CN113827180B - Multi-point parallel acquisition anterior ocular segment analysis device - Google Patents

Multi-point parallel acquisition anterior ocular segment analysis device Download PDF

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CN113827180B
CN113827180B CN202110923565.7A CN202110923565A CN113827180B CN 113827180 B CN113827180 B CN 113827180B CN 202110923565 A CN202110923565 A CN 202110923565A CN 113827180 B CN113827180 B CN 113827180B
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light
optical fiber
sample
spectroscope
autocollimator
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CN113827180A (en
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赵鹏
王雪乔
武辰
王元
张雪峰
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Tianjin Suowei Electronic Technology Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/107Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for determining the shape or measuring the curvature of the cornea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/117Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for examining the anterior chamber or the anterior chamber angle, e.g. gonioscopes

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
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  • Biophysics (AREA)
  • Ophthalmology & Optometry (AREA)
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  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
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Abstract

The invention relates to a multipoint parallel acquisition anterior ocular segment analysis device, which is characterized in that: the optical fiber optical system comprises a light source, a first collimating mirror, a spectroscope, a reference arm, a sample arm and a demodulation system, wherein the first collimating mirror is arranged right behind the light source, the spectroscope is arranged right behind the first collimating mirror, the reference arm is arranged on one side of the reference light of the spectroscope, the sample arm is arranged behind the sample light of the spectroscope, the demodulation system is arranged below the sample light of the spectroscope, the reference arm is used for forming reference return light, the sample arm is used for forming sample return light carrying tissue information, the sample return light interferes with the beam of the reference return light in the spectroscope of the reference arm, the interference enters the demodulation system, data reconstruction is carried out in the demodulation system, and the front eye section form is restored. The device has simple structure, the devices are all common optical devices, and the light utilization efficiency is high. The optical fiber device is not limited by space, and the sampling form can be used for experimental hand-held and mobile operation, and is flexible and changeable.

