CN101905015A

CN101905015A - Medicine capable of decomposing alcohol, preventing drunkenness and protecting liver

Info

Publication number: CN101905015A
Application number: CN2010102330046A
Authority: CN
Inventors: 银小龙
Original assignee: Individual
Current assignee: Individual
Priority date: 2010-07-19
Filing date: 2010-07-19
Publication date: 2010-12-08
Anticipated expiration: 2030-07-19
Also published as: CN101905015B

Abstract

The invention relates to a medicine for protecting the liver, in particular to a medicine capable of decomposing alcohol, preventing drunkenness and protecting the liver, which can relieve the body pain of the people who drink and protect the body health, aiming at solving the problem of the injury of the alcohol for human body, avoiding liver injury and preventing and treating fatty liver and alcoholic liver. The medicine is prepared by the raw materials comprising the root of kudzu vine, radix paeoniae alba, liquorice, orange peel oil, plantain seed, fructus amomi, histidine, arginine, cysteine, glycin, glutamine, proteolytic peptide powder, fumaric acid, malic acid, vitamin C, vitamin E and zinc. Due to the action mechanism which is completely different from other dealcoholic drugs, the medicine does not hurt the liver when being used for antialcoholism, and effectively protects the liver.

Description

Can decomposing alcohol, prevent drunk, liver-protective medicine

Technical field

The present invention relates to a kind of liver-protective medicine, be specially a kind of back health of drinking that can solve and feel bad, the protection health can decomposing alcohol, prevent drunk, liver-protective medicine.

Background technology

China is the country that long spirits culture history is arranged, and drinks and links up in friendship, in amusement and recreation and the inter personal contact public relations irreplaceable social agency is arranged, yet drunk serious negative social effect and the human body of causing damages.The heart disease that can raise greatly of drinking for a long time, hypertension, fatty liver, the incidence rate of alcoholic cirrhosis and cerebrovascular.The serious harm health.Ethanol is mainly derived from excessive drinking for a long time to the harm of human body and causes liver poisoning.Studies show that normal adult male's harmless ethanol intake is to restrain women 20-30 gram every day less than 40.Epidemiology shows widely: adult male is drunk 40 degree ethanol 100-200 milliliters every day, and women 50-100 milliliter, 10-12 just can cause alcoholic hepatitis.Numerous cases prove that disposable excessive consumption of alcohol in large quantities can directly cause acute alcoholism and grievous injury liver, kidney, human body vitals such as brain.In the crowd of long-term excessive consumption of alcohol, there is the probability of 90-100% to suffer from alcoholic fatty liver approximately, the people of 10-35% suffers from alcoholic hepatitis, and the people of 8-20% suffers from alcoholic cirrhosis.So wine is called as chronic hepatotoxin.In western countries, have approximately 50% hepatopathy with drink relevant.In the U.S., in the lethal case, have 44% to be the liver cirrhosis that causes owing to excessively drinking approximately owing to liver cirrhosis.Simultaneously, liver cirrhosis 5-10, non-alcoholic liver cirrhosis patient survival rate is 23%, and alcoholic cirrhosis patient survival rate only is 7%.In case suffer from alcoholic hepatitis, the ratio that develops into liver cirrhosis every year is 10-20%, has 70% people finally to develop into the alcoholic liver canceration approximately.

Clinical observation is found, drink every day and surpass the patient of 50 grams, usually aspartate transaminase (Aspartate Transaminase, AST) level and alanine aminotransferase (Alanise Transaminase, ALT) obviously rising (50% sensitivity) of level in the blood.Nearly all patient's AST level all is higher than the ALT level.Work as AST: the ALT ratio surpasses 2, has suffered from alcoholic hepatitis with regard to diagnosable this patient so.The pathological process of the dirty infringement of alcoholic liver is normally drunk and is caused fatty liver, is further development of alcoholic hepatitis, finally develops into hepatitis interstitialis chronica.

