CN113712849A - Spray with high skin affinity and preparation method thereof - Google Patents

Spray with high skin affinity and preparation method thereof Download PDF

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CN113712849A
CN113712849A CN202110598388.XA CN202110598388A CN113712849A CN 113712849 A CN113712849 A CN 113712849A CN 202110598388 A CN202110598388 A CN 202110598388A CN 113712849 A CN113712849 A CN 113712849A
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spray
surfactant
modified
skin
polyglycol
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CN113712849B (en
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王祥
冯静静
毛海华
曹艳华
李晨煜
王文龙
胡新成
李维
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Shanghai Zhongyi Daily Chemical Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/046—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/596—Mixtures of surface active compounds

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Cosmetics (AREA)

Abstract

The invention relates to the field of cosmetics, in particular to a high-skin-affinity spray and a preparation method thereof, wherein the high-skin-affinity spray comprises 0.5-10 wt% of surfactant, 0-4 wt% of humectant and water which is supplemented to 100 wt%; the surfactant is a polyglycol modified surfactant. The high-skin-affinity spray has the characteristics of low contact angle and excellent lipophilicity, and the skin affinity is remarkably improved; the formula is simple, and the preparation is convenient; the spray is safe and non-irritant; the moisturizing spray is used in a skin makeup state, and the effect is better; the hanging effect of water drops is obviously reduced, so that the glass can be applied to the fields of rainy glass and the like; the spray is transparent, good in stability, good in dispersion effect, fine and uniform in water mist, easy to absorb by skin, free of phase splitting phenomenon when sprayed on skin coated with squalane and other oils, free of water drops hanging on the skin, faster in permeation effect, and stable for a long time.

