CN113750167A - Composition for dispelling effects of alcohol, protecting liver and protecting stomach - Google Patents
Composition for dispelling effects of alcohol, protecting liver and protecting stomach Download PDFInfo
- Publication number
- CN113750167A CN113750167A CN202111231553.4A CN202111231553A CN113750167A CN 113750167 A CN113750167 A CN 113750167A CN 202111231553 A CN202111231553 A CN 202111231553A CN 113750167 A CN113750167 A CN 113750167A
- Authority
- CN
- China
- Prior art keywords
- protecting
- liver
- composition
- vitamin
- stomach
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004185 liver Anatomy 0.000 title claims abstract description 59
- 239000000203 mixture Substances 0.000 title claims abstract description 37
- 210000002784 stomach Anatomy 0.000 title claims abstract description 34
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title description 54
- 230000000694 effects Effects 0.000 title description 31
- 208000007848 Alcoholism Diseases 0.000 claims abstract description 44
- 201000007930 alcohol dependence Diseases 0.000 claims abstract description 43
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims abstract description 42
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 38
- 239000000843 powder Substances 0.000 claims abstract description 38
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 claims abstract description 28
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims abstract description 27
- 229940041514 candida albicans extract Drugs 0.000 claims abstract description 24
- RQFQJYYMBWVMQG-IXDPLRRUSA-N chitotriose Chemical compound O[C@@H]1[C@@H](N)[C@H](O)O[C@H](CO)[C@H]1O[C@H]1[C@H](N)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)N)[C@@H](CO)O1 RQFQJYYMBWVMQG-IXDPLRRUSA-N 0.000 claims abstract description 24
- 239000012138 yeast extract Substances 0.000 claims abstract description 24
- 244000010000 Hovenia dulcis Species 0.000 claims abstract description 23
- 235000008584 Hovenia dulcis Nutrition 0.000 claims abstract description 23
- 229930182816 L-glutamine Natural products 0.000 claims abstract description 22
- 241000233838 Commelina Species 0.000 claims abstract description 21
- 240000001659 Oldenlandia diffusa Species 0.000 claims abstract description 21
- GUJOJGAPFQRJSV-UHFFFAOYSA-N dialuminum;dioxosilane;oxygen(2-);hydrate Chemical compound O.[O-2].[O-2].[O-2].[Al+3].[Al+3].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O GUJOJGAPFQRJSV-UHFFFAOYSA-N 0.000 claims abstract description 21
- 229910052901 montmorillonite Inorganic materials 0.000 claims abstract description 21
- 229960003080 taurine Drugs 0.000 claims abstract description 21
- 235000019156 vitamin B Nutrition 0.000 claims abstract description 21
- 239000011720 vitamin B Substances 0.000 claims abstract description 21
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 19
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 19
- 229960001983 magnesium aspartate Drugs 0.000 claims abstract description 19
- 239000011718 vitamin C Substances 0.000 claims abstract description 19
- 235000019154 vitamin C Nutrition 0.000 claims abstract description 19
- 241000155182 Monochasma Species 0.000 claims abstract description 14
- 229940046001 vitamin b complex Drugs 0.000 claims abstract description 12
- 238000002360 preparation method Methods 0.000 claims abstract description 10
- 239000002994 raw material Substances 0.000 claims abstract description 8
- 229960002743 glutamine Drugs 0.000 claims abstract description 6
- 210000003813 thumb Anatomy 0.000 claims abstract description 4
- 210000000582 semen Anatomy 0.000 claims abstract description 3
- RXMQCXCANMAVIO-CEOVSRFSSA-L magnesium;(2s)-2-amino-4-hydroxy-4-oxobutanoate Chemical compound [H+].[H+].[Mg+2].[O-]C(=O)[C@@H](N)CC([O-])=O.[O-]C(=O)[C@@H](N)CC([O-])=O RXMQCXCANMAVIO-CEOVSRFSSA-L 0.000 claims abstract 5
- 241000411851 herbal medicine Species 0.000 claims description 28
- 238000004880 explosion Methods 0.000 claims description 22
- 238000007710 freezing Methods 0.000 claims description 18
- 230000008014 freezing Effects 0.000 claims description 18
- 239000000463 material Substances 0.000 claims description 18
- 238000002156 mixing Methods 0.000 claims description 14
- 239000012065 filter cake Substances 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 206010019133 Hangover Diseases 0.000 claims description 8
- 150000001875 compounds Chemical class 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- 238000010257 thawing Methods 0.000 claims description 8
- 244000025254 Cannabis sativa Species 0.000 claims description 7
- 229930003270 Vitamin B Natural products 0.000 claims description 7
- 239000000706 filtrate Substances 0.000 claims description 7
- 238000001914 filtration Methods 0.000 claims description 7
- 238000002791 soaking Methods 0.000 claims description 7
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 238000004108 freeze drying Methods 0.000 claims description 2
- 238000010298 pulverizing process Methods 0.000 claims description 2
- 235000019441 ethanol Nutrition 0.000 description 40
- 241000700159 Rattus Species 0.000 description 23
- 239000002158 endotoxin Substances 0.000 description 22
- 239000003814 drug Substances 0.000 description 17
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 17
- 210000001035 gastrointestinal tract Anatomy 0.000 description 16
- CRSJYWPXKKSOCQ-CBAPHJFVSA-L magnesium;(2s)-2-aminobutanedioate;hydron;tetrahydrate Chemical compound O.O.O.O.[Mg+2].[O-]C(=O)[C@@H](N)CC(O)=O.[O-]C(=O)[C@@H](N)CC(O)=O CRSJYWPXKKSOCQ-CBAPHJFVSA-L 0.000 description 14
- 230000001154 acute effect Effects 0.000 description 12
- 230000035622 drinking Effects 0.000 description 12
- 206010061218 Inflammation Diseases 0.000 description 10
- 230000004060 metabolic process Effects 0.000 description 10
- 102000007698 Alcohol dehydrogenase Human genes 0.000 description 9
- 108010021809 Alcohol dehydrogenase Proteins 0.000 description 9
- 230000006378 damage Effects 0.000 description 9
- 230000004054 inflammatory process Effects 0.000 description 9
- 239000000126 substance Substances 0.000 description 9
- 108010081577 aldehyde dehydrogenase (NAD(P)+) Proteins 0.000 description 8
- 210000004369 blood Anatomy 0.000 description 8
- 239000008280 blood Substances 0.000 description 8
- 229940079593 drug Drugs 0.000 description 8
- 229960003180 glutathione Drugs 0.000 description 8
- 230000002829 reductive effect Effects 0.000 description 8
- 241000894006 Bacteria Species 0.000 description 6
- 102000004190 Enzymes Human genes 0.000 description 6
- 108090000790 Enzymes Proteins 0.000 description 6
- 108010024636 Glutathione Proteins 0.000 description 6
- 230000009471 action Effects 0.000 description 6
- 230000002075 anti-alcohol Effects 0.000 description 6
- 230000001965 increasing effect Effects 0.000 description 6
- 210000005228 liver tissue Anatomy 0.000 description 6
- 230000035699 permeability Effects 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 230000004224 protection Effects 0.000 description 6
- 230000003078 antioxidant effect Effects 0.000 description 5
- 238000001035 drying Methods 0.000 description 5
- 230000036541 health Effects 0.000 description 5
- 238000001727 in vivo Methods 0.000 description 5
- 210000005229 liver cell Anatomy 0.000 description 5
- -1 oxygen ions Chemical class 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 206010067125 Liver injury Diseases 0.000 description 4
- 238000009825 accumulation Methods 0.000 description 4
- 230000001476 alcoholic effect Effects 0.000 description 4
- 239000003963 antioxidant agent Substances 0.000 description 4
- 230000004888 barrier function Effects 0.000 description 4
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 4
- 210000004347 intestinal mucosa Anatomy 0.000 description 4
