CN101905015B

CN101905015B - Medicine capable of decomposing alcohol, preventing drunkenness and protecting liver

Info

Publication number: CN101905015B
Application number: CN 201010233004
Authority: CN
Inventors: 银小龙
Original assignee: Individual
Current assignee: Individual
Priority date: 2010-07-19
Filing date: 2010-07-19
Publication date: 2013-06-05
Anticipated expiration: 2030-07-19
Also published as: CN101905015A

Abstract

The invention relates to a medicine for protecting the liver, in particular to a medicine capable of decomposing alcohol, preventing drunkenness and protecting the liver, which can relieve the body pain of the people who drink and protect the body health, aiming at solving the problem of the injury of the alcohol for human body, avoiding liver injury and preventing and treating fatty liver and alcoholic liver. The medicine is prepared by the raw materials comprising the root of kudzu vine, radix paeoniae alba, liquorice, orange peel oil, plantain seed, fructus amomi, histidine, arginine, cysteine, glycin, glutamine, proteolytic peptide powder, fumaric acid, malic acid, vitamin C, vitamin E and zinc. Due to the action mechanism which is completely different from other dealcoholic drugs, the medicine does not hurt the liver when being used for antialcoholism, and effectively protects the liver.

Description

Can decomposing alcohol, prevent drunk, liver-protective medicine

Technical field

The present invention relates to a kind of liver-protective medicine, be specially a kind of rear health of drinking that can solve and feel bad, the protection health can decomposing alcohol, prevent drunk, liver-protective medicine.

Background technology

China is the country that long spirits culture history is arranged, and drinks and links up in friendship, in amusement and recreation and inter personal contact public relations, irreplaceable social agency is arranged, yet drunkly causes serious negative social effect and human body infringement.The heart disease that can greatly raise of drinking for a long time, hypertension, fatty liver, the incidence rate of alcoholic cirrhosis and cerebrovascular.The serious harm health.Ethanol is mainly derived from excessive drinking for a long time to the harm of human body and causes liver poisoning.Studies show that, normal adult male's harmless Ethanol intake amount be every day less than 40 grams, women 20-30 gram.Epidemiology shows widely: adult male is drunk 40 degree ethanol 100-200 milliliters every day, and women 50-100 milliliter, 10-12 just can cause alcoholic hepatitis.Numerous cases prove that disposable excessive consumption of alcohol in large quantities can directly cause acute alcoholism and grievous injury liver, kidney, the human body vitals such as brain.In the crowd of long-term excessive consumption of alcohol, approximately there is the probability of 90-100% to suffer from alcoholic fatty liver, the people of 10-35% suffers from alcoholic hepatitis, and the people of 8-20% suffers from alcoholic cirrhosis.So wine is called as the Chronic Liver toxin.In western countries, approximately have 50% hepatopathy with drink relevant.In the U.S., in lethal case, approximately have 44% to be the liver cirrhosis that causes owing to excessively drinking due to liver cirrhosis.Simultaneously, liver cirrhosis 5-10, evaluation of non-alcoholic cirrhotic patients patient survival rate is 23%, and alcoholic cirrhosis patient survival rate is only 7%.In case suffer from alcoholic hepatitis, the ratio that develops into liver cirrhosis every year is 10-20%, approximately has 70% people finally to develop into the alcoholic liver canceration.

Clinical observation is found, drink every day and surpass the patient of 50 grams, usually obviously rising (50% sensitivity) of aspartate transaminase (Aspartate Transaminase, AST) level and alanine aminotransferase (Alanise Transaminase, ALT) level in blood.Nearly all patient's AST level is all higher than the ALT level.Work as AST: the ALT ratio surpasses 2, has suffered from alcoholic hepatitis with regard to diagnosable this patient so.The pathological process of Alcoholic liver infringement is normally drunk and is caused fatty liver, is further development of alcoholic hepatitis, finally develops into hepatitis interstitialis chronica.

