CN113812622A - Chinese wolfberry tablet for improving human intestinal flora and preparation method thereof - Google Patents
Chinese wolfberry tablet for improving human intestinal flora and preparation method thereof Download PDFInfo
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- CN113812622A CN113812622A CN202111061952.0A CN202111061952A CN113812622A CN 113812622 A CN113812622 A CN 113812622A CN 202111061952 A CN202111061952 A CN 202111061952A CN 113812622 A CN113812622 A CN 113812622A
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
- A23L19/09—Mashed or comminuted products, e.g. pulp, purée, sauce, or products made therefrom, e.g. snacks
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L7/00—Cereal-derived products; Malt products; Preparation or treatment thereof
- A23L7/10—Cereal-derived products
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
- A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/51—Bifidobacterium
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
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Abstract
The invention relates to the technical field of health-care food, and particularly discloses a medlar tablet for improving human intestinal flora and a preparation method thereof. The Chinese wolfberry tablet for improving human intestinal flora is characterized by being prepared from the following raw materials in parts by weight: 65-75 parts of medlar, 0.5-0.7 part of bifidobacterium, 0.5-0.7 part of lactobacillus, 2-3 parts of algal polysaccharide, 5-10 parts of isomaltooligosaccharide, 0.1-0.3 part of thickening agent, 15-18 parts of barley seedling powder and 10-12 parts of oat powder. The preparation method disclosed by the invention is simple in preparation, low in production cost, strong in product bioactivity and high in safety, effectively improves the intestinal flora and the metabolic effect, and can realize industrial and large-scale production.
Description
Technical Field
The invention relates to the technical field of health-care food, in particular to a medlar tablet for improving human intestinal flora and a preparation method thereof.
Background
The intestinal flora is the normal health of human intestinal tract and mainly comprises bacteria, archaea, fungi, viruses and the like. The total number of intestinal bacteria is 100 trillion, which is 10 times of the total number of human cells, and the intestinal bacteria mainly comprise scleroderma, bacteroides, actinomycetes and proteus, wherein the number of strict anaerobes is 2-3 orders of magnitude more than that of facultative anaerobes and aerobes. They can affect body weight and digestive ability, protect against the risk of infection and autoimmune diseases, and control the response of the human body to cancer therapeutic drugs.
Dysbacteriosis refers to the condition of the body where the ratio of the bacteria species in the normal flora is changed greatly and exceeds the normal range, and the disorder caused by the change is dysbacteriosis or alternaria. When the flora is dysregulated, a superinfection or superinfection is caused, i.e. in the treatment of primary infection, another new pathogenic bacterium is infected. The occurrence of dysbacteriosis is frequently seen in the use of antibiotics, chronic wasting diseases, and the like. After a large amount of broad-spectrum antibiotics are clinically applied for a long time, most sensitive bacteria and normal flora are inhibited or killed, and drug-resistant bacteria obtain survival advantage and propagate in large quantities to cause diseases, such as diarrhea and septicemia caused by drug-resistant staphylococcus aureus, thrush, vaginitis, intestinal tract and anus infection and the like caused by antibiotic-insensitive candida albicans.
In the traditional concept, people can improve the intestinal structure by eating fruits or vegetables with skins so as to change the flora ecology of the intestinal tract, but in practice, some people can find that the fruits and vegetables cannot be continuously obtained or eaten for a long time because of the problems of eating habits, regions and the like, such as children who do not like to eat the fruits or vegetables, or people living in remote areas, although the fruits and vegetables can be regulated by taking medicines/probiotics, other harm can be caused to the body by taking medicines for a long time, and the daily expenditure of people is increased; in addition, the biological activity of the traditional probiotics is not ideal, and the research on inhibiting harmful intestinal bacteria, enhancing the immunity of human bodies and further improving the phagocytosis of macrophages on the harmful bacteria so as to improve the intestinal probiotic flora is less.
Disclosure of Invention
The invention provides the medlar tablet which is simple to prepare, has strong probiotics and can obviously improve the immunity of a human body and improve the intestinal flora of the human body and the preparation method thereof in order to make up the defects of the prior art.
The invention is realized by the following technical scheme:
a Chinese wolfberry tablet for improving human intestinal flora is prepared from the following raw materials in parts by weight:
65-75 parts of medlar, 0.5-0.7 part of bifidobacterium, 0.5-0.7 part of lactobacillus, 2-3 parts of algal polysaccharide, 5-10 parts of isomaltooligosaccharide, 0.1-0.3 part of thickening agent, 15-18 parts of barley seedling powder and 10-12 parts of oat powder.
The more preferable weight ratio of the raw materials is as follows:
70 parts of medlar, 0.6 part of bifidobacterium, 0.6 part of lactobacillus, 2.5 parts of algal polysaccharide, 8 parts of isomaltooligosaccharide, 0.2 part of thickening agent, 16 parts of barley seedling powder and 11 parts of oat powder.