- 230000003908 liver function Effects 0.000 description 4
- 210000000056 organ Anatomy 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 229920001661 Chitosan Polymers 0.000 description 3
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- IKHGUXGNUITLKF-XPULMUKRSA-N acetaldehyde Chemical compound [14CH]([14CH3])=O IKHGUXGNUITLKF-XPULMUKRSA-N 0.000 description 3
- 230000003213 activating effect Effects 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 229940024606 amino acid Drugs 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 210000003056 antler Anatomy 0.000 description 3
- 230000000975 bioactive effect Effects 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 230000003467 diminishing effect Effects 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 231100000234 hepatic damage Toxicity 0.000 description 3
- 208000014674 injury Diseases 0.000 description 3
- 230000000968 intestinal effect Effects 0.000 description 3
- 230000008818 liver damage Effects 0.000 description 3
- 239000011777 magnesium Substances 0.000 description 3
- 229910052749 magnesium Inorganic materials 0.000 description 3
- 229940091250 magnesium supplement Drugs 0.000 description 3
- 230000036542 oxidative stress Effects 0.000 description 3
- 230000008092 positive effect Effects 0.000 description 3
- 239000002243 precursor Substances 0.000 description 3
- 230000035882 stress Effects 0.000 description 3
- 229930003231 vitamin Natural products 0.000 description 3
- 235000013343 vitamin Nutrition 0.000 description 3
- 239000011782 vitamin Substances 0.000 description 3
- 229940088594 vitamin Drugs 0.000 description 3
- 208000012639 Balance disease Diseases 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 206010019233 Headaches Diseases 0.000 description 2
- 206010028813 Nausea Diseases 0.000 description 2
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 description 2
- 102000003992 Peroxidases Human genes 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 235000006708 antioxidants Nutrition 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 208000019425 cirrhosis of liver Diseases 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 208000001848 dysentery Diseases 0.000 description 2
- 206010016256 fatigue Diseases 0.000 description 2
- 229930003935 flavonoid Natural products 0.000 description 2
- 150000002215 flavonoids Chemical class 0.000 description 2
- 235000017173 flavonoids Nutrition 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 231100000869 headache Toxicity 0.000 description 2
- 230000005802 health problem Effects 0.000 description 2
- 230000001976 improved effect Effects 0.000 description 2
- 230000002757 inflammatory effect Effects 0.000 description 2
- 210000002490 intestinal epithelial cell Anatomy 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 230000008693 nausea Effects 0.000 description 2
- 210000005036 nerve Anatomy 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 230000008816 organ damage Effects 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 108040007629 peroxidase activity proteins Proteins 0.000 description 2
- 238000006116 polymerization reaction Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 238000002798 spectrophotometry method Methods 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 235000007586 terpenes Nutrition 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 150000003722 vitamin derivatives Chemical class 0.000 description 2
- 206010000117 Abnormal behaviour Diseases 0.000 description 1
- 102000007469 Actins Human genes 0.000 description 1
- 108010085238 Actins Proteins 0.000 description 1
- 208000022309 Alcoholic Liver disease Diseases 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- RGJOEKWQDUBAIZ-IBOSZNHHSA-N CoASH Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCS)O[C@H]1N1C2=NC=NC(N)=C2N=C1 RGJOEKWQDUBAIZ-IBOSZNHHSA-N 0.000 description 1
- 206010010071 Coma Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 208000004930 Fatty Liver Diseases 0.000 description 1
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 description 1
- 229920002488 Hemicellulose Polymers 0.000 description 1
- 206010019728 Hepatitis alcoholic Diseases 0.000 description 1
- 208000008454 Hyperhidrosis Diseases 0.000 description 1
- RWSXRVCMGQZWBV-PHDIDXHHSA-N L-Glutathione Natural products OC(=O)[C@H](N)CCC(=O)N[C@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-PHDIDXHHSA-N 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- 241000239218 Limulus Species 0.000 description 1
- 208000008167 Magnesium Deficiency Diseases 0.000 description 1
- MSFSPUZXLOGKHJ-UHFFFAOYSA-N Muraminsaeure Natural products OC(=O)C(C)OC1C(N)C(O)OC(CO)C1O MSFSPUZXLOGKHJ-UHFFFAOYSA-N 0.000 description 1
- 208000007101 Muscle Cramp Diseases 0.000 description 1
- BAWFJGJZGIEFAR-NNYOXOHSSA-N NAD zwitterion Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-N 0.000 description 1
- 206010029216 Nervousness Diseases 0.000 description 1
- 206010029240 Neuritis Diseases 0.000 description 1
- 102000003940 Occludin Human genes 0.000 description 1
- 108090000304 Occludin Proteins 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 108010013639 Peptidoglycan Proteins 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 206010041349 Somnolence Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- 102000000591 Tight Junction Proteins Human genes 0.000 description 1
- 108010002321 Tight Junction Proteins Proteins 0.000 description 1
- 102000004243 Tubulin Human genes 0.000 description 1
- 108090000704 Tubulin Proteins 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 206010000059 abdominal discomfort Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 208000038016 acute inflammation Diseases 0.000 description 1
- 230000006022 acute inflammation Effects 0.000 description 1
- 231100001133 acute intoxication condition Toxicity 0.000 description 1
- 235000013334 alcoholic beverage Nutrition 0.000 description 1
- 208000002353 alcoholic hepatitis Diseases 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 150000004056 anthraquinones Chemical class 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 230000008827 biological function Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000005779 cell damage Effects 0.000 description 1
- 208000037887 cell injury Diseases 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 108010089807 chitosanase Proteins 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000007882 cirrhosis Effects 0.000 description 1
- RGJOEKWQDUBAIZ-UHFFFAOYSA-N coenzime A Natural products OC1C(OP(O)(O)=O)C(COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCS)OC1N1C2=NC=NC(N)=C2N=C1 RGJOEKWQDUBAIZ-UHFFFAOYSA-N 0.000 description 1
- 239000005515 coenzyme Substances 0.000 description 1
- 239000005516 coenzyme A Substances 0.000 description 1
- 229940093530 coenzyme a Drugs 0.000 description 1
- 230000001149 cognitive effect Effects 0.000 description 1
- 210000004292 cytoskeleton Anatomy 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- KDTSHFARGAKYJN-UHFFFAOYSA-N dephosphocoenzyme A Natural products OC1C(O)C(COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCS)OC1N1C2=NC=NC(N)=C2N=C1 KDTSHFARGAKYJN-UHFFFAOYSA-N 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002212 flavone derivatives Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 238000003988 headspace gas chromatography Methods 0.000 description 1
- 231100000753 hepatic injury Toxicity 0.000 description 1
- 230000008105 immune reaction Effects 0.000 description 1
- 230000007365 immunoregulation Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000028709 inflammatory response Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 210000005027 intestinal barrier Anatomy 0.000 description 1
- 230000007358 intestinal barrier function Effects 0.000 description 1
