CN107997987A - Hyaluronic acid nanometer emulsion formulation and preparation method thereof - Google Patents
Hyaluronic acid nanometer emulsion formulation and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/068—Microemulsions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
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Abstract
This application discloses a kind of hyaluronic acid nanometer emulsion formulation.The nano-emulsion preparation is made of the component of following percetage by weight：0.1% 3% hyaluronic acid, 0.1% 16% surfactant, 0.1% 8% cosurfactant, 3% 10% solvent, 0.5% 8% oil phase, 0.01% 1% preservative, 0.01% 1% spices, 1% 3.3% water-retaining agent and 54% 89% distilled water.It is of the invention compared with other prior arts, the hyaluronic acid nanometer emulsion formulation for skin care item prepared by the present invention, diminution hyaluronic acid particle size in aqueous, greatly improve hyaluronic acid transdermal absorption factor, using simple, skin-friendly is good, noresidue after absorption.
Description
Technical field
The present invention relates to skin care field, and in particular to a kind of hyaluronic acid nanometer emulsion formulation, the system of the nano-emulsion preparation
Preparation Method and purposes.
Background technology
Hyaluronic acid, also known as sodium hyaluronate, it is extensive in beauty and shaping field as a kind of packing material for going wrinkle
With.Numerous studies show that human skin top layer (cuticula) moisture accounts for 15-30%, makes below or above this value
People is uncomfortable, has dry sense or soapy feeling, for a long time in this way, chapped skin or oedema can be made, so that skin follows the string, it is coarse old
Change.And hyaluronic acid (sodium hyaluronate) HA is acted on inside skin after nursing one's health, it can in different environments automatically adjust, maintain skin all the time
Skin moisture keeps moistening, clearly for skin, makes skin more high resilience in 25-30%, play it is crease-resistant it is wrinkle resistant, delay the full skin of people
Skin aging, the effect of beautifying face and moistering lotion.Hyaluronic acid is the one of which composition of human body skin corium, possesses the ability for keeping moisture content,
Deal is more up to 100 times of itself weight, using the skin care products containing hyaluronic acid HA, can improve dry and wrinkle
The skin of line, makes its recovery original smooth and elastic.
Although in skin care industry, hyaluronic acid is considered as to improve dry and aged skin most ideal product,
Since its molecular weight is excessive, the reason such as transdermal characteristic difference, limits its development in skin-care cosmetics field.
The content of the invention
It is a primary object of the present invention to provide the hyaluronic acid preparation for skin care item, for improving hyaluronic acid
Transdermal absorption factor.
To achieve these goals, according to an aspect of the invention, there is provided a kind of hyaluronic acid nanometer emulsion formulation, by
The component composition of following percetage by weight：The hyaluronic acid of 0.1%-3%, the surfactant of 0.1%-16%, 0.1%-8%
Cosurfactant, the solvent of 3%-10%, the oil phase of 0.5%-8%, the preservative of 0.01%-1%, 0.01%-1%
The distilled water of spices, the water-retaining agent of 1%-3.3% and 54%-89%.
Further, the surfactant is twen-80, Tween-60, triglycerides, laruyl alcohol sodium sulfovinate, polyoxy
At least one of ethene bay ether and polyoxyethylene hydrogen flower castor oil.
Further, the cosurfactant is sorbitan monostearate, propylene glycol monostearate, single tristearin
At least one of acid glyceride, span 20, sorbester p18 and sorbester p17.
Further, the oil phase is edible tricaprylin, caprylic capric glyceryl ester, soybean oil, medicinal fluid
At least one of paraffin, edible salad oil, castor oil, isopropyl myristate and ethyl oleate.
Further, the solvent is in absolute ethyl alcohol, pentanediol, n-butanol, glycerine, isopropanol and 1,3-BDO
It is at least one.
Further, the preservative is Phenoxyethanol, Sensiva SC50, benzoic acid, sodium benzoate, sorbic acid, mountain
At least one of potassium sorbate and calcium propionate.
Further, the water-retaining agent is at least one of mannitol and sucrose.
Further, the formulation of nano-emulsion preparation is Essence, toner or spray.