Description

Multi-point parallel acquisition anterior ocular segment analysis device
Technical Field
The invention belongs to the technical field of ophthalmic medical equipment, and relates to a multipoint parallel acquisition anterior ocular segment analysis device.
Background
The eyes are the most important sense organs of the human body, and more than 80% of the external information received by people is obtained through the eyes. In the context of medical ocular dissection concepts, the anterior segment of the eye includes the cornea to the ocular tissue portion of the lens. In recent years, optical Coherence Tomography (OCT) technology has been rapidly developed, and is widely used in medical research due to its advantages such as rapidity and non-invasiveness. The advantages are obvious in the diagnosis of cornea, sclera, iris and atrial angle, and the situation of crystalloid lesions is also particularly important in the diagnosis of glaucoma, cataract and refractive vision problems. The traditional OCT adopts single-point scanning to improve the scanning speed to restrain image distortion and position offset caused by living jitter, when the scanning speed is high enough, the corresponding distortion is also greatly reduced, but the system cost caused by the distortion is also greatly increased, and the obtained sampling point information is not acquired at the same time.
Patent CN103271721B discloses a parallel OCT detection method based on spectral coding and orthogonal light splitting, in which an advanced optical device virtual image phased array (Virtual Imaged Phased Array, VIPA) is adopted in a system to divide an incident light source into a plurality of frequency sub light sources, which are arranged in a linear shape, the device realizes chromatic dispersion based on an optical FP cavity, the manufacturing process is complex and the cost is expensive, and the system cost is increased. Patent CN104870930a discloses a parallel acquisition system using a turntable for scanning, which designs a series of holes on the turntable, and when a light source is permeable, can acquire an optical signal of the hole column position, and the turntable rotates to complete the scanning. The method is also line sampling, and still cannot meet the requirement of simultaneous acquisition of volume data.
Based on the most important data synchronism among sampling points in living body imaging, most of the prior art is single sampling points or line sampling points, and the sampling points are matched with a vibrating mirror to move the positions of the sampling points so as to obtain surface sampling points, namely, volume data, wherein time difference exists among the sampling points. In order to obtain information of all sampling points at the same time, an analysis device capable of performing surface sampling is required to acquire sample volume data at one time.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides a device capable of collecting anterior ocular segment analysis in a multipoint parallel manner.
The invention solves the technical problems by adopting the following technical scheme:
the utility model provides a anterior ocular segment analytical equipment is gathered to multiple spot parallel which characterized in that: the optical system comprises a light source, a first collimating mirror, a spectroscope, a reference arm, a sample arm and a demodulation system, wherein the first collimating mirror is arranged right behind the light source, the spectroscope is arranged right behind the first collimating mirror, the reference arm is arranged on one side of the reference light of the spectroscope, the sample arm is arranged on one side of the sample light of the spectroscope, the demodulation system is arranged on one side of the beam combination of the spectroscope, the reference arm is used for forming reference return light, the sample arm is used for forming sample return light carrying tissue information, the sample return light and the reference return light are combined at the spectroscope to interfere, and enter the demodulation system, data reconstruction is carried out in the demodulation system, and the anterior ocular segment form is restored.
Moreover, the light source is a low-coherence broadband laser light source.
The reference arm comprises a first focusing mirror and a reflecting mirror, and the first focusing mirror and the reflecting mirror are sequentially arranged on one side of the reference light formed by the spectroscope from near to far.
The sample arm comprises a first optical fiber autocollimator group and a 4F system, wherein the first optical fiber autocollimator group comprises an optical fiber autocollimator with a tail fiber, the 4F system is arranged behind the first optical fiber autocollimator, and the 4F system is opposite to human eyes.
The 4F system is composed of a first lens and a second lens disposed in front and back.
The demodulation system comprises a second optical fiber autocollimator group, a second collimating mirror, a grating, a second focusing mirror and an area array photoelectric conversion device, wherein the second optical fiber autocollimator group, the second collimating mirror, the grating, the second focusing mirror and the area array photoelectric conversion device are sequentially arranged on one side of sample light formed by the spectroscope from near to far;
the spectral directions of the gratings form spectral curves along the transverse direction of the area array photoelectric conversion device, all spectrums are separated and separated along the vertical direction and are not overlapped with each other in space, n spectral curves are subjected to wave number conversion respectively, then fourier conversion is carried out to obtain depth information of n sampling points, data are reconstructed and restored into a three-dimensional data set according to the arrangement mode of the first optical fiber autocollimator group, and calculation and analysis are carried out on biological parameters of the front section of human eyes.
The optical fiber autocollimators a1, a2 … an in the first optical fiber autocollimator group and the second optical fiber autocollimator group are all in square tight arrangement or polygonal tight arrangement or circular tight arrangement, and are used for obtaining n point light source groups with mutually independent optical parameters.
And, the tail fibers of the fiber autocollimator in the second fiber autocollimator group of the demodulation system are vertically and linearly arranged according to the sequence of x1, x2 … xn and aligned with the center of the optical path.
The planar array photoelectric conversion device is a planar array CCD or a planar array CMOS.
The invention has the advantages and positive effects that:
according to the multi-point parallel acquisition anterior ocular segment analysis device, the first optical fiber autocollimator group divides the incident light of the sample arm into a plurality of sub point light sources, the sub point light sources are output by the optical fiber tail fibers and are a point light source array, the sampling array is focused near the cornea position of the human eye, the multi-point simultaneous sampling of the anterior ocular segment structure of the human eye is realized, the depth information of all sampling points is obtained, the data volume drawing is completed at one time, and the sampling information error caused by the shaking of a living body during the scanning of the sampling points is avoided. The device has simple structure, the devices are all common optical devices, and the light utilization efficiency is high. The optical fiber device is not limited by space, and the sampling form can be used for experimental hand-held and mobile operation, and is flexible and changeable.
Drawings
FIG. 1 is a schematic view of the structure of the device of the present invention;
FIG. 2 is a schematic illustration of an arrangement of fiber optic autocollimator banks according to the present invention;
FIG. 3 is a schematic view of the fiber end face arrangement of the sample arm fiber autocollimator set of the present invention;
fig. 4 is a schematic diagram of the spectroscopic principle of the demodulation system of the present invention.
Description of the reference numerals
