AU 2020100688 A4 AU2020100688 A4 AU 2020100688A4 AU 2020100688 A AU2020100688 A AU 2020100688A AU 2020100688 A AU2020100688 A AU 2020100688A AU 2020100688 A4 AU2020100688 A4 AU 2020100688A4
Authority
AU
Australia
Prior art keywords
optical fiber
micropump
photothermal
capillary
microfluidic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2020100688A
Inventor
Libo Yuan
Tingting YUAN
Xiaotong Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Guilin University of Electronic Technology
Original Assignee
Guilin University of Electronic Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guilin University of Electronic Technology filed Critical Guilin University of Electronic Technology
Priority to AU2020100688A priority Critical patent/AU2020100688A4/en
Assigned to GUILIN UNIVERSITY OF ELECTRONIC TECHNOLOGY, YUAN, LIBO reassignment GUILIN UNIVERSITY OF ELECTRONIC TECHNOLOGY Amend patent request/document other than specification (104) Assignors: Guilin Univ Electr Tech, LIBO YUAN, TINGTING YUAN, XIAOTONG ZHANG
Application granted granted Critical
Publication of AU2020100688A4 publication Critical patent/AU2020100688A4/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/02—Optical fibres with cladding with or without a coating
    • G02B6/02295—Microstructured optical fibre
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/02—Optical fibres with cladding with or without a coating
    • G02B6/036—Optical fibres with cladding with or without a coating core or cladding comprising multiple layers
    • G02B6/03605—Highest refractive index not on central axis
    • G02B6/03611—Highest index adjacent to central axis region, e.g. annular core, coaxial ring, centreline depression affecting waveguiding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0442—Moving fluids with specific forces or mechanical means specific forces thermal energy, e.g. vaporisation, bubble jet
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces

Abstract

The invention provides a photothermal micropump based on capillary optical fiber. Its characteristics are: the photothermal micropump consists of a section of a micromachined annular core capillary optical fiber and an optical source. The annular optical fiber core is heat fusion and thinned, until the capillary pore of the optical fiber is sealed, forming a solid optical wave channel, thereby becoming an optical interface connected with an external optical source. The other unprocessed end is an open channel port, which acts as the outlet of the micropump but also the inlet for chip microfluidics. Using femtosecond laser micro-drilling technology to prepare an inlet for microfluids near the melt-shrunk end of the capillary optical fiber. The inlet will correspond to the position of the injection port outside the chip, and the liquid outlet at the other end can be connected to the microfluidic channel in the microfluidic chip to be used. 1-1 1-2 1-3 (a) 1-2 1-3 (b) Microfluid 2-3 Mixed Microfluid - liquid 2-1 2-2