The people is after drinking, and in wine, contained ethanol is absorbed, and is acetaldehyde by oxydasis in vivo.Human body also has the Bearing degree problem to ethanol.Whether the people is drunk, depends on the concentration of ethanol in blood.When ethanol in blood concentration during at 0.05-0.1%, that the people begins is dim, be under the weather freely; And when reaching 0.3%, the people will inarticulateness, lurchs, Here it is we often say drunk; If reached 0.7%, the people will be dead.So how at short notice the alcohol content in body being reduced to the level of a safety is exactly the target that the mankind pursue, so liver-protecting sobering up good medicine more and more receives the drinks consumer group's of the whole society concern always.There are at present a large amount of disintoxicating products or method to be developed, formed new " solution spirits culture ".For example antialcoholic drug totally can be divided into three kinds of chemical drugss, Chinese medicine preparation, health product.Chemical drugs is the toxic and side effects that ethanol was resisted and suppressed to drug application, as utilizes glucose, coffee, tranquilizer.Can relief of symptoms, but health is damaged, and the side effect of generation is large.Curative effect is not good enough.Relieving mechanism is only to promote ethanol to decompose, and plays temporary mitigation, is difficult to play liver protection effect.The Chinese medicine preparation composition mostly is Japanese raisintree fruit, flower of Radix Puerariae, the Radix Paeoniae Alba, Semen Myristicae, and these Chinese medicines can play fine antialcoholism action, the effect of whole body conditioning simultaneously, but effect is slow a little.Be free from side effects, also liver and gall diseases had good curative effect simultaneously at Dealcoholic sobering-up.The health product Medicament for Alcoholism is in fact also Chinese medicine preparation.Also have in addition some vegetable foods etc., as Chinese cabbage, Radix Raphani, Fructus Citri junoris, Fructus Lycopersici esculenti, Fructus Myricae rubrae, pears egg and bean curd etc.In prior art, also utilize Chinese medicine, the relieving alcoholism and protecting the liver medicine of the common preparation of aminoacid and vitamin, the production method of 200510127313.4 described drunk-sobering tablets for example, method is: (1) gets the raw materials ready and proportioning (following be weight ratio) glucose: 10-25%; Wheat germ powder: 10-25%; Semen Hoveniae (Fructus Hoveniae) powder: 5-15%; Radix Puerariae 5-15%:5-15%; VC:5-10%: food flavor: 0.25%; VPP:1-3 ‰; VB1:1-3 ‰; VB2:1-3 ‰; VB12:1-3 ‰; Inositol six phosphatidase 10 .01-0.1 ‰.

Clinical research for many years finds that ethanol to the main mechanism of liver effect is:

(1) oxidative metabolism causes producing in body overdosage toxicity chemical substance-acetaldehyde.

Under normal circumstances, it is interior by stomach that ethanol enters body, and intestinal absorption enters liver by blood.Oxidation of ethanol is become acetaldehyde by ethanol dehydrogenase (Alcohol Dehydrogenase, ADH) in liver, acetaldehyde is acetic acid and per urethra excretes through aldehyde dehydrogenase (Aldehyde Dehydrogenase, ALDH) metabolism.Disposable a large amount of or chronic long absorption Alcoholic beverage will seriously surpass the liver detoxification ability, and cause accumulating in blood and liver a large amount of ethanol and acetaldehyde.Acetaldehyde is a kind of poisonous chemical substance.Retaining in vivo the acetaldehyde that can't metabolism falls produces liver and threatens.The too much flushing that occurs of alcohol user, excitement, the symptom such as headache is felt sick, and is dizzy and acetaldehyde have direct or indirect relation.

(2) living radical ROS and RNS cause hepatocyte injury and liver dysfunction.

But acetaldehyde and alcohol oxidation metabolite inducing hepatocyte microsomal enzyme cytochrome p450 system excessive in liver are active, and particularly the CYP2E1 relevant with alcohol metabolism is active raises.CYP2E1 is a kind of oxide of high activity metabolic enzyme, and the oxidative metabolism by CYP2E1 can produce a large amount of reactive oxygen free radical (ROS) and active nitrogen free radical (RNS).ROS and RNS have extremely strong oxidation and attack characteristic, but the direct aggression organelle, and DNA and have the protein signal factor of critical function causes hepatocyte injury and liver dysfunction.

(3) metabolite directly stimulates body to produce cytotoxin.

The ethanol of accumulating in liver and oxidative metabolism product thereof can directly stimulate body to produce endotoxin.Endotoxin in blood raises (as lipid peroxide, LPS) induce activation liver spider cell (Kupffer cell), make its secretion and discharge a large amount of α-tumornecrosisfactors (Tumour necrosis factor-α, TNF-α), PGE2 (PGE2), interleukin IL-6, IL-8 etc.TNF-α can directly cause hepatic cell fattydegeneration, inflammation and necrosis.PGE2 can cause the oxygen consumption too much, causes the hepatocyte anoxia.In addition, TNF-α can promote body periphery steatolysis, makes free fatty enter liver and accumulate by blood; TNF-α also can reduce the elimination to low density lipoprotein, LDL (a kind of harmful lipoprotein).Therefore TNF-α plays an important role in the carcinogenesis of human of alcoholism and alcoholic liver disease.