1-light source, 2-first collimating mirror, 3-spectroscope, 4-reflecting mirror, 5-first focusing mirror, 6-first optical fiber autocollimator group, 7-optical fiber autocollimator with tail fiber, 8-first lens, 9-second lens, 10-human eye, 11-second collimating mirror, 12-grating, 13-second focusing mirror, 14-area array photoelectric conversion device and 15-second optical fiber autocollimator group.
Detailed Description
Embodiments of the invention are described in further detail below with reference to the attached drawing figures:
the multi-point parallel acquisition anterior ocular segment analysis device comprises a light source 1, a first collimating mirror 2, a spectroscope 3, a reference arm, a sample arm and a demodulation system, wherein the reference arm is composed of a reflecting mirror 4 and a first focusing mirror 5; the sample arm consists of a first optical fiber auto-collimator group 6, a first lens 8 and a second lens 9; the demodulation system consists of a second optical fiber autocollimator group 15, a second collimating mirror 11, a grating 12, a second focusing mirror 13 and an area array photoelectric conversion device 14; the first optical fiber autocollimator group and the second optical fiber autocollimator group are composed of a plurality of optical fiber autocollimators 7 with tail fibers.
The invention has the innovation that the first optical fiber autocollimator group divides the incident light of the sample arm into a plurality of sub point light sources, the sub point light sources are output by the optical fiber tail fibers and are a point light source array, the sampling array is focused near the cornea position of the human eye 10, the simultaneous sampling of the anterior segment structure of the human eye is realized, the depth information of all sampling points is obtained, the data volume drawing is completed at one time, and the sampling information error caused by the shaking of living bodies when the sampling points are scanned is avoided. The system has simple structure, the devices are all common optical devices, and the light utilization efficiency is high. The optical fiber device is not limited by space, and the sampling form can be used for experimental hand-held and mobile operation, and is flexible and changeable.
The light source forms a beam of parallel light through the first collimating mirror, and forms a beam of reference light and a beam of sample light through the spectroscope. The reference light is converged by the first focusing mirror and reflected by the reflecting mirror to form reference return light, the sample light enters the first optical fiber autocollimator group, the incident light is divided into a plurality of sub-beams, the first lens 8 and the second lens 9 form a 4F system, the sub-beams are relayed to the cornea position of the human eye, and the multi-point simultaneous acquisition of the sample information is realized. The sample return light carrying the tissue information and the reference return light interfere in the beam splitting of the spectroscope, enter a demodulation system, firstly, the interference light is sampled and separated by a second optical fiber autocollimator group, then, parallel light is formed by a second collimating mirror, and the parallel light is converged on an area array photoelectric conversion device through grating beam splitting. The area array photoelectric conversion device is transversely in a spectrum direction, and vertically in a sampling point arrangement direction, and spectrums of all sampling points are not interfered and overlapped with each other. After the calculation and analysis of the spectrum group, the data can be reconstructed to restore the anterior ocular segment morphology.
The working principle of the multipoint parallel acquisition anterior ocular segment analysis device is as follows:
the light source is a low coherence broadband laser light source such as an SLD laser. The light source is collimated and expanded by a first collimating mirror with a large caliber to form a parallel light source which is incident on a spectroscope, and the spectroscope divides the incident light source into reference light and sample light;
the reference light is converged by the first focusing mirror and then reflected by the reflecting mirror to form reference return light;
the sample light is split by the first fiber autocollimator group into a number of sub-beams, the number of sub-beams being determined by the number n of fiber autocollimators comprised by the first fiber autocollimator group. As shown in fig. 2, the optical fiber autocollimators a1, a2 and … an in the first optical fiber autocollimator group are tightly arranged, and can be square arranged, polygonal arranged or circular arranged according to requirements, so as to reduce light energy loss in the coupling process to the greatest extent and improve the light source utilization rate. The sub-beams are decoupled into the pigtail, and point light sources are formed at the end face of the pigtail, so that n point light source groups with mutually independent optical parameters can be obtained. Because the optical fibers have small diameters and are easy to be closely arranged, a high-density arranged point light source array can be obtained, as shown in fig. 3, the tail fiber of the first optical fiber autocollimator a1 corresponds to the point light source x1, and similarly, the tail fiber of the first optical fiber autocollimator an corresponds to the point light source xn.
The point light source array is relayed by a 4F system and focused at the front position of the human eye, and the focal length of two lenses in the 4F system is adjusted according to the requirement of sampling resolution. The sample return light carries tissue information and returns through the same light path, interference occurs between the sample return light and the reference return light in the beam splitter, and the interference light enters the demodulation system for analysis.
The demodulation system includes a second set of fiber autocollimators arranged in the same manner as the first set of fiber autocollimators in the sample arm. The interference light is sampled in a separated mode according to an arrangement mode, and the subareas covered by each fiber autocollimator in the second fiber autocollimator group contain depth information of one sampling point. Unlike in the sample arm, the pigtails of the second fiber autocollimator group of the demodulation system are aligned vertically in the order x1, x2 … xn and aligned with the center of the optical path.
The interference light is output by a point light source formed by the separated interference light through the tail fiber through the second optical fiber autocollimator group, the interference light is collimated by the second collimating mirror and is incident to the grating, the light after grating dispersion is converged on the area array photoelectric conversion device through the second focusing mirror, and the area array photoelectric conversion device can be an area array CCD or an area array CMOS. The grating beam splitting direction is along the transverse direction of the planar array photoelectric conversion device to form a spectrum curve, and because the pigtail lattice is arranged along the vertical direction, all spectrums are separated along the vertical direction and are not overlapped with each other in space, as shown in fig. 4, the interval between the spectrums is determined by the pigtail arrangement interval and the optical design of spectrum sampling resolution. The n spectral curves are subjected to wave number transformation respectively, then fourier transformation is performed, depth information of n sampling points can be obtained, and according to the arrangement mode of the first optical fiber autocollimator group shown in fig. 2, the data are reconstructed and restored into a three-dimensional data set, so that calculation and analysis can be performed on biological parameters of the anterior segment of human eyes.
Although the embodiments of the present invention and the accompanying drawings have been disclosed for illustrative purposes, those skilled in the art will appreciate that: various substitutions, changes and modifications are possible without departing from the spirit and scope of the invention and the appended claims, and therefore the scope of the invention is not limited to the embodiments and the disclosure of the drawings.