Description

DESCRIPTION
TITLE OF INVENTION
A photothermal micropump based on capillary optical fiber
TECHNICAL FIELD
[0001] The invention relates to a photothermal micropump based on capillary optical fiber, which can be easily connected to a microfluidic chip. Similarly, in the operation of micrometerscale tinyliquid, it can replace micro-injection pumps and micro fluidic peristaltic pumps and other large-scale sample injection devices, providing micro fluidic chips a convenient method for high-throughput analysis and detection peripheral controlling device in the fields of chemistry, biology, medicine, etc. The invention belongs to the field of op to fluidics technology.
BACKGROUND ART
[0002] Microfluidics or Lab-on-a-chip refers to a system that uses microchannels of tens of micrometers or hundreds of micrometers to process or manipulate microfluid. After decades of development, Microfluidics has become an emerging interdisciplinary discipline involving chemistry, fluid physics, optics, microelectronics, new materials, biology, and biomedical engineering. Due to the small sample volume and short detection optical path of the microfluidic chip, high-sensitivity, fast-responding and low-power-consumption optical detectors and new detection methods are essential for the practical development of Micro fluidics. Moreover, whether it is biological testing, drug testing, or chemical analysis, environmental monitoring,
2020100688 04 May 2020 more and more systems need microliter-grade fluids. In addition to the chip as the main technical integration units in the micro fluidic system, many other peripheral devices are required, such as sample injection devices, fluid drive control device, temperature control, and detection control, etc. These devices are then connected to microfluidic chip units with different uses to fulfill functional requirements.
[0003] The current existing microfluidic chips and applications that have been combined with optical fibers includes: optical fiber microfluidic electrophoresis chip [B. Su, et al., Development of Optical Fiber Microfluidic Electrophoresis Chip. Measurement and Control, 2005, 24(11): 58]. The chip achieves the fabrication of micro fluidic channels and optical fiber channels with different depths on polydimethylsiloxane (PDMS) so that the optical fibers and microfluidic channels can be easily aligned. There is also an embedded optical fiber microfluidic chip [Y. L. Jin, et al., Fabrication of an Embedded Optical Fiber Microfluidic Device Based on Excimer Laser Processing Technology. Chinese Journal of Lasers, 2008, 35(11): 1821-1824], its fabricating method is to use a 248 nm KrF excimer laser to micromachined on polydimethylsiloxane (PDMS) substrate, to form the structure of the chip, and embed a corroded single-mode optical fiber of a diameter of 35pm, thereby forming an embedded optical-fiber-type chip. Both of these are achieved by traditional micro fluidic chip combined with optical fiber. In addition, special optical fibers with air holes can be used as parts of the chip microchannel, such as the hollow optical channel of the hollow photonic crystal optical fiber is directly used as the micro fluidic channel [C. Jiang, Femtosecond Laser Pulse Precision Fabrication of Micro fluidic Fiber Device and Its Applications. Laser Journal, 2009, 30(5): 6-8]. The working principle of this microfluidic measuring device is to change the characteristics of the optical wave in the optical fiber, based on the interaction of the light field transmitted in the optical fiber directly interacting with the microfluidic substance. There are also micromachining of optical fibers through certain processing technologies, to achieve the functions of microfluidic chips. For example, the femtosecond laser-assisted processing method can also process a microfluidic channel parallel to the core in a single-mode optical fiber, thereby making a new type of optical fiber microfluidic device that can be applied to liquid refractive index sensing [X. Li, Femtosecond Laser Fabrication of Optical Fiber Microfluidic Device and Liquid Refractive Index Sensing. Harbin
2020100688 04 May 2020
Institute of Technology, 2013; Η. H. Sun, Femtosecond Laser Preparation and Temperature-salt Sensing Characteristics of Mach-Zehnder Interferometric Microcavity in Optical Fiber. Harbin Institute of Technology, 2015]. This micro fluidic device has the characteristics of a hightemperature resistance, the liquid flows inside the microfluidic channel, avoiding the measured liquid from contacting the outside world, and has a strong anti-interference ability. Patent CN1065 82903 proposes a photothermal waveguide micro fluidic chip, the photothermal waveguide is immersed in the bottom of the rectangular microfluidic chamber, and the length, width, and height of the microfluidic chamber are fixed. The surface of the optical waveguide is coated with a nano-material with thermal conductivity, and the fluid flow strength is positively related to the optical power.
