AU2020100684A4 - A photothermal microfluidic mixer based on holey optical fiber - Google Patents

A photothermal microfluidic mixer based on holey optical fiber Download PDF

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AU2020100684A4
AU2020100684A4 AU2020100684A AU2020100684A AU2020100684A4 AU 2020100684 A4 AU2020100684 A4 AU 2020100684A4 AU 2020100684 A AU2020100684 A AU 2020100684A AU 2020100684 A AU2020100684 A AU 2020100684A AU 2020100684 A4 AU2020100684 A4 AU 2020100684A4
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optical fiber
mixer
microfluidic
holey
photothermal
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Libo Yuan
Tingting YUAN
Xiaotong Zhang
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Guilin University of Electronic Technology
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Guilin University of Electronic Technology
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/3033—Micromixers using heat to mix or move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
    • B01F33/3017—Mixing chamber
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Micromachines (AREA)

Abstract

The invention provides a photothermal microfluidic mixer based on holey optical fiber. Its characteristics are: the photothermal microfluidic mixer consists of a section of micromachined holey optical fiber and an optical source. A mixing chamber is prepared by processing holey optical fibers through air pressure and simultaneously hot-met-heat it, the cladding in the air holes of the mixing chamber expands and thins until it is heat-melted to disappear, the core runs through the entire heating chamber and suspends in the middle. After a variety of liquids enter into the mixing chamber at the same time, due to the heat radiation from the suspended fiber core to the microfluid, the molecules accelerate movements to achieve the purpose of mixing. 32 Mixed liquid 3-1 3-1 Microfluidic 4- Microfluidic (b) 3-2 Microfluidic -. - * ~Mixed liquid (C)

Description

DESCRIPTION
TITLE OF INVENTION
A photothermal micro fluidic mixer based on holey optical fiber
TECHNICAL FIELD
[0001] The invention relates to a photothermal micro fluidic mixer based on holey optical fiber, which is convenient to use with microfluidic chips. Also is a microfluidic channel structural unit that can replace the in-chip mixing function in micrometer-scale operation of tinyliquids, this belongs to the optofluidics field.
BACKGROUND ART
[0002] Microfluidics or Lab-on-a-chip refers to a system that uses microchannels of tens of micrometers or hundreds of micrometers to process or manipulate microfluid. After decades of development, Microfluidics has become an emerging interdisciplinary discipline involving chemistry, fluid physics, optics, microelectronics, new materials, biology, and biomedical engineering. Due to the small sample volume in the microfluidic chip and short detection optical path, high-sensitivity, fast-responding and low-power-consumption optical detectors and new detection methods are essential for the practical development of Micro fluidics. Moreover, whether it is biological testing, drug testing, or chemical analysis, environmental monitoring, more and more systems need microliter-grade fluids.
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[0003] The micro fluidic control system generally includes various functional units such as microchannels, microfluidic mixers, microvalves, micro-reactors, microsensors, micro-detectors, and integrate them on a tiny chip. Then control the flow of tinyliquids in it to complete the micro-analysis system of sample preparation, mixing, reaction, separation, detection, biochemical analysis and other functions involved in the biological and chemical fields. The microfluidic system has extremely fast analysis speed, minimal reagent consumption, volume integration, function integration, simple operation, cheap price and many other unique features.
[0004] The application of the microfluidic control system in the fields of chemistry, biology and others is mainly based on the mixing reaction of different tinyliquid substances, hence mixing is one of the important links of the microfluidic control system. The purpose of mixing is to make the different substances participating in the reaction evenly distributed in the reaction chamber. In general, the mixing of solutes in a solution is based on two principles: convection mixing and diffusion mixing. Under the effect of convection, the solute mass will be divided into fine fragments, which will increase the contact area between the solutions; the diffusion distance will become smaller, thereby increasing the mixing efficiency between the micro fluids. The diffusion coefficient of the solutes in the solution is related to the temperature, so the temperature will also affect the mixing efficiency of the micro fluids.