Further, the molecular weight of the hyaluronic acid is 850~950.
To achieve these goals, according to another aspect of the present invention, there is provided sodium hyaluronate rice milk of the invention
The preparation method of preparation, comprises the following steps：
Step 1：It is spare that each raw material components are weighed in proportion；
Step 2：Surfactant and hyaluronic acid are mixed, stirred using constant temperature blender with magnetic force under the speed of 270rpm
Mix, controlled at 70 DEG C, be partly dissolved hyaluronic acid；
Step 3：Adding water-retaining agent, cosurfactant and solvent is completely dissolved hyaluronic acid, and that is clarified is molten
Liquid；
Step 4：Institute's oil phase is added into solution made from step 3, carries out 70 DEG C of water bath with thermostatic control, and adds half
Distilled water；
Step 5：The distilled water of preservative, spices and half is added, is mixed, up to sodium hyaluronate rice milk system
Agent.
It is a variety of that a kind of hyaluronic acid nanometer emulsion formulation of the present invention can make Essence, toner, spray etc. thoroughly
Liquid forms, also can further be diluted to the nano-emulsion of stable any concentration with the moisture of arbitrary proportion, and be made each
The corresponding formulation of kind.
The nano-emulsion that the present invention uses is made of oil, water, surfactant, cosurfactant and five part of solvent, is
A kind of emulsion droplet of particle diameter between 5~100nm is dispersed in the isotropic thermodynamically stable glue formed in another liquid
Body decentralized system.
The present invention Formulation principle be：As the carrier of hyaluronic acid, nano-emulsion should meet general skin type first
The requirement of cosmetics carrier, i.e., it is nontoxic, non-stimulated, without adverse side effect, have good biocompatibility, do not influence hyalomitome
The stability of acid；Additionally, due to the characteristic of nano-emulsion itself, it also has each composition special requirement, has to hyaluronic acid
Stronger solubilising power simultaneously can form stable nano-emulsion area interior in a big way.The present invention follows this principle.Due to major part
The formation of nano-emulsion is required for the participation of cosurfactant, it, which is acted on, mainly assists surfactant to reduce interface between grease
Tension force；The mutually exclusive power and charge repulsion of surfactant are reduced, promotes interfacial film that there is good compliance and mobility,
Interface bending energy required during nano-emulsion generation is reduced, is easily formed nano-emulsion；Adjust the HLB value of surfactant.It is common
Cosurfactant have, sorbester p17 and 60.The low chain alcohol used in the present invention has enhancing cosurfactant as solvent
Effect.Due to the use of cosurfactant, it can allow the oil phase used in nano-emulsion should be with interfacial film upper surface activating agent
Infiltration and contact are kept between molecule, and is easy to form interfacial film with surfactant, so that the formation beneficial to nano-emulsion.
It is of the invention compared with other prior arts, the present invention prepared by the sodium hyaluronate rice milk system for skin care item
Agent, reduces the particle size of hyaluronic acid in aqueous, greatly improves hyaluronic acid transdermal absorption factor, use simple, pro-skin
Good, the noresidue after absorption of property.
Brief description of the drawings
The attached drawing for forming the part of the application is used for providing a further understanding of the present invention so that the application's is other
Feature, objects and advantages become more apparent upon.The illustrative examples attached drawing and its explanation of the present invention is used to explain the present invention, not
Form inappropriate limitation of the present invention.In the accompanying drawings：
Fig. 1 is the transmission electron microscope photo of the hyaluronic acid nanometer emulsion formulation of the embodiment of the present invention, and wherein a~f is represented respectively
Embodiment 1~6；
Fig. 2 is the particle size distribution figure of the hyaluronic acid nanometer emulsion formulation of the embodiment of the present invention.
Embodiment
In order to make those skilled in the art more fully understand application scheme, below in conjunction with the embodiment of the present application
Attached drawing, is clearly and completely described the technical solution in the embodiment of the present application, it is clear that described embodiment is only
The embodiment of the application part, instead of all the embodiments.Based on the embodiment in the application, ordinary skill people
Member's all other embodiments obtained without making creative work, should all belong to the model of the application protection
Enclose.