[0004] In the above micro fluidic systems related to optical waveguides, the injection liquid often needs to be driven, controlled, or performed through various operations, which have not used the photothermal effect characteristics of the optical fiber. In the above microfluidic systems, the injection method still needs to be connected to a micro-pump, such as a peristaltic pump or a microfluidic syringe and other large-volume peripheral devices.
[0005] Micropumps are an important part of a micro fluidic system. Their main role is to transmit liquid flow and distribute liquid flow. They can be divided into mechanical micropumps and non-mechanical micropumps. Mechanical micropumps rely on mechanical moving parts to transmit and control microfluidics, while non-mechanical micropumps rely on various physical actions or effects to transform certain non-mechanical energy into microfluidic kinetic energy to achieve microfluidic drive. Mechanical micropumps mainly have piezoelectric, electrostatic type, electromagnetic, pneumatic and other driving methods. Such micropumps usually have complicated manufacturing processes, high cost, high power consumption, poor long-term reliability, and are difficult to integrate. Non-mechanical micropumps mainly have electroosmotic, surface tension, magnetic fluid, thermal bubble and other drive methods. These micropumps have certain advantages in manufacturing process and reliability, and there will be no problems such as membrane deformation and fatigue as a result of mechanical micropumps
2020100688 04 May 2020 working for a long-term. However, such micropumps require complex drive circuits or equipment, these additional components often increase the complexity of the system and reduce the portability of the system, thereby limiting the application of micro fluidic systems.
[0006] In order to further improve the integration and miniaturization of the microfluidic chip, and to overcome the above shortcomings and deficiencies in advanced technology, the invention proposes a photothermal micropump based on capillary optical fiber. The capillary optical fiber photothermal micropump that can be used with a micro fluidic chip is simple to prepare, has good consistency, is easy to connect to the chip, avoids optical alignment and adjustment in the case of separation, and is suitable for large-scale mass production.
SUMMARY OF INVENTION
[0007] The objective of the invention is to provide a pho to thermal micropump that can replace the peripheral large-scale sample injection device of the micro fluidic chip when operating tinyliquids at the micrometer scale.
[0008] The objective of the invention is achieved as follows:
[0009] A photothermal micropump based on capillary optical fiber, its main characteristics are: the micropump is prepared and processed by an annular core capillary optical fiber shown in FIG. 1. One end of the capillary optical fiber is heat-fusion, so the capillary pore is collapsed and closed, forming a solid optical wave channel 2-1, thereby becoming an optical interface to connect with an optical source. The other unprocessed end is an open channel port 2-2, which acts as the outlet of the micropump but also the inlet for chip microfluidics. Using the side femtosecond laser micro-drilling technology, on the outer surface of the optical fiber near the
2020100688 04 May 2020 melt-shrunk end, to prepare a micro fluidic microhole inlet, which acts as micro fluids inlet 2-3, as shown in FIG. 2.
[0010] In order to achieve the function of the micropump in the micro fluidic chip, the fiber core which collapsed into a solid optical wave channel is connected to an external optical source. When the capillary optical fiber is injected with optical energy, the optic propagates along with the annular core. When the air hole in the optical fiber is filled with liquid, the inner wall of the optical fiber core is in full contact with the liquid. The optical energy is converted into heat energy absorbed by the liquid and then into molecular kinetic energy, pushing the liquid forward. After the heated liquid is quickly pushed into the microchannel of the microfluidic chip, the pressure in the chamber of the micropump decreases and is less than the outside atmospheric pressure, the liquid outside the photothermal micropump enters the chamber of the micropump through the etched microfluidic microhole channel. In this way, it is only necessary to add the liquid to be tested to the outside of the microfluidic chip, and no additional peripheral device is needed.
[0011] The specific principles are as follows:
[0012] As we all know, optic is a type of electromagnetic wave, and the optical energy provided by the optical source connected to the photothermal micropump is an electromagnetic wave, and is radiated through the surface of the annular core. Because the inner wall of the optical fiber core is in direct contact with the microfluid, this electromagnetic wave is transmitted in the core and reaches the microfluid again to be converted into internal energy. When the energy of the optical source is stronger, the temperature of the optical core is higher, and the radioactive energy is also greater. Therefore, the micropump transfers heat from high-temperature objects (optical fiber core) to low-temperature objects (microfluid) in the form of electromagnetic waves.