- 230000004673 intestinal mucosal barrier function Effects 0.000 description 1
- 230000003870 intestinal permeability Effects 0.000 description 1
- 230000035987 intoxication Effects 0.000 description 1
- 231100000566 intoxication Toxicity 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 229920005610 lignin Polymers 0.000 description 1
- 230000003859 lipid peroxidation Effects 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 235000004764 magnesium deficiency Nutrition 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 210000004379 membrane Anatomy 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 210000004688 microtubule Anatomy 0.000 description 1
- 229950006238 nadide Drugs 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- 230000004112 neuroprotection Effects 0.000 description 1
- 230000004768 organ dysfunction Effects 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000004792 oxidative damage Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 108010023506 peroxygenase Proteins 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000026731 phosphorylation Effects 0.000 description 1
- 238000006366 phosphorylation reaction Methods 0.000 description 1
- 206010036067 polydipsia Diseases 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 230000005195 poor health Effects 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000011552 rat model Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 230000011506 response to oxidative stress Effects 0.000 description 1
- 229920002477 rna polymer Polymers 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000000405 serological effect Effects 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 230000005062 synaptic transmission Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000001839 systemic circulation Effects 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 150000003573 thiols Chemical group 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 210000001578 tight junction Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 239000011573 trace mineral Chemical class 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 230000005945 translocation Effects 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 238000000870 ultraviolet spectroscopy Methods 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
- 210000004916 vomit Anatomy 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
- A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/064—Saccharomycetales, e.g. baker's yeast
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/748—Oldenlandia or Hedyotis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Inorganic Chemistry (AREA)
- Toxicology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses a composition for relieving alcoholism, protecting liver and protecting stomach, which comprises the following raw materials: chitosan oligosaccharide, montmorillonite, N-acetyl-L-cysteine, L-glutamine, taurine, vitamin C, vitamin B complex, magnesium aspartate, yeast extract powder, cornu Cervi Pantotrichum, herba Hedyotidis Diffusae, herba Commelinae, and semen Hoveniae; the weight ratio of chitosan oligosaccharide, montmorillonite, N-acetyl-L-cysteine, L-glutamine, taurine, vitamin C, vitamin B complex, magnesium aspartate, yeast extract powder, savoury monochasma herb, spreading hedyotis herb, dayflower and hovenia dulcis thumb is 60-100: 100-300: 20-80: 20-80: 3-10: 5-20: 5-10: 5-20: 20-800: 3500-4500: 1500-2500: 1500-2500: 3500-4500. The invention also discloses a preparation method of the composition for relieving alcoholism, protecting liver and protecting stomach.
Description
Technical Field
The invention relates to the technical field of anti-alcohol products, in particular to an anti-alcohol liver-protecting and stomach-protecting composition and a preparation method thereof.
Background
With the rapid development of socioeconomic, alcoholic beverages have become an essential part of people's daily life, especially in the places of gathering together such as holidays and wedding celebration. The world health organization surveys that 2016 (15 years old) of people drinking alcohol accounts for about 43% of the global population (31.13 billion) except for countless areas. Since 2000, the proportion of people who drunk wine has decreased, but the amount of wine drunk by all people has increased, and the health problems caused by drinking wine still remain inconstant. However, health problems associated with drinking are often overlooked by people. After long-term drinking or a large amount of alcohol is taken at one time, the whole body inflammation reaction can be excited, further organism organs are damaged, organism tissues or organ dysfunction is caused, and chronic diseases such as chronic liver diseases, gastrointestinal cancer, inflammatory bowel syndrome and the like are finally caused.
The Gastrointestinal tract (GIT), as the first line of defense against ingested material, is very vulnerable to toxins, and poor health of the gi tract can have a serious impact on the overall health of the body. Excessive drinking is the leading cause of high mortality from liver-related diseases. Alcohol-induced liver damage includes a spectrum of changes in liver steatosis, alcoholic hepatitis, liver fibrosis and cirrhosis, and these underlying pathologies can occur either separately or simultaneously or sequentially on the patient. The occurrence and development of alcoholic liver diseases are closely related to drinking manner (acute or chronic), drinking amount (excessive or not), environmental and genetic factors and the like.
Once drinking too much, it is easy to show drunkenness state, abnormal behavior and consciousness, gastrointestinal and liver are liable to alcoholic acute inflammation, vegetative nerve balance disorder causes heart beat acceleration, water and electrolyte balance disorder in blood, and it can also cause encephaledema and functional neuritis, serious or even coma or even death, especially, after night rest, there will be hangover phenomenon, often with symptoms of headache, dizziness, fatigue, nausea, stomach discomfort, drowsiness, sweating, extreme thirst and cognitive ambiguity. This is because after drinking a large amount of alcohol, the liver cells cannot completely remove harmful substances after alcohol metabolism, such as acetaldehyde, and the like, thereby causing acute intoxication symptoms.
Exposure to alcohol promotes the growth of gram negative bacteria in the gut, which may lead to the accumulation of endotoxins. Furthermore, alcohol metabolism by gram-negative bacteria and intestinal epithelial cells leads to accumulation of acetaldehyde, thereby increasing the permeability of the intestinal tract to endotoxins by increasing tyrosine phosphorylation of tight junction and adhesion junction proteins. Alcohol-induced nitric oxide production may also increase the permeability to endotoxins by reacting with tubulin, which may lead to damage of the microtubule cytoskeleton and subsequent disruption of the intestinal barrier function. Increased intestinal permeability leads to the translocation of endotoxin from the gut to the liver and systemic circulation, where it may trigger inflammatory changes in the liver and other organs. Alcohol may also increase the permeability of the intestinal tract to peptidoglycan, thereby triggering an inflammatory response in the liver and other organs. Reducing the number of gram-negative bacteria in the gut leads to a reduction in the production of endotoxin and acetaldehyde, which is expected to reduce the permeability of the gut to endotoxin. Thus, reducing the number of gram negative bacteria in the gut and maintaining gut permeability to endotoxin may reduce alcoholic liver and other organ damage.