Description

Spray with high skin affinity and preparation method thereof
Technical Field
The invention relates to the field of cosmetics, in particular to a spray with high skin affinity and a preparation method thereof.
Background
With the enhancement of aesthetic concepts, people pay more and more attention to cosmetics. Cosmetics refer to products that are applied, sprayed or otherwise attached to the skin surface, and healthy and safe skin care products are receiving increasing attention from consumers.
Emollient and absorbent properties are fundamental requirements of all cosmetic products, which are related to the affinity of the cosmetic product to the skin. The improvement of the skin-friendly property of aqueous cosmetics is also a subject of continuous research in the industry. Moisture is also a very promising research direction if it can improve the affinity with the skin and reduce the contact angle with the skin in the presence of skin oil. At present, many cosmetics are generally added with some components such as surfactants and plant extracts in order to maintain the skin moisturizing property, but the obtained cosmetics have poor appearance, turbidity and poor stability, and are not high in affinity, exhibit a pearl hanging phenomenon and are not strong in practicability when applied to the surface of greasy skin.
Disclosure of Invention
In view of the problems of the prior art, the invention provides a high skin affinity spray in a first aspect, which comprises 0.5-10 wt% of surfactant, 0-4 wt% of humectant and water in balance of 100 wt%; the surfactant is a polyglycol modified surfactant.
In a preferred embodiment of the present invention, the polymerization degree of the polyglycol in the polyglycol-modified surfactant is 3 to 15.
In a preferred embodiment of the present invention, the polyglycol-modified surfactant is one or more selected from polyethylene glycol-modified oils and fats, polypropylene glycol-modified polyethers, and polyglycol-modified polyol surfactants.
In a preferred embodiment of the present invention, the weight ratio of the polyethylene glycol-modified fat to oil, the polypropylene glycol-modified polyether, and the polyglycol-modified polyol surfactant is (5-8): 1: (1-5).
In a preferred embodiment of the present invention, the polyethylene glycol-modified fat contains a cocoate group.
In a preferred embodiment of the present invention, the polypropylene glycol-modified polyether contains a C8-15 aliphatic branch chain.
In a preferred embodiment of the present invention, the polyglycol-modified polyol surfactant is PEG/PPG/polytetramethylene glycol-8/5/3 glycerin.
As a preferred technical solution of the present invention, the humectant is selected from one or more of polyhydric alcohol, polyethylene glycol, sodium hyaluronate, ceramide, lactic acid, allantoin, collagen, trehalose, tremella polysaccharide, panthenol, and plant extracts.
In a preferred embodiment of the present invention, the polyol comprises glycerol.
In a second aspect, the present invention provides a method for preparing the high skin affinity spray, comprising: mixing surfactant, humectant and water, and stirring.
Compared with the prior art, the invention has the following beneficial effects:
the high-skin-affinity spray has the characteristics of low contact angle and excellent lipophilicity, and the skin affinity is remarkably improved; the formula is simple, and the preparation is convenient; the spray is safe and non-irritant; the moisturizing spray is used in a skin makeup state, and the effect is better; the hanging effect of water drops is obviously reduced, so that the glass can be applied to the fields of rainy glass and the like; the spray is transparent, good in stability, good in dispersion effect, fine and uniform in water mist, easy to absorb by skin, free of phase splitting phenomenon when sprayed on skin coated with squalane and other oils, free of water drops hanging on the skin, faster in permeation effect, and stable for a long time.
Drawings
FIG. 1 is a graph of the skin-friendly effect of sprays from examples 29 and 32 of the present invention;
FIG. 2 is a graph showing the change in contact angle of sprays of examples 29 and 33 of the present invention;
FIG. 3 is a graph showing changes in contact angle after spray dilution 5 times in examples 29 and 33 of the present invention.
Detailed Description
The present invention is illustrated by the following specific embodiments, but is not limited to the specific examples given below.
The invention provides a high-skin-affinity spray, which comprises 0.5-10 wt% of surfactant, 0-4 wt% of humectant and water, wherein the water is supplemented to 100 wt%; the surfactant is a polyglycol modified surfactant.
In one embodiment, the high skin substantivity spray further comprises 0.05-1 wt% of a preservative.
Preferably, the surfactant content is 1.65 wt%.
The preservative of the present invention is not particularly limited and may be conventionally selected by those skilled in the art.
The preservative includes, but is not limited to, phenoxyethanol, parabens, imidazolidinyl ureas, cardon, bisimidazolidinyl ureas, and the like.
In one embodiment, the preservative is phenoxyethanol.
The humectant described herein is not particularly limited and may be routinely selected by those skilled in the art.
The moisturizer includes, but is not limited to, polyhydric alcohol, polyethylene glycol, sodium hyaluronate, ceramide, lactic acid, allantoin, collagen, trehalose, tremella polysaccharide, panthenol, plant extracts, and the like.
In one embodiment, the humectant is a polyol.
Preferably, the polyol comprises glycerol.
In one embodiment, the polyglycol-modified surfactant has a degree of polymerization of the polyglycol of 3 to 15.
Preferably, the polymerization degree of the polyglycol in the polyglycol modified surfactant is 7-13.
Preferably, the polyglycol is polyethylene glycol and/or polypropylene glycol.
In one embodiment, the polyglycol modified surfactant is selected from one or more of polyethylene glycol modified oils, polypropylene glycol modified polyethers, polyglycol modified polyol surfactants.
Preferably, the weight ratio of the polyethylene glycol modified grease, the polypropylene glycol modified polyether and the polyglycol modified polyol surfactant is (5-8): 1: (1-5); more preferably 6.7: 1: 3.3.
preferably, the polyethylene glycol modified oil contains a cocoate group; more preferably, the polyethylene glycol modified grease is PEG-7 glycerol cocoate.
Preferably, the polypropylene glycol modified polyether contains C8-15 fatty branched chain; more preferably, the polypropylene glycol modified polyether is PPG-13-decyltetradecanol polyether-24.
Preferably, the polyglycol modified polyol surfactant is PEG/PPG/polytetramethylene glycol-8/5/3 glycerin.
The preservative of the present invention is not particularly limited and may be conventionally selected by those skilled in the art.
In one embodiment, the preservatives include, but are not limited to, phenoxyethanol, parabens, imidazolidinyl ureas, carbazoles, bisimidazolidinyl ureas, and the like.
According to the theory of colloid interface chemistry, the applicant adds a surfactant into the water-based spray for reducing the interfacial tension of water and oil phases, but the applicant finds that the water-based spray does not achieve good effect, the phenomenon of dripping of the spray on the skin is obvious, and the spray is layered, turbid and opaque, so that a commercialized product cannot be formed.
In addition, applicants have unexpectedly found that in the particular spray humectant system herein, polyglycol modified surfactants, especially those which are PEG-7 glyceryl cocoate, PPG-13-decyltetradecyl polyether-24 and PEG/PPG/polytetramethylene glycol-8/5/3 glycerin, were added in the weight ratios (5-8): 1: (1-5), the spray obtained at this time is not only transparent and stable, does not bead on the skin surface containing squalane, is absorbed quickly, is good in skin-friendliness and has a low contact angle, and the applicant believes that the reason why it is possible in the present application that a specific polymerization degree and a specific length of branched chain allow the spray to spread on the surface containing squalane, while 3 specific surfactants have good compatibility dispersion in the spray system and maintain a transparent and stable system for a long period of time.
Examples
Hereinafter, the present invention will be described in more detail by way of examples, but it should be understood that these examples are merely illustrative and not restrictive. The starting materials used in the examples which follow are all commercially available unless otherwise stated.
Examples 1 to 32
Examples 1 to 32 of the present invention provide a spray having the following composition: 2 wt% of glycerin, 0.5 wt% of surfactant, 0.5 wt% of phenoxyethanol and water added to 100 wt%.
Wherein, the kinds and contents of the surfactants in examples 1 to 32 are shown in Table 1.
TABLE 1
Figure BDA0003092033410000041
Figure BDA0003092033410000051
Figure BDA0003092033410000061
Figure BDA0003092033410000071
The appearance and use of the high skin substantivity sprays obtained in examples 1-32 are shown in Table 2.
TABLE 2
Figure BDA0003092033410000072
Figure BDA0003092033410000081
Figure BDA0003092033410000091
From the test results of table 2, it can be seen that the surfactant in the present application has a unique skin-friendly effect advantage, and the effect graph is shown in fig. 1.
FIG. 1 illustrates the following steps: the back of the hand was first coated with a 100 wt% pure layer of grease (squalane) and the spray sample was then sprayed onto the back of the hand. The right hand in FIG. 1 is a graph showing the effect of the high skin affinity spray of example 29, sample number. The left hand of fig. 1 is the effect diagram of the spray of example 32 of the present application.
Examples 1-28, 30-32 sprays were prepared as follows: adding surfactant into water, stirring and heating to 75 deg.C, cooling to 42 deg.C, adding the rest raw materials, stirring, and cooling to 32 deg.C.
Example 29 the spray was prepared by: adding PEG-7 glyceryl cocoate into water, stirring and heating to 75 deg.C, cooling to 42 deg.C, adding the rest raw materials, stirring, and cooling to 32 deg.C.
Example 33
Example 33 of the present invention provides a spray formulation similar to example 29 except that the surfactant has PEG-7 glyceryl cocoate in an amount of 0.
The preparation method of the spray comprises the following steps: adding the raw materials at 42 deg.C, stirring, and cooling to 32 deg.C.
The sprays of example 29 and example 33 were subjected to contact angle tests using a contact angle measuring instrument of model DSA20 of kruss, germany, and the test results are shown in table 3.
TABLE 3
Figure BDA0003092033410000101
The resulting contact angle change is shown in FIG. 2.
The contact angle test was performed again using the same method with 5-fold dilution of the spray of example 29 and example 33, respectively, and the results are shown in table 4 and fig. 3.
TABLE 4
Figure BDA0003092033410000102
As can be seen from tables 3 and 4 and fig. 2-3, the spray in this application has higher skin-friendliness, very small contact angle, and the unique effect of no water-beading visually, and the contact angle is particularly significantly reduced, which is demonstrated both theoretically and experimentally.
The foregoing examples are merely illustrative and serve to explain some of the features of the method of the present invention. The appended claims are intended to claim as broad a scope as is contemplated, and the examples presented herein are merely illustrative of selected implementations in accordance with all possible combinations of examples. Accordingly, it is applicants' intention that the appended claims are not to be limited by the choice of examples illustrating features of the invention. Also, where numerical ranges are used in the claims, subranges therein are included, and variations in these ranges are also to be construed as possible being covered by the appended claims.