2020100688 04 May 2020
[0013] So how is the microfluid pushed into the micro fluidic channel of the chip? It can be simply understood that two convection heat transfer phenomena coincide in the micropump, the intramolecular energy in the microfluid is increased, which accelerates the movement. This induces the phenomenon where the microfluid in the micropump chamber is pushed into the microfluidic channel of the chip. The first convection heat transfer phenomenon is: the heat transfer method of the heated fluid of the high-temperature object (the surface of the inner wall of the annular core) to the low-temperature object (the center liquid of the micropump) is convection heat transfer. If the fluid on the surface of the object is stationary, the heat conduction between the surface of the object and the fluid will also transfer heat. In other words, convection heat transfer is based on the heat transfer of heat conduction and the fluid flow (i.e. convection). The second convection heat transfer phenomenon is: the heat transfer method between the heated microfluid in the capillary optical fiber photothermal micropump chamber and the microfluid that has entered the microfluidic channel of the chip with a slightly lower temperature belongs to convection heat transfer. After this fluid heats up, the liquid density changes, so convection occurs, and free convection occurs.
[0014] If the light intensity injected into the photothermal micropump is constant, and the energy is stable, assuming that the core temperature of the capillary optical fiber is Ί\, the surface area is A, and there are fluids with a temperature of T) flowing around. Since there is a difference in the temperatures between the surface of the optical fiber core and the fluid, thereby forming a convection heat transfer. The fluid on the surface of the optical fiber core has the same temperature as the surface of the optical fiber core because it contacts the optical fiber core. In addition, the temperature of the fluid far enough from the optical fiber core is T2, and there is a boundary layer in which the temperature and the flow velocity changes in the vicinity of the optical fiber core. Assuming that the area is <L4(m2) and the heat transfer is , then the relationship between the local heat flux density — anc[ the temperature difference can be expressed by Newton's Law of Cooling, q = h(/-T/ (1)
In which MW/(m gK)) transf'cr coefficient. The heat transfer coefficient is different from the thermal conductivity, where the thermal conductivity is the inherent physical property
2020100688 04 May 2020 of the substance and the heat transfer coefficient changes with the flow state of the fluid.
[0015] In addition, when the microfluid is in contact with the annular core, a thin layer of thermal fluid, whose temperature changes rapidly from the temperature of the optical fiber core to the temperature of the liquid, is formed around the inner wall of the optical fiber core, and this is called the temperature boundary layer. Similarly, when a liquid flows, the fluid will adhere to the optical fiber core, and a thin layer of flow starting from zero speed changing rapidly will be formed on the surface of the optical fiber core, and this is called the velocity boundary layer (as shown in FIG. 3). The faster the fluid flows around the core, the thicker the boundary layer is.
[0016] It can be seen that the thermal conductivity equation can be derived from Fourier's Law and the mass conservation equation, the following thermal balances exist within the time interval At(s) .
(Variable quantity of thermodynamic energy) = [(The heat of the micro-body introduced)-(The heat of the micro-body derived)] + (The heat generated in the micro-body)xAz(.s) (2)
[0017] In the environment of micro fluid in the capillary tube of the micropump, the situation where the solid wall surface surrounds the fluid, is the classic pipeline flow.
[0018] Therefore, the heat equation of the cylindrical coordinates is:
dT 1 d z, dT\ 1 d „ d7\ d z, dT\ .
PC— =--(kr—) +—— (k—) + —(k —) +q, dt r dr dt r2 d0 οθ dz dz
In the equation, the thermal conductivity coefficient k is a constant, r is the radius of the cylinder, (3) p(kg/m ) |s jens^y op the object5 c(J/(kgEK.)) js specific heat, and in addition,
7v.(W/m ) calorific value per unit time and unit volume in the micro-body.
2020100688 04 May 2020
[0019] Considering that the photothermal micropump proposed by the invention is mainly used in the field of microfluidic chips, the micropump structure and the microfluidic channel of the chip are in the order of micrometers, so the Reynolds number is low, and the liquid flow is laminar. Below is a brief analysis made on when the photothermal micropump chamber is a circular-tube structure.
[0020] The First scenario is when the Reynolds number is low, the flow is laminar, and the temperature difference between the optical fiber core and the fluid is also small.