In recent years, as people demand more and more alcohol consumption, the physical harm caused by alcoholism is more and more serious. However, the existing anti-alcoholics in the market only focus on liver health, and do not pay attention to the influence of alcohol on gastrointestinal tract health. The anti-alcohol drugs on the market have doubts in the aspects of safety and the effects of relieving alcoholism, protecting liver and protecting stomach. Therefore, the research of the subject aims to make up the defects of the dealcoholic drugs on the market in the aspects of dealcoholic action, liver protection and stomach protection, selects vitamins, modified amino acids and trace elements required in the dealcoholic action process, also selects natural substances capable of forming gastrointestinal protection barriers, searches compound traditional Chinese medicine substances in medicinal and edible dealcoholic drugs, explores the mechanism of dealcoholic action and liver protection, and verifies the effect and safety of the dealcoholic action to provide a theoretical basis for the research and development of the dealcoholic action product.
Disclosure of Invention
The invention aims to solve the defects in the prior art and provides a composition for relieving alcoholism, protecting liver and protecting stomach and a preparation method thereof.
The composition for relieving alcoholism, protecting liver and protecting stomach is characterized by comprising the following raw materials: chitosan oligosaccharide, montmorillonite, N-acetyl-L-cysteine, L-glutamine, taurine, vitamin C, vitamin B complex, magnesium aspartate, yeast extract powder, cornu Cervi Pantotrichum, herba Hedyotidis Diffusae, herba Commelinae, and semen Hoveniae; the weight ratio of chitosan oligosaccharide, montmorillonite, N-acetyl-L-cysteine, L-glutamine, taurine, vitamin C, vitamin B complex, magnesium aspartate, yeast extract powder, savoury monochasma herb, spreading hedyotis herb, dayflower and hovenia dulcis thumb is 60-100: 100-300: 20-80: 20-80: 3-10: 5-20: 5-10: 5-20: 20-800: 3500-4500: 1500-2500: 1500-2500: 3500-4500.
Preferably, the mass ratio of the pilose antler grass, the spreading hedyotis herb, the dayflower herb and the hovenia dulcis thunb is 38-42: 18-22: 16-24: 37-43.
Preferably, the mass sum of the pilose antler grass, the spreading hedyotis herb, the dayflower herb and the hovenia dulcis thunb is a, and the mass of the montmorillonite is b, so that the mass ratio of a: 109-: 1-3.
Preferably, the mass ratio of the N-acetyl-L-cysteine to the L-glutamine is 1-4: 1-4.
Preferably, the sum of the mass of the N-acetyl-L-cysteine and the mass of the L-glutamine is C, the mass of the yeast extract powder is d, the mass of the vitamin C is e, C: d: e-4-16: 2-80: 0.5-2.
Chitosan Oligosaccharide (COS) is obtained by degrading Chitosan (CS) by enzymes such as chitosanase, and the polymerization degree of the COS is 2-20. Compared with CS, COS has good water solubility and biocompatibility, and is easier to absorb, convert and utilize in vivo, so as to exert biological functions of anti-inflammation, antioxidation, immunoregulation, neuroprotection and the like. By relieving the damage of alcohol to the structure and the function of the small intestine of a rat, the oxidative stress reaction is inhibited, the intestinal microbial environment is improved, and the intestinal mucosa barrier is obviously protected.
N-acetyl-L-cysteine (NAC) is a modified amino acid, one of the important bioactive substances in vivo, and has antioxidant activity. NAC is a precursor of L-glutathione, which has a thiol side chain in its structure and is also a major source of Glutathione (GSH) synthesis. Currently, there are studies that demonstrate that NAC has some protective effect on alcohol liver damage and can alleviate hangover symptoms, including nausea, headache and anxiety.
Glutamine (Gln) is one of important energy substances of intestinal epithelial cells, can provide about 70% of energy for the metabolic activity of intestinal tracts, is also an important precursor for synthesis of Glutathione (GSH) and the like, and can participate in regulation of cellular redox to restore actin cytoskeleton, promote expression of intestinal Occludin protein and inhibit inflammatory reaction, so that the intestinal mucosal barrier is enhanced, and the injury degree of intestinal mucosa is reduced. In many domestic reports, glutamine has a significant therapeutic effect on alcohol-induced intestinal inflammation.
Magnesium is a good muscle supplement, providing the body with a number of key enzymes that support metabolic processes, plays the most important role in maintaining and promoting effective muscle mass function and neurotransmission, and may also help minimize stress, nervousness and insomnia. Magnesium is an important nutrient for a number of cellular chemicals that are involved in the energy production and metabolic processes of the system. Alcohol deprives the body of magnesium, causing the body to feel tired. Magnesium deficiency may also lead to muscle spasms, dehydration and lactic acid accumulation.
Yeast is a unicellular eukaryotic microorganism, is rich in nutrients such as protein, fat, B vitamins and amino acids, and also contains rich bioactive substances such as coenzyme I, coenzyme A, glutathione and ribonucleic acid. When the liver is damaged, the zinc and B vitamins contained in the yeast extract powder, and bioactive components such as reductive glutathione and coenzyme contained in the yeast extract powder can effectively remove oxygen ions and free radicals in vivo, protect liver cell membranes, promote the activity of the liver enzyme, and achieve the effects of relieving alcoholism and fatigue.
The cornu Cervi Pantotrichum has antiinflammatory and cough relieving effects, and its main chemical components are phenylethanoid glycosides, flavonoids, etc.; herba Commelinae has pharmacological effects of resisting inflammation, relieving pain, resisting oxidation, resisting influenza virus, and protecting liver, and contains flavone, alkaloid, coumarin, terpenes, and steroid; herba Hedyotidis Diffusae has anticancer, antioxidant, and antiinflammatory effects, and its main chemical components are terpenes, flavonoids, anthraquinones, and polysaccharides. The three traditional Chinese medicines have the effects of clearing away heat and toxic materials, diminishing inflammation, stopping dysentery and the like.
Active ingredients such as peroxygenase contained in the hovenia dulcis thunb have the effects of sobering up and soothing nerves, and the hovenia dulcis thunb is also widely used for treating alcoholism in folks. Taurine can regulate Ca in liver cell2+Balancing, improving activity of alcohol dehydrogenase and acetaldehyde dehydrogenase in liver, reducing release of peroxidase, and effectively protecting liver cells.
In conclusion, the invention adopts the matching of N-acetyl-L-cysteine and glutamine to effectively supplement the content of a synthetic precursor of glutathione in an organism, and then is matched with yeast extract powder and vitamin C, so that the organism can quickly synthesize reducing substances such as glutathione and the like when the liver detoxifies and is damaged in a drunkenness state, oxygen ions and free radicals in the organism are effectively eliminated, and liver cells are protected; the yeast extract powder is compounded with the vitamin B complex and the magnesium aspartate, so that an organism quickly synthesizes reaction enzyme, the metabolism of ethanol is accelerated, and the activity of alcohol dehydrogenase and acetaldehyde dehydrogenase in liver is further improved by matching with taurine, the release of peroxidase is reduced, and liver cells can be effectively protected.
