CN113855629A - 一种清新润喉草本配方及制作方法 - Google Patents
一种清新润喉草本配方及制作方法 Download PDFInfo
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- CN113855629A CN113855629A CN202111321392.8A CN202111321392A CN113855629A CN 113855629 A CN113855629 A CN 113855629A CN 202111321392 A CN202111321392 A CN 202111321392A CN 113855629 A CN113855629 A CN 113855629A
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Abstract
本发明提供了一种清新润喉的组合物，其特征在于：它包括如下组份：西瓜提取物1‑10份，甜瓜提取物1‑10份、薄荷脑0.1‑10份。本发明使用全草本配方，采用现代植物提取技术，将各原料配伍使用后，发挥了协同增效作用，能够清除口腔异味，具有提神醒脑、去除口臭、清凉润喉。
Description
技术领域
本发明属于天然植物提取物领域。
背景技术
随着环境污染日趋严重，以及长期过度用嗓、熬夜等不健康的生活方式，咽喉不适、慢性咽炎等危害咽喉健康的情况频繁出现，常见的咽喉部肿痛、干燥、堵塞、声音嘶哑、吞咽不适、口腔异味等情况越发被人们所重视。
润喉糖作为一种能够缓解减轻不适感的产品，被广泛接受，成为很多人随身携带的必备品之一。
很有必要设计研发一种具有很好的清除口腔中的异味，具有清凉润喉功效的产品。
发明内容
为了克服现有技术的不足，提供一种滋味清香、口感自然，同时具有保持口气清新、清凉润喉的草本产品。
本发明具体提供了一种清新润喉的组合物，它包括如下组份：
西瓜提取物1-10份，甜瓜提取物1-10份、薄荷脑0.1-10份。
进一步地，薄荷脑为0.1-1份。
其中，所述西瓜提取物选自西瓜水提物、西瓜醇提物中的一种或两种以上的混合物。
其中，所述甜瓜提取物选自甜瓜水提物、甜瓜叶醇提物中的一种或两种以上的混合物。
其中，它还包括润喉糖。
其中，它还包括甜味剂、甘油。
其中，它包括如下组份：西瓜提取物5-10份，甜瓜提取物5-10份、薄荷脑0.1-5份。
本发明还提供了一种清新润喉的口服产品，它包括本发明所述的组合物。
本发明还提供了一种清新润喉的外用产品，它包括本发明所述的组合物。
本发明还提供了一种清新润喉的鼻腔吸入产品，它包括本发明所述的组合物。
西瓜(学名：Citrullus lanatus(Thunb.)Matsum.et Nakai)一年生蔓生藤本；茎、枝粗壮，具明显的棱。果肉味甜，能降温去暑；种子含油，可作消遣食品；果皮药用，有清热、利尿、降血压之效。
甜瓜(Cucumis melo L.)又称香瓜、哈密瓜等。是葫芦科一年生蔓性草本植物。全草药用，有祛炎败毒、催吐、除湿、退黄疸等功效。
薄荷脑也叫薄荷醇是一种有机化合物，化学式为C10H20O。薄荷脑系由薄荷的叶和茎中所提取，白色晶体，为薄荷和欧薄荷精油中的主要成分。薄荷醇一般有两种异构体(D型和L型)，天然的薄荷醇主要为左旋异构体(L-薄荷醇)，这里的薄荷脑一般指消旋的薄荷醇(DL-薄荷醇)。薄荷脑可用作牙膏；香水；饮料和糖果等的赋香剂。在医药上用作刺激药，作用于皮肤或粘膜，有清凉止痒作用；内服可作为驱风药，用于头痛及鼻；咽；喉炎症等。其酯也可用于香料和药物。
本发明所述提取，采用本领域常规的方法即可，例如回流、浸渍、超声、微波辅助等等。
本发明“水提”，可以采用煎煮提取、浸渍提取、超声提取、微波辅助提取等等，提取时，可以使用不同温度的水进行提取，可以是0～30℃(大于0)，也可以是温度更高的热水，例如采用50℃以上的水提取，例如，50℃、51℃、52℃、53℃、54℃、55℃……60℃……65℃……70℃……75℃……80℃……85℃……90℃……95℃……100℃等等。