The thickening agent is food-grade sodium carboxymethylcellulose, has extremely excellent emulsifying property on animal and vegetable oil, protein and aqueous solution, can form homogeneous emulsion with stable performance, and is safe and reliable.
The invention takes medlar as a main raw material, combines barley grass powder and oat powder, fully utilizes rich nutrient elements of medlar, and adds dietary fiber, soluble fiber and the like to obtain mixed grains; and bifidobacteria, lactic acid bacteria, algal polysaccharide, isomaltooligosaccharide and a food adhesive are added to endow the feed with higher biological activity, so that the intestinal flora environment is effectively improved.
In the invention, the properties of the raw materials are as follows:
fructus Lycii is plant of genus Lycium of family Solanaceae. The medlar is a general name of commercial medlar, plant Ningxia medlar, Chinese medlar and other medlar species, the medlar has sweet and mild nature and taste, and Chinese medicine considers that the medlar can better nourish liver and kidney, benefit essence, improve eyesight, nourish blood and enhance immunity of people. The medlar contains rich carotene and a plurality of vitamins, and the carotene and the vitamins can better prevent heart diseases and cancers. The medlar has good health care efficacy, and is particularly suitable for pregnant women with weak constitution and poor resistance.
The barley seedling powder is a powdery substance obtained by grinding barley, contains rich dietary fiber, and has the main use effects of treating constipation, and helping to lose weight, expel toxin and keep young.
Oat flour is highly refined from flour made from oat groats, is free of cholesterol, has a low amount of whole grain fats, is rich in soluble fiber, starch and gluten, and is useful for lowering blood cholesterol, controlling blood glucose, promoting wound healing, improving constipation, and the like.
Bifidobacterium is a name for a genus of bacteria. The genus bifidobacterium is a gram-positive, immotile, rod-shaped, sometimes bifurcated, strictly anaerobic genus of bacteria with cells at one end, which is found in the human and animal habitat in the digestive tract, vagina and oral cavity. Bacteria of the genus bifidobacterium are one of the important members of the human and animal intestinal flora.
Lactic acid bacteria are a general term for a group of bacteria that can utilize fermentable carbohydrates to produce large amounts of lactic acid. The bacteria are widely distributed in nature and have abundant species diversity; it can change the composition of intestinal flora, improve gastrointestinal function, restore flora balance in intestinal tract, form antibacterial biological barrier, and maintain health.
Algal polysaccharides are a multi-component mixture mainly derived from seaweeds such as kelp, rhaponticum carthamoides (sargassum fusiforme), kelp, Ascophyllum nodosum, Fucus vesiculosus, etc. The algal polysaccharide mainly comprises algin, fucoidan and algin, and mainly has the functions of immunoregulation, antivirus, antioxidation, antitumor, antibiosis and anti-inflammation.
Isomaltooligosaccharides are a mixture of saccharides with different degrees of polymerization, and the main components of the isomaltooligosaccharides comprise: isomaltose, panose, isomaltotriose, isomaltotetraose, and the like. Since the intestinal tract of animals does not have an enzymatic hydrolysis system for hydrolyzing isomaltooligosaccharides, they are not digested and absorbed, but directly enter the large intestine and are preferentially utilized by bifidobacteria, and therefore isomaltooligosaccharides are said to be a growth factor of bifidobacteria, i.e., a bifidus factor. Also called as prebiotics because of its high efficiency in proliferating beneficial bacteria in the intestinal tract.
The preparation method of the medlar tablet comprises the following steps:
(1) freezing and dehydrating the medlar at low temperature to prepare dry fruits;
(2) putting the barley grass powder and the oat powder into a baking oven, and baking the barley grass powder and the oat powder into a cooked product;
(3) mixing, crushing and granulating dried medlar, cooked barley grass powder and oat powder to obtain mixed granules;
(4) placing bifidobacterium, lactobacillus, algal polysaccharide, isomaltooligosaccharide and a thickening agent into a mixer to be uniformly mixed to obtain a mixed auxiliary material;
(5) adding the mixed granules into the mixed auxiliary materials, uniformly mixing, and feeding the mixed raw materials into a tablet machine for forming to obtain a tablet product.
Preferably, in the step (1), the medlar is put into a vacuum freezing drying agent to be frozen to-40 ℃, then the medlar is vacuumized, the heating is started when the vacuum degree reaches 10Pa, and the highest temperature of a clapboard does not exceed 40 ℃; and freeze-drying the medlar for 18-22 hours to obtain dried medlar. The freeze-drying technology is adopted to ensure that the fresh medlar fruits achieve the purpose of biochemical dehydration in the freeze-dried state, the original natural state of the fresh medlar fruits is maintained, the nutrient components or active substances of the fresh medlar fruits are completely maintained, and the color, the appearance shape, the shape after rehydration and the taste of the fresh medlar fruits are basically consistent with those of the fresh fruits.