In the drunkenness state, the organism presents stress reaction of internal heat, and symptoms such as dryness-heat, vomit, diarrhea and the like can be caused, and simultaneously, because the alcohol can promote the growth of gram-negative bacteria in the intestinal tract, the accumulation and the penetration of endotoxin are caused, the invention adopts the antlerpilose grass, the spreading hedyotis herb, the dayflower and the hovenia dulcis thunb as the traditional Chinese medicine components to be matched with montmorillonite, on one hand, the stress and the inflammatory reaction of the organism such as sobering up and calming, clearing heat and detoxifying, diminishing inflammation and stopping dysentery and inhibiting diarrhea can be realized, on the other hand, the intestinal tract endotoxin can be effectively adsorbed, and the endotoxin is prevented from further inducing the immune reaction of the organism along with the running of a circulating system; and chitosan oligosaccharide, taurine, N-acetyl-L-cysteine and glutamine are matched, so that the invention has the functions of diminishing inflammation and lightens the inflammatory reaction of organisms.
The preparation method of the composition for relieving alcoholism, protecting liver and protecting stomach comprises the following steps:
step 1, mixing and soaking the savatier monochasma herb, the spreading hedyotis herb, the dayflower herb and the hovenia dulcis thunb in water, freezing, then thawing, filtering, and freeze-drying the filtrate to obtain herbal medicine filter powder;
step 2, feeding the filter cake obtained in the step 1 into a steam explosion tank, introducing steam at the speed of 60-80mL/min, adjusting the pressure in the steam explosion tank to be 2.8-3.6Mpa, maintaining the pressure for 8-16min, and instantly opening a valve at the bottom of the steam explosion tank to obtain a herbal medicine prefabricated material;
and 3, crushing the herbal medicine prefabricated material at low temperature, adding chitosan oligosaccharide, yeast extract powder, taurine, vitamin C, compound vitamin B, N-acetyl-L-cysteine, L-glutamine, magnesium aspartate, herbal medicine filter powder and montmorillonite, and mixing to obtain the composition for relieving alcoholism and protecting liver and stomach.
Preferably, in the step 1, the temperature of the freezing treatment is-8 to-12 ℃, and the time of the freezing treatment is 1 to 2 hours.
Preferably, the temperature is continuously maintained at 10-15 ℃ during the low-temperature pulverization in the step 3.
According to the invention, the antlerpilose grass, the spreading hedyotis herb, the dayflower herb and the hovenia dulcis thunb are subjected to freezing treatment, so that the cell wall is subjected to freeze thawing, the cell content flows out, and the thermosensitive active ingredients are prevented from being damaged, however, the freezing treatment is not thorough, and a large amount of active ingredients still exist in a filter cake, so that the filter cake is not convenient for an organism to absorb; the invention continuously adopts steam explosion treatment, realizes the separation and change of the microstructure of the filter cake by instant pressure release, the polymerization degree of cellulose and hemicellulose is reduced under the action of high-temperature and high-pressure steam, the transverse connection strength is reduced, and water vapor in pores is rapidly expanded and the lignin is stripped during the instant pressure release, thereby weakening the bonding between fibers and enabling an organism to more easily absorb active effective components.
Detailed Description
The present invention will be further illustrated with reference to the following specific examples.
Example 1
A composition for relieving alcoholism, protecting liver and protecting stomach comprises the following raw materials: 600mg of chitosan oligosaccharide, 3000mg of montmorillonite, 200mg of N-acetyl-L-cysteine, 800mg of L-glutamine, 30mg of taurine, 200mg of vitamin C200mg, 50mg of vitamin B complex, 200mg of magnesium aspartate, 200mg of yeast extract powder, 45000mg of savatier monochasma herb, 15000mg of spreading hedyotis herb, 25000mg of dayflower herb and 35000mg of hovenia dulcis thunb.
The preparation method of the composition for relieving alcoholism, protecting liver and protecting stomach comprises the following steps:
step 1, mixing and soaking the savatier monochasma herb, the spreading hedyotis herb, the dayflower and the hovenia dulcis thunb in water, freezing for 2 hours at the temperature of-8 ℃, then thawing and filtering, and freezing and drying the filtrate to obtain herbal medicine filter powder;
step 2, feeding the filter cake obtained in the step 1 into a steam explosion tank, introducing steam at the speed of 80mL/min, adjusting the pressure in the steam explosion tank to be 2.8Mpa, maintaining the pressure for 16min, and instantly opening a valve at the bottom of the steam explosion tank to obtain a herbal medicine prefabricated material;
and 3, crushing the herbal medicine prefabricated material at a low temperature, continuously maintaining the temperature at 10 ℃ in the process of crushing at the low temperature, and adding chitosan oligosaccharide, yeast extract powder, taurine, vitamin C, compound vitamin B, N-acetyl-L-cysteine, L-glutamine, magnesium aspartate, herbal medicine filter powder and montmorillonite for mixing to obtain the composition for relieving alcoholism and protecting liver and stomach.
Example 2
A composition for relieving alcoholism, protecting liver and protecting stomach comprises the following raw materials: 1000mg of chitosan oligosaccharide, 1000mg of montmorillonite, 800mg of N-acetyl-L-cysteine, 200mg of L-glutamine, 100mg of taurine, 50mg of vitamin C, 100mg of vitamin B complex, 50mg of magnesium aspartate, 8000mg of yeast extract powder, 35000mg of savatier monochasma herb, 25000mg of oldenlandia diffusa, 15000mg of dayflower and 45000mg of hovenia dulcis thunb.
The preparation method of the composition for relieving alcoholism, protecting liver and protecting stomach comprises the following steps:
step 1, mixing and soaking antlerpilose grass, spreading hedyotis herb, dayflower and hovenia dulcis thunb in water, freezing for 1h at the temperature of-12 ℃, then thawing and filtering, and freezing and drying the filtrate to obtain herbal medicine filter powder;
step 2, feeding the filter cake obtained in the step 1 into a steam explosion tank, introducing steam at the speed of 60mL/min, adjusting the pressure in the steam explosion tank to be 3.6Mpa, maintaining the pressure for 8min, and instantly opening a valve at the bottom of the steam explosion tank to obtain a herbal medicine prefabricated material;
and 3, crushing the herbal medicine prefabricated material at a low temperature, continuously maintaining the temperature at 15 ℃ in the process of crushing at the low temperature, adding chitosan oligosaccharide, yeast extract powder, taurine, vitamin C, compound vitamin B, N-acetyl-L-cysteine, L-glutamine, magnesium aspartate, herbal medicine filter powder and montmorillonite, and mixing to obtain the composition for relieving alcoholism and protecting liver and stomach.