In addition, term " comprising " and his any deformation, it is intended that cover it is non-exclusive include, for example, containing
A series of product of raw materials or the method for series of steps are not necessarily limited to those raw materials clearly listed or step, but can wrap
Include not listing clearly or for the intrinsic other steps of these methods, product or raw material.
It should be noted that in the case where there is no conflict, the feature in embodiment and embodiment in the application can phase
Mutually combination.Describe the application in detail below with reference to the accompanying drawings and in conjunction with the embodiments.
Embodiment 1：
A kind of hyaluronic acid nanometer breast Essence, is made of the component of following percetage by weight：0.8% hyaluronic acid,
10% Tween 80,5% sorbester p17,5% n-butanol, 8% isopropyl myristate, 0.01% Phenoxyethanol,
0.5% spices, 2% mannitol and 68.69% distilled water.
Its preparation method is：
(1) weigh 0.8g hyaluronic acids, 10g Tween 80s, 5g sorbester p17s, 5g n-butanols, 8g isopropyl myristates,
0.01g Phenoxyethanols, 0.5g spices, 2g mannitol and 68.69g distilled water.
(2) Tween 80 of above-mentioned weight, hyaluronic acid are mixed, using constant temperature blender with magnetic force under the speed of 270rpm
Stirring, controlled at 70 DEG C, is partly dissolved hyaluronic acid；
(3) adding the mannitol, sorbester p17 and n-butanol of above-mentioned weight is completely dissolved hyaluronic acid, is clarified
Solution；
(4) above-mentioned weight isopropyl myristate is added, carries out 70 DEG C of water bath with thermostatic control, and adds half
The distilled water of (34.345g)；
(5) distilled water of the Phenoxyethanol of above-mentioned weight, spices and half (34.345g) is finally added, is mixed,
Up to the hyaluronic acid nanometer breast Essence of the present invention；
(6) it is encapsulated into Packaging Bottle.
Embodiment 2：
A kind of hyaluronic acid nanometer breast Essence, is made of the component of following percetage by weight：1% hyaluronic acid,
16% Tween 80,8% sorbester p17,5% glycerine, 6% atoleine, 0.5% Phenoxyethanol, 0.5% spices,
2% sucrose and 61% distilled water.
Its preparation method is：
(1) weigh 1g hyaluronic acids, 16g Tween 80s, 8g sorbester p17s, 5g glycerine, 6g atoleines, 0.5g Phenoxyethanols,
0.5g spices, 2g sucrose and 61g distilled water.
(2) Tween 80 of above-mentioned weight, hyaluronic acid are mixed, using constant temperature blender with magnetic force under the speed of 270rpm
Stirring, controlled at 70 DEG C, is partly dissolved hyaluronic acid；
(3) adding the sucrose, sorbester p17 and glycerine of above-mentioned weight is completely dissolved hyaluronic acid, and that is clarified is molten
Liquid；
(4) atoleine of above-mentioned weight is added, carries out 70 DEG C of water bath with thermostatic control, and adds half (30.5g)
Distilled water；
(5) distilled water of the Phenoxyethanol of above-mentioned weight, spices and half (30.5g) is finally added, is mixed, i.e.,
Obtain hyaluronic acid nanometer breast Essence of the invention；
(6) it is encapsulated into Packaging Bottle.
Embodiment 3：
Sodium hyaluronate rice milk is sprayed, and is made of the component of following percetage by weight：0.2% hyaluronic acid, 8% are spat
Temperature 60,4% sorbester p17,5% isopropanol, 3% salad oil, 0.5% Phenoxyethanol, 0.01% spices, 2% it is sweet
Reveal alcohol and 77.29% distilled water.
Its preparation method is：
(1) weigh 0.2g hyaluronic acids, 8g polysorbate60s, 4g sorbester p17s, 5g isopropanols, 3g salad oils, 0.5g Phenoxyethanols,
0.01g spices, 2g mannitol and 77.29g distilled water.
