WO2024083001A1

WO2024083001A1 - Steady-state double-layer toner and preparation method therefor

Info

Publication number: WO2024083001A1
Application number: PCT/CN2023/123793
Authority: WO
Inventors: 倪向梅; 冯春波; 康静; 金日昇
Original assignee: 上海家化联合股份有限公司
Priority date: 2022-10-20
Filing date: 2023-10-10
Publication date: 2024-04-25
Also published as: CN115501123A

Abstract

A steady-state double-layer toner, comprising: 5-20 wt% of a grease; 0.1-1 wt% of an emulsifier, which is an ester or ether oil-in-water emulsifier having an HLB value of 13 to 17 and containing or not containing a structural modification via ethoxylation or propoxylation; 1-10 wt% of a humectant; and water, wherein the weight ratio of the emulsifier to the grease is 1:15 to 1:33; the upper layer of the double-layer toner is an emulsion phase, and the lower layer thereof is a water phase; and the visual layering time of the double-layer toner is 5 minutes to 4 hours. The present invention further relates to a preparation method for the steady-state double-layer toner.

Description

Stable double-layer lotion and preparation method thereof

Technical Field

The invention relates to the field of cosmetics, in particular to a lotion with a double-layer appearance. The invention also relates to a preparation method of the double-layer lotion.

Background technique

Ordinary lotions are single-layer type. One is a single-layer water-based lotion, which is usually transparent or translucent in appearance. It only contains water-soluble basic moisturizing ingredients and does not contain oil. It can only meet basic moisturizing needs and cannot provide long-lasting moisturizing and nourishing effects on the skin. Another type of single-layer lotion contains both oil and emulsifiers, and forms a semi-milky to milky appearance through the emulsification process. Its moisturizing and nourishing effect is better than that of single-layer water-based lotions. However, this type of milky white lotion often has problems such as oil precipitation and uneven milky white bands due to the enlargement of emulsified particles. It is often necessary to increase the amount of emulsifier or compound the suspension stabilizer, which may cause stickiness and irritation, affecting the user experience.

With the development of the cosmetics industry and technological advancement, in addition to skin care effects, some lotion products with new appearance characteristics have also appeared on the market, such as double-layer dosage forms such as oil-on-top and water-off, oil droplet suspension, and emulsion-on-top and water-off. These lotions have novel and high-value visual characteristics, attracting consumers to buy and experience them.

We have found that the use of inulin lauryl carbamate can achieve the preparation of this double-layer lotion with the appearance of milk on top and water on the bottom. When the inulin lauryl carbamate/oil meets a certain ratio, the use of only a single inulin lauryl carbamate can achieve the stability of the double-layer lotion at 25°C to 48°C for more than 2 months, and slight oil floating will occur at 4°C for only 3 months. At the same time, we also found that when inulin lauryl carbamate is compounded with a small amount of non-ionic emulsifier containing PEG or ester or polyether structure (such as PEG-40 hydrogenated castor oil, polysorbate-20, etc.), it can help the formula achieve stability in a low temperature (0-10°C) environment, and meet the requirements of 3 months of stability without oil at 0-48°C. After standing for 3 minutes to 3 hours, this double-layer lotion has an emulsion phase on the upper layer and a water phase on the lower layer. After shaking, it becomes a milky white uniform liquid. After standing for another 3 minutes to 3 hours, the stratification process will be completed again, and the stratification state of milk on top and water on the bottom will be presented again.

The present invention unexpectedly discovered that the use of PEG-40 hydrogenated castor oil alone can also achieve the preparation of a double-layer lotion with milk-like upper and moisturizing properties.

PEG-40 hydrogenated castor oil is an ethoxylate of hydrogenated castor oil, also known as polyoxyethylene 40 hydrogenated castor oil. It is a white to yellow viscous liquid or paste at room temperature and is an excellent non-ionic solubilizer and emulsifier. PEG-40 hydrogenated castor oil contains two parts, hydrophilic and hydrophobic groups, with an HLB value between 13 and 14. It has a good solubilizing effect on some active ingredients that are not easily soluble in water. In the pharmaceutical industry, it is mainly used for the solubilization of vitamins. It can also play a good solubilizing role for certain drugs and aromatic oils for oral and topical applications. For example, in the invention patent CN 104173248 A (patent application number 201410453948.2), PEG-40 hydrogenated castor oil is used as a solubilizer, compounded with litsea cubeba essential oil and sweet orange essential oil to finally obtain a disinfectant hand sanitizer containing natural plant essential oils. For example, the invention patent CN 106176567 A (patent application number 201610714882.7) provides a double-layer skin care lotion and a preparation method thereof. Although PEG-40 hydrogenated castor oil is also used, it is not used alone. Sodium myristoyl glutamate and PPG-25-laureth-25 are also compounded as emulsifiers.

The present invention unexpectedly found that when PEG-40 hydrogenated castor oil/grease meets a certain ratio, only a single PEG-40 hydrogenated castor oil is needed to prepare a double-layer lotion, which is more streamlined and has a lower manufacturing cost. The present invention also found that other hydrogenated castor oil ethoxylates with similar structures, such as PEG-60 hydrogenated castor oil, with an HLB value of 14-15, can also be used to prepare a double-layer lotion with this appearance feature.

The present invention also finds that ethoxylated or propoxylated modified esters and ethers of water-in-oil emulsifiers having a PEG or PPG structure, such as PEG-20 methyl glucose sesquistearate, PEG-6 caprylic/capric glycerides, polysorbate-20 (PEG-20 sorbitan laurate), etc., can also be used to prepare double-layer lotions. The HLB ester of such emulsifiers is between 13 and 17.

The purpose of the present invention is to provide a double-layer lotion with the appearance of milk on top and water on the bottom. The double-layer lotion is a stable double-layer dosage form with a stable and controllable stratification time and a stable water content of the milk layer. The present invention also provides a preparation method of the double-layer lotion.

