CN113735037B - Closed cap removal device and method for removing caps from sample tubes - Google Patents
Closed cap removal device and method for removing caps from sample tubes Download PDFInfo
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- CN113735037B CN113735037B CN202010477888.3A CN202010477888A CN113735037B CN 113735037 B CN113735037 B CN 113735037B CN 202010477888 A CN202010477888 A CN 202010477888A CN 113735037 B CN113735037 B CN 113735037B
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- cap
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- closed space
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
- B67B—APPLYING CLOSURE MEMBERS TO BOTTLES JARS, OR SIMILAR CONTAINERS; OPENING CLOSED CONTAINERS
- B67B7/00—Hand- or power-operated devices for opening closed containers
- B67B7/14—Hand- or power-operated devices for opening closed containers for removing tightly-fitting lids or covers, e.g. of shoe-polish tins, by gripping and rotating
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- Automatic Analysis And Handling Materials Therefor (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The present application relates to a closed uncapping device and method for removing a cap from a sample tube. The device comprises: the side wall of the fixing mechanism is attached to the outer wall of the sample tube; the cover removing device comprises a cover body and a cover pulling mechanism accommodated in the cover body, wherein the cover body is matched with the fixing mechanism to form a closed space, and the cover body of the sample tube is accommodated in the closed space; the negative pressure source is connected with the cover body and is used for extracting gas in the closed space after the closed space is formed; and the first driver is used for driving the cap pulling mechanism to pull out the cap of the sample tube in the closed space. The device can effectively prevent the diffusion of aerosol generated when the sample tube cover is removed.
Description
Technical Field
The application relates to the field of medical instruments, in particular to a closed cap removing device and a method for removing a cap from a sample tube.
Background
In the field of biochemical immunodetection, it is often necessary to uncap a sample tube before the sample is sent to an analytical instrument for detection. In a fully automated laboratory (Total Laboratory Automation, TLA) system, two ways of removing sample tube caps are currently used, one for manual cap removal and one for equipping the laboratory automation system (Laboratory Automation System, LAS) with cap removal modules. However, whether in a manual or automatic uncapping mode, the uncapping operation is usually performed in an open space. Studies have shown that aerosols are extremely easily generated at the instant when the sample cap is pulled out of the sample tube. Meanwhile, before the sample is tested, it is often necessary to perform centrifugation operation, which is usually performed in a high-speed running environment, and in TLA systems, the decapping module is usually performed in the next stage of the centrifugation module. Thus, the sample tube just centrifuged is more prone to aerosol generation when the sample cap is removed.
The aerosol has great biological potential safety hazard, so that the propagation of the aerosol needs to be controlled to ensure the environmental safety of a laboratory, and particularly, the propagation of the aerosol needs to be restrained in an operation link which is a cap removing operation and is extremely easy to generate the aerosol.
Disclosure of Invention
The application aims to provide a sealing cap removing device and a sealing cap removing method which are suitable for a TLA system and can effectively prevent the diffusion of aerosol generated when a sample tube cap is removed.
In order to effectively solve the technical problems, the aim of the application is achieved by the following technical scheme.
According to a first aspect of the present application there is provided a closed uncapping device for removing a cap from a sample tube, the device comprising:
the side wall of the fixing mechanism is attached to the outer wall of the sample tube;
the cover removing device comprises a cover body and a cover pulling mechanism accommodated in the cover body, wherein the cover body is matched with the fixing mechanism to form a closed space, and the cover body of the sample tube is accommodated in the closed space;
the negative pressure source is connected with the cover body and is used for extracting gas in the closed space after the closed space is formed;
and the first driver is used for driving the cap pulling mechanism to pull out the cap of the sample tube in the closed space.
In one embodiment, the upper surface of the fixing mechanism is provided with a sealing groove, and the bottom of the cover body can be embedded into the sealing groove to form the closed space.
In one embodiment, the first driver drives the cap pulling mechanism to clamp the cap body to move upwards along the axis direction of the cap body so as to pull out the cap body.