Correspondingly, the physical property values such as fluid viscosity, thermal conductivity, and specific heat are fixed, and the influences of internal heat generation and buoyancy caused by viscous friction can be ignored. The fully-developed temperature field achieved at the downstream of the flow (at the open liquid outlet near the photothermal micropump) is shown in FIG. 4 (a), with the temperature field of the same distribution form, and the origin of its coordinates is taken as the micropump chamber channel center. For the flow in the chamber, the difference between the temperature T\ on the surface of the optical fiber core and the average temperature T) of the microfluid is selected as the reference temperature difference. The average fluid temperature represents the temperature of the fluid in the cross-section of the selected flow channel, which is defined by the following formula:
T2(x) = f uTdA
JI_______ u2A (4)
[0021] When the difference between the temperatures of the surface of the optical fiber core and the average temperature of the microfluid is selected as the reference temperature difference, the temperature distribution of the fully-developed temperature field can be described by the following expression
In which, the dimensionless independent variable η is defined as r> in the cylindrical coordinate system.
2020100688 04 May 2020
[0022] Correspondingly, the fully-developed temperature field can be interpreted as the temperature field where the heat transfer coefficient does not change with the axis coordinate x, which can be obtained from equation (5), dT dx (6)
First, to consider the condition of equal wall heat flux density, at this time, for the fullydeveloped temperature field, since q and h are fixed, the temperature difference (7] - T2) is also fixed by Newton’s Cooling Law q = h(7\ - T2), therefore, from the fully-developed temperature field as in equation (6), gr _ dT] _ dT2 (7) dx dr dr
That is, as shown in FIG. 4 (b), for a fully-developed temperature field under equal wall heat flux conditions, as the fluid flows downstream, the temperature of the fluid in the cross-section of the flow channel rises by a specific temperature difference.
[0023] The photothermal micropump device can be further combined with the traditional microfluidic chip, and the microfluidic microhole channel corresponds to the position of the injection port outside of the chip. After the pho to thermal micropump is injected with optical energy, the microfluid to be measured outside the chip will be sucked into the micropump chamber through the microhole inlet without external force, and it will help the liquid in the chip to propel. The liquid outlet at the other end of the micropump can be connected to the micro fluidic chip used, which can completely replace a micro fluidic injection pump and other sample injection devices in the micro fluidic chip system.
[0024] To further expand the structure of the fluid inlet of the capillary optical fiber photothermal micropump, the micropump can be expanded into a micropump device with a multiple microfluidic microhole inlets structure. It is characterized by the increase in the number of microfluidic microhole inlets on the side of the hollow annular core capillary optical fiber m ίο
2020100688 04 May 2020 (m>l, m is an integer), each microhole can be used as an inlet for micro fluid, this can achieve the purpose of increasing the liquid flow per unit time.
[0025] In addition to the described photothermal micropump based on capillary optical fiber, the photothermal micropump can change the optical energy injected to adjust the speed and input volume of the microfluid in the microchannel of the chip. When the number of microholes is fixed, the greater the optical energy, the faster the micropump will push the liquid, and vice versa.
[0026] Furthermore, in the photothermal micropump based on annular core capillary optical fiber, the micro fluidic microhole inlet of the photothermal micropump can be of various sizes and shapes. Depending on requirements of the length and injection type of the micropump, the required microhole size and shape can be prepared by femtosecond laser micro-drilling technology, such as circular microholes, square microholes, oval microholes, rectangular microholes, etc. as shown in FIG. 5.
[0027] In practical applications, the appropriate micropump should be selected according to the specific system requirements. Micropumps are widely used in microsensors, microbiology, chemical analysis, and various applications involving micro fluidic transportation. At present, micropumps have been greatly developed, the structure and principles are rich and diverse, and the stability has also been greatly improved. In order to further improve the integration and miniaturization of the microfluidic chip, and to overcome the above shortcomings and deficiencies in advanced technology, the invention proposes a photothermal micropump based on capillary optical fiber. The capillary optical fiber photothermal micropump that can be used with a microfluidic chip is simple to prepare, has good consistency, is easy to connect to the chip, avoids optical alignment and adjustment in the case of separation, and is suitable for large-scale mass production. In the operation of micrometer-scale tinyliquid, it can replace microfluidic injection pump and other large-scale sample injection devices, providing excellent research and
