CN113727706A - 新型脂溶性维生素递送系统 - Google Patents

新型脂溶性维生素递送系统 Download PDF

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Publication number
CN113727706A
CN113727706A CN202080031457.2A CN202080031457A CN113727706A CN 113727706 A CN113727706 A CN 113727706A CN 202080031457 A CN202080031457 A CN 202080031457A CN 113727706 A CN113727706 A CN 113727706A
Authority
CN
China
Prior art keywords
delivery system
fat
inner coating
coating
product
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202080031457.2A
Other languages
English (en)
Chinese (zh)
Inventor
艾勒格·范纳
奥迪尔·科瑞恩兹
罗伯特·斯坦尼特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM IP Assets BV
Original Assignee
DSM IP Assets BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM IP Assets BV filed Critical DSM IP Assets BV
Publication of CN113727706A publication Critical patent/CN113727706A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/592—9,10-Secoergostane derivatives, e.g. ergocalciferol, i.e. vitamin D2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Jellies, Jams, And Syrups (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN202080031457.2A 2019-04-30 2020-04-09 新型脂溶性维生素递送系统 Pending CN113727706A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19171752 2019-04-30
EP19171752.9 2019-04-30
PCT/EP2020/060161 WO2020221572A1 (en) 2019-04-30 2020-04-09 New delivery system for fat soluble vitamins

Publications (1)

Publication Number Publication Date
CN113727706A true CN113727706A (zh) 2021-11-30

Family

ID=66429183

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080031457.2A Pending CN113727706A (zh) 2019-04-30 2020-04-09 新型脂溶性维生素递送系统

Country Status (7)

Country Link
US (1) US12419841B2 (https=)
EP (1) EP3962461A1 (https=)
JP (1) JP7657725B2 (https=)
KR (1) KR20220003039A (https=)
CN (1) CN113727706A (https=)
BR (1) BR112021021390A2 (https=)
WO (1) WO2020221572A1 (https=)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1058904A (zh) * 1990-07-10 1992-02-26 信越化学工业株式会社 在大肠内具有释放能力的包衣固体药物型
US20040169298A1 (en) * 2002-11-20 2004-09-02 Shin-Etsu Chemical Co., Ltd. Microcapsule and production method thereof
CN103874422A (zh) * 2011-10-14 2014-06-18 帝斯曼知识产权资产管理有限公司 新的涂层系统
CN108401418A (zh) * 2016-11-17 2018-08-14 上海交通大学医学院 口服结肠靶向的递送系统及其制备方法和应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4389419A (en) * 1980-11-10 1983-06-21 Damon Corporation Vitamin encapsulation
US4670247A (en) * 1983-07-05 1987-06-02 Hoffman-Laroche Inc. Process for preparing fat-soluble vitamin active beadlets
JP2939403B2 (ja) * 1993-02-05 1999-08-25 義秀 萩原 プロラクチン又は成長ホルモンの分泌促進剤
US6620431B1 (en) * 2000-04-17 2003-09-16 Charles Signorino Shellac film coatings providing release at selected pH and method
US7097868B2 (en) * 2001-08-23 2006-08-29 Bio-Dar Ltd. Stable coated microcapsules
JP4593846B2 (ja) * 2001-09-07 2010-12-08 信越化学工業株式会社 医薬品又は食品用マイクロカプセルの製造方法
EP1940249B1 (en) * 2005-10-21 2015-06-03 DSM IP Assets B.V. Novel formulations of fat-soluble active ingredients with high bioavailability
US20070098790A1 (en) 2005-10-31 2007-05-03 David Jiang Nutritional supplement for the enhancement of the health of the liver
JP2010121028A (ja) 2008-11-19 2010-06-03 Ina Food Industry Co Ltd 改質キサンタンガム、改質アラビアガム、及び改質タマリンドシードガム、並びにキサンタンガム、アラビアガム、及びタマリンドシードガムの架橋方法
US20160158174A1 (en) 2014-12-09 2016-06-09 Intercontinental Great Brands Llc Enteric-Coated Functional Food Ingredients And Methods For Making The Enteric-Coated Functional Food Ingredients
JP6659075B2 (ja) 2014-12-26 2020-03-04 ポーラ化成工業株式会社 カプセル体及びその製造方法
US20170296476A1 (en) * 2016-04-15 2017-10-19 Grünenthal GmbH Modified release abuse deterrent dosage forms
JP2020536930A (ja) * 2017-10-13 2020-12-17 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 放出調節乱用防止剤形
CN109511785A (zh) * 2018-12-25 2019-03-26 乐山市瑞和祥动物保健药业有限公司 一种兽用复合维生素微丸及其制备方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1058904A (zh) * 1990-07-10 1992-02-26 信越化学工业株式会社 在大肠内具有释放能力的包衣固体药物型
US20040169298A1 (en) * 2002-11-20 2004-09-02 Shin-Etsu Chemical Co., Ltd. Microcapsule and production method thereof
CN103874422A (zh) * 2011-10-14 2014-06-18 帝斯曼知识产权资产管理有限公司 新的涂层系统
CN108401418A (zh) * 2016-11-17 2018-08-14 上海交通大学医学院 口服结肠靶向的递送系统及其制备方法和应用

Also Published As

Publication number Publication date
US20220226254A1 (en) 2022-07-21
KR20220003039A (ko) 2022-01-07
EP3962461A1 (en) 2022-03-09
JP7657725B2 (ja) 2025-04-07
US12419841B2 (en) 2025-09-23
BR112021021390A2 (pt) 2021-12-21
WO2020221572A1 (en) 2020-11-05
JP2022530307A (ja) 2022-06-29

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