Summary of the invention

When the present invention drinks in order to solve, the injury of ethanol to health, avoid hepar damnification, and the problem of control fatty liver, alcoholic liver and a kind of decomposing alcohol is provided prevents drunkly, and the rear health of drinking is not felt bad, the liver protecting, the medicine of protection health.

the present invention is realized by following technical scheme, a kind of can decomposing alcohol, prevent drunk, liver-protective medicine, to be made by the raw material of following weight ratio example, Radix Puerariae 25-35 part, Radix Paeoniae Alba 2-4 part, Radix Glycyrrhizae 1-3 part, peel of Citrus reticulata Blanco 2-5 part, Semen Plantaginis 5-9 part, Fructus Amomi 4-6 part, histidine 1-5 part, arginine 1-3 part, cysteine 6-18 part, glycine 12-15 part, glutamine 8-12 part, Proteolytic enzyme Gly-His-Lys 10-13 part fumaric acid 0.1-0.3 part, malic acid 0.2-0.4 part, vitamin C 0.1-5 part, vitamin E 0.3-0.6 part, vitamin B 0.3-0.6 part, zinc 0.02-0.03 part.

Above-mentioned each raw material pulverizing is 50-80 order fine powder, mixes, and can make capsule, pill or tablets and other formulations and use.The present invention with various material combination together, effective decomposing alcohol prevents drunkly, the liver protecting is not felt bad people's health after drinking, and reduces the transaminase, stops hepatic lesions.

According to alcoholism and detoxifcation mechanism, of the present invention comprehensive, both comprised in multipath Antialcoholic liver-protecting prescription element and relieved the effect of alcohol, reduced Alcoholism, promote alcohol metabolism excretion composition, added again the composition that adds quick-recovery after drunk and alcoholism.Consider simultaneously the factor of alcohol user's liver damage, also added the hepatoprotective composition in prescription.Of the present invention comprehensive, the multipath Antialcoholic liver-protecting, its pharmacological action and effect are remarkable.

Because medicine of the present invention adopts and the diverse mechanism of action of other antialcoholic drug, thus this medicine impairing the liver not when adjusting is relieved the effect of alcohol, but also the liver protecting effectively.

Show by zoopery and clinical test results, the present invention is respond well to decomposing alcohol.

(1), zoopery

1, with the medicine of the listed raw material consumption of the embodiment of the present invention 1 configuration to rat feeding ethanol after the effect of blood alcohol concentration, see accompanying drawing 1

2, two groups of rat LPS are induced with the medicine of the listed raw material consumption configuration of the embodiment of the present invention 1 impact that produces TNF-α, see Fig. 2.

3, with the medicine of the listed raw material consumption of the embodiment of the present invention 2 configuration to the drink effect of alcohol concentration in rear expiration of human body, see Table 1,2,3 and corresponding accompanying

drawing

4,5,6

Table 1

Table 2

Table 3

Experiment shows, the present invention reduces blood, expired gas alcohol concentration to promoting alcohol metabolism, and the liver protecting has obvious effect, gives the obviously recovery of acceleration of alcohol hepatocyte injury of medicine of the present invention.

Description of drawings

Fig. 1 is that the present invention is on the impact of rat feeding ethanol

Fig. 2 is for inducing the impact that produces TNF-α on two groups of rat LPS

Fig. 3 be the present invention on rat feeding ethanol after the impact of blood glutamic oxaloacetic transaminase, GOT AST level

Fig. 4,5,6 is that after taking this medicine after three personages that drink drink, BAC situation of change figure series1 need not take product of the present invention by any medicine Series2

The specific embodiment

Embodiment 1, a kind of can decomposing alcohol, prevent drunkly, liver-protective medicine is to be made by the raw material of following weight ratio example; 25 parts of Radix Puerariaes, 4 parts of the Radix Paeoniae Albas, 1 part, Radix Glycyrrhizae, 5 parts of peel of Citrus reticulata Blanco, 5 parts of Semen Plantaginiss, 6 parts of Fructus Amomis; 1 part of histidine, 3 parts of arginine, 6 parts of cysteine; 15 parts of glycine, 8 parts of glutamine, 13 parts of Proteolytic enzyme Gly-His-Lys; 0.1 part of fumaric acid, 0.4 part of malic acid, 0.1 part of vitamin C; 0.6 part of vitamin E, 0.3 part of vitamin B, 0.03 part, zinc.

Described Proteolytic enzyme Gly-His-Lys, for the vegetable protein range of hydrolysed peptides, as soybean protein powder, Zein powder;

Zinc can be selected inorganic zinc, and as zinc sulfate, zinc oxide, zinc carbonate, perhaps organic zinc is as zinc gluconate, zinc methionine etc.