[0005] Depends on different mixing methods, the micro mixer can be divided into active mixing and passive mixing. Active mixing refers to the mixing of solutions through the input of external energy from the outside world. For example, pressure, magnetic force, electric field force, sound field force and thermodynamic force can all be used as the source of energy for active mixing. Passive mixing mainly relies on the geometric structure of the channels, achieving mixing through diffusion. Generally, a more homogenous and fast mixing can be achieved by designing the structure of the microfluidic channel. For example, Brody et al. for the first time proposed a + shaped microfluidic channel, where a narrow band is formed by the extrusion of the middle solution by the side solution, which is mixed with the middle solution by diffusion [Brody, James P., et al. “Biotechnology at low Reynolds numbers.” Biophysical journal, 1996:71(6),
2020100684 04 May 2020
3430-3441.]. Some people use the method of adding modifiers in the channel to increase the mixing efficiency. For example, in 2002 Stroock et al. first proposed a microfluidic channel with a staggered A structure inside, which effectively improved the mixing effect [Stroock, A. D., et al. “Chaotic mixer for microchannels.” Science, 2002: 295(5555), 647-651.]. Patent CN1065 82903 proposes a pho to thermal waveguide micro fluidic chip. The pho to thermal waveguide is immersed in the bottom of a rectangular microfluidic chamber, and the length, width and height of the micro fluidic chamber and the volume of the injected liquid are required to be fixed. The surface of the optical waveguide is coated with thermal conductive Nanomaterials, the liquid near the waveguide is vortexed and then mixed.
[0006] The micro fluidic mixers described above, whether based on active, passive or photothermal effects, mostly require complex technical and size requirements, the preparation method is complicated and the cost is high. Based on this, the invention proposes a photothermal microfluidic mixer based on holey optical fiber with a simple structure. In terms of manufacturing materials and cost, since the structure of the optical fiber contains multiple air holes, the size matches the microliter grade of the micro fluidic chip. Relatively speaking, the production volume of optical fiber is larger, and the micromachining technology used in the preparation process of the micro-mixer is relatively simple and easy to implement. The micromixers produced in this way have an average low cost, is suitable for mass production, and also helps optimize the integration and miniaturization of micro fluidic systems. In terms of mixing effect, the invention uses a photothermal effect to form a temperature gradient. When the liquid absorbs optical energy, it can increase the diffusion rate of molecules in the solution.
[0007] In order to further improve the integration and miniaturization of the microfluidic chip and overcome the above shortcomings and deficiencies in advanced technology, the invention proposes a photothermal microfluidic mixer based on holey optical fiber. This holey optical fiber photothermal microfluidic mixer that can be used for microfluidic chips is simple to prepare, has good consistency, is easy to use with microfluidic chips, avoids optical alignment and adjustment in the case of separation, and is suitable for large-scale mass production.
2020100684 04 May 2020
SUMMARY OF INVENTION
[0008] The objective of the invention is to provide a mixer that operates tinyliquids on a micrometer-scale, it can replace the integrated unit in the microfluidic chip, that achieves microfluid mixing through microfluidic channel geometry, further improving the integration and miniaturization of microfluidic chips.
[0009] The objective of the invention is achieved as follows:
[0010] A photothermal micro fluidic mixer based on holey optical fiber, its characteristics are: the photothermal microfluidic mixer consists of a section of a micromachined holey optical fiber and an optical source. A mixing chamber is prepared by processing the holey optical fiber shown in FIG. 1 through air pressure and simultaneously hot-met-heat it, the cladding in the air holes of the mixing chamber expands and thins until it is heat-melted to disappear, the core runs through the entire heating chamber and suspends in the middle. After a variety of liquids enter into the mixing chamber at the same time, due to the heat radiation from the suspended fiber core to the microfluid, the molecules accelerate movements to achieve the purpose of mixing. The holey optical fiber photothermal micro fluidic mixer can be used for micro fluidic chips is simple to prepare, has good consistency, is easy to use with microfluidic chips, is easy and fast connection with optical source, and is suitable for large-scale mass production.
[0011] Further, the photothermal micro fluidic mixer can change the optical energy injected to adjust the mixing degree of multiple liquids in the air holes.