2020100688 04 May 2020 application platform for high-throughput chemistry, biology, pharmaceutical analysis, and detection. This also provides microfluidic chips a convenient method for high-throughput analysis and detection of peripheral controlling devices in the fields of chemistry, biology, medicine, etc.
BRIEF DESCRIPTION OF DRAWINGS
[0028] FIG. 1 (a) is a cross-sectional structural diagram of a capillary optical fiber; (b) is a photo of a cross-section of a capillary optical fiber, including an air hole 1-1, a core 1-2, and a cladding 1-3.
[0029] FIG. 2 is a schematic diagram of a capillary optical fiber photothermal micropump.
[0030] FIG. 3 is a schematic diagram of the boundary layer in the case of convection heat transfer.
[0031] FIG. 4 shows (a) the fully-developed temperature field and (b) the temperature change of the circular tube-type micropump chamber under the condition of equal wall heat flux.
[0032] FIG. 5 is a schematic diagram of a capillary optical fiber photothermal micropump with a multiple micro fluidic microhole inlets structure, including an optical waveguide 2-1, an open channel port 2-2 and an inlet 2-3 for microfluid.
[0033] FIG. 6 is a structural schematic diagram of a microfluidic chip embedded with a capillary
2020100688 04 May 2020 optical fiber pho to thermal micropump.
DESCRIPTION OF EMBODIMENTS
[0034] The invention will be further described below combining the drawings and specific embodiments.
[0035] FIG. 1 shows a cross-sectional view of a capillary optical fiber. The capillary optical fiber is composed of a thin layer, an annular core with a slightly higher refractive index than the cladding material, and an air hole structure that micro fluidics can enter into.
[0036] FIG. 2 shows that one end of the capillary optical fiber core is heat-fusion so the capillary pore is collapsed and closed to form a solid optical wave channel 2-1, thereby becoming an optical interface connected with optical source. The other unprocessed end is an open channel port 2-2, which acts as the outlet of the micropump but also the inlet for chip micro fluidics.
Using the side femtosecond laser micro-drilling technology, on the outer surface of the optical fiber near the melt-shrunk end, to process and prepare a microfluidic microhole inlet, which acts as micro fluids inlet 2-3.
[0037] Without loss of generality, we will elaborate on the specific implementation steps and implementation methods of the invention in detail with the specific embodiment of the capillary optical fiber photothermal micropump with one circular micro fluidic microhole inlet shown in FIG. 6
[0038] (1) Firstly, take a section of the capillary optical fiber as shown in FIG. 1 and remove the
2020100688 04 May 2020 coating layer for use.
[0039] (2) Then, use the heating method to melt, collapse and shrink one end of it, to make it completely closed. At this time, the closed annular core optical fiber inner-wall waveguide layer will form a circular solid optical waveguide 6-1.
[0040] (3) Next, using femtosecond laser etching technology, one circular microhole is etched perpendicular to the surface of the optical fiber near the closed end of the optical fiber, as the inlet 6-3 for the micro fluid to be injected. The other open end of the optical fiber act as the outlet 6-2 which connects to the micro fluidic chip.
[0041] (4) Finally, the solid optical waveguide which collapsed is connected to an optical source, and the photodynamic force is used as the liquid driving force to complete the functions of the micro fluidic chip.
[0042] (5) Add the liquid to be tested into the liquid storage tank 6-4 outside the chip, the liquid is pushed into the chip channel through the microhole outlet, replacing the traditional peripheral large-scale injection pump to complete the function of injection devices, and the waste liquid is discharged from the discharge hole 6-5 outside the chip.
[0043] Since different liquids have different absorption rates for optical sources of different wavelengths, combined with the wavelength of the connected optical source and the absorption rate of the liquid to be measured, the velocity and discharge of the microfluidic substance can be adjusted according to the functional requirements of the chip.
2020100688 04 May 2020
[0044] In this embodiment, the number m of microfluidic microhole channels of the photothermal micropump based on capillary optical fiber is 1, and the micro hole shape is circular. Similarly, the number of microholes can be expanded to multiple (m> 1, m is an integer), shapes can be expanded into a square, an oval, a rectangle, etc. These changes in number, shape, and size will affect the test index of the micro-thruster, and this requires specific parameter design according to the functional requirements of the chip in specific practical applications.