In one embodiment, the device further comprises a second driver, and the first driver drives the cap pulling mechanism to clamp the cap body to move upwards along the axis direction of the cap body, and simultaneously drives the cap pulling mechanism to rotate so as to pull out the cap body.
In one embodiment, the cover pulling mechanism comprises a fixed support and a pulling claw connected with the fixed support, and the pulling claw can be opened and contracted around the fixed support.
In one embodiment, the device further comprises a cover waste bin, the cover waste bin comprises a bin body and a bin door, when the cover removing device conveys the sample cover to the cover waste bin, the bin door is opened, and the sample cover enters a closed space formed by the bin body and the cover body in a matched mode; when the cover body waste cabin finishes receiving the waste sample cover, the cabin door is closed, and the cabin body and the cabin door are matched to form a closed space.
In one embodiment, the upper surface of the cabin body is provided with a sealing groove, and the bottom of the cover body can be embedded into the sealing groove to form the closed space.
In one embodiment, the device further comprises an ultraviolet light source lamp, wherein the ultraviolet light source lamp is accommodated in the cover body and used for inactivating the cover body.
According to a second aspect of the present application, there is provided a sample analyzer comprising a closed cap removing device, a lancet for sucking a sample in a sample tube and injecting the sample into the reaction container to react with a reagent, a reaction container, and an analyzing device for analyzing a mixed solution in the reaction container.
According to a third aspect of the present application there is provided a closed uncapping method of removing a cap from a sample tube, the method comprising:
the driving fixing mechanism is used for fixing the sample tube;
the cover removing device is driven to remove the cover, the cover removing device comprises a cover body and a cover removing mechanism accommodated in the cover body, the cover body moves to the fixing mechanism to form a closed space, and the cover body of the sample tube is accommodated in the closed space;
extracting gas in the closed space;
and driving the cap pulling mechanism to move to pull out the sample cap when or during the process of extracting the gas in the closed space.
In one embodiment, the cap pulling mechanism is driven to clamp the cap body to move upwards along the axis direction of the cap body, and simultaneously the cap pulling mechanism is driven to rotate so as to pull out the sample cap.
In one embodiment, the method further comprises, after removing the sample lid, driving the decapping device to move to the lid discard bin to discard the sample lid.
In one embodiment, the method further comprises, after removing the sample cap, standing for a preset time, and driving the cap removing device to move to a cap discard bin to discard the sample cap.
Drawings
FIG. 1 is a schematic view of a closed decapping device for removing a cap from a sample tube;
FIG. 2 is a schematic view of a process of securing a sample tube by a securing mechanism;
FIG. 3 is a schematic view of a process of forming a closed space between a capping device and a fixing mechanism;
fig. 4 is a schematic diagram of the process of discarding the sample cap by the cap removal device.
Detailed Description
The present application will be described in further detail with reference to the drawings and examples, in order to make the objects, technical solutions and advantages of the present application more apparent. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the application.
The terms used in the present application will be explained first.
A "sample tube," also interchangeably referred to herein as a "tube," has a closed end and an open end closed by a cap, which may be made of different materials, and take on different shapes.
"sample cap", also interchangeably referred to herein as "cap", is used herein to refer to any type of cap, including screw caps and rubber caps, that can be opened and/or closed by pulling/pushing and/or tightening, respectively.
"coupled" when referring to the relationship between the driver and the securing mechanism, cover, or cap removal mechanism means that the driver is coupled to the securing mechanism, cover, or cap removal mechanism, thereby enabling transmission of force or energy from the driver to the securing mechanism, cover, or cap removal mechanism.
As shown in fig. 1-4, a closed cap removing device for removing a sample cap 2 from a sample tube 1 comprises a fixing mechanism 3, a cap removing device 4, a negative pressure source (not shown) and a first driver (not shown).
The side wall of the fixing mechanism 3 is attached to the outer wall of the sample tube 1. Preferably, the upper surface of the fixing mechanism 3 has a sealing groove 6, and the sealing groove 6 cooperates with the cap removing device 4 to form a closed space. The fixing mechanism 3 not only can fix the sample tube 1, but also has a sealing function, so that the cap removing device 4 can remove the sample cap 2 in a narrower space.
