CN113727991A - Ras抑制肽 - Google Patents

Ras抑制肽 Download PDF

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Publication number
CN113727991A
CN113727991A CN202080030445.8A CN202080030445A CN113727991A CN 113727991 A CN113727991 A CN 113727991A CN 202080030445 A CN202080030445 A CN 202080030445A CN 113727991 A CN113727991 A CN 113727991A
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CN
China
Prior art keywords
group
cys
pro
amino acid
peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202080030445.8A
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English (en)
Chinese (zh)
Inventor
坂元孝太郎
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ichimaru Pharcos Co Ltd
Original Assignee
Ichimaru Pharcos Co Ltd
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Filing date
Publication date
Application filed by Ichimaru Pharcos Co Ltd filed Critical Ichimaru Pharcos Co Ltd
Publication of CN113727991A publication Critical patent/CN113727991A/zh
Pending legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64Cyclic peptides containing only normal peptide links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202080030445.8A 2019-05-14 2020-05-12 Ras抑制肽 Pending CN113727991A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2019-091419 2019-05-14
JP2019091419 2019-05-14
PCT/JP2020/018956 WO2020230780A1 (ja) 2019-05-14 2020-05-12 Ras阻害ペプチド

Publications (1)

Publication Number Publication Date
CN113727991A true CN113727991A (zh) 2021-11-30

Family

ID=73289428

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080030445.8A Pending CN113727991A (zh) 2019-05-14 2020-05-12 Ras抑制肽

Country Status (5)

Country Link
US (1) US20220227813A1 (https=)
EP (1) EP3970801A4 (https=)
JP (1) JPWO2020230780A1 (https=)
CN (1) CN113727991A (https=)
WO (1) WO2020230780A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022234639A1 (ja) * 2021-05-07 2022-11-10 中外製薬株式会社 変異型ras(g12d)に対する選択的結合性を示す結合分子
JP2023047726A (ja) * 2021-09-27 2023-04-06 富士通株式会社 初期構造生成装置、初期構造生成方法及び初期構造生成プログラム
JP2026027576A (ja) * 2022-11-22 2026-02-19 一丸ファルコス株式会社 Ras阻害ペプチドを含む組成物
WO2025162428A1 (en) * 2024-01-29 2025-08-07 Syneron Technology Co. Ltd. Cyclic peptide compounds and compositions as ras inhibitors

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995033765A1 (en) * 1994-06-08 1995-12-14 Peptor Ltd. Conformationally constrained backbone cyclized peptide analog
CN106573032A (zh) * 2014-05-21 2017-04-19 哈佛大学的校长及成员们 Ras抑制肽和其用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3534989A (en) * 1988-04-08 1989-11-03 Scripps Clinic And Research Foundation Polypeptides stabilized by covalent hydrogen bond replacements
CN1230441C (zh) * 2000-04-12 2005-12-07 安盛药业有限公司 结合整联蛋白的肽衍生物
US20110223149A1 (en) * 2009-10-14 2011-09-15 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
ES2705068T3 (es) * 2013-05-23 2019-03-21 Ohio State Innovation Foundation Síntesis química y cribado de bibliotecas de péptidos bicíclicos
CN105683211B (zh) * 2013-10-28 2020-10-20 拜斯科阿迪有限公司 新型多肽

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995033765A1 (en) * 1994-06-08 1995-12-14 Peptor Ltd. Conformationally constrained backbone cyclized peptide analog
US5811392A (en) * 1994-06-08 1998-09-22 Yissum Research Development Co. Of The Hebrew University Conformationally constrained backbone cyclized peptide analogs
CN106573032A (zh) * 2014-05-21 2017-04-19 哈佛大学的校长及成员们 Ras抑制肽和其用途

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
AYUMU NIIDA等: "Investigation of the structural requirements of K-Ras(G12D) selective inhibitory peptide KRpep-2d using alanine scans and cysteine bridging", 《BIOORGANIC & MEDICINAL CHEMISTRY LETTERS》, vol. 27, 21 April 2017 (2017-04-21), pages 2759 - 2761 *
THI B. TRINH等: "Discovery of a Direct Ras Inhibitor by Screening a Combinatorial Library of Cell-Permeable Bicyclic Peptides", 《ACS COMB. SCI.》, vol. 18, 8 December 2015 (2015-12-08), pages 75 - 85, XP055431276, DOI: 10.1021/acscombsci.5b00164 *

Also Published As

Publication number Publication date
WO2020230780A1 (ja) 2020-11-19
EP3970801A4 (en) 2022-11-02
JPWO2020230780A1 (https=) 2020-11-19
EP3970801A1 (en) 2022-03-23
US20220227813A1 (en) 2022-07-21

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