Summary of the invention

In one aspect, the present invention provides a stable double-layer lotion comprising:

5-20% by weight of fat;

0.1-1 wt% of an emulsifier, wherein the emulsifier is an oil-in-water emulsifier having an HLB value between 13 and 17 and containing or not containing ethoxylated or propoxylated structurally modified esters or ethers;

1-10 wt % of a humectant; and

water;

Wherein, the weight ratio of the emulsifier to the oil is 1:15 to 1:33;

Wherein, the upper layer of the double-layer lotion is the emulsion phase, and the lower layer is the water phase;

Wherein, the visual stratification time of the double-layer lotion is 5 minutes to 4 hours.

In a preferred embodiment, the emulsifier in the two-layer lotion of the present invention contains an ethoxylate of hydrogenated castor oil.

In a preferred embodiment, the emulsifier in the double-layer lotion of the present invention is selected from: PEG-40 hydrogenated castor oil, PEG-60 hydrogenated castor oil, PEG-20 methyl glucose sesquistearate, PEG-6 caprylic/capric glycerides, polysorbate-20, sucrose laurate or a combination thereof.

In a preferred embodiment, the oil in the double-layer lotion of the present invention is a plant oil, liquid ester, synthetic oil, silicone oil, mineral oil or a combination thereof that is liquid at room temperature. For example, the oil is selected from: sunflower seed oil, isopropyl palmitate, isopropyl myristate, isononyl isononanoate, C12-C15 alkyl benzoate, dicaprylyl carbonate, caprylic/capric triglyceride, silicone oil (such as polydimethylsiloxane and cyclopentasiloxane), squalane, pentaerythritol tetraoctanoate, mineral oil or a combination thereof.

In a preferred embodiment, the humectant in the double-layer lotion of the present invention is a polyol selected from glycerin, 1,3-propylene glycol, butylene glycol, dipropylene glycol, methyl propanediol, pentylene glycol, hexylene glycol, caprylyl glycol, ethylhexylglycerin or a combination thereof.

In a preferred embodiment, the double-layer lotion of the present invention further comprises one or a combination of two or more water-soluble, fat-soluble, or amphiphilic cosmetic active substances. For example, the cosmetic active substance is selected from: vitamins, vitamin A or its derivatives, vitamin B or its derivatives, vitamin C or its derivatives, folic acid or its derivatives, vitamin D or its derivatives, vitamin E or its derivatives, carotenoids or carotene, proteins, amino acids, polypeptides, carnosine and decarboxylated carnosine, collagen and hydrolyzed collagen, ferulic acid, astaxanthin, ergothioneine, coenzymes, hyaluronic acid, ceramides, sugar or polysaccharide biomacromolecules, salicylic acid and its derivatives, tranexamic acid, tetrahydromethylpyrimidine carboxylic acid, bisabolol, lactobacillus and yeast fermentation broth, licorice-derived extracts, dipotassium glycyrrhizinate, glycyrrhetinic acid stearate, peony glycosides, asiaticoside, natural product extracts or one or more thereof. A combination of two or more.

In another aspect, the present invention provides a method for preparing a double-layer lotion, comprising the following steps:

(a) mixing a moisturizer, an emulsifier and water at room temperature to 90° C. to form a first phase;

(b) keeping the oil at room temperature to 90°C as the second phase;

(c) adding the second phase to the first phase at room temperature to 90° C. and homogenizing to a uniform milky white liquid;

(d) Cooling to room temperature to 45° C., adding other optional ingredients, and mixing well to obtain a double-layer lotion.

In a preferred embodiment, the steps (a), (b) and (c) are carried out at 70-90°C.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG1 is a photograph of the double-layer lotion of Example 23 after being prepared and left to stand for 8 hours.

FIG2 is a photograph of the double-layer lotion of Example 23 after being prepared and left to stand for 3 to 25 minutes.

FIG3 is a photograph of the double-layer lotion of Example 23 after being left to stand for 30 minutes to 1 hour and 20 minutes.

FIG4 is a photograph of the double-layer lotion of Example 23 left to stand for 1.5 hours to 3.5 hours.

FIG5 is a photograph of the double-layer lotion of Example 23 left to stand for 4 hours to 10-12 hours.

FIG6 is a photograph of the double-layer lotion of Example 23 left to stand for 24-26 hours to 1 week.

Detailed ways

The present invention provides a double-layer lotion, which is prepared by using an oil-in-water emulsifier (e.g., PEG-40 hydrogenated castor oil) with an HLB value between 13 and 17, which contains or does not contain ethoxylated (PEG) or propoxylated (PPG) structure-modified esters or ethers. After standing, the upper layer is an emulsion phase and the lower layer is an aqueous phase. After being shaken, it becomes a uniform milky white liquid, which is more skin-friendly when applied. Moreover, after standing again, the layered appearance of upper emulsion and lower water will be restored, which has novel and high-value visual characteristics, attracting consumers' attention.

The double-layer stable lotion of the present invention has excellent skin feel of moisturizing, being light and easy to absorb, and having a water-oil balance, and is favored by consumers.

In order to provide a more concise description, some quantitative expressions given herein are not modified by the term "about". It should be understood that each quantity given herein is intended to be used regardless of whether the term "about" is explicitly used. It is intended to refer to the actual given values, and also to refer to the approximations to these given values that could be reasonably estimated by one of ordinary skill in the art, including approximations to these given values caused by experimental and/or measurement conditions.

grease

The stable double-layer lotion of the present invention may contain various liquid oils and fats acceptable in the cosmetics field.

As used herein, "oil" means one or more hydrophobic compounds having a melting point below 30°C. Suitable examples of compounds that can be used as the oil component of the double-layer type lotion of the present invention include: vegetable oils, liquid esters (glycerides and triglycerides of fatty acids), synthetic oils, silicone oils, mineral oils, etc. Specific non-limiting examples include, but are not limited to: sunflower seed oil, isopropyl palmitate, isopropyl myristate, isononyl isononanoate, C12-C15 alkyl benzoate, dicaprylyl carbonate, caprylic/capric triglyceride, silicone oil (such as polydimethylsiloxane and cyclopentasiloxane), squalane, pentaerythritol tetraoctanoate and mineral oil, etc.

In some embodiments, the oil contained in the double-layer lotion of the present invention is selected from: sunflower seed oil, caprylic/capric triglyceride, squalane, polydimethylsiloxane, mineral oil or any combination thereof.