Claims (10)

1. A high skin affinity spray is characterized by comprising 0.5-10 wt% of surfactant, 0-4 wt% of humectant and water to make up to 100 wt%; the surfactant is a polyglycol modified surfactant.
2. The high skin substantivity spray of claim 1 wherein the polymerization degree of the polyglycol of said polyglycol-modified surfactant is from 3 to 15.
3. The high skin substantivity spray of claim 2 wherein said polyglycol-modified surfactant is selected from one or more of polyethylene glycol-modified oils, polypropylene glycol-modified polyethers, and polyglycol-modified polyol surfactants.
4. The high skin substantivity spray according to claim 3, wherein the weight ratio of said polyethylene glycol-modified oil/fat, polypropylene glycol-modified polyether, and polyglycol-modified polyol surfactant is (5-8): 1: (1-5).
5. The high skin substantivity spray of claim 4 wherein said polyethylene glycol modified oil comprises cocoate groups.
6. The high skin substantivity spray of claim 4 wherein said polypropylene glycol modified polyether contains C8-15 fatty branches.
7. The high skin substantivity spray of claim 6 wherein said polyglycol-modified polyol surfactant is PEG/PPG/polytetramethylene glycol-8/5/3 glycerin.
8. The high skin substantivity spray of any one of claims 1 to 7 wherein said moisturizer is selected from the group consisting of one or more of polyols, polyethylene glycol, sodium hyaluronate, ceramide, lactic acid, allantoin, collagen, trehalose, tremella polysaccharides, panthenol, and plant extracts.
9. The high skin substantivity spray of claim 8 wherein said polyhydric alcohol comprises glycerin.
10. A method of preparing a high skin substantivity spray according to any one of claims 1 to 9, comprising: mixing surfactant, humectant and water, and stirring.
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114712274A (en) * 2021-12-23 2022-07-08 上海交通大学医学院附属第九人民医院 Soothing and anti-allergy nano vesicle composition and application thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
上海格致实业有限公司: "格美致润颜喷雾", 《国产普通化妆品备案信息》 *
珠海雅莎生物科技股份有限公司: "兰檬神经酰胺保湿喷雾", 《国产普通化妆品备案信息》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114712274A (en) * 2021-12-23 2022-07-08 上海交通大学医学院附属第九人民医院 Soothing and anti-allergy nano vesicle composition and application thereof
CN114712274B (en) * 2021-12-23 2023-05-16 上海康华时代生物医学科技有限公司 Nanometer vesicle composition for relieving and resisting allergy and application thereof

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