Claims (6)

1. The utility model provides a anterior ocular segment analytical equipment is gathered to multiple spot parallel which characterized in that: the system comprises a light source, a first collimating mirror, a spectroscope, a reference arm, a sample arm and a demodulation system, wherein the first collimating mirror is arranged right behind the light source, the spectroscope is arranged right behind the first collimating mirror, the reference arm is arranged on one side of the reference light of the spectroscope, the sample arm is arranged on one side of the sample light of the spectroscope, the demodulation system is arranged on one side of the beam combination of the spectroscope, the reference arm is used for forming reference return light, the sample arm is used for forming sample return light carrying tissue information, the sample return light and the reference return light are combined at the spectroscope to interfere, and enter the demodulation system, and data reconstruction is carried out in the demodulation system to restore the anterior ocular segment form;
the light source forms a beam of parallel light through the first collimating mirror, a beam of reference light and a beam of sample light are formed through the spectroscope, the reference light is converged through the first focusing mirror and reflected by the reflecting mirror to form reference return light, the sample light enters the first optical fiber autocollimator group, the incident light is divided into a plurality of sub-beams, the first lens and the second lens form a 4F system, the sub-beams are relayed to the cornea position of a human eye, and the simultaneous acquisition of sample information at multiple points is realized;
the demodulation system comprises a second optical fiber autocollimator group, a second collimating mirror, a grating, a second focusing mirror and an area array photoelectric conversion device, wherein the second optical fiber autocollimator group, the second collimating mirror, the grating, the second focusing mirror and the area array photoelectric conversion device are sequentially arranged on one side of sample light formed by the spectroscope from near to far, and the second optical fiber autocollimator group comprises an optical fiber autocollimator with a tail fiber;
the method comprises the steps that a spectrum curve is formed in the light splitting direction of the grating along the transverse direction of an area array photoelectric conversion device, all spectrums are separated and separated along the vertical direction and are not overlapped with each other in space, n spectrum curves are subjected to wave number conversion respectively, then fourier conversion is carried out to obtain depth information of n sampling points, data are reconstructed and restored into a three-dimensional data set according to the arrangement mode of a first optical fiber autocollimator group, and calculation analysis is carried out on biological parameters of the front section of human eyes;
the optical fiber autocollimators a1, a2 … an in the first optical fiber autocollimator group and the second optical fiber autocollimator group are closely arranged in square or polygon or round shape and are used for obtaining n point light source groups with mutually independent optical parameters;
the tail fibers of the optical fiber autocollimators in the second optical fiber autocollimator group of the demodulation system are vertically and linearly arranged according to the sequence of x1, x2 … xn and are aligned with the center of the optical path.
2. A multi-point parallel acquisition anterior ocular segment analysis device as in claim 1, wherein: the light source is a low-coherence broadband laser light source.
3. A multi-point parallel acquisition anterior ocular segment analysis device as in claim 1, wherein: the reference arm comprises a first focusing mirror and a reflecting mirror, and the first focusing mirror and the reflecting mirror are sequentially arranged on one side of the reference light formed by the spectroscope from near to far.
4. A multi-point parallel acquisition anterior ocular segment analysis device as in claim 1, wherein: the sample arm comprises a first optical fiber autocollimator group and a 4F system, wherein the first optical fiber autocollimator group comprises an optical fiber autocollimator with a tail fiber, the 4F system is arranged behind the first optical fiber autocollimator, and the 4F system is opposite to human eyes.
5. A multi-point parallel acquisition anterior ocular segment analysis device as in claim 4, wherein: the 4F system is composed of a first lens and a second lens which are arranged front and back.
6. A multi-point parallel acquisition anterior ocular segment analysis device as in claim 1, wherein: the planar array photoelectric conversion device is a planar array CCD or a planar array CMOS.
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