Preferably, in the step (2), the barley grass powder and the oat flour are baked in an oven at 90-100 ℃ for 40-50 minutes to obtain a cooked product.
The invention carries out freeze-drying and dehydration treatment on the medlar, and after the barley seedling powder and the oat powder are cured, the barley seedling powder and the oat powder are matched with the combination and the cooperative application of bifidobacterium, lactobacillus, algal polysaccharide and isomaltooligosaccharide, thereby effectively realizing the repair of gastrointestinal cell tissues, having the functions of resisting ulcer, resisting oxidation and removing free radicals, promoting the growth and the propagation of bifidobacterium, regulating the micro-ecological balance in the stomach and intestine, improving the gastrointestinal function, obviously improving the integral immunity of a human body and enhancing the physical strength. The product of this application is not the stack of simple raw materials function, and each raw materials component is through scientific compatibility, and the effect of production far exceeds the stack of single component function and effect, has better advance and practicality.
The preparation method disclosed by the invention is simple in preparation, low in production cost, strong in product bioactivity and high in safety, effectively improves the intestinal flora and the metabolic effect, and can realize industrial and large-scale production.
Detailed Description
The technical solutions of the present invention are described in detail below with reference to specific examples to facilitate understanding of the present invention, but the present invention is not limited thereto.
Example 1:
a Chinese wolfberry tablet for improving human intestinal flora is prepared from the following raw materials in parts by weight:
65kg of medlar, 0.5kg of bifidobacterium, 0.5kg of lactobacillus, 2kg of algal polysaccharide, 5kg of isomaltooligosaccharide, 0.1kg of food-grade sodium carboxymethyl cellulose, 15kg of barley seedling powder and 10kg of oat powder.
The preparation method comprises the following steps:
(1) freezing fructus Lycii in vacuum freezing desiccant to-40 deg.C, vacuumizing, heating when vacuum degree reaches 10Pa, and maintaining the highest temperature of the partition board at no more than 40 deg.C; freeze-drying the medlar for 18 hours to obtain dried medlar;
(2) putting the barley grass powder and the oat powder in a baking oven, and baking for 50 minutes at 90 ℃ to obtain a cooked product;
(3) mixing, crushing and granulating dried medlar, cooked barley grass powder and oat powder to obtain mixed granules;
(4) placing bifidobacterium, lactobacillus, algal polysaccharide, isomaltooligosaccharide and food-grade sodium carboxymethylcellulose into a mixer to be uniformly mixed to obtain mixed auxiliary materials;
(5) adding the mixed granules into the mixed auxiliary materials, uniformly mixing, and feeding the mixed raw materials into a tablet press for forming to obtain a tablet product; the tablet product is 1g per tablet, and is chewable.
Example 2:
a Chinese wolfberry tablet for improving human intestinal flora is prepared from the following raw materials in parts by weight:
75kg of medlar, 0.7kg of bifidobacterium, 0.7kg of lactobacillus, 3kg of algal polysaccharide, 10kg of isomaltooligosaccharide, 0.3kg of food-grade sodium carboxymethyl cellulose, 18kg of barley grass powder and 12kg of oat powder.
The preparation method comprises the following steps:
(1) freezing fructus Lycii in vacuum freezing desiccant to-40 deg.C, vacuumizing, heating when vacuum degree reaches 10Pa, and maintaining the highest temperature of the partition board at no more than 40 deg.C; freeze-drying the medlar for 22 hours to obtain dried medlar;
(2) putting the barley grass powder and the oat powder in a baking oven, and baking for 40 minutes at 100 ℃ to obtain a cooked product;
(3) mixing, crushing and granulating dried medlar, cooked barley grass powder and oat powder to obtain mixed granules;
(4) placing bifidobacterium, lactobacillus, algal polysaccharide, isomaltooligosaccharide and food-grade sodium carboxymethylcellulose into a mixer to be uniformly mixed to obtain mixed auxiliary materials;
(5) adding the mixed granules into the mixed auxiliary materials, uniformly mixing, and feeding the mixed raw materials into a tablet press for forming to obtain a tablet product; the tablet product is 1g per tablet, and is chewable.
Example 3:
a Chinese wolfberry tablet for improving human intestinal flora is prepared from the following raw materials in parts by weight:
70kg of medlar, 0.6kg of bifidobacterium, 0.6kg of lactobacillus, 2.5kg of algal polysaccharide, 8kg of isomaltooligosaccharide, 0.2kg of food-grade sodium carboxymethyl cellulose, 16kg of barley seedling powder and 11kg of oat powder.