Example 3
A composition for relieving alcoholism, protecting liver and protecting stomach comprises the following raw materials: 700mg of chitosan oligosaccharide, 2500mg of montmorillonite, 400mg of N-acetyl-L-cysteine, 600mg of L-glutamine, 40mg of taurine, 180mg of vitamin C, 60mg of vitamin B complex, 150mg of magnesium aspartate, 1000mg of yeast extract powder, 42000mg of pilose antler grass, 18000mg of oldenlandia diffusa, 24000mg of dayflower and 37000mg of hovenia dulcis thunb.
The preparation method of the composition for relieving alcoholism, protecting liver and protecting stomach comprises the following steps:
step 1, mixing and soaking the savatier monochasma herb, the spreading hedyotis herb, the dayflower and the hovenia dulcis thunb in water, freezing for 100min at the temperature of minus 9 ℃, then thawing and filtering, and freezing and drying the filtrate to obtain herbal medicine filter powder;
step 2, feeding the filter cake obtained in the step 1 into a steam explosion tank, introducing steam at the speed of 75mL/min, adjusting the pressure in the steam explosion tank to be 3Mpa, maintaining the pressure for 14min, and instantly opening a valve at the bottom of the steam explosion tank to obtain a herbal medicine prefabricated material;
and 3, crushing the herbal medicine prefabricated material at a low temperature, continuously maintaining the temperature at 12 ℃ in the process of crushing at the low temperature, adding chitosan oligosaccharide, yeast extract powder, taurine, vitamin C, compound vitamin B, N-acetyl-L-cysteine, L-glutamine, magnesium aspartate, herbal medicine filter powder and montmorillonite, and mixing to obtain the composition for relieving alcoholism and protecting liver and stomach.
Example 4
A composition for relieving alcoholism, protecting liver and protecting stomach comprises the following raw materials: 900mg of chitosan oligosaccharide, 1500mg of montmorillonite, 600mg of N-acetyl-L-cysteine, 400mg of L-glutamine, 80mg of taurine, 80mg of vitamin C, 90mg of vitamin B complex, 90mg of magnesium aspartate, 7000mg of yeast extract powder, 38000mg of savatier monochasma herb, 22000mg of spreading hedyotis herb, 16000mg of dayflower and 43000mg of hovenia dulcis thumb.
The preparation method of the composition for relieving alcoholism, protecting liver and protecting stomach comprises the following steps:
step 1, mixing and soaking the savatier monochasma herb, the spreading hedyotis herb, the dayflower and the hovenia dulcis thunb in water, freezing for 80min at the temperature of-11 ℃, then thawing and filtering, and freezing and drying the filtrate to obtain herbal medicine filter powder;
step 2, feeding the filter cake obtained in the step 1 into a steam explosion tank, introducing steam at the speed of 65mL/min, adjusting the pressure in the steam explosion tank to be 3.4Mpa, maintaining the pressure for 10min, and instantly opening a valve at the bottom of the steam explosion tank to obtain a herbal medicine prefabricated material;
and 3, crushing the herbal medicine prefabricated material at a low temperature, continuously maintaining the temperature at 14 ℃ in the process of crushing at the low temperature, adding chitosan oligosaccharide, yeast extract powder, taurine, vitamin C, compound vitamin B, N-acetyl-L-cysteine, L-glutamine, magnesium aspartate, herbal medicine filter powder and montmorillonite, and mixing to obtain the composition for relieving alcoholism and protecting liver and stomach.
Example 5
A composition for relieving alcoholism, protecting liver and protecting stomach comprises the following raw materials: 800mg of chitosan oligosaccharide, 2000mg of montmorillonite, 500mg of N-acetyl-L-cysteine, 500mg of L-glutamine, 60mg of taurine, 130mg of vitamin C130mg, 75-75 mg of vitamin B complex, 120mg of magnesium aspartate, 4000mg of yeast extract powder, 40000mg of savatier monochasma herb, 20000mg of spreading hedyotis herb, 20000mg of dayflower herb and 40000mg of hovenia dulcis thunb.
The preparation method of the composition for relieving alcoholism, protecting liver and protecting stomach comprises the following steps:
step 1, mixing and soaking the savatier monochasma herb, the spreading hedyotis herb, the dayflower and the hovenia dulcis thunb in water, freezing for 90min at the temperature of-10 ℃, then thawing and filtering, and freezing and drying the filtrate to obtain herbal medicine filter powder;
step 2, feeding the filter cake obtained in the step 1 into a steam explosion tank, introducing steam at the speed of 70mL/min, adjusting the pressure in the steam explosion tank to be 3.2Mpa, maintaining the pressure for 12min, and instantly opening a valve at the bottom of the steam explosion tank to obtain a herbal medicine prefabricated material;
and 3, crushing the herbal medicine prefabricated material at a low temperature, continuously maintaining the temperature at 13 ℃ in the process of crushing at the low temperature, and adding chitosan oligosaccharide, yeast extract powder, taurine, vitamin C, compound vitamin B, N-acetyl-L-cysteine, L-glutamine, magnesium aspartate, herbal medicine filter powder and montmorillonite for mixing to obtain the composition for relieving alcoholism and protecting liver and stomach.
Test of
Now, according to the invention, rats with the weight of about 200g and age at 7 weeks are randomly divided into a blank control group, a model group, a domestic anti-inebriation medicine group (the manufacturer is Shenzhen Shangwang health science and technology development Limited company), a Japanese imported anti-inebriation medicine group (the manufacturer is Kabushiki Kaisha ファンケル (Fancl CORPORATION)), an example 5 group, and 5 groups are selected, wherein each group comprises 10 rats. A large amount of 56-degree Hongxing Erguotou white spirit is adopted to perform primary intragastric administration to replicate an acute alcoholism animal model.
Test example 1 Effect of anti-hangover drug on alcohol metabolism in acute alcoholism rats
According to the metabolism characteristics of alcohol in vivo, blood samples are respectively taken at different time points (0.5h, 1h, 1.5h, 2h, 3h and 6h) after drinking, and the ethanol concentration in blood is detected by using a headspace gas chromatography.
Effect of acute alcoholism rat blood concentration of intoxication:
the blood ethanol concentration of the control group, the model group and each experimental group continuously rises after the wine is fed, the ethanol concentration peak is continuously reduced after 90min, and the ethanol peak concentration of rats in the example 5 group is obviously lower than that of other groups at 90 min.
Compared with the model group, the alcohol effect dispelling medicine group made in China, the imported alcohol effect dispelling medicine group and the group in the embodiment 5 can obviously reduce the concentration of the ethanol in the blood after 5 hours, and the composition obtained in the embodiment 5 has a good treatment effect on the aspect of promoting the metabolism of the ethanol and shows a good alcohol effect dispelling effect. The invention shows better treatment effect and has better anti-inebriation effect on the aspect of accelerating alcohol metabolism.