Claims (5)

1. A photothermal micropump based on capillary optical fiber, its characteristics are: the micropump is made of annular core capillary optical fiber. One end of the capillary optical fiber core is heat-fusion, to collapse and close the capillary pore, forming a solid optical wave channel 2-1, thereby becoming an optical interface to connect with an optical source. The other unprocessed end is an open channel port 2-2, which acts as the outlet of the micropump but also the inlet for chip micro fluidics. Using the femtosecond laser micro-drilling technology, on the outer surface of the optical fiber near the melt-shrunk end, to prepare a microfluidic microhole inlet, which acts as micro fluids inlet 2-3.
2. As claimed in claim 1, a photothermal micropump based on capillary optical fiber, its characteristics are: the photothermal micropump is a micropump device with a multiple microfluidic microhole inlets structure. It is characterized by the number of microfluidic microhole channels m (m>l, m is an integer) on the surface of the capillary optical fiber, multiple microholes can all be the inlets for micro fluid.
3. As claimed in claim 1, a photothermal micropump based on capillary optical fiber, its characteristics are: the micropump can change the optical energy injected into 2-1, to adjust the speed and input volume of the micro fluid in the microchannel of the chip.
4. As claimed in claim 1 and 2, a photothermal micropump based on capillary optical fiber, its characteristics are: the micro fluidic microhole inlet of the photothermal micropump can be of various sizes and shapes. Depending on requirements of the length and injection type of the micropump, the required microhole size and shape are prepared by femtosecond laser microdrilling technology, such as circular microholes, square microholes, oval microholes, rectangular microholes, etc.
2020100688 04 May 2020
5. As claimed in claim 1, a photothermal micropump based on capillary optical fiber, its characteristics are: the micropump device can be further combined with traditional microfluidic chips, to be integrated into the chips and embedded into the microflute of the chips. This can completely replace peripheral sample injection devices such as a micro fluidic injection pump.
AU2020100688A 2020-05-04 2020-05-04 A photothermal micropump based on capillary optical fiber Ceased AU2020100688A4 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2020100688A AU2020100688A4 (en) 2020-05-04 2020-05-04 A photothermal micropump based on capillary optical fiber