[0012] Further, the holey optical fiber used in the micro fluidic mixer can be expanded as, the optical fiber has a middle core as an optical channel, a plurality of air holes n are around the fiber
2020100684 04 May 2020 core that are closely connected to the fiber core, and each air hole at the optical fiber ends can be used as a liquid inlet, i.e., n air holes can mix 2n liquids simultaneously (η>1, n is an integer).
[0013] Further, the liquid outlet of the photothermal mixer can be extended to be an open fiber end of the other end (as shown in FIG. 3 (a)), or an open mixing chamber (as shown in FIG. 3 (c)), or microholes can be prepared as outlets by using femtosecond laser micro-drilling technology on the outer surface of the mixing chamber (as shown in FIG. 3 (b)).
[0014] Further, the pho to thermal mixer can have a multiple microhole outlets structure, m microholes (m>l, m is an integer) can be increased on the surface of the mixing chamber, each microhole can be used as a liquid outlet.
[0015] Further, according to the length and injection requirements of the pho to thermal microfluidic mixer, the desired microhole size and shape can be prepared by femtosecond laser micro-drilling technology, such as circular microholes, square microholes, oval microholes, rectangular microholes, etc.
[0016] In order to achieve the functions of the micro fluidic mixer in the micro fluidic chip, the middle core is connected to an external optical source. When the holey optical fiber is injected with optical energy, the optics propagates along the core. When the mixing chamber in the optical fiber is filled with liquid, the optical fiber is in full contact with the liquid, the optical energy is converted into the heat energy absorbed by the liquid and then into molecules kinetic energy. The diffusion phenomenon of the heated liquid is accelerated, to achieve the effect of fully mixing various liquids.
[0017] The specific principle is as follows:
2020100684 04 May 2020
[0018] As we all know, optic is a type of electromagnetic wave, and the optical energy provided by the optical source connected to the photothermal microfluidic mixer is an electromagnetic wave, and is radiated through the surface of the core. Because the fiber core is direct contact to the microfluid, this electromagnetic wave is transmitted in the core and reaches the microfluid again to be converted into internal energy. When the energy of the optical source is stronger, the temperature of the fiber core is higher, and the radioactive energy is also greater. Therefore, the micro fluidic mixer transfers heat from high-temperature objects (optical fiber core) to lowtemperature objects (microfluid) in the form of electromagnetic waves.
[0019] So how are different micro fluids get mixed evenly? It can be simply understood that two convection heat transfer phenomena coincide in the microfluidic mixer, the intramolecular energy in the microfluid is increased and the movement is accelerated, which induces the phenomenon of the diffusion of various liquids in the mixing chamber. The first convection heat transfer phenomenon is: the heat transfer method of the heated fluid on the surface of the hightemperature object (surface of the fiber core) to the surface of the low-temperature object (away from the fiber core) is convection heat transfer. If the fluid on the surface of an object is stationary, then heat is also transferred between the surface of the object and the fluid through thermal conduction. The second convection heat transfer phenomenon is: the heat transfer between the heated liquid in the mixing chamber of the holey optical fiber optic microfluidic mixer and the slightly lower-temperature liquid belongs to convection heat transfer. After this fluid heats up, the liquid density changes, so convection occurs.
[0020] Considering that the photothermal microfluidic mixer proposed by the invention is mainly used in the field of micro fluidic chips, the micro fluidic mixer structure and the microfluidic channel of the chip are in the micrometer-scale, so the Reynolds number is low, the liquid flow is laminar, and the temperature difference between the optical fiber core and the fluids are is rather little. Correspondingly, the physical properties such as fluid viscosity, thermal conductivity and specific heat are fixed, and the effects of internal heating and buoyancy of the fluid due to viscous friction are negligible. Under this circumstance, we will briefly analyze the
2020100684 04 May 2020 principles in the mixing chamber of the photothermal microfluidic mixer.