(2) polysorbate60 of above-mentioned weight, hyaluronic acid are mixed, using constant temperature blender with magnetic force under the speed of 270rpm
Stirring, controlled at 70 DEG C, is partly dissolved hyaluronic acid；
(3) adding the mannitol, sorbester p17 and isopropanol of above-mentioned weight is completely dissolved hyaluronic acid, is clarified
Solution；
(4) salad oil of above-mentioned weight is added, carries out 70 DEG C of water bath with thermostatic control, and adds half (38.645g)
Distilled water；
(5) distilled water of the Phenoxyethanol of above-mentioned weight, spices and half (38.645g) is finally added, is mixed,
Spray up to the sodium hyaluronate rice milk of the present invention；
(6) it is encapsulated into Packaging Bottle.
Embodiment 4：
Sodium hyaluronate rice milk toner, is made of the component of following percetage by weight：0.1% hyaluronic acid, 2%
Tween 80,1.5% sorbester p17,3% absolute ethyl alcohol, 2% isopropyl myristate, 1% Phenoxyethanol, 0.4%
Spices, 1% mannitol and 89% distilled water.
Its preparation method is：
(1) weigh 0.1g hyaluronic acids, 2g Tween 80s, 1.5g sorbester p17s, 3g absolute ethyl alcohols, 2g isopropyl myristates,
1g Phenoxyethanols, 0.4g spices, 1g mannitol and 89g distilled water.
(2) Tween 80 of above-mentioned weight, hyaluronic acid are mixed, using constant temperature blender with magnetic force under the speed of 270rpm
Stirring, controlled at 70 DEG C, is partly dissolved hyaluronic acid；
(3) adding the mannitol, sorbester p17 and absolute ethyl alcohol of above-mentioned weight is completely dissolved hyaluronic acid, is clarified
Solution；
(4) isopropyl myristate of above-mentioned weight is added, carries out 70 DEG C of water bath with thermostatic control, and adds half
The distilled water of (44.5g)；
(5) distilled water of the Phenoxyethanol of above-mentioned weight, spices and half (44.5g) is finally added, is mixed, i.e.,
Obtain sodium hyaluronate rice milk toner of the invention；
(6) it is encapsulated into Packaging Bottle.
Embodiment 5：
Sodium hyaluronate rice milk toner, is made of the component of following percetage by weight：3% hyaluronic acid, 0.1%
Triglycerides, 0.1% sorbitan monostearate, 10% 1,3-BDO, 0.5% caprylic capric glyceryl ester,
1% Sensiva SC50,1% spices, 3.3% mannitol and 54% distilled water.
Its preparation method is：
(1) 3g hyaluronic acids, 0.1g triglycerides, 0.1g sorbitan monostearates, 10g1 are weighed, 3- butanediols,
0.5g caprylic caprics glyceryl ester, 1g Sensiva SC50s, 1g spices, 3.3g mannitol and 54g distilled water.
(2) by the triglycerides of above-mentioned weight, hyaluronic acid mix, using constant temperature blender with magnetic force 270rpm speed
Lower stirring, controlled at 70 DEG C, is partly dissolved hyaluronic acid；
(3) adding the mannitol, sorbitan monostearate and 1,3-BDO of above-mentioned weight makes hyaluronic acid complete
Fully dissolved, the solution clarified；
(4) the caprylic capric glyceryl ester of above-mentioned weight is added, carries out 70 DEG C of water bath with thermostatic control, and adds half
The distilled water of (27g)；
(5) distilled water of the Sensiva SC50 of above-mentioned weight, spices and half (27g) is finally added, is mixed,
Up to the sodium hyaluronate rice milk toner of the present invention；
(6) it is encapsulated into Packaging Bottle.
Embodiment 6：
Sodium hyaluronate rice milk toner, is made of the component of following percetage by weight：2% hyaluronic acid, 0.1%
Laruyl alcohol sodium sulfovinate, 0.1% propylene glycol monostearate, 5% n-butanol, 0.5% castor oil, 1% calcium propionate,
1% spices, 3.3% sucrose and 60% distilled water.
Its preparation method is：
(1) weigh 2g hyaluronic acids, 0.1g laruyl alcohol sodium sulfovinates, 0.1g propylene glycol monostearates, 5g n-butanols,
0.5g castor oil, 1g calcium propionates, 1g spices, 3.3g sucrose and 60g distilled water.