In some embodiments, the double-layer lotion of the present invention comprises about 5-20% by weight of fat. In a preferred embodiment, the double-layer lotion of the present invention comprises about 5-15% by weight of fat. In a preferred embodiment, the double-layer lotion of the present invention comprises about 8-15% by weight of fat.

In some embodiments, the double-layer lotion of the present invention comprises about 8-10% by weight of oil. In other embodiments, the double-layer lotion of the present invention comprises about 10-12% by weight of oil.

Emulsifier

An "emulsifier" is an additive that stabilizes a mixture of two or more liquids that are usually immiscible. The present invention uses an oil-in-water emulsifier of an ester or ether type with or without ethoxylated (PEG) or propoxylated (PPG) structure modification, and the HLB value of such emulsifier is between 13 and 17.

In some embodiments, PEG-40 hydrogenated castor oil is used alone to prepare a double-layer lotion with an upper emulsion and a lower watering agent. PEG-40 hydrogenated castor oil is an ethoxylate of hydrogenated castor oil, also known as polyoxyethylene 40 hydrogenated castor oil. It is a white to yellow viscous liquid or paste at room temperature and is an excellent non-ionic solubilizer and emulsifier. PEG-40 hydrogenated castor oil contains two parts, hydrophilic and hydrophobic groups. HLB The value is between 13 and 14.

In other embodiments, other hydrogenated castor oil ethoxylates with a similar structure to PEG-40 hydrogenated castor oil and an HLB value between 13-17, such as PEG-n hydrogenated castor oil (n=20-80), are used. For example, PEG-60 hydrogenated castor oil is used alone to prepare a double-layer lotion with an upper emulsion and a lower water content. When PEG-60 hydrogenated castor oil is used alone as an emulsifier, a stable double-layer lotion can also be prepared. PEG-60 hydrogenated castor oil has a similar structure to PEG-40 hydrogenated castor oil. Both are ethoxylates of hydrogenated castor oil and are commonly used in the formulation development of cosmetics. The HLB value of PEG-60 hydrogenated castor oil is in the HLB value of 14-15. It can be foreseen that when the emulsifier meets the ethoxylate structure of hydrogenated castor oil (i.e., PEG-n hydrogenated castor oil, n=20-80) and the HLB value is between 13-15, the double-layer lotion of the present invention can be prepared.

A stable double-layer lotion can be prepared by using PEG-40 hydrogenated castor oil or PEG-60 hydrogenated castor oil as an emulsifier. After standing, the upper layer of the double-layer lotion is an emulsion phase and the lower layer is an aqueous phase. After being shaken, it becomes a uniform milky white liquid, which is more skin-friendly when applied. At the same time, after standing again (for example, 3 minutes to 3 hours), the double-layer lotion will restore the layered appearance of upper emulsion and lower water, which has a novel and high-value visual feature.

In other embodiments, other water-in-oil emulsifiers containing or not containing ethoxylated (PEG) or propoxylated (PPG) structure-modified esters or ethers are used, and the HLB value of such emulsifiers is between 13 and 17. For example, in some embodiments, PEG-20 methyl glucose sesquistearate, PEG-6 caprylic/capric glycerides, polysorbate-20 (PEG-20 sorbitan laurate), sucrose laurate or a combination thereof are used to prepare a double-layer cosmetic.

In a preferred embodiment, a double-layer cosmetic is prepared by combining other water-in-water oil-emulsifiers with HLB values between 13 and 17 that may or may not contain ethoxylated (PEG) or propoxylated (PPG) structure-modified esters or ethers with PEG-40 hydrogenated castor oil or PEG-60 hydrogenated castor oil.

In some embodiments, the double-layer type lotion of the present invention comprises about 0.1-1% by weight of an emulsifier. In a preferred embodiment, the double-layer type lotion of the present invention comprises about 0.1-0.8% by weight of an emulsifier. In a preferred embodiment, the double-layer type lotion of the present invention comprises about 0.3-0.8% by weight of an emulsifier.

In some embodiments, the weight ratio of the emulsifier to the oil in the double-layer lotion of the present invention is 1:15 to 1:33.

moisturizer

Moisturizers are a type of cosmetic raw material that can increase or maintain moisture in the upper layer of the skin over a wide relative humidity range and for a long period of time. These raw materials have low volatility, can retain moisture, and are absorbed on the skin surface. They are a type of skin conditioner.

The humectant used in the double-layer lotion of the present invention is a polyol. For example, the humectant can be selected from: glycerol, 1,3-propylene glycol, butylene glycol, dipropylene glycol, methyl propanediol, pentanediol, hexylene glycol, caprylyl glycol, ethylhexylglycerin or any combination thereof.

In some embodiments, the double-layer type lotion of the present invention comprises about 1-10% by weight of a moisturizer. In a preferred embodiment, the double-layer type lotion of the present invention comprises about 2-8% by weight of a moisturizer. In a preferred embodiment, the double-layer type lotion of the present invention comprises about 2-5% by weight of a moisturizer. In a preferred embodiment, the double-layer type lotion of the present invention comprises about 5-8% by weight of a moisturizer.

Other Ingredients

The double-layer lotion of the present invention may contain other ingredients. For example, the double-layer lotion of the present application may contain water-soluble, fat-soluble, or amphiphilic cosmetic active substances.

In a preferred embodiment, the cosmetic active substance is selected from one or more combinations of ingredients with moisturizing, nourishing, soothing, acne removal, oil control, freckle removal and whitening, exfoliation, sun protection, firming, anti-wrinkle, and repair effects. In a preferred embodiment, the cosmetic active substance is selected from one or more combinations of vitamins, vitamin A or its derivatives, vitamin B or its derivatives, vitamin C or its derivatives, folic acid or its derivatives, vitamin D or its derivatives, vitamin E or its derivatives, carotenoids or carotene, proteins, amino acids, polypeptides, carnosine and decarboxylated carnosine, collagen and hydrolyzed collagen, ferulic acid, astaxanthin, ergothioneine, coenzymes, hyaluronic acid, ceramides, sugar or polysaccharide biomacromolecules, salicylic acid and its derivatives, tranexamic acid, tetrahydromethylpyrimidine carboxylic acid, bisabolol, lactobacillus and yeast fermentation broth, licorice-derived extracts, dipotassium glycyrrhizinate, glycyrrhetinic acid stearate, peony glycosides, centella asiatica, and natural product extracts.