Test example 2 Effect of antialcoholic drugs on liver function, liver alcohol dehydrogenase activity and acetaldehyde dehydrogenase activity of acute alcoholism rats
According to the metabolism characteristics of alcohol in vivo, the materials are respectively taken 5h after drinking, and the activity of alcohol dehydrogenase in liver is detected by using an ultraviolet-visible spectrophotometry.
The results are as follows:
from the above table, it can be seen that:
1. a rat model of acute alcoholism is established by intragastric administration of 0.12ml/10g of 56-degree Hongxing Erguotou, and the composition obtained in example 5 is found to have an activating effect on both Alcohol Dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH). The anti-alcoholism mechanism of the invention is to relieve acute alcoholism by activating ADH and ALDH.
2. Effect of liver function in acute alcoholism rats: the liver function (ALT and AST levels) is detected by taking the material 5h after drinking according to the characteristics of serological and enzymatic changes. Compared with the model group, each experimental group can reduce the AST and ALT levels in the serum of the rat to different degrees, thereby improving the liver function of the rat.
The invention is superior to other administration groups in the aspect of improving abnormal liver AST and ALT levels caused by alcohol (5 hours after drinking), namely the invention has better liver protection effect on alcohol-induced liver injury.
Test example 3 Effect of anti-hangover pharmaceutical composition on oxidative stress of liver tissue in rats with acute alcoholism
Detecting SOD and MDA in rat liver tissue 5h after drinking by using an ultraviolet spectrophotometry, measuring the absorbance of ROS in the liver tissue by using a fluorescence spectrophotometry, and calculating the activity of the ROS in the tissue. The results are as follows:
from the above table, it can be seen that: compared with the blank group, after the rats in the model group are subjected to liquor gavage for 5 hours, the liver SOD activity is obviously reduced, and the MDA and ROS contents are obviously increased, so that the oxidative stress injury of the rats can be caused by continuous large-amount alcohol intake.
Compared with the model group, the domestic anti-inebriation medicine group, the imported anti-inebriation medicine group and the example 5 group all enhance the expression of antioxidant enzyme SOD in the liver, accelerate the catabolism of lipid peroxides (MDA and ROS) and reduce the damage of alcohol to the liver tissue of rats.
In addition, the group of example 5 is superior to other administration groups in enhancing the antioxidant capacity of rats, alleviating lipid peroxidation, and improving oxidative stress-induced cell damage, i.e., the present invention shows a positive effect on alleviating alcohol-induced liver damage.
Test example 4 Effect of antialcoholic drugs on the content of endotoxin (LPS) in plasma of rats with acute alcoholism
The protective effect of the alcohol drug on the intestinal mucosa barrier is discussed in a rat acute alcoholism model. The intestinal mucosa barrier protection effect of the chitosan oligosaccharide is explored by measuring the content of endotoxin (LPS) in the plasma of rats. Endotoxin was measured according to the limulus kit instructions of the quantitative chromogenic matrix method.
The results show that: the anti-alcoholism drug can remarkably reduce the LPS content in the plasma of rats, and inhibit the endotoxin transfer to the whole body caused by alcohol and the rise of the endotoxin content in the blood caused by the endotoxin transfer. Example 5 the group was superior to the other groups administered in increasing or decreasing the number of gram-negative bacteria in the intestine and maintaining the permeability of the intestine to endotoxin, i.e. the present invention showed a positive effect on a broad reduction in alcoholic liver, intestinal tract and other organ damage.
In conclusion, an acute alcoholism model is established by intragastrically feeding the rats with 0.12ml/10g of 56-degree Hongxing Erguotou every day, which shows that the anti-alcoholism medicine composition can reduce the blood alcohol concentration of the rats and has an activating effect on liver Alcohol Dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH). Serum biochemical indicators ALT, AST and endotoxin (LPS) are reduced to different degrees, namely the composition has positive effect on reducing alcoholic liver, intestinal tract and other organ injuries. In liver tissues, the invention enhances the expression of antioxidant enzyme SOD in the liver, accelerates the catabolism of lipid peroxides (MDA and ROS), and reduces the oxidative damage of alcohol to the liver tissues of rats. The invention can effectively relieve the harm caused by chronic alcoholism and has good oxidation damage resistance.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (8)
1. The composition for relieving alcoholism, protecting liver and protecting stomach is characterized by comprising the following raw materials: chitosan oligosaccharide, montmorillonite, N-acetyl-L-cysteine, L-glutamine, taurine, vitamin C, vitamin B complex, magnesium aspartate, yeast extract powder, cornu Cervi Pantotrichum, herba Hedyotidis Diffusae, herba Commelinae, and semen Hoveniae; the weight ratio of chitosan oligosaccharide, montmorillonite, N-acetyl-L-cysteine, L-glutamine, taurine, vitamin C, vitamin B complex, magnesium aspartate, yeast extract powder, savoury monochasma herb, spreading hedyotis herb, dayflower and hovenia dulcis thumb is 60-100: 100-300: 20-80: 20-80: 3-10: 5-20: 5-10: 5-20: 20-800: 3500-4500: 1500-2500: 1500-2500: 3500-4500.
2. The composition for relieving alcoholism, protecting liver and protecting stomach according to claim 1, wherein the mass ratio of the pilose grass, the spreading hedyotis herb, the dayflower herb and the hovenia dulcis thunb is 38-42: 18-22: 16-24: 37-43.
3. The composition for alleviating hangover, protecting the liver and protecting the stomach as claimed in claim 1, wherein the sum of the mass of the savatier monochasma herb, the spreading hedyotis herb, the dayflower herb and the hovenia dulcis thunb is a, and the mass of the montmorillonite is b, so that a: 109-: 1-3.
4. The composition for relieving alcoholism, protecting liver and protecting stomach according to claim 1, wherein the mass ratio of N-acetyl-L-cysteine to L-glutamine is 1-4: 1-4.
5. The composition for alleviating hangover, protecting the liver and protecting the stomach according to claim 1, wherein the sum of the mass of N-acetyl-L-cysteine and L-glutamine is C, the mass of yeast extract powder is d, the mass of vitamin C is e, and the mass of C: d: e-4-16: 2-80: 0.5-2.
6. A process for preparing the composition for sobering up, protecting liver and protecting stomach as claimed in any one of claims 1 to 5, comprising the steps of:
step 1, mixing and soaking the savatier monochasma herb, the spreading hedyotis herb, the dayflower herb and the hovenia dulcis thunb in water, freezing, then thawing, filtering, and freeze-drying the filtrate to obtain herbal medicine filter powder;
step 2, feeding the filter cake obtained in the step 1 into a steam explosion tank, introducing steam at the speed of 60-80mL/min, adjusting the pressure in the steam explosion tank to be 2.8-3.6Mpa, maintaining the pressure for 8-16min, and instantly opening a valve at the bottom of the steam explosion tank to obtain a herbal medicine prefabricated material;
and 3, crushing the herbal medicine prefabricated material at low temperature, adding chitosan oligosaccharide, yeast extract powder, taurine, vitamin C, compound vitamin B, N-acetyl-L-cysteine, L-glutamine, magnesium aspartate, herbal medicine filter powder and montmorillonite, and mixing to obtain the composition for relieving alcoholism and protecting liver and stomach.