The people is after drinking, and contained ethanol is absorbed in the wine, is acetaldehyde by oxydasis in vivo.Human body also bears the degree problem to ethanol.Whether the people is drunk, depends on the concentration of ethanol in blood.When ethanol in blood concentration during at 0.05-0.1%, that the people begins is dim, be under the weather freely; And reach at 0.3% o'clock, the people will inarticulateness, lurchs, Here it is we often say drunk; If reached 0.7%, the people will be dead.So how at short notice intravital alcohol content to be reduced to the level of a safety is exactly the human target of always pursuing, so liver-protecting sobering up good medicine more and more receives the drinks consumer group's of the whole society concern.There are a large amount of disintoxicating products or method to be developed at present, formed new " separating spirits culture ".For example antialcoholic drug totally can be divided into three kinds of chemical drugss, Chinese medicine preparation, health product.Chemical drugs is the toxic and side effects that ethanol was resisted and suppressed to drug application, as utilizes glucose, coffee, tranquilizer.Can relief of symptoms, but health is damaged, and the side effect of generation is big.Curative effect is not good enough.Relieving mechanism is only to promote ethanol to decompose, and plays temporary mitigation, is difficult to play liver protection effect.The Chinese medicine preparation composition mostly is Japanese raisintree fruit, flower of Radix Puerariae, the Radix Paeoniae Alba, Semen Myristicae, and these Chinese medicines can play fine antialcoholism action, the effect of whole body conditioning simultaneously, but effect is slow a little.Be free from side effects, also liver and gall diseases had better curative effect simultaneously at Dealcoholic sobering-up.The health product Medicament for Alcoholism in fact also is a Chinese medicine preparation.Also have some vegetable foods etc. in addition, as Chinese cabbage, Radix Raphani, Fructus Citri junoris, Fructus Lycopersici esculenti, Fructus Myricae rubrae, pears egg and bean curd etc.In the prior art, also utilize Chinese medicine, the relieving alcoholism and protecting the liver medicine of aminoacid and vitamin co-production, the production method of 200510127313.4 described drunk-sobering tablets for example, method is: (1) gets the raw materials ready and proportioning (following be weight ratio) glucose: 10-25%; Wheat germ powder: 10-25%; Semen Hoveniae (Fructus Hoveniae) powder: 5-15%; Radix Puerariae 5-15%:5-15%; VC:5-10%: food flavor: 0.25%; VPP:1-3 ‰; VB1:1-3 ‰; VB2:1-3 ‰; VB12:1-3 ‰; Inositol six phosphatidase 10 .01-0.1 ‰.

Clinical research for many years finds that ethanol to the main mechanism of liver effect is:

(1) oxidative metabolism causes producing in the body overdosage toxicity chemical substance-acetaldehyde.

Under the normal condition, ethanol enters in the body after stomach, and little intestinal absorption enters liver by blood.(Alcohol Dehydrogenase ADH) becomes acetaldehyde with oxidation of ethanol, and (Aldehyde Dehydrogenase, ALDH) metabolism is an acetic acid and per urethra excretes to acetaldehyde through aldehyde dehydrogenase by ethanol dehydrogenase in liver.Disposable a large amount of or chronic long-term absorption ethanol beverage will seriously surpass the liver detoxification ability, and cause accumulating in blood and the liver a large amount of ethanol and acetaldehyde.Acetaldehyde is a kind of poisonous chemical substance.Retaining in vivo the acetaldehyde that can't metabolism falls produces liver and threatens.The too much flushing that occurred of alcohol user, excitement, symptom such as headache is felt sick, dizziness and acetaldehyde have direct or indirect relation.

(2) living radical ROS and RNS cause hepatocyte injury and liver dysfunction.

But excessive acetaldehyde and alcohol oxidation metabolite inducing hepatocyte microsomal enzyme cytochrome p450 system activity in the liver, particularly relevant with alcohol metabolism CYP2E1 is active to raise.CYP2E1 is a kind of oxide of high activity metabolic enzyme, and the oxidative metabolism by CYP2E1 can produce a large amount of reactive oxygen free radical (ROS) and active nitrogen free radical (RNS).ROS and RNS have extremely strong oxidation and attack characteristic, but the direct aggression organelle, and DNA and have the protein signal factor of critical function causes hepatocyte injury and liver dysfunction.

(3) metabolite directly stimulates body to produce cytotoxin.

Ethanol of accumulating in the liver and oxidative metabolism product thereof can directly stimulate body to produce endotoxin.Endotoxin in the blood raises (as lipid peroxide, LPS) induce activation liver spider cell (Kupffer cell), make its secretion and discharge a large amount of α-Zhong Liuhuaisiyinzis (Tumour necrosis factor-α, TNF-α), PGE2 (PGE2), interleukin IL-6, IL-8 etc.TNF-α can directly cause hepatic cell fattydegeneration, inflammation and necrosis.PGE2 can cause the oxygen consumption too much, causes the hepatocyte anoxia.In addition, TNF-α can promote body periphery steatolysis, makes free fatty enter liver by blood and accumulates; TNF-α also can reduce the elimination to low density lipoprotein, LDL (a kind of harmful lipoprotein).Therefore TNF-α plays an important role in the generation evolution of alcoholism and alcoholic liver disease.