Further, referring to fig. 2, the fixing mechanism 3 includes a clamping block 3-1 and a clamping block 3-2 capable of clamping the sample tube 1. The clamping blocks 3-1 and 3-2 are located on both sides of the LAS rail 11, respectively, in a direction perpendicular to the LAS rail 11. The inner walls of the clamping block 3-1 and the clamping block 3-2 are circular arc-shaped and are attached to the outer wall of the sample tube 1. The clamping blocks 3-1 and 3-2 are connected to a fourth driver 16 and a fifth driver 17, respectively. Preferably, the fourth driver 16 and the fifth driver 17 are connected with the clamping block 3-1 and the clamping block 3-2 through screw rods, and the fourth driver 16 and the fifth driver 17 respectively drive the clamping block 3-1 and the clamping block 3-2 to horizontally move in a direction approaching the sample tube 1 to clamp the sample tube 1.
Further, rubber sheets are arranged on the inner walls of the clamping block 3-1 and the clamping block 3-2. When the sample tube 1 is clamped, the rubber sheet not only can play a role in buffering, but also can enable the clamping block 3-1 and the clamping block 3-2 to be attached to the sample tube 1 more tightly, and further plays a role in sealing.
Referring to fig. 3 and 4, the cap removing device 4 includes a cover 4-1 and a cap removing mechanism 4-2 accommodated in the cover 4-1. The cover 4-1 cooperates with the fixing mechanism 3 to form a closed space, and the sample cover 2 is accommodated in the closed space. Preferably, the cover 4-1 and the fixing mechanism 3 may form a closed space by contact, insertion, or the like. Preferably, the end of the cover 4-1 can be inserted into the sealing groove 6 to form a closed space. The cap removing mechanism 4-2 is used for removing the sample cap 2. Further, the cover 4-1 is provided with a gas passage 12 for gas circulation in the closed space. Preferably, the left wall and the right wall of the cover 4-1 are provided with gas passages 12. The housing 4-1 is connected to a negative pressure source (not shown) for extracting the gas in the enclosed space after the enclosed space is formed. The cover 4-1 is connected to a third driver 5. The third driver 5 drives the cover 4-1 to move to form a closed space with the fixing mechanism 3. Further, the third driver 5 may drive the cover 4-1 to move horizontally along the axial direction of the sample cover 2 to the fixing mechanism 3 to form a closed space. According to practical requirements, the third driver 5 may also drive the cover 4-1 to move vertically along the axial direction of the sample cover 2, so as to adjust the position of the cover 4-1. The third driver 5 may comprise a driving motor, and may drive the cover 4-1 to move horizontally and/or vertically along the axial direction of the sample cover 2; and the device can also comprise two driving motors, wherein one driving motor drives the cover body 4-1 to horizontally move along the axial direction of the sample cover 2, and the other driving motor drives the cover body 4-1 to vertically move along the axial direction of the sample cover 2. The number of the driving motors can be flexibly selected according to actual requirements and operation difficulty.
Further, the cover pulling mechanism 4-2 comprises a fixed bracket 4-2 'and a plurality of pulling claws 4-2' connected with the fixed bracket. The fixed support 4-2' is connected with the inner wall of the cover body 4-1 through a blind hole. Preferably, the fixing bracket 4-2' is connected with the upper inner wall of the cover 4-1. The pulling claw 4-2 'can do expansion and contraction movement around the fixed bracket 4-2'. The fingers 4-2 "cooperate with each other to clamp or screw the sample cap 2. The "clamping" or "tightening" described in the embodiments may also be accomplished in other similar ways.