In some embodiments, the double-layer type lotion of the present invention comprises about 0.1-0.5 wt % of dipotassium glycyrrhizinate. In a preferred embodiment, the double-layer type lotion of the present invention comprises about 0.1-0.2 wt % of dipotassium glycyrrhizinate.

In a preferred embodiment, the two-layer type lotion of the present invention comprises about 0.1-0.5 wt % of the bifid yeast fermentation lysate filtrate. In a preferred embodiment, the two-layer type lotion of the present invention comprises about 0.2-0.5 wt % of the bifid yeast fermentation lysate filtrate.

Preparation method of double-layer lotion

The present invention also provides a method for preparing a stable double-layer lotion. In some embodiments, the double-layer lotion can be prepared according to the following method:

(a) mixing a moisturizer, an emulsifier and water at room temperature (e.g., 25-30° C.) to 90° C. to form a first phase;

(b) allowing the oil to be at room temperature (e.g., 25-30° C.) to 90° C. as the second phase;

(c) adding the second phase to the first phase at room temperature (e.g., 25-30° C.) to 90° C. and homogenizing until a uniform milky white liquid is formed;

(d) cooling to room temperature (eg, 25-30° C.) to 45° C., adding other optional ingredients, and mixing well to obtain a double-layer lotion.

In a preferred embodiment, the obtained two-layer lotion is left to stand for 5 minutes to 4 hours to obtain a two-layer lotion after first stratification, wherein the upper layer is a white emulsion phase and the lower layer is an aqueous phase.

In a preferred embodiment, the layered lotion is shaken and then allowed to stand again. The layers can be separated again after 5 minutes to 4 hours, presenting an appearance of an upper layer of the emulsion phase and a lower layer of the water phase.

In a preferred embodiment, the above steps (a), (b) and (c) are carried out at 70-90°C. In a more preferred embodiment, the above steps (a), (b) and (c) are carried out at 80-90°C.

In a preferred embodiment, the homogenization in step (c) is carried out at 2000-5000 rpm. In a preferred embodiment, the homogenization in step (c) is carried out at 3000-5000 rpm. In a more preferred embodiment, the homogenization in step (c) is carried out at 5000 rpm.

In a preferred embodiment, the homogenization in step (c) is maintained for 10-20 minutes.

In a specific embodiment, deionized water, polyols, and emulsifiers are mixed uniformly at room temperature to 90°C as the first phase, and the oil is kept at room temperature to 90°C as the second phase. The second phase is added to the first phase at room temperature to 90°C, homogenized at 2000-5000 rpm, maintained for 10-20 minutes, cooled to room temperature to 45°C, and optional other ingredients are added, stirred uniformly, and the preparation is completed and allowed to stand for use.

Advantages of double-layer lotion

The core of the double-layer lotion of the present invention is to achieve a double-layer stable state, and its stable state is mainly manifested in the following four aspects:

(1) The time it takes for stratification to begin is controllable

After shaking the stable double-layer lotion, let it stand for about 5 minutes and you can observe the beginning of stratification, that is, the upper emulsion phase and the lower water phase begin to separate, and a translucent water phase layer appears at the bottom. This process is the beginning stage of the stratification phenomenon.

The advantage is that consumers can observe visible stratification in a relatively short time of about 5 minutes, which not only satisfies consumers' interest in product experience, but also satisfies consumers' convenience of use. When consumers use it, the whole process from shaking to pouring on the hands basically takes about ten seconds to one minute, so about 5 minutes is enough, and it also ensures that the product poured out after each shaking is uniform and consistent, and the upper and lower layers will not be inconsistent when pouring due to too fast stratification, which may cause differences in skin feel and efficacy.

(2) The time required to complete the visualization layering process is controllable

During the standing time of 5 minutes to 1.5 hours, as time goes by, the emulsion phase gradually rises and the water phase layer gradually becomes higher. In this process, the water phase has a semi-permeable appearance, and the interface between the emulsion phase and the water phase gradually changes from blurred to clear. This process is the process of gradual separation of the emulsion phase and the water phase, and the initial stratification is basically completed.

During the standing time of 1.5 minutes to 4 hours, the emulsion phase and the water phase are still in the equilibrium process of phase separation, which is manifested in that the height of the emulsion phase is decreasing and the water phase is becoming more transparent. This process is the equilibrium stage of stratification.

During the standing time of 4 to 7-8 hours, the height of the emulsion phase is basically close, and the transparency of the water phase is basically the same. Consumers understand that the stratification process is basically completed. Therefore, 4 to 7-8 hours can be regarded as the completion stage of the visual stratification process.

The advantage is that this visualized layering time is not only controllable, but also very consistent with consumers' usage habits. When consumers use the product every morning and evening, they can ensure that they can observe the change process of the steady-state double-layer lotion restoring the layers after shaking, and they can shake it again when they use it again; for a small number of consumers, if they need to use the product three times a day, morning, noon and evening, then a 4-hour layering time can also meet the above requirements.

(3) The time to reach the final stable state is controllable

When left standing for 10-12 hours, or even further for 24-26 hours, the height of the emulsion phase only decreases very slightly during this period, which is basically unobservable by consumers in daily use; when the standing time is further extended from 24-26 hours, the height of the emulsion phase remains unchanged, indicating that after 24-26 hours, the double-layer lotion reaches a final stable state.

In the present invention, the upper emulsion phase of the double-layer lotion that reaches the final stable state is called "snow top" because it has the appearance of snow on the top of a mountain. After shaking, the upper emulsion phase and the lower water phase will quickly merge into one, and after standing, they will quickly show the stratification characteristics. The entire visual dynamic stratification process is completed after 5 minutes to 4 hours.

In summary, the double-layer lotion of the present invention has controllable visual stratification time and controllable stable state standing time, and is a stable double-layer lotion. The stable double-layer lotion of the present invention has a fixed ratio of emulsion and water layers, and the water content of the upper emulsion phase of the stable double-layer lotion is also relatively stable.