The preparation method comprises the following steps:
(1) freezing fructus Lycii in vacuum freezing desiccant to-40 deg.C, vacuumizing, heating when vacuum degree reaches 10Pa, and maintaining the highest temperature of the partition board at no more than 40 deg.C; freeze-drying the medlar for 18-22 hours to obtain dried medlar;
(2) placing the barley grass powder and the oat powder in a baking oven, and baking at 90-100 ℃ for 40-50 minutes to obtain a cooked product;
(3) mixing, crushing and granulating dried medlar, cooked barley grass powder and oat powder to obtain mixed granules;
(4) placing bifidobacterium, lactobacillus, algal polysaccharide, isomaltooligosaccharide and food-grade sodium carboxymethylcellulose into a mixer to be uniformly mixed to obtain mixed auxiliary materials;
(5) adding the mixed granules into the mixed auxiliary materials, uniformly mixing, and feeding the mixed raw materials into a tablet press for forming to obtain a tablet product; the tablet product is 1g per tablet, and is chewable.
Application test:
200 patients with symptoms of dyspepsia, constipation, abdominal pain, diarrhea and the like caused by intestinal dysbacteriosis are selected, and the patients are 62 years old at the maximum age and 12 years old at the minimum age. Patients were randomized into two groups, 100 in the experimental group and 100 in the control group.
The experimental group used the tablet product prepared in example 3 of the present invention, and the control group used commercially available probiotics; the other management conditions were the same, the observation period was 15 days, and the experimental results were as follows:
experimental groups: 95 patients are cured, 4 patients are effective, 1 patient is ineffective, and the total effective rate is 99%;
control group: the cure rate is 44, the effective rate is 32, the ineffective rate is 24, and the total effective rate is 76%;
wherein, the cured indicates that the discomfort symptom disappears and the disease does not recur; effective means that the discomfort symptoms are reduced or partially disappeared; null refers to no change or recurrence of malaise symptoms.
The application tests show that the medlar tablet is obviously superior to the general probiotic preparation on the market, the gastrointestinal function is improved more comprehensively and thoroughly, no side effect is caused during use, the intestinal flora is improved, and simultaneously the symptoms caused by intestinal dysfunction such as abdominal pain, diarrhea, vomiting, nausea, dyspepsia, constipation and the like caused by intestinal dysbacteriosis can be relieved, and the application effect is obvious.
In the above embodiments, the best mode of the present invention has been described, and it is apparent that many changes can be made under the inventive concept of the present invention. It should be noted here that any changes made under the inventive concept of the present invention shall fall within the protective scope of the present invention.
Claims (6)
1. The Chinese wolfberry tablet for improving human intestinal flora is characterized by being prepared from the following raw materials in parts by weight: 65-75 parts of medlar, 0.5-0.7 part of bifidobacterium, 0.5-0.7 part of lactobacillus, 2-3 parts of algal polysaccharide, 5-10 parts of isomaltooligosaccharide, 0.1-0.3 part of thickening agent, 15-18 parts of barley seedling powder and 10-12 parts of oat powder.
2. The medlar tablet for improving human intestinal flora according to claim 1, which is prepared from the following raw materials in parts by weight: 70 parts of medlar, 0.6 part of bifidobacterium, 0.6 part of lactobacillus, 2.5 parts of algal polysaccharide, 8 parts of isomaltooligosaccharide, 0.2 part of thickening agent, 16 parts of barley seedling powder and 11 parts of oat powder.
3. A lycium barbarum tablet for improving human intestinal flora according to claim 1 or 2, characterized in that: the thickening agent is food-grade sodium carboxymethyl cellulose.
4. The method of claim 1, wherein the method comprises the steps of: (1) freezing and dehydrating the medlar at low temperature to prepare dry fruits; (2) putting the barley grass powder and the oat powder into a baking oven, and baking the barley grass powder and the oat powder into a cooked product; (3) mixing, crushing and granulating dried medlar, cooked barley grass powder and oat powder to obtain mixed granules; (4) placing bifidobacterium, lactobacillus, algal polysaccharide, isomaltooligosaccharide and a thickening agent into a mixer to be uniformly mixed to obtain a mixed auxiliary material; (5) adding the mixed granules into the mixed auxiliary materials, uniformly mixing, and feeding the mixed raw materials into a tablet machine for forming to obtain a tablet product.
5. The method of claim 4, wherein: in the step (1), the medlar is placed in a vacuum freezing drying agent to be frozen to-40 ℃, then the medlar is vacuumized, the medlar is heated when the vacuum degree reaches 10Pa, and the highest temperature of a clapboard does not exceed 40 ℃; and freeze-drying the medlar for 18-22 hours to obtain dried medlar.
6. The method of claim 4, wherein: in the step (2), the barley grass powder and the oat flour are placed in a baking oven and baked at 90-100 ℃ for 40-50 minutes to obtain a cooked product.
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