(2) laruyl alcohol sodium sulfovinate of above-mentioned weight, hyaluronic acid are mixed, using constant temperature blender with magnetic force in 270rpm
Speed under stir, controlled at 70 DEG C, be partly dissolved hyaluronic acid；
(3) adding the sucrose, propylene glycol monostearate and n-butanol of above-mentioned weight is completely dissolved hyaluronic acid, obtains
To the solution of clarification；
(4) castor oil of above-mentioned weight is added, carries out 70 DEG C of water bath with thermostatic control, and adds the steaming of half (30g)
Distilled water；
(5) distilled water of the calcium propionate of above-mentioned weight, spices and half (30g) is finally added, is mixed, up to this
The sodium hyaluronate rice milk toner of invention；
(6) it is encapsulated into Packaging Bottle.
For hyaluronic acid nanometer emulsion formulation made from the embodiment of the present invention 1~6, carried out by 80,000 times of transmission electron microscopes
Observation, its image is as shown in a~f in Fig. 1, it can be seen that the path length scope of its particle is about 0~120nm；
For hyaluronic acid nanometer emulsion formulation made from the embodiment of the present invention 2, its grain is tested by laser particle tester
Degree distribution, test result are as shown in Figure 2, it is seen that its granularity is concentrated mainly on 20~120nm, median particle diameter 46.66nm.
Test by contrast, under equal skin effect, used hyaluronic acid amount is than similar production generally on the market
Product are low, so as to reduce manufacture cost；The product that the preparation method of the present invention obtains can increase the dispersiveness of hyaluronic acid, improve
The bioavilability of medicine, promotes skin regeneration, repairs scar, long-acting moisturizing and other effects and greatly improves；Do each embodiment of invention
Nano-emulsion preparation can further add the moisture dilution of arbitrary proportion, form the nano-emulsion of clear, steady with thermodynamics
The characteristics of determining, can be with filtration sterilization, easily prepared and storage；The formula and method simple possible that various embodiments of the present invention use,
Can be in order to large-scale industrial production.
The foregoing is only a preferred embodiment of the present invention, is not intended to limit the invention, for the skill of this area
For art personnel, the invention may be variously modified and varied.Within the spirit and principles of the invention, that is made any repaiies
Change, equivalent substitution, improvement etc., should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of hyaluronic acid nanometer emulsion formulation, it is characterised in that be made of the component of following percetage by weight：0.1%-3%
Hyaluronic acid, the surfactant of 0.1%-16%, the cosurfactant of 0.1%-8%, 3%-10% solvent,
The oil phase of 0.5%-8%, the preservative of 0.01%-1%, the spices of 0.01%-1%, the water-retaining agent and 54%- of 1%-3.3%
89% distilled water.
2. hyaluronic acid nanometer emulsion formulation according to claim 1, it is characterised in that the surfactant is soil temperature
80th, in polysorbate60, triglycerides, laruyl alcohol sodium sulfovinate, polyoxyethylene laurel ether and polyoxyethylene hydrogen flower castor oil at least
It is a kind of.
3. hyaluronic acid nanometer emulsion formulation according to claim 1, it is characterised in that the cosurfactant is sorb
In alcohol acid anhydride monostearate, propylene glycol monostearate, glycerin monostearate, span 20, sorbester p18 and sorbester p17 at least
It is a kind of.
4. hyaluronic acid nanometer emulsion formulation according to claim 1, it is characterised in that the oil phase is sweet for edible tri octanoic acid
Grease, caprylic capric glyceryl ester, soybean oil, medicinal liquid paraffin, edible salad oil, castor oil, isopropyl myristate and
At least one of ethyl oleate.
5. hyaluronic acid nanometer emulsion formulation according to claim 1, it is characterised in that the solvent is absolute ethyl alcohol, penta
At least one of glycol, n-butanol, glycerine, isopropanol and 1,3-BDO.
6. hyaluronic acid nanometer emulsion formulation according to claim 1, it is characterised in that the preservative for Phenoxyethanol,
At least one of Sensiva SC50, benzoic acid, sodium benzoate, sorbic acid, potassium sorbate and calcium propionate.