The present invention is further described below in conjunction with specific examples. It is necessary to point out that the examples are only used to further illustrate the present invention and cannot be construed as limiting the scope of the present invention. Those skilled in the art in this field can make some non-essential improvements and adjustments based on the content of the present invention described above. The test methods in the following examples that do not specify specific conditions are usually based on conventional conditions or the conditions recommended by the manufacturer. Unless otherwise specified, all percentages and parts are by weight.

The sources, names and appearances of the experimental materials used in the examples of the present invention are shown in the following table:

The experimental instruments used in the embodiments of the present invention include:

1. Stationary agitator IKA RW20

2. Constant temperature water bath Shanghai Yiheng Scientific Instrument Co., Ltd. HWS 28

3. Weighing balance METTLER TOLEDO PL602-S

4. Homogenizer Polytron PT 3100 D

5. 48℃ oven: MMM group MMM707

6. 4℃ refrigerator: MMM group FRIOCELL707 90570

7. -18℃ refrigerator: Haier DW-40L

Example 1

Heat 84.5 parts by mass of deionized water, 5 parts by mass of glycerin, and 0.5 parts by mass of PEG-40 hydrogenated castor oil to 75-80° C. and mix them evenly as the first phase. Add 10 parts by mass of sunflower seed oil as the second phase. Add the second phase to the first phase at 75-80° C. and homogenize at 3000 rpm for 10 minutes to obtain a uniform milky white liquid. After the preparation is completed, let it stand until a double layer of lotion is applied for standby use.

Example 2

84.5 parts by mass of deionized water, 5 parts by mass of glycerol, and 0.5 parts by mass of PEG-40 hydrogenated castor oil were mixed uniformly at 75-80° C. as the first phase, and 10 parts by mass of caprylic/capric triglyceride were heated to 75-80℃ is used as the second phase. The second phase is added to the first phase at 75-80℃ and homogenized at 3000 rpm for 10 minutes to obtain a uniform milky white liquid. After the preparation is completed, let it stand until a double layer of lotion water is formed and set aside.

Example 3

84.5 parts by mass of deionized water, 5 parts by mass of glycerin, and 0.5 parts by mass of PEG-40 hydrogenated castor oil are mixed uniformly at 75-80°C as the first phase, 10 parts by mass of squalane are heated to 75-80°C as the second phase, the second phase is added to the first phase at 75-80°C, and homogenized at 3000 rpm for 10 minutes to obtain a uniform milky white liquid; after the preparation is completed, let it stand until a double layer of lotion is formed and set aside.

Example 4

84.5 parts by mass of deionized water, 5 parts by mass of glycerin, and 0.5 parts by mass of PEG-40 hydrogenated castor oil are mixed uniformly at 75-80° C. as the first phase, 10 parts by mass of polydimethylsiloxane are heated to 75-80° C. as the second phase, the second phase is added to the first phase at 75-80° C., and homogenized at 3000 rpm for 10 minutes to obtain a uniform milky white liquid; after the preparation is completed, let it stand until a double layer of lotion is formed and set aside.

Example 5

84.5 parts by mass of deionized water, 5 parts by mass of glycerin, and 0.5 parts by mass of PEG-40 hydrogenated castor oil are mixed uniformly at 75-80°C as the first phase, 10 parts by mass of mineral oil are heated to 75-80°C as the second phase, the second phase is added to the first phase at 75-80°C, homogenized at 3000 rpm, and maintained for 10 minutes, that is, homogenized to obtain a uniform milky white liquid; after the preparation is completed, let it stand until a double layer of lotion is formed and set aside.

Example 6

84.6 parts by mass of deionized water, 5 parts by mass of glycerol, and 0.4 parts by mass of PEG-40 hydrogenated castor oil were mixed uniformly at 75-80°C as the first phase, 10 parts by mass of caprylic/capric triglyceride were heated to 75-80°C as the second phase, the second phase was added to the first phase at 75-80°C, homogenized at 4000 rpm, maintained for 15 minutes, and homogenized to obtain a uniform milky white liquid; after the preparation was completed, it was allowed to stand until the double layer was formed. Use after applying makeup.

Example 7

84.7 parts by mass of deionized water, 5 parts by mass of glycerin, and 0.3 parts by mass of PEG-40 hydrogenated castor oil are mixed uniformly at 75-80°C as the first phase, 10 parts by mass of caprylic/capric triglyceride are heated to 75-80°C as the second phase, the second phase is added to the first phase at 75-80°C, homogenized at 5000 rpm, and maintained for 20 minutes, that is, homogenized to obtain a uniform milky white liquid; after the preparation is completed, let it stand until a double layer of lotion is formed and set aside.

Example 8

86.7 parts by mass of deionized water, 5 parts by mass of glycerin, and 0.3 parts by mass of PEG-40 hydrogenated castor oil are mixed uniformly at 75-80°C as the first phase, 8 parts by mass of caprylic/capric triglyceride are heated to 75-80°C as the second phase, the second phase is added to the first phase at 75-80°C, homogenized at 4500 rpm, and maintained for 12 minutes, that is, homogenized to obtain a uniform milky white liquid; after the preparation is completed, let it stand until a double layer of lotion is formed and set aside.

Example 9

82.2 parts by mass of deionized water, 5 parts by mass of glycerin, and 0.8 parts by mass of PEG-40 hydrogenated castor oil are mixed uniformly at 75-80° C. as the first phase, 12 parts by mass of caprylic/capric triglyceride are heated to 75-80° C. as the second phase, the second phase is added to the first phase at 75-80° C., and homogenized at 3500 rpm for 18 minutes to obtain a uniform milky white liquid; after the preparation is completed, let it stand until a double layer of lotion is formed and set aside.

Example 10

Mix 79.2 parts by mass of deionized water, 5 parts by mass of glycerol, and 0.8 parts by mass of PEG-40 hydrogenated castor oil at 75-80°C as the first phase, heat 15 parts by mass of caprylic/capric triglyceride to 75-80°C as the second phase, add the second phase to the first phase at 75-80°C, homogenize at 4000 rpm, and keep for 10 minutes to obtain a uniform milky white liquid; after the preparation is completed, let it stand until a double layer of lotion is formed and set aside.