进一步地，提取次数为2次以上，可以是2次、3次、4次、5次……等等。
提取次数可以通过辅助检测方式进行判定，例如对每次提取物进行含量检测，查看其中的目标物含量多少，在平衡经济、环保原则的前提下，得到一个合理的提取次数。
本发明在制备产品时，除了活性成分外，还可以加入辅料或/和辅助性成分。
本发明中所述的“辅料”，是药物制剂中除主药以外的一切附加材料的总称，辅料应当具备如下性质：(1)对人体无毒害作用，几无副作用；(2)化学性质稳定，不易受温度、pH、保存时间等的影响；(3)与主药无配伍禁忌，不影响主药的疗效和质量检查；(4)不与包装材料相互发生作用。
药学上可以接受的辅料，如纤维素及其衍生物(如羧甲基纤维素钠、乙基纤维素钠、纤维素乙酸酯等)、明胶、滑石、固体润滑剂(如硬脂酸、硬脂酸镁)、硫酸钙、植物油(如豆油、芝麻油、花生油、橄榄油等)、多元醇(如丙二醇、甘油、甘露醇、山梨醇等)、乳化剂(如
)、润湿剂(如十二烷基硫酸钠)、着色剂、调味剂、稳定剂、抗氧化剂、防腐剂、无热原水等。
用于口服的固体剂型包括胶囊剂、片剂、丸剂、散剂、颗粒剂、袋泡剂等，不限于上述剂型。在这些固体剂型中，原料或提取物与至少一种常规惰性赋形剂(或载体)混合，如柠檬酸钠或磷酸二钙，或与下述成分混合：(a)填料或增容剂，例如，淀粉、乳糖、蔗糖、葡萄糖、甘露醇和硅酸；(b)粘合剂，例如，羟甲基纤维素、藻酸盐、明胶、聚乙烯基吡咯烷酮、蔗糖和阿拉伯胶；(c)保湿剂，例如，甘油；(d)崩解剂，例如，琼脂、碳酸钙、马铃薯淀粉或木薯淀粉、藻酸、某些复合硅酸盐、和碳酸钠；(e)缓溶剂，例如石蜡；(f)吸收加速剂，例如，季胺化合物；(g)润湿剂，例如鲸蜡醇和单硬脂酸甘油酯；(h)吸附剂，例如，高岭土；和(i)润滑剂，例如，滑石、硬脂酸钙、硬脂酸镁、固体聚乙二醇、十二烷基硫酸钠，或其混合物。胶囊剂、片剂和丸剂中，剂型也可包含缓冲剂。
固体剂型如片剂、糖丸、胶囊剂、丸剂和颗粒剂可采用包衣和壳材制备，如肠衣和其它本领域公知的材料。它们可包含不透明剂，并且，这种组合物中活性化合物或化合物的释放可以延迟的方式在消化道内的某一部分中释放。可采用的包埋组分的实例是聚合物质和蜡类物质。必要时，原料或提取物也可与上述赋形剂中的一种或多种形成微胶囊形式。
用于口服的液体剂型包括药学上可接受的乳液、溶液、悬浮液、糖浆或酊剂。除了原料或提取物外，液体剂型可包含本领域中常规采用的惰性稀释剂，如水或其它溶剂，增溶剂和乳化剂，例知，乙醇、异丙醇、碳酸乙酯、乙酸乙酯、丙二醇、1,3-丁二醇、二甲基甲酰胺以及油，特别是棉籽油、花生油、玉米胚油、橄榄油、蓖麻油和芝麻油或这些物质的混合物等。
除了这些惰性稀释剂外，组合物也可包含助剂，如润湿剂、乳化剂和悬浮剂、甜味剂、矫味剂和香料。除了原料或提取物外，悬浮液可包含悬浮剂，例如，乙氧基化异十八烷醇、聚氧乙烯山梨醇和脱水山梨醇酯、微晶纤维素、甲醇铝和琼脂或这些物质的混合物等。
薄荷脑的加入，可以使用固体粉末形式，也可以使用适当的溶剂溶解后加入到产品中，如利用乙醇进行溶解。
本发明所述鼻腔吸入产品，是以雾化、液态、凝胶、混悬等不同方式，通过鼻腔吸入的产品。
本发明产品不限于固体产品，也可以是液体产品或其他形态。
本发明的有益效果是：
本发明使用全草本配方，采用现代植物提取技术，将各原料配伍使用后，发挥了协同增效作用，能够清除口腔异味，具有提神醒脑、去除口臭、清凉润喉。
具体实施方式
以下通过实施例形式的具体实施方式，对本发明的上述内容再作进一步的详细说明。但不应将此理解为本发明上述主题的范围仅限于以下的实例。凡基于本发明上述内容所实现的技术均属于本发明的范围。
实施例1
取西瓜、甜瓜，分别加水提取2-3次，得到西瓜提取物、甜瓜提取物。
取西瓜提取物10g，甜瓜提取物10g，薄荷脑0.5g(少量乙醇溶解)，混合均匀，超滤膜过滤后，所得液体即为本发明清新润喉组合物。
实施例2
取西瓜、甜瓜，分别加70％乙醇提取2-3次，得到西瓜提取物、甜瓜提取物。
取西瓜提取物10g，甜瓜提取物50g，薄荷脑5g，混合均匀，即得本发明清新润喉组合物。