7. hyaluronic acid nanometer emulsion formulation according to claim 1, it is characterised in that the water-retaining agent is mannitol and sugarcane
At least one of sugar.
8. hyaluronic acid nanometer emulsion formulation according to claim 1, it is characterised in that the formulation of nano-emulsion preparation is elite
Liquid, toner or spray.
9. hyaluronic acid nanometer emulsion formulation according to claim 1, it is characterised in that the molecular weight of the hyaluronic acid is
850~950.
10. the preparation method of claim 1 to 9 any one of them hyaluronic acid nanometer emulsion formulation, it is characterised in that including with
Lower step：
Step 1：It is spare that each raw material components are weighed in proportion；
Step 2：Surfactant and hyaluronic acid are mixed, stirred using constant temperature blender with magnetic force under the speed of 270rpm,
Controlled at 70 DEG C, it is partly dissolved hyaluronic acid；
Step 3：Adding water-retaining agent, cosurfactant and solvent is completely dissolved hyaluronic acid, the solution clarified；
Step 4：Institute's oil phase is added into solution made from step 3, carries out 70 DEG C of water bath with thermostatic control, and adds the steaming of half
Distilled water；
Step 5：The distilled water of preservative, spices and half is added, is mixed, hyaluronic acid nanometer emulsion formulation.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111870542A (en) * | 2020-08-11 | 2020-11-03 | 广州伽晟健康科技有限责任公司 | Glabridin micro-molecule based nano whitening emulsion preparation and preparation method thereof |
| CN111904877A (en) * | 2020-08-11 | 2020-11-10 | 广州伽晟健康科技有限责任公司 | Nanoemulsion preparation based on hyaluronic acid micro molecules and preparation method thereof |
| CN112957277A (en) * | 2021-02-06 | 2021-06-15 | 武汉百思凯瑞生物科技有限公司 | Multiple hyaluronic acid nano composition and preparation method and application thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1887270A (en) * | 2006-07-31 | 2007-01-03 | 西北农林科技大学 | Nanometer berberine hydrochloride emulsion and its prepn process |
| CN102166254A (en) * | 2011-04-06 | 2011-08-31 | 西北农林科技大学 | Oil-in-water type spearmint oil nano emulsion and method for preparing same |
| CN107412014A (en) * | 2017-05-02 | 2017-12-01 | 上海应用技术大学 | A kind of nanometer system containing oil and fat of sacha inchi imports liquid and preparation method thereof |
| CN107496196A (en) * | 2017-09-08 | 2017-12-22 | 苏州大学 | Ultrasonic nanodrop spray liquid preparation and preparation method thereof |
-
2017
- 2017-12-25 CN CN201711423796.1A patent/CN107997987A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1887270A (en) * | 2006-07-31 | 2007-01-03 | 西北农林科技大学 | Nanometer berberine hydrochloride emulsion and its prepn process |
| CN102166254A (en) * | 2011-04-06 | 2011-08-31 | 西北农林科技大学 | Oil-in-water type spearmint oil nano emulsion and method for preparing same |
| CN107412014A (en) * | 2017-05-02 | 2017-12-01 | 上海应用技术大学 | A kind of nanometer system containing oil and fat of sacha inchi imports liquid and preparation method thereof |
| CN107496196A (en) * | 2017-09-08 | 2017-12-22 | 苏州大学 | Ultrasonic nanodrop spray liquid preparation and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111870542A (en) * | 2020-08-11 | 2020-11-03 | 广州伽晟健康科技有限责任公司 | Glabridin micro-molecule based nano whitening emulsion preparation and preparation method thereof |
| CN111904877A (en) * | 2020-08-11 | 2020-11-10 | 广州伽晟健康科技有限责任公司 | Nanoemulsion preparation based on hyaluronic acid micro molecules and preparation method thereof |
| CN112957277A (en) * | 2021-02-06 | 2021-06-15 | 武汉百思凯瑞生物科技有限公司 | Multiple hyaluronic acid nano composition and preparation method and application thereof |
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