By analyzing Examples 1-10, it can be seen that when PEG-40 hydrogenated castor oil is used alone as an emulsifier, within the range of PEG-40 hydrogenated castor oil/oil = 1:15 to 1:33, whether it is vegetable oil, ester synthetic oil, non-polar alkane oil, silicone oil or mineral oil, a double-layer lotion can be prepared, and there is no special restriction on the selectivity of oil.

Embodiment 11

79.2 parts by mass of deionized water, 5 parts by mass of glycerin, and 0.8 parts by mass of PEG-40 hydrogenated castor oil are mixed evenly at room temperature as the first phase, and 15 parts by mass of caprylic/capric triglyceride are used as the second phase. The second phase is added to the first phase at room temperature, and homogenized at 4500 rpm for 15 minutes to obtain a uniform milky white liquid. After the preparation is completed, let it stand until a double layer of lotion water is formed and set aside.

Example 12

84.6 parts by mass of deionized water, 5 parts by mass of glycerin, and 0.4 parts by mass of PEG-40 hydrogenated castor oil are mixed uniformly at 40-50° C. as the first phase, 10 parts by mass of caprylic/capric triglyceride are heated to 40-50° C. as the second phase, the second phase is added to the first phase at 40-50° C., homogenized at 4000 rpm, and maintained for 18 minutes, that is, homogenized to obtain a uniform milky white liquid; after the preparation is completed, let it stand until a double layer of lotion is formed and set aside.

Example 13

86.7 parts by mass of deionized water, 5 parts by mass of glycerin, and 0.3 parts by mass of PEG-40 hydrogenated castor oil are mixed uniformly at 50-65° C. as the first phase, 8 parts by mass of caprylic/capric triglyceride are heated to 50-65° C. as the second phase, the second phase is added to the first phase at 50-65° C., and homogenized at 5000 rpm for 10 minutes to obtain a uniform milky white liquid; after the preparation is completed, let it stand until a double layer of lotion is formed and set aside.

Embodiment 14

84.6 parts by mass of deionized water, 5 parts by mass of glycerol, and 0.4 parts by mass of PEG-40 hydrogenated castor oil were mixed uniformly at 65-70° C. as the first phase, and 10 parts by mass of caprylic/capric triglyceride were heated to 65-70℃ is used as the second phase. The second phase is added to the first phase at 65-70℃ and homogenized at 3500 rpm for 15 minutes to obtain a uniform milky white liquid. After the preparation is completed, let it stand until a double layer of lotion is formed and set aside.

Embodiment 15

86.7 parts by mass of deionized water, 5 parts by mass of glycerin, and 0.3 parts by mass of PEG-40 hydrogenated castor oil are mixed uniformly at 80-90° C. as the first phase, 8 parts by mass of caprylic/capric triglyceride are heated to 80-90° C. as the second phase, the second phase is added to the first phase at 80-90° C., and homogenized at 3000 rpm for 10 minutes to obtain a uniform milky white liquid; after the preparation is completed, let it stand until a double layer of lotion is formed and set aside.

By analyzing Examples 11-15 and comparing them with Example 10, it can be seen that when the addition amount and relative proportion of PEG-40 hydrogenated castor oil and fat remain unchanged, even if the emulsification process is carried out in different temperature ranges, a double-layer lotion can be prepared in the end. It can be seen that PEG-40 hydrogenated castor oil has a wide emulsification temperature range. Combined with Examples 10-15, it is shown that within the range of room temperature to 90°C, PEG-40 hydrogenated castor oil has a good emulsification ability for preparing a double-layer lotion.

Example 16

84.5 parts by mass of deionized water, 5 parts by mass of glycerin, and 0.5 parts by mass of PEG-60 hydrogenated castor oil are mixed uniformly at 75-80°C as the first phase, 10 parts by mass of caprylic/capric triglyceride are heated to 75-80°C as the second phase, the second phase is added to the first phase at 75-80°C, and homogenized at 3000 rpm for 10 minutes to obtain a uniform milky white liquid; after the preparation is completed, let it stand until a double layer of lotion is formed and set aside.

Embodiment 17

84.7 parts by mass of deionized water, 5 parts by mass of glycerol, and 0.3 parts by mass of PEG-60 hydrogenated castor oil were mixed uniformly at 75-80°C as the first phase, 10 parts by mass of caprylic/capric triglyceride were heated to 75-80°C as the second phase, the second phase was added to the first phase at 75-80°C, homogenized at 5000 rpm, maintained for 20 minutes, and homogenized to obtain a uniform milky white liquid; after the preparation was completed, it was allowed to stand until the double layer was formed. Use after applying makeup.

Embodiment 18

86.7 parts by mass of deionized water, 5 parts by mass of glycerin, and 0.3 parts by mass of PEG-60 hydrogenated castor oil are mixed uniformly at 75-80°C as the first phase, 8 parts by mass of caprylic/capric triglyceride are heated to 75-80°C as the second phase, the second phase is added to the first phase at 75-80°C, homogenized at 4500 rpm, and maintained for 12 minutes, that is, homogenized to obtain a uniform milky white liquid; after the preparation is completed, let it stand until a double layer of lotion is formed and set aside.

Embodiment 19

82.2 parts by mass of deionized water, 5 parts by mass of glycerin, and 0.8 parts by mass of PEG-60 hydrogenated castor oil are mixed uniformly at 75-80° C. as the first phase, 12 parts by mass of caprylic/capric triglyceride are heated to 75-80° C. as the second phase, the second phase is added to the first phase at 75-80° C., and homogenized at 3500 rpm for 18 minutes to obtain a uniform milky white liquid; after the preparation is completed, let it stand until a double layer of lotion is formed and set aside.

Embodiment 20

Mix 79.2 parts by mass of deionized water, 5 parts by mass of glycerin, and 0.8 parts by mass of PEG-60 hydrogenated castor oil at 75-80°C as the first phase, heat 15 parts by mass of caprylic/capric triglyceride to 75-80°C as the second phase, add the second phase to the first phase at 75-80°C, homogenize at 4000 rpm, and keep for 10 minutes to obtain a uniform milky white liquid; after the preparation is completed, let it stand until a double layer of lotion is formed and set aside.