[0021] If the optical intensity injected into the holey optical fiber is constant, and the energy is stable, assuming that the core temperature of the optical fiber is 1\, the surface area is A, and there are fluids with a temperature of Ti flowing around. Since there is a difference in the temperatures of the surface of the optical fiber core and the fluid, thereby forming a convection heat transfer. As the fluid on the surface of optical fiber core has contact with the optical fiber core, it has the same temperature as the surface of the optical fiber core. In addition, the temperature of the fluid far enough from the optical fiber core is T2, and there is a boundary layer in which the temperature and the flow velocity changes in the vicinity of the optical fiber core. Assuming that the area is <L4(m2) and the heat transfer is W) ? then the relationship between the local heat flux density _ d(j/cL4 anj temperature difference can be expressed by Newton's Law of Cooling, q = h(T\-T2) (1)
In which ^(W/(m gK)) transfer coefficient. The heat transfer coefficient is different from the thermal conductivity, where the thermal conductivity is the inherent physical property of the substance and the heat transfer coefficient changes with the flow state of the fluid.
[0022] In addition, when the micro fluid is in contact with the core, a thin layer of thermal fluid, whose temperature changes rapidly from the temperature of the optical fiber core to the temperature of the liquid, is formed on the surface of the optical fiber core, and this is called the temperature boundary layer. Similarly, when a liquid flows, the fluid will adhere to the optical fiber core, and a thin layer of flow starting from zero speed changing rapidly will be formed on the surface of the optical fiber core, and this is called the velocity boundary layer (as shown in FIG. 2). The faster the fluid flows near the core, the thicker the boundary layer is.
2020100684 04 May 2020
[0023] It can be seen that the thermal conductivity equation can be derived from Fourier's Law and the mass conservation equation, the following thermal balances exist within the time interval A/(s) .
(Variable quantity of thermodynamic energy) = [(The heat of the micro-body introduced)-(The heat of the micro-body derived)] + (The heat generated in the micro-body)xAz(.s') (2)
[0024] In the environment of the micro fluid in the mixing chamber, the situation where the solid wall surface surrounds the fluid, is the classic pipeline flow.
[0025] Therefore, the heat equation of the cylindrical coordinates is:
dT 1 d z, dl\ 1 d z, dT. d z, ST pc— =--(kr—) + -7 — (k —) + — (k — dt r dr dt r2 d0 dO dz dz (3)
In the equation, the thermal conductivity coefficient k is a constant, r is the radius of the cylinder, p(kg/m3) is the density of the object, c(J/(kgJ<)) is the specific heat, and in addition, <7v(W/m3) is the calorific value per unit time and unit volume in the micro-body.
[0026] The optical fiber micro fluidic mixer can be further combined with traditional micro fluidic chips, and the liquid outlet of the mixer can be connected to the microfluidic chip used, to mix the liquids that has not yet entered the chip.
[0027] In practical applications, the appropriate microfluidic mixer should be selected according to the specific system requirements. Micro fluidic mixers are widely used in microsensors, microbiology, chemical analysis, and various applications involving microfluidic transportation. At present, microfluidic mixers has been greatly developed, the structure and principles are rich and diverse, and the stability has also been greatly improved. In order to further improve the integration and miniaturization of the micro fluidic chip, and to overcome the above
2020100684 04 May 2020 shortcomings and deficiencies in advanced technology, the invention proposes a photothermal micro fluidic mixer based on holey optical fiber. The holey optical fiber photothermal micro fluidic mixer that can be used in micro fluidic chips is simple to prepare, has good consistency, is easy to use with microfluidic chips, avoids optical alignment and adjustment in the case of separation, and is suitable for large-scale mass production. In the operation of micrometer-scale tinyliquid, it can replace microfluidic channel structural units for mixing functions in the chips, providing excellent research and application platform for high-throughput chemistry, biology and pharmaceutical analysis detection, providing a variety of options for mixing-function units within the micro fluidic chips.
BREIF DESCRIPTION OF DRAWINGS
[0028] FIG. 1 (a) is a structural schematic view of the cross-section of a holey optical fiber; (b) is a photo of three kinds of holey optical fibers, including an air hole 1-1, a core 1-2 and a cladding 1-3.
[0029] FIG.2 is a schematic diagram of the boundary layer in the case of convection heat transfer.