The cap drawing mechanism 4-2 is connected to a first driver (not shown) which drives the drawing claw 4-2 "to open and/or contract to clamp/screw the sample cap 2, and after the drawing claw 4-2" clamps/screws the sample cap 2, drives the fixing bracket 4-2' to move to draw out the sample cap 2. Preferably, the first driver (not shown) drives the fixing bracket 4-2' upward in the axial direction of the sample cap 2 to withdraw the sample cap 2. According to practical requirements, the first driver (not shown) may also drive the fixing bracket 4-2' to move vertically along the axial direction of the sample cap 2, so as to adjust the position of the cap pulling mechanism 4-2. The first driver (not shown) may comprise a driving motor for driving the pulling claw 4-2 "to clamp/screw the sample cap 2, and for driving the fixing bracket 4-2' to move (including horizontal movement and/or vertical movement) to pull out the sample cap 2; two driving motors may be included, one driving motor drives the pulling claw 4-2 "to clamp/screw the sample cover 2, and the other driving motor drives the fixing bracket 4-2' to move (including horizontal movement and/or vertical movement) along the axial direction of the sample cover 2 so as to pull out the sample cover 2; three driving motors may be included, one driving motor driving the pulling claw 4-2 "to clamp/screw the sample cap 2, one driving motor driving the fixing bracket 4-2 'to move upwards along the axial direction of the sample cap 2 so as to pull out the sample cap 2, and one driving motor driving the fixing bracket 4-2' to move vertically along the axial direction of the sample cap 2 so as to adjust the position of the cap pulling mechanism 4-2. The number of the driving motors can be flexibly selected according to actual requirements.
Preferably, the cap removing mechanism 4-2 is further connected to a second driver (not shown) which drives the fixing bracket 4-2 'to rotate to remove the sample cap 2 while the first driver (not shown) drives the fixing bracket 4-2' to move upward along the axial direction of the sample cap 2. The cap pulling mechanism 4-2 is driven to move upwards along the axial direction of the sample cap 2, and meanwhile the cap pulling mechanism 4-2 is driven to rotate, so that the cap pulling mechanism is more beneficial to the pulling of the sample cap 2, and particularly for a spiral sample cap, the effect is more obvious.
Referring to fig. 4, the airtight cap removing apparatus further includes a cap discard chamber 13 for receiving the discarded sample caps 2. The cover reject bin 13 includes a bin door 13-1 and a bin body 13-2. When the cap removing device conveys the sample cap 2 to the cap body waste bin 13, the bin door 13-1 is opened, and the sample cap 2 enters a closed space formed by the bin body 13-2 and the cover body 4-1. When the cover discarding compartment 13 finishes receiving the discarded sample cover 2, the compartment door 13-1 is closed, and the compartment body 13-2 and the compartment door 13-1 cooperate to form a closed space. Further, the hatch 13-1 may open/close the waste compartment 13 by sliding or the like. Further, the upper surface of the cabin 13-2 is provided with a sealing groove 15, and the bottom of the cover 4-1 can be embedded into the sealing groove 15 to form the closed space. When the sample cap 2 is discarded, the residual aerosol on the sample cap 2 is easy to diffuse into the air, and the sample cap 2 is discarded in a closed space, so that the residual aerosol can be effectively prevented from diffusing.
Preferably, the cap removing device further comprises an ultraviolet light source lamp 14, and the ultraviolet light source lamp 14 is accommodated in the cover 4-1. The ultraviolet light source lamp 14 is used for inactivating the sample cover 2. Further, the cap removing device may be provided with a plurality of ultraviolet light source lamps 14.
Further, the capping device also comprises an air treatment device (shown and labeled) for treating the gas or aerosol extracted from the enclosed space.
As shown in fig. 2, in the LAS system, the sample tubes 1 from which the sample caps are to be removed are located in a sample tube buffer zone 9, and the sample tubes 1 are placed on sample holders 7, respectively. The front end of the sample tube buffer area 9 can be provided with a cover-removing buffer stop block 8-1. When the uncapping operation is performed, the sample holder 7, on which the sample tube 1 is placed, is transported to the uncapping station 10 by the LAS track 11. The front end of the cap removing station 10 can be provided with a cap removing work stop block 8-2.
