CN113727720A - 用于治疗表达cldn6的癌症的嵌合抗原受体修饰的细胞 - Google Patents

用于治疗表达cldn6的癌症的嵌合抗原受体修饰的细胞 Download PDF

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CN113727720A
CN113727720A CN202080026088.8A CN202080026088A CN113727720A CN 113727720 A CN113727720 A CN 113727720A CN 202080026088 A CN202080026088 A CN 202080026088A CN 113727720 A CN113727720 A CN 113727720A
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cell
cells
car
immune effector
cldn6
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U·沙欣
P·厄姆
B·伦斯特尔
K·赖因哈德
K·米歇尔
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Biontech Cell and Gene Therapies GmbH
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CN202080026088.8A 2019-02-08 2020-02-05 用于治疗表达cldn6的癌症的嵌合抗原受体修饰的细胞 Pending CN113727720A (zh)

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EPPCT/EP2019/053156 2019-02-08
EP2019053156 2019-02-08
PCT/EP2020/052867 WO2020161186A1 (en) 2019-02-08 2020-02-05 Chimeric antigen receptor-modified cells for the treatment of cldn6-expressing cancers

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114478802A (zh) * 2022-01-28 2022-05-13 郑州大学 一种嵌合抗原受体及其应用
WO2024022512A1 (en) * 2022-07-29 2024-02-01 Nanjing Legend Biotech Co., Ltd. Claudin-6 binding moieties and uses thereof
WO2024088325A1 (zh) * 2022-10-25 2024-05-02 科济生物医药（上海）有限公司 抗体及其应用
CN120484126A (zh) * 2022-07-28 2025-08-15 乐普创一生物科技（上海）有限公司 抗MerTK抗体及其用途

Families Citing this family (5)

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WO2021129927A1 (en) * 2019-12-23 2021-07-01 Biontech Cell & Gene Therapies Gmbh Treatment with immune effector cells engineered to express an antigen receptor
WO2024046572A1 (en) * 2022-09-01 2024-03-07 BioNTech SE Chimeric antigen receptor-modified cells for the treatment of cldn6 expressing cancer
CA3242106A1 (en) * 2021-12-09 2023-06-15 BioNTech SE Chimeric antigen receptor-modified cells for the treatment of cldn6 expressing cancer
CN114410588B (zh) * 2022-01-29 2022-11-04 西安电子科技大学 一种α1β1整合素依赖增强型CAR巨噬细胞及其制备方法和应用
WO2025184170A1 (en) 2024-02-27 2025-09-04 Overt Bio, Inc. Methods and compositions for improving t cell function in an immunosuppressive environment

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CN106146666A (zh) * 2015-03-26 2016-11-23 科济生物医药（上海）有限公司 靶向cldn6的免疫效应细胞及其制备方法和应用
CN106459165A (zh) * 2014-04-01 2017-02-22 拜恩科技细胞&基因治疗有限公司 密封蛋白‑6特异性免疫受体和t细胞表位
CN107207580A (zh) * 2014-11-05 2017-09-26 艾伯维施特姆森特克斯有限责任公司 抗‑cldn嵌合抗原受体和使用方法
CN107743399A (zh) * 2015-05-11 2018-02-27 拜恩科技细胞&基因治疗有限公司 通过核酸接种增强car‑工程化的t细胞的作用

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ES2918501T3 (es) 2013-12-19 2022-07-18 Novartis Ag Receptores de antígenos quiméricos de mesotelina humana y usos de los mismos
AU2018289428B2 (en) * 2017-06-21 2024-06-27 The General Hospital Corporation Methods and compositions for chimeric antigen receptor targeting cancer cells
WO2019060425A1 (en) * 2017-09-19 2019-03-28 Massachusetts Institute Of Technology COMPOSITIONS FOR CHIMERIC ANTIGENIC RECEPTOR T CELL THERAPY AND USES THEREOF
CN109206524B (zh) * 2018-09-25 2022-04-05 山东兴瑞生物科技有限公司 抗Claudin18A2嵌合抗原受体、其修饰的T细胞及T细胞制备方法和用途

Patent Citations (4)

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CN106459165A (zh) * 2014-04-01 2017-02-22 拜恩科技细胞&基因治疗有限公司 密封蛋白‑6特异性免疫受体和t细胞表位
CN107207580A (zh) * 2014-11-05 2017-09-26 艾伯维施特姆森特克斯有限责任公司 抗‑cldn嵌合抗原受体和使用方法
CN106146666A (zh) * 2015-03-26 2016-11-23 科济生物医药（上海）有限公司 靶向cldn6的免疫效应细胞及其制备方法和应用
CN107743399A (zh) * 2015-05-11 2018-02-27 拜恩科技细胞&基因治疗有限公司 通过核酸接种增强car‑工程化的t细胞的作用

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114478802A (zh) * 2022-01-28 2022-05-13 郑州大学 一种嵌合抗原受体及其应用
CN114478802B (zh) * 2022-01-28 2023-05-26 郑州大学 一种嵌合抗原受体及其应用
CN120484126A (zh) * 2022-07-28 2025-08-15 乐普创一生物科技（上海）有限公司 抗MerTK抗体及其用途
WO2024022512A1 (en) * 2022-07-29 2024-02-01 Nanjing Legend Biotech Co., Ltd. Claudin-6 binding moieties and uses thereof
WO2024088325A1 (zh) * 2022-10-25 2024-05-02 科济生物医药（上海）有限公司 抗体及其应用

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BR112021015429A2 (pt) 2021-10-05
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AU2020217868A1 (en) 2021-08-12
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SMT202500012T1 (it) 2025-03-12
KR20210124237A (ko) 2021-10-14
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US20220184119A1 (en) 2022-06-16
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