[0030] FIG. 3 is a schematic diagram of a four-hole optical fiber photothermal microfluidic mixer, (a) one end of the mixer acts as the liquid inlet and the open tail fiber end of the other end acts as the liquid outlet; (b) both ends of the mixer act as liquid inlets and the microholes on the outer surface of the mixing chamber act as liquid outlets; (c) cut off the structure in (a) in the mixing chamber, with one end of the mixer acting as the liquid inlet and the cut-off mixing chamber acting as the liquid outlet.
2020100684 04 May 2020 ίο
[0031] FIG. 4 is a schematic diagram of a holey optical fiber photothermal micro fluidic mixer with multiple-microhole liquid outlets.
DESCRIPTION OF EMBODIMENTS
[0032] The invention will be further described below in conjunction with the drawings and specific embodiments.
[0033] FIG. 1 shows a cross-sectional structure of a holey optical fiber, which consists of an air hole 1-1 acting as the inlet for micro fluids to enter, a core 1-2 having a slightly higher refractive index than a cladding material, and a cladding 1-3.
[0034] FIG. 3 shows the structure of processing and preparing a holey optical fiber into a photothermal micro fluidic mixer. A mixing chamber is prepared by processing holey optical fibers through air pressure and simultaneously hot-met-heat it, the cladding in the air holes of the mixing chamber expands and thins until it is heat-melted to disappear, the core runs through the entire heating chamber and suspends in the middle. After a variety of liquids enter into the mixing chamber at the same time, due to the heat radiation from the suspended fiber core to the microfluid, the molecules accelerate movements to achieve the purpose of mixing.
[0035] Without loss of generality, we elaborate on the specific implementation steps and implementation methods of the invention with a specific example of a holey optical fiber optic photothermal microfluidic mixer, in which the two ends acting as liquid inlets as shown in FIG. 3 (b) and the microholes on the outer surface of the chamber acting as liquid outlets.
2020100684 04 May 2020
[0036] (1) First, take a section of the four-hole optical fiber 4-4 shown in FIG. 1, remove the coating layer for use. The air holes at both ends of the optical fiber act as liquid inlets, and are respectively connected to eight microfluidic injection devices 4-1. The injection pump is fed with different liquids ABCDEFGH through the liquid connector 4-3, the middle core acts as an optical wave channel and is welded to the single-mode optical fiber 4-5 and connected to an optical source 4-2.
[0037] (2) Then a mixing chamber is prepared by the method of pressurized hot-melt-heating, because the air pressure inside the air hole is greater than the external atmospheric pressure, making the air hole inner chamber expands and becomes larger, and the cladding between the air holes thins until completely disappears, eventually forming a hollow chamber. The middle core is thinned due to air hole expansion and extrusion, but still suspends in the hollow spherical chamber, forming a mixing chamber.
[0038] (3) Next, using femtosecond laser etching technique, three circular microholes are etched on the outer surface of the mixing chamber, acting as liquid outlets.
[0039] (4) Finally, the mixer is embedded into the chip 4-6, the liquid outlets are connected correspondingly to the microchannels of the micro fluidic chip. After the liquids ABCDEFGH entering into the mixing chamber, they absorb the heat radiated by the core suspended in the middle, a violent proliferation phenomenon occurs. Finally, a mixture of eight different liquids K is discharged from the microhole outlet into the microfluidic channel inside the chip and then into the other functional unit 4-7 in the chip.
[0040] Since different liquids have different absorption rates for optical sources of different wavelengths, combining the wavelength of the connected optical source and the absorption rate of the liquid to be tested, the mixing degree of the microfluid can be adjusted according to the
2020100684 04 May 2020 functional requirements of the chip.
[0041] In this embodiment, number of air holes n contained in the holey optical fiber used in this pho to thermal micro fluidic mixer is four, the liquid types injected simultaneously 2n is eight, the microhole outlets m is three, and the shape of the microholes is circular. Similarly, the number of air holes and microholes in a holey optical fiber can also be expanded to other numbers, and the shape can also be expanded to a square, an oval, a rectangle, etc. These changes in numbers, shape, and size will affect the test index of the microfluidic mixer. This requires specific parameter design based on the functional requirements of the chip in specific practical applications.