Summary of the invention

Ethanol was avoided hepar damnification to the injury of health when the present invention drank in order to solve, and the problem of control fatty liver, alcoholic liver and a kind of decomposing alcohol is provided prevents drunkly, and the back health of drinking is not felt bad, the liver protecting, the medicine of protection health.

The present invention is realized by following technical scheme; a kind of can decomposing alcohol; prevent drunkly, liver-protective medicine is to be made by the raw material of following weight ratio example; Radix Puerariae 25-35 part; Radix Paeoniae Alba 2-4 part; Radix Glycyrrhizae 1-3 part; peel of Citrus reticulata Blanco 2-5 part; Semen Plantaginis 5-9 part, Fructus Amomi 4-6 part, histidine 1-5 part; arginine 1-3 part; cysteine 6-18 part, glycine 12-15 part, glutamine 8-12 part; Proteolytic enzyme peptide powder 10-13 part fumaric acid 0.1-0.3 part; malic acid 0.2-0.4 part, vitamin C 0.1-5 part, vitamin E 0.3-0.6 part; vitamin B 0.3-0.6 part, zinc 0.02-0.03 part.

Above-mentioned each raw material pulverizing is a 50-80 order fine powder, mixes, and can make capsule, pill or tablets and other formulations and use.The present invention with various material combination together, effective decomposing alcohol prevents drunkly, the liver protecting makes the people not feel bad at the back health of drinking, transaminase lowering stops hepatic lesions.

According to alcoholism and detoxifcation mechanism, of the present invention comprehensive, both comprised in the multipath Antialcoholic liver-protecting prescription element and relieved the effect of alcohol, reduced ethanol toxicity, promote alcohol metabolism to drain composition, added composition drunk and that the alcoholism after-acceleration recovers again.Consider the factor of alcohol user's liver damage simultaneously, in prescription, also added the hepatoprotective composition.Of the present invention comprehensive, the multipath Antialcoholic liver-protecting, its pharmacological action and effect are remarkable.

Because medicine of the present invention adopts and the diverse mechanism of action of other antialcoholic drug, thus this medicine impairing the liver not when adjusting is relieved the effect of alcohol, but also the liver protecting effectively.

Show that by zoopery and clinical test results the present invention is respond well to decomposing alcohol.

(1), zoopery

1, with the medicine of the listed raw material consumption configuration of the embodiment of the invention 1 to rat feeding ethanol after the effect of blood alcohol concentration, see accompanying drawing 1

2, with the medicine of the listed raw material consumption configuration of the embodiment of the invention 1 to rat feeding ethanol after the influence of blood glutamic oxaloacetic transaminase, GOT AST level, see Fig. 2.

3, with the medicine of the listed raw material consumptions configuration of the embodiment of the invention 2 to human body drink the back exhale in the effect of alcohol concentration, see Table 1,2,3 and corresponding accompanying

drawing

4,5,6

Table 1

Table 2

Table 3

Experiment shows that the present invention reduces blood, expired gas alcohol concentration to promoting alcohol metabolism, and the liver protecting has tangible effect, gives the obviously recovery of acceleration of alcohol hepatocyte injury of medicine of the present invention.

Description of drawings

Fig. 1 is the influence of the present invention to rat feeding ethanol

Fig. 2 is for inducing the influence that produces TNF-α to two groups of rat LPS

Fig. 3 for the present invention to rat feeding ethanol after the influence of blood glutamic oxaloacetic transaminase, GOT AST level

Fig. 4,5,6 is that BAC situation of change figure series1 need not take product of the present invention by any medicine Series2 after taking this medicine after three personages that drink drink

The specific embodiment

Embodiment 1, a kind of can decomposing alcohol, prevent drunkly, liver-protective medicine is to be made by the raw material of following weight ratio example; 25 parts of Radix Puerariaes, 4 parts of the Radix Paeoniae Albas, 1 part in Radix Glycyrrhizae, 5 parts of peel of Citrus reticulata Blanco, 5 parts of Semen Plantaginiss, 6 parts of Fructus Amomis; 1 part of histidine, 3 parts of arginine, 6 parts of cysteine; 15 parts of glycine, 8 parts of glutamine, 13 parts in Proteolytic enzyme peptide powder; 0.1 part of fumaric acid, 0.4 part of malic acid, 0.1 part of vitamin C; 0.6 part of vitamin E, 0.3 part of vitamin B, 0.03 part on zinc.

Described Proteolytic enzyme peptide powder, for the vegetable protein range of hydrolysed peptides, as soybean protein powder, Zein powder;

Zinc can be selected inorganic zinc, and as zinc sulfate, zinc oxide, zinc carbonate, perhaps organic zinc is as zinc gluconate, zinc methionine etc.