7. The preparation method of the composition for alleviating hangover, protecting the liver and protecting the stomach as claimed in claim 6, wherein in the step 1, the temperature of the freezing treatment is-8 to-12 ℃, and the time of the freezing treatment is 1 to 2 hours.
8. The method for preparing the composition for alleviating hangover, protecting the liver and protecting the stomach as claimed in claim 6, wherein the temperature is continuously maintained at 10-15 ℃ during the low-temperature pulverization in the step 3.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111231553.4A CN113750167A (en) | 2021-10-22 | 2021-10-22 | Composition for dispelling effects of alcohol, protecting liver and protecting stomach |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111231553.4A CN113750167A (en) | 2021-10-22 | 2021-10-22 | Composition for dispelling effects of alcohol, protecting liver and protecting stomach |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113750167A true CN113750167A (en) | 2021-12-07 |
Family
ID=78784276
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111231553.4A Pending CN113750167A (en) | 2021-10-22 | 2021-10-22 | Composition for dispelling effects of alcohol, protecting liver and protecting stomach |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113750167A (en) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101766672A (en) * | 2008-12-31 | 2010-07-07 | 克科 | Composite for disintoxicating and sobering |
| CN101905015A (en) * | 2010-07-19 | 2010-12-08 | 银小龙 | Medicine capable of decomposing alcohol, preventing drunkenness and protecting liver |
| CN102772545A (en) * | 2012-08-14 | 2012-11-14 | 惠州市九惠制药股份有限公司 | Yanning sugar-free granules and preparation method thereof |
| CN102864671A (en) * | 2012-09-03 | 2013-01-09 | 潍坊天健源新农业科技有限公司 | Reuse method and application of rhizome traditional Chinese medicine dregs |
| CN107494871A (en) * | 2017-09-05 | 2017-12-22 | 刘爱民 | A kind of hoveniae semoveniae semen chitosan oligosaccharide pressed candy to relieve the effect of alcohol |
| CN107920577A (en) * | 2015-06-19 | 2018-04-17 | 哈沙·奇古鲁帕蒂 | Cooperate with beverage composition for treating dental erosion |
| CN109758570A (en) * | 2019-03-27 | 2019-05-17 | 汤臣倍健股份有限公司 | A kind of pair of alcoholic liver injury has the composition and its health care product, application of auxiliary protection function |
-
2021
- 2021-10-22 CN CN202111231553.4A patent/CN113750167A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101766672A (en) * | 2008-12-31 | 2010-07-07 | 克科 | Composite for disintoxicating and sobering |
| CN101905015A (en) * | 2010-07-19 | 2010-12-08 | 银小龙 | Medicine capable of decomposing alcohol, preventing drunkenness and protecting liver |
| CN102772545A (en) * | 2012-08-14 | 2012-11-14 | 惠州市九惠制药股份有限公司 | Yanning sugar-free granules and preparation method thereof |
| CN102864671A (en) * | 2012-09-03 | 2013-01-09 | 潍坊天健源新农业科技有限公司 | Reuse method and application of rhizome traditional Chinese medicine dregs |
| CN107920577A (en) * | 2015-06-19 | 2018-04-17 | 哈沙·奇古鲁帕蒂 | Cooperate with beverage composition for treating dental erosion |
| CN107494871A (en) * | 2017-09-05 | 2017-12-22 | 刘爱民 | A kind of hoveniae semoveniae semen chitosan oligosaccharide pressed candy to relieve the effect of alcohol |
| CN109758570A (en) * | 2019-03-27 | 2019-05-17 | 汤臣倍健股份有限公司 | A kind of pair of alcoholic liver injury has the composition and its health care product, application of auxiliary protection function |
Non-Patent Citations (1)
| Title |
|---|
| 严峻,等: "金樱子、枳椇子、牛磺酸混合物对小鼠酒精性肝损伤的保护作用研究", 《预防医学》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO2020052074A1 (en) | Extract for improving liver detoxification, dispelling alcohol and protecting liver, and preparation method therefor | |
| CN101889679A (en) | Composition with disintoxicating and liver-protecting effects and application thereof in food and health-care food | |
| MX2010009015A (en) | Leaves extract of panax sp., a process of making the same and uses thereof. | |
| CN102526698A (en) | Cordyceps polypeptide amino acid nutrient solution | |
| CN112772813A (en) | Compound peptide solid beverage capable of improving immunity and relieving fatigue and preparation method thereof | |
| CN112715957A (en) | Biological small molecular peptide composition for dispelling effects of alcohol and protecting liver and preparation method thereof | |
| JP2001122791A (en) | Meal enhancer comprising aqueous extract of red vine leaf for alleviation and prophylaxis of chronic venous insufficiency in lower extremity | |
| CN105505728A (en) | Vinegar drink for dispelling effect of alcohol and protecting liver and preparing method thereof | |
| CN102659917A (en) | Method for separating and preparing crude protein and enzymolysis peptide from pollen pini | |
| CN108815230A (en) | Chinese medicine composition and its preparation method and application for treating diabetes | |
| CN104739964B (en) | A kind of snail sobering preparation and preparation method thereof | |
| CN113750167A (en) | Composition for dispelling effects of alcohol, protecting liver and protecting stomach | |
| KR20110121246A (en) | Natural functional food for anti-obesity wellbeing diet and its producing method | |
| KR102536812B1 (en) | Composition for anti-allergy comprising extract of forsythia velutina | |
| CN106937923A (en) | Lucid ganoderma-pollen skin care health care frost | |
| CN102197879A (en) | Health beverage for relieving or neutralizing the effect of alcohol | |
| CN114712424B (en) | Traditional Chinese medicine preparation with effects of dispelling effects of alcohol and protecting liver as well as preparation method and application thereof | |
| CN110859912A (en) | Traditional Chinese medicine composition for prostatitis and preparation method and application thereof | |
| CN108720013A (en) | The formula and processing technology of the health food of one group of Soboring-up liver-protecting being made of fructose and tea extract | |
| AU2021104015A4 (en) | Composition of nadh for relieving alcohol and protecting liver and use thereof | |
| US20240123019A1 (en) | Composition for treating or ameliorating liver disease and liver dysfunction comprising zizania latifolia extract | |
| CN108570116A (en) | Yellowish green frizzle mushroom polysaccharide and preparation method and the medical application in preventing diabetes | |
| CN108477597A (en) | A kind of functional dietary composition adjusting glycometabolism | |
| CN114668830B (en) | Anti-alcohol and liver-protecting composition and preparation method thereof | |
| KR20040097813A (en) | Composition containing Diet Neurotrophic Factor having anti-fatness functions |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20211207 |