Claims (5)

1. A photothermal micro fluidic mixer based on holey optical fiber, its characteristics are: the microfluidic mixer is prepared and processed from holey single-core optical fiber, where the middle core of the holey optical fiber acts as an optical interface with external optical sources. Each air hole at the end of the holey optical fiber can be used as a channel port for a liquid. A mixing chamber is prepared by processing holey optical fibers through air pressure and simultaneously hot-met-heat it, the cladding in the air holes of the mixing chamber expands and thins until it is heat-melted to disappear, the core runs through the entire heating chamber and suspends in the middle.
2. As claimed in claim 1, a photothermal micro fluidic mixer based on holey optical fiber, its characteristics are: the liquid inlet of the mixer can be air holes at the optical fiber end and the liquid outlet can be the open optical fiber end or an open mixing chamber at the other end. The optical fiber used in the mixer has an middle core as the optical channel, and a plurality of air holes n are around the fiber core that are closely connected to the fiber core, and each air hole at the optical fiber ends can be used as a liquid inlet, i.e., n air holes can mix 2n liquids simultaneously (η>1, n is an integer).
3. As claimed in claim 1, a photothermal micro fluidic mixer based on holey optical fiber, its characteristics are: the liquid inlet of the mixer can be an air hole on the optical fiber end, the liquid outlet can be the microholes on the mixing chamber. Using femtosecond laser microdrilling technology, m microhole structure (m>l, m is an integer) can be prepared on the outer surface of the mixing chamber, each microhole can be a liquid outlet. Microhole size and shape can be changed according to the requirements of the mixer, such as circular microholes, square microholes, oval microholes, rectangular microholes, etc.
2020100684 04 May 2020
4. As claimed in claim 1, a photothermal micro fluidic mixer based on holey optical fiber, its characteristics are: the photothermal micro fluidic mixer can adjust the optical energy injected to adjust the mixing degree of various liquids in the air holes.
5. As claimed in claim 1, a photothermal micro fluidic mixer based on holey optical fiber, the microfluidic mixer can be further combined with a traditional microfluidic chip, and the liquid outlet of the mixer can be connected to the microfluidic chip used, and has the effect of mixing liquid that has not yet entered the chip.
AU2020100684A 2020-05-04 2020-05-04 A photothermal microfluidic mixer based on holey optical fiber Ceased AU2020100684A4 (en)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113274956A (en) * 2021-05-08 2021-08-20 袁相质 Microchannel reaction system and method for preparing epoxy compound
CN113607688A (en) * 2021-06-03 2021-11-05 天津工业大学 Micro-fluidic refractive index sensor based on double-hole microstructure optical fiber
CN113866127A (en) * 2021-10-26 2021-12-31 天津工业大学 Micro-fluidic sensing device in fibre based on four-hole microstructure optical fiber integration
CN114815039A (en) * 2022-03-30 2022-07-29 中国船舶重工集团公司第七0七研究所 Method for manufacturing optical fiber optical fluid channel

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113274956A (en) * 2021-05-08 2021-08-20 袁相质 Microchannel reaction system and method for preparing epoxy compound
CN113607688A (en) * 2021-06-03 2021-11-05 天津工业大学 Micro-fluidic refractive index sensor based on double-hole microstructure optical fiber
CN113607688B (en) * 2021-06-03 2024-03-19 天津工业大学 Microfluidic refractive index sensor based on double-hole microstructure optical fiber
CN113866127A (en) * 2021-10-26 2021-12-31 天津工业大学 Micro-fluidic sensing device in fibre based on four-hole microstructure optical fiber integration
CN113866127B (en) * 2021-10-26 2024-01-16 天津工业大学 Intra-fiber micro-fluidic sensing device based on four-hole microstructure optical fiber integration
CN114815039A (en) * 2022-03-30 2022-07-29 中国船舶重工集团公司第七0七研究所 Method for manufacturing optical fiber optical fluid channel

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