When the sample holder 7 reaches the cap removing station 10, the fourth driver 16 and the fifth driver 17 respectively drive the clamping block 3-1 and the clamping block 3-2 to move towards the direction approaching the sample tube 1 to clamp the sample tube 1, and the inner walls of the clamping block 3-1 and the clamping block 3-2 are attached to the outer wall of the sample tube 1.
As shown in fig. 3, after the sample tube 1 is clamped by the sample tube clamping blocks 3-1 and 3-2, the first driver (not shown) drives the fingers 4-2 "to open. The third driver 5 drives the cover body 4-1 to move downwards, and the lower end of the cover body 4-1 is embedded into the sealing grooves 6 of the sample tube clamping blocks 3-1 and 3-2 to complete sealing work. The cover body 4-1 cooperates with the sample tube clamping block 3-1 and the clamping block 3-2 to form a closed space, and the sample cover 2 is sealed in the closed space. The step of driving the pulling claw 4-2 "to open by the first driver (not shown) may be adjusted according to actual requirements, for example: can be driven before the fourth driver 5 drives the cover body 4-1 to move, or can be driven after the fourth driver 5 drives the cover body 4-1, the clamping block 3-1 and the clamping block 3-2 form the closed space; or in the process that the fourth driver 5 drives the cover body 4-1 and the clamping blocks 3-1 and 3-2 to form the closed space.
As shown in fig. 1, after the closed space is formed, the negative pressure source draws the gas in the closed space to generate a directional airflow, so that the gas or aerosol in the closed space flows to the air treatment device. The first driver (not shown) drives the pulling claw 4-2 "to screw the sample cap 2 when or during the extraction of the gas in the closed space. After the pulling claw 4-2″ has screwed the sample cap 2, the first driver 5 (not shown) drives the fixing bracket 4-2' to move upward to pull out the sample cap 2. Preferably, after the pulling claw 4-2″ is screwed to the sample cap 2, the first driver (not shown) drives the fixing bracket 4-2 'to rotate and simultaneously drives the fixing bracket 4-2' to pull out the sample cap 2.
Preferably, the ultraviolet light source lamp 14 is kept on after the enclosed space is formed.
As shown in fig. 4, after the sample cap 2 is pulled out, the third driver 5 drives the cap removing means 4 to move to the cap discard compartment 13. When the cap removing device 4 conveys the sample cap 2 to the cap body waste bin 13, the third driver 5 drives the cap body 4-1 to move downwards to the sealing groove 15 of the bin body 13-2 so as to form a closed space, and the sample cap 2 is accommodated in the closed space. The hatch door 13-1 is slid open and the first driver (not shown) drives the fingers 4-2 "open and the sample cap 2 enters the waste compartment 13. When the discarding of the sample cover 2 is completed, the cabin door 13-1 slides to close the discarding cabin 13, and the cabin body 13-2 and the cabin door 13-1 cooperate to form a closed space.
Further, after the cap removing mechanism 4-2 removes the sample cap 2, the cap removing device 4 is left to stand for a predetermined time, for example, 1s,2s,3s, etc., and the fourth driver 5 drives the cap removing device 4 to move to the sample tube disposal compartment 13.
The above examples illustrate only a few embodiments of the application, which are described in detail and are not to be construed as limiting the scope of the application. It should be noted that it will be apparent to those skilled in the art that several variations and modifications can be made without departing from the spirit of the application, which are all within the scope of the application. Accordingly, the scope of protection of the present application is to be determined by the appended claims.
Claims (10)
1. A closed cap removal device for removing a cap from a sample tube, the closed cap removal device being adapted for use in a fully automated laboratory system, the sample being a blood sample; the airtight cap removing device is characterized by comprising:
the side wall of the fixing mechanism is attached to the outer wall of the sample tube;
the cover removing device comprises a cover body and a cover pulling mechanism accommodated in the cover body, wherein the cover body is matched with the fixing mechanism to form a closed space, and the cover body of the sample tube is accommodated in the closed space;
the negative pressure source is connected with the cover body and is used for extracting gas in the closed space after the closed space is formed to generate directional airflow so that the gas or aerosol in the closed space flows to the air treatment device; wherein the sample tube is in an air environment prior to forming the enclosed space;
a first driver for driving the cap removing mechanism to remove the cap from the sample tube in the closed space; wherein, when the gas in the closed space is extracted, or in the process of extracting the gas in the closed space, the cover is pulled out;
the closed cap removing device further comprises a cap body waste bin, the cap body waste bin comprises a bin body and a bin door, when the cap removing device conveys the sample cap to the cap body waste bin, the bin door is opened, and the sample cap enters a closed space formed by the bin body and the cover body in a matched mode; when the cover body waste cabin finishes receiving the waste sample cover, the cabin door is closed, and the cabin body and the cabin door are matched to form a closed space.