实施例3
取西瓜、甜瓜，分别依次用水、95％乙醇提取2-3次，混合提取液，得到西瓜提取物、甜瓜提取物。
取西瓜提取物50g，甜瓜提取物50g、薄荷脑10g，混合均匀，即得本发明清新润喉组合物。
实施例4
取步骤2制备的西瓜提取物50g，甜瓜提取物50g、薄荷脑5g，甜味剂2g、甘油50g，混合均匀，即得本发明生津止渴组合物。
实验例1安全性试验
(1)采取喷雾给药的方式，使用实施例1制备的液体，每日早中晚3次给大白兔进行喷雾，连续四周，持续观察兔子的状态，第八周采取个体器官切片观察，观测器官活性以及状态，收集数据，并与喷雾前以及喷雾中的数据对比，得出本组合物对生命体征的作用以及影响。
结果：喷雾后的大白兔的体重正常增长，发育良好，没有不良现象。各项生化指数表明大白兔各项指数都呈现健康良好的发育，说明本组合物对生命体的健康无害性，有一定的养护和滋润作用，能使生物体征保持健康良好的发育，不会产生病变以及其他不良反应。大白兔五脏和器官的切片解剖图，从显微镜上观察，切片健康，发育良好，没有病变阴影，各项指标以及形态都良好，无其他特征出现。
(2)采取静脉注射的方式给猪食用实施例2制备的液体，每日早中晚混合食物一起喂食3次，连续24周，持续观察猪的状态，12周时，检查一次猪的体重增长对比和健康状况对比，收集数据，与没有喂食的猪对比，24周时采取个体器官切片观察，观测器官活性以及状态，收集数据，并与喷雾前以及喷雾中的数据对比，得出本组合物对生命体征的作用以及影响。
结果：喷雾后的猪的体重正常增长，发育良好，没有不良现象。各项生化指数表明猪各项指数都呈现健康良好的发育，说明本组合物对生命体的健康无害性，有一定的养护和滋润作用，能使生物体征保持健康良好的发育，不会产生病变以及其他不良反应。猪五脏和器官的切片解剖图，从显微镜上观察，切片健康，发育良好，没有病变阴影，各项指标以及形态都良好，无其他特征出现。
实验例2效果实验
选取40名烟龄2年以上的成年人，年龄在30-50岁之间，男女各半，且每位个体都存在咽喉不适、口臭等状况，受试期间，该人群不接受其他治疗或辅助治疗。将上述受试人群随机分为2组(注意每组男女数量相同)，空白组给予生理盐水喷雾，受试组给与本发明在临睡前以实施例1制备的液体产品进行喷雾(通过常规的喷雾设备)，连续使用1个月后，通过对受试人群每日的口腔异味、咽喉异样等方面进行评判，其中：
(1)空白组有5人(25％)认为其咽喉不适的感觉得以缓解；口腔异味无明显变化。
(2)受试组中，有13人(65％)认为咽喉清爽，以前偶有的干哑感觉基本消失，且口腔异味明显减少，几乎消失；有6位认为咽喉不适的感觉得以缓解，口腔异味也有好转；仍有1位受试者认为本发明产品并未对其产生明显效果。
由此可见，本发明有效率高达95％，且痊愈或接近痊愈者高达65％，与空白组相比，本发明具备良好的清新润喉功效。
Claims (9)
1.一种清新润喉的组合物，其特征在于：它包括如下组份：
西瓜提取物1-10份，甜瓜提取物1-10份、薄荷脑0.1-10份。
2.根据权利要求1所述的组合物，其特征在于：所述西瓜提取物选自西瓜水提物、西瓜醇提物中的一种或两种以上的混合物。
3.根据权利要求1所述的组合物，其特征在于：所述甜瓜提取物选自甜瓜水提物、甜瓜叶醇提物中的一种或两种以上的混合物。
4.根据权利要求1所述的组合物，其特征在于：它还包括润喉糖。
5.根据权利要求1所述的组合物，其特征在于：它还包括甜味剂、甘油。
6.根据权利要求1所述的组合物，其特征在于：它包括如下组份：
西瓜提取物5-10份，甜瓜提取物5-10份、薄荷脑0.1-5份。
7.一种清新润喉的口服产品，其特征在于：它包括权利要求1-5任意一项所述的组合物。
8.一种清新润喉的外用产品，其特征在于：它包括权利要求1-5任意一项所述的组合物。
9.一种清新润喉的鼻腔吸入产品，其特征在于：它包括权利要求1-5任意一项所述的组合物。
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