From the analysis of Examples 16-20, it can be seen that when PEG-60 hydrogenated castor oil is used alone as an emulsifier, a double-layer lotion can also be prepared within the range of PEG-60 hydrogenated castor oil/grease = 1:15 to 1:33. PEG-60 hydrogenated castor oil has a similar structure to PEG-40 hydrogenated castor oil. Both are ethoxylates of hydrogenated castor oil and are commonly used in the formulation development of cosmetics. Among them, the HLB value of PEG-40 hydrogenated castor oil is 13-14, while the HLB value of PEG-60 hydrogenated castor oil is 14-15. It can be foreseen that when the ethoxylates of hydrogenated castor oil are met, The double-layer lotion of the present invention can be prepared by using an emulsifier having a chemical structure (i.e., PEG-n hydrogenated castor oil, n=20-80) and an HLB value between 13-15.

Embodiment 21

83.5 parts by mass of deionized water, 2 parts by mass of glycerin, 3 parts by mass of butylene glycol, and 0.5 parts by mass of PEG-40 hydrogenated castor oil are uniformly mixed at 75-80° C. as the first phase, 3 parts by mass of sunflower seed oil, 2 parts by mass of caprylic/capric triglyceride, 4 parts by mass of squalane, and 2 parts by mass of polydimethylsiloxane are heated to 75-80° C. as the second phase, the second phase is added to the first phase at 75-80° C., homogenized at 4000 rpm, and maintained for 12 minutes, that is, homogenized to obtain a uniform milky white liquid; after the preparation is completed, let it stand until a double-layer lotion is formed for standby use.

Embodiment 22

83.5 parts by weight of deionized water, 2 parts by weight of glycerin, 3 parts by weight of 1,3-propylene glycol, and 0.5 parts by weight of PEG-40 hydrogenated castor oil are uniformly mixed at 75-80° C. as the first phase, 2 parts by weight of sunflower seed oil, 3 parts by weight of caprylic/capric triglyceride, 4 parts by weight of squalane, 1 part by weight of polydimethylsiloxane, and 1 part by weight of mineral oil are heated to 75-80° C. as the second phase, the second phase is added to the first phase at 75-80° C., homogenized at 4000 rpm, and maintained for 15 minutes, that is, homogenized to obtain a uniform milky white liquid; after the preparation is completed, let it stand until a double-layer lotion is obtained for standby use.

Embodiment 23

83.6 parts by mass of deionized water, 3 parts by mass of glycerol, 2 parts by mass of butylene glycol, and 0.4 parts by mass of PEG-40 hydrogenated castor oil are mixed uniformly at 75-80° C. as the first phase, 1 part by mass of sunflower seed oil, 4 parts by mass of caprylic/capric triglyceride, and 6 parts by mass of squalane are heated to 75-80° C. as the second phase, the second phase is added to the first phase at 75-80° C., homogenized at 4500 rpm, and maintained for 12 minutes, that is, homogenized to obtain a uniform milky white liquid; after the preparation is completed, let it stand until a double-layer lotion is formed for standby use.

Embodiment 24

85.7 parts by mass of deionized water, 2 parts by mass of glycerol, 2 parts by mass of butylene glycol, 2 parts by mass of 1,3-propylene glycol, and 0.3 parts by mass of PEG-40 hydrogenated castor oil were mixed uniformly at 75-80° C. as the first phase. Heat 3 parts by mass of caprylic/capric triglyceride, 3 parts by mass of squalane and 2 parts by mass of mineral oil to 75-80°C as the second phase, add the second phase into the first phase at 75-80°C, homogenize at 5000 rpm, and keep for 16 minutes to obtain a uniform milky white liquid; after the preparation is completed, let it stand until a double-layer lotion is formed and set aside.

Embodiment 25

83.2 parts by mass of deionized water, 1 part by mass of glycerin, 2 parts by mass of butylene glycol, 2 parts by mass of 1,3-propylene glycol, and 0.8 parts by mass of PEG-40 hydrogenated castor oil are uniformly mixed at 75-80° C. as the first phase, 2 parts by mass of sunflower seed oil, 3 parts by mass of caprylic/capric triglyceride, 3 parts by mass of squalane, 1 part by mass of polydimethylsiloxane, and 2 parts by mass of mineral oil are heated to 75-80° C. as the second phase, the second phase is added to the first phase at 75-80° C., homogenized at 3500 rpm, and maintained for 20 minutes, that is, homogenized to obtain a uniform milky white liquid; after the preparation is completed, let it stand until a double-layer lotion is prepared for use.

From the analysis of Examples 21-25, it can be seen that when PEG-40 hydrogenated castor oil is used as an emulsifier to prepare a double-layer lotion, the oil can be one or more combinations of different types of oils including vegetable oils, synthetic ester oils, alkanes, silicone oils and mineral oils.

Test Example 1: Stability Study of Examples 1-25

The samples of Examples 1-25 were stored at 25° C., 40° C., 48° C., and 4° C. for 4 weeks, 8 weeks, and 12 weeks, respectively, to investigate the stability of the samples of each Example. The results are shown in Table 1.

Table 1: Stability results of Examples 1-25

Embodiment 26

84.5 parts by mass of deionized water, 5 parts by mass of glycerin, and 0.5 parts by mass of PEG-20 methyl glucose sesquistearate are mixed uniformly at 75-80°C as the first phase, 10 parts by mass of caprylic/capric triglyceride are heated to 75-80°C as the second phase, the second phase is added to the first phase at 75-80°C, homogenized at 4000 rpm, and maintained for 15 minutes, that is, homogenized to obtain a uniform milky white liquid; after the preparation is completed, let it stand until a double layer of lotion is formed and set aside.

Embodiment 27

84.7 parts by mass of deionized water, 5 parts by mass of glycerol and 0.3 parts by mass of polysorbate-20 are mixed uniformly at 75-80°C as the first phase, 10 parts by mass of caprylic/capric triglyceride are heated to 75-80°C as the second phase, the second phase is added to the first phase at 75-80°C, homogenized at 4000 rpm, maintained for 15 minutes, and a uniform milky white liquid is obtained by homogenization; after the preparation is completed, let it stand until a double layer of lotion is formed and set aside for use.