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AU2020100688A AU2020100688A4 (en) 2020-05-04 2020-05-04 A photothermal micropump based on capillary optical fiber

Publications (1)

Publication Number Publication Date
AU2020100688A4 true AU2020100688A4 (en) 2020-06-25

Family

ID=71104093

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2020100688A Ceased AU2020100688A4 (en) 2020-05-04 2020-05-04 A photothermal micropump based on capillary optical fiber

Country Status (1)

Country Link
AU (1) AU2020100688A4 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112701097A (en) * 2020-12-25 2021-04-23 北京大学 Embedded microfluid cooling system and silicon-based adapter plate
CN113866127A (en) * 2021-10-26 2021-12-31 天津工业大学 Micro-fluidic sensing device in fibre based on four-hole microstructure optical fiber integration
CN115825005A (en) * 2022-09-26 2023-03-21 哈尔滨工程大学 Method for rapidly measuring and calculating liquid refractive index based on micro-fluidic chip

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112701097A (en) * 2020-12-25 2021-04-23 北京大学 Embedded microfluid cooling system and silicon-based adapter plate
CN112701097B (en) * 2020-12-25 2022-12-16 北京大学 Embedded microfluid cooling system and silicon-based adapter plate
CN113866127A (en) * 2021-10-26 2021-12-31 天津工业大学 Micro-fluidic sensing device in fibre based on four-hole microstructure optical fiber integration
CN113866127B (en) * 2021-10-26 2024-01-16 天津工业大学 Intra-fiber micro-fluidic sensing device based on four-hole microstructure optical fiber integration
CN115825005A (en) * 2022-09-26 2023-03-21 哈尔滨工程大学 Method for rapidly measuring and calculating liquid refractive index based on micro-fluidic chip
CN115825005B (en) * 2022-09-26 2023-08-25 哈尔滨工程大学 Method for rapidly measuring refractive index of liquid based on microfluidic chip

Similar Documents

Publication Publication Date Title
AU2020100688A4 (en) A photothermal micropump based on capillary optical fiber
AU2020100684A4 (en) A photothermal microfluidic mixer based on holey optical fiber
Golonka et al. LTCC based microfluidic system with optical detection
Ruano-Lopez et al. A new SU-8 process to integrate buried waveguides and sealed microchannels for a Lab-on-a-Chip
Cho et al. Optofluidic waveguides in Teflon AF-coated PDMS microfluidic channels
CN102183462A (en) Embedded type fiber taper nanofiber micro-fluidic control chip sensor and production method thereof
CN109752793A (en) Hybrid integrated Michelson formula optical fiber micro flow chip
Bamshad et al. Capillary-based micro-optofluidic viscometer
CN111637032A (en) Photo-thermal micropump based on capillary optical fiber
CN111637034A (en) Photo-thermal micro-thruster based on annular core capillary optical fiber
AU2020100686A4 (en) A photothermal micro-thruster based on annular core capillary optical fiber
AU2020100685A4 (en) A photothermal micro-thruster based on holey microstructure optical fiber
CN112871750B (en) Particle sorting chip based on cascade type micro heat source and particle sorting method thereof
CN206351047U (en) Microfluid tweezers based on micro-nano fiber
AU2020100687A4 (en) A micro-chamber photothermal micropump based on annular core capillary fiber
Ma et al. Photothermally generated bubble on fiber (BoF) for precise sensing and control of liquid flow along a microfluidic channel
Wang et al. A new bubble-driven pulse pressure actuator for micromixing enhancement
CN111632534B (en) Photo-thermal micro-flow mixer based on single-hole optical fiber
CN111617683B (en) Photothermal microfluidic mixer based on porous optical fiber
Lee et al. Experimental and numerical investigation into mixing efficiency of micromixers with different geometric barriers
CN111637033A (en) Micro-cavity type photo-thermal micro-pump based on annular core capillary optical fiber
AU2020100689A4 (en) A photothermal microfluidic mixer based on single hole optical fiber
Gervinskas et al. Optofluidic Fabry-Pérot sensor for water solutions at high flow rates
CN111637031A (en) Photothermal booster based on porous optical fiber
Bao et al. Measurement of flow in microfluidic networks with micrometer‐sized flow restrictors

Legal Events

Date Code Title Description
HB Alteration of name in register

Owner name: GUILIN UNIVERSITY OF ELECTRONIC TECHNOLOGY

Free format text: FORMER NAME(S): GUILIN UNIV ELECTR TECH; LIBO YUAN; TINGTING YUAN; XIAOTONG ZHANG

Owner name: YUAN, L.

Free format text: FORMER NAME(S): GUILIN UNIV ELECTR TECH; LIBO YUAN; TINGTING YUAN; XIAOTONG ZHANG

FGI Letters patent sealed or granted (innovation patent)
MK22 Patent ceased section 143a(d), or expired - non payment of renewal fee or expiry