2. The sealed cap removing device according to claim 1, wherein the upper surface of the fixing mechanism is provided with a sealing groove, and the bottom of the cover body can be embedded into the sealing groove to form the sealed space.
3. The closure de-capping device of any one of claims 1 to 2 wherein the first driver drives the cap extraction mechanism to grip the cap in an upward direction along a cap axis to extract the cap.
4. The sealed uncapping apparatus of claim 3 further comprising a second driver that drives the uncapping mechanism to rotate to extract the cap while the first driver drives the cap extracting mechanism to clamp the cap up in the cap axis direction.
5. The closure de-capping device of claim 1 wherein the capping mechanism comprises a fixed bracket and a pulling pawl connected to the fixed bracket, the pulling pawl being expandable and contractible about the fixed bracket.
6. The sealed decapping device of claim 1, wherein the upper surface of the capsule has a sealing groove into which the bottom of the cap can be inserted to form the sealed space.
7. The sealed uncapping apparatus of claim 1, further comprising an ultraviolet light source lamp housed in the housing for inactivating the housing.
8. A sample analyzer comprising the sealed cap removing device according to any one of claims 1 to 7, a lancet for sucking a sample in a sample tube and injecting the sample into the reaction container to react with a reagent, a reaction container, and an analyzing device for analyzing a mixed solution in the reaction container.
9. A closed uncapping method for removing a cap from a sample tube, suitable for use in a fully automated laboratory system, the method comprising:
the driving fixing mechanism is used for fixing the sample tube; the sample tube is used for containing a blood sample;
the cover removing device is driven to remove the cover, the cover removing device comprises a cover body and a cover removing mechanism accommodated in the cover body, the cover body moves to the fixing mechanism to form a closed space, and the cover body of the sample tube is accommodated in the closed space;
extracting gas in the closed space to generate directional airflow, so that the gas or aerosol in the closed space flows to an air treatment device; wherein the sample tube is in an air environment prior to forming the enclosed space;
when the gas in the closed space is extracted, or in the process of extracting the gas in the closed space, the cap extracting mechanism is driven to move so as to extract the sample cap;
the method further comprises the step of driving the cap removing device to move to a cap body discarding cabin to discard the sample cap after the sample cap is removed and the sample cap is kept stand for a preset time.
10. The method of claim 9, wherein the cap removal mechanism is driven to rotate to remove the sample cap while the cap removal mechanism is driven to clamp the cap upward in the cap axis direction.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010477888.3A CN113735037B (en) | 2020-05-29 | 2020-05-29 | Closed cap removal device and method for removing caps from sample tubes |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010477888.3A CN113735037B (en) | 2020-05-29 | 2020-05-29 | Closed cap removal device and method for removing caps from sample tubes |
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| Publication Number | Publication Date |
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| CN113735037A CN113735037A (en) | 2021-12-03 |
| CN113735037B true CN113735037B (en) | 2023-10-20 |
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| CN202010477888.3A Active CN113735037B (en) | 2020-05-29 | 2020-05-29 | Closed cap removal device and method for removing caps from sample tubes |
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| CN106395708A (en) * | 2016-08-31 | 2017-02-15 | 兰州空间技术物理研究所 | Device for unsealing sealed extraterrestrial celestial body sample packaging container |
| CN206645790U (en) * | 2017-03-28 | 2017-11-17 | 谭飞 | A kind of test tube pulls out lid arrangement |
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