Getting above-mentioned each raw material adds forming agent can make tablet again, the dosage forms such as pill, each dosage form is produced and is common process, after preparing tablet and exactly each raw material pulverizing sieved as dry granulation and granulate then after binding agent mixing that tabletting gets final product, perhaps adopt wet granulation, dry after disintegrating agent, wetting agent are mixed with each raw material, granulate, tabletting gets final product.

Embodiment 2, a kind of can decomposing alcohol, prevent drunkly, liver-protective medicine is to be made by the raw material of following weight ratio example; 30 parts of Radix Puerariaes, 3 parts of the Radix Paeoniae Albas, 2 parts, Radix Glycyrrhizae, 4 parts of peel of Citrus reticulata Blanco, 7 parts of Semen Plantaginiss, 5 parts of Fructus Amomis; 3 parts of histidine, arginase 12 part, 12 parts of cysteine; 13 parts of glycine, 10 parts of glutamine, 11 parts of Proteolytic enzyme Gly-His-Lys; 0.2 part of fumaric acid, 0.3 part of malic acid, Catergen part; 0.4 part of vitamin E, 0.5 part of vitamin B, 0.025 part, zinc.

Described Proteolytic enzyme Gly-His-Lys is the animal proteinum range of hydrolysed peptides.As liver Proteolytic enzyme powder, collagen protein powder etc.

Zinc can be selected zinc sulfate, zinc oxide, zinc carbonate, and perhaps organic zinc is as zinc gluconate, zinc methionine etc.Take said medicine and pulverize as 50-80 order fine powder, be mixed and made into capsule and get final product.

Embodiment 3, a kind of can decomposing alcohol, prevent drunk, liver-protective medicine; to be made by the raw material of following weight ratio example, 35 parts of Radix Puerariaes, 2 parts of the Radix Paeoniae Albas, 3 parts, Radix Glycyrrhizae, 2 parts of peel of Citrus reticulata Blanco, 9 parts of Semen Plantaginiss; 4 parts of Fructus Amomis, 5 parts of histidine, 1 part of arginine; 18 parts of cysteine, 12 parts of glycine, 12 parts of glutamine; 10 parts of Proteolytic enzyme Gly-His-Lys, 0.3 part of fumaric acid, 0.2 part of malic acid; 5 parts of vitamin Cs, 0.3 part of vitamin E, vitamin B ₁₂0.6 part, 0.02 part, zinc.

Described Proteolytic enzyme Gly-His-Lys can be the vegetable protein range of hydrolysed peptides, can be also the animal proteinum range of hydrolysed peptides.Vegetable protein such as soybean protein powder, Zein powder; Animal proteinum is as liver Proteolytic enzyme powder, collagen protein powder etc.

Zinc can be selected zinc sulfate, zinc oxide, zinc carbonate, and perhaps organic zinc is as zinc gluconate, zinc methionine etc.Take said medicine and pulverize and to be 50-80 order fine powder, make pill after adding some binding materials to mix.

Claims

One kind can decomposing alcohol; prevent drunk; liver-protective medicine is characterized in that being made by the raw material of following weight ratio example, Radix Puerariae 25-35 part, Radix Paeoniae Alba 2-4 part, Radix Glycyrrhizae 1-3 part, peel of Citrus reticulata Blanco 2-5 part; Semen Plantaginis 5-9 part; Fructus Amomi 4-6 part, histidine 1-5 part, arginine 1-3 part; cysteine 6-18 part; glycine 12-15 part, glutamine 8-12 part, Proteolytic enzyme Gly-His-Lys 10-13 part; fumaric acid 0.1-0.3 part; malic acid 0.2-0.4 part, vitamin C 0.1-5 part, vitamin E 0.3-0.6 part; vitamin B 0.3-0.6 part, zinc 0.02-0.03 part.
2. according to claim 1 can decomposing alcohol, prevent drunkly, liver-protective medicine is characterized in that being made by the raw material of following weight ratio example; 30 parts of Radix Puerariaes, 3 parts of the Radix Paeoniae Albas, 2 parts, Radix Glycyrrhizae, 4 parts of peel of Citrus reticulata Blanco, 7 parts of Semen Plantaginiss, 5 parts of Fructus Amomis; 3 parts of histidine, arginase 12 part, 12 parts of cysteine; 13 parts of glycine, 10 parts of glutamine, 11 parts of Proteolytic enzyme Gly-His-Lys; 0.2 part of fumaric acid, 0.3 part of malic acid, Catergen part; 0.4 part of vitamin E, 0.5 part of vitamin B, 0.025 part, zinc.