Getting above-mentioned each raw material adds forming agent again and can make tablet, dosage forms such as pill, each dosage form is produced and is common process, preparing tablet as dry granulation sieves each raw material pulverizing exactly and granulates then after back and the binding agent mixing that tabletting gets final product, perhaps adopt wet granulation, with disintegrating agent, wetting agent and each raw material mixing after drying, granulate, tabletting gets final product.

Embodiment 2, a kind of can decomposing alcohol, prevent drunkly, liver-protective medicine is to be made by the raw material of following weight ratio example; 30 parts of Radix Puerariaes, 3 parts of the Radix Paeoniae Albas, 2 parts in Radix Glycyrrhizae, 4 parts of peel of Citrus reticulata Blanco, 7 parts of Semen Plantaginiss, 5 parts of Fructus Amomis; 3 parts of histidine, arginase 12 part, 12 parts of cysteine; 13 parts of glycine, 10 parts of glutamine, 11 parts in Proteolytic enzyme peptide powder; 0.2 part of fumaric acid, 0.3 part of malic acid, Catergen part; 0.4 part of vitamin E, 0.5 part of vitamin B, 0.025 part on zinc.

Described Proteolytic enzyme peptide powder is the animal proteinum range of hydrolysed peptides.As liver Proteolytic enzyme powder, collagen protein powder etc.

Zinc can be selected zinc sulfate, zinc oxide, zinc carbonate, and perhaps organic zinc is as zinc gluconate, zinc methionine etc.Take by weighing said medicine and pulverize, be mixed and made into capsule and get final product to 50-80 order fine powder.

Embodiment 3, a kind of can decomposing alcohol, prevent drunk, liver-protective medicine; be to make by the raw material of following weight ratio example, 35 parts of Radix Puerariaes, 2 parts of the Radix Paeoniae Albas, 3 parts in Radix Glycyrrhizae, 2 parts of peel of Citrus reticulata Blanco, 9 parts of Semen Plantaginiss; 4 parts of Fructus Amomis, 5 parts of histidine, 1 part of arginine; 18 parts of cysteine, 12 parts of glycine, 12 parts of glutamine; 10 parts in Proteolytic enzyme peptide powder, 0.3 part of fumaric acid, 0.2 part of malic acid; 5 parts of vitamin Cs, 0.3 part of vitamin E, vitamin B ₁₂0.6 part, 0.02 part on zinc.

Described Proteolytic enzyme peptide powder can be the vegetable protein range of hydrolysed peptides, also can be the animal proteinum range of hydrolysed peptides.Vegetable protein such as soybean protein powder, Zein powder; Animal proteinum is as liver Proteolytic enzyme powder, collagen protein powder etc.

Zinc can be selected zinc sulfate, zinc oxide, zinc carbonate, and perhaps organic zinc is as zinc gluconate, zinc methionine etc.Take by weighing the said medicine pulverizing and be 50-80 order fine powder, add and make pill after some binding materials mix.

Claims

One kind can decomposing alcohol; prevent drunk; liver-protective medicine is characterized in that being made by the raw material of following weight ratio example, Radix Puerariae 25-35 part, Radix Paeoniae Alba 2-4 part, Radix Glycyrrhizae 1-3 part, peel of Citrus reticulata Blanco 2-5 part; Semen Plantaginis 5-9 part; Fructus Amomi 4-6 part, histidine 1-5 part, arginine 1-3 part; cysteine 6-18 part; glycine 12-15 part, glutamine 8-12 part, Proteolytic enzyme peptide powder 10-13 part; fumaric acid 0.1-0.3 part; malic acid 0.2-0.4 part, vitamin C 0.1-5 part, vitamin E 0.3-0.6 part; vitamin B 0.3-0.6 part, zinc 0.02-0.03 part.
2. according to claim 1 can decomposing alcohol, prevent drunkly, liver-protective medicine is characterized in that being made by the raw material of following weight ratio example; 30 parts of Radix Puerariaes, 3 parts of the Radix Paeoniae Albas, 2 parts in Radix Glycyrrhizae, 4 parts of peel of Citrus reticulata Blanco, 7 parts of Semen Plantaginiss, 5 parts of Fructus Amomis; 3 parts of histidine, arginase 12 part, 12 parts of cysteine; 13 parts of glycine, 10 parts of glutamine, 11 parts in Proteolytic enzyme peptide powder; 0.2 part of fumaric acid, 0.3 part of malic acid, Catergen part; 0.4 part of vitamin E, 0.5 part of vitamin B, 0.025 part on zinc.