Embodiment 28

84.4 parts by mass of deionized water, 5 parts by mass of glycerin, 0.5 parts by mass of PEG-20 methyl glucose sesquistearate, and 0.1 parts by mass of PEG-40 hydrogenated castor oil are mixed uniformly at 75-80° C. as the first phase, 10 parts by mass of caprylic/capric triglyceride are heated to 75-80° C. as the second phase, the second phase is added to the first phase at 75-80° C., homogenized at 4000 rpm, maintained for 15 minutes, and a uniform milky white liquid is obtained by homogenization; after the preparation is completed, let it stand until a double layer of lotion is formed for standby use.

Embodiment 29

84.5 parts by mass of deionized water, 5 parts by mass of glycerin, 0.3 parts by mass of PEG-20 methyl glucose sesquistearate, and 0.2 parts by mass of PEG-40 hydrogenated castor oil are mixed uniformly at 75-80° C. as the first phase, 10 parts by mass of caprylic/capric triglyceride are heated to 75-80° C. as the second phase, the second phase is added to the first phase at 75-80° C., homogenized at 4000 rpm, maintained for 15 minutes, and a uniform milky white liquid is obtained by homogenization; after the preparation is completed, let it stand until a double layer of lotion is formed for standby use.

Embodiment 30

84.5 parts by mass of deionized water, 5 parts by mass of glycerol, 0.3 parts by mass of polysorbate-20, and 0.2 parts by mass of PEG-40 hydrogenated castor oil are mixed uniformly at 75-80° C. as the first phase, 10 parts by mass of caprylic/capric triglyceride are heated to 75-80° C. as the second phase, the second phase is added to the first phase at 75-80° C., homogenized at 4000 rpm, and maintained for 15 minutes, that is, homogenized to obtain a uniform milky white liquid; after the preparation is completed, let it stand until a double layer of lotion is obtained for standby use.

Test Example 2: Stability Study of Examples 26-30

The samples of Examples 26-30 were stored at 25° C., 40° C., 48° C., and 4° C. for 4 weeks, 8 weeks, and 12 weeks, respectively, to investigate the stability of the samples of each Example. The results are shown in Table 2.

Table 2: Stability results of Examples 26-30

From the analysis of Examples 26-30, it can be seen that if other water-in-oil emulsifiers containing or not containing ethoxylated (PEG) or propoxylated (PPG) structure-modified esters or ethers are used, the HLB value of such emulsifiers is between 13 and 17. For example, PEG-20 methyl glucose sesquistearate and polysorbate-20 used in Examples 26 and 27 can also prepare double-layer lotions in the initial stage, but there are certain risks in long-term stability, which is manifested in slight oiling of the surface of the emulsion after storage for 8 weeks at 4°C and 25°C. On this basis, if a small amount of PEG-40 hydrogenated castor oil is compounded, the oiling of the emulsion can be improved, thereby helping to improve the stability of the product during the shelf life.

Comparative Example 1

84.5 parts by mass of deionized water, 5 parts by mass of glycerol, 0.3 parts by mass of PEG-20 methyl glucose sesquistearate, and 0.2 parts by mass of sodium methyl stearoyl taurate were mixed uniformly at 75-80°C as the first phase, 10 parts by mass of caprylic/capric triglyceride were heated to 75-80°C as the second phase, the second phase was added to the first phase at 75-80°C, homogenized at 4000 rpm, maintained for 15 minutes, the preparation was completed, and allowed to stand until the double-layer lotion was used. Overnight, it was observed that the double-layer lotion was not clearly separated, and the transparency of the water phase after separation was low, there was precipitation at the bottom, and the interface between the water phase and the upper emulsion was unclear, indicating that the double-layer lotion was not successfully prepared.

Comparative Example 2

84.5 parts by mass of deionized water, 5 parts by mass of glycerol, 0.3 parts by mass of PEG-20 methyl glucose sesquistearate, and 0.2 parts by mass of glyceryl stearate citrate were mixed uniformly at 75-80°C as the first phase, 10 parts by mass of caprylic/capric triglyceride were heated to 75-80°C as the second phase, the second phase was added to the first phase at 75-80°C, homogenized at 4000 rpm, maintained for 15 minutes, the preparation was completed, and allowed to stand until the double-layer lotion was used. It was observed overnight that the transparency of the water phase after the double-layer lotion was separated was low, and the surface of the milk layer had a skinning and creaming phenomenon, indicating that the double-layer lotion was not successfully prepared.

Test Example 3: Observation of the stratification of double-layer lotion

Taking the double-layer lotion obtained in Example 23 as an example, 180 ml of the double-layer lotion was put into a colorless transparent PET wide-mouth bottle, shaken up and down 10 times to fully mix, and then allowed to stand. The stratification state was observed and photographed at different time points, as shown in Figures 2 to 6.

(1) After the stable double-layer lotion is shaken and left to stand for about 5 minutes, the beginning of stratification can be observed, i.e., the upper emulsion phase and the lower water phase begin to separate, and a translucent water phase layer appears at the bottom. This process is the beginning stage of the stratification phenomenon;

(2) During the period of standing for 5 minutes to 1.5 hours, as time goes by, the emulsion phase gradually rises and the water phase layer gradually becomes higher. During this process, the water phase has a semi-transparent appearance, and the interface between the emulsion phase and the water phase gradually changes from fuzzy to clear. This process is the process of gradual separation of the emulsion phase and the water phase, and the initial stratification is basically completed;

(3) During the period of standing for 1.5 to 4 hours, the emulsion phase and the aqueous phase are still in the equilibrium process of phase separation, which is manifested by the emulsion phase height decreasing and the aqueous phase becoming more transparent; this process is the equilibrium stage of stratification;

(4) During the period of 4 to 7-8 hours of standing, the height of the emulsion phase is basically close, and the transparency of the water phase is basically consistent. Consumers understand that the stratification process is basically completed. Therefore, 4 to 7-8 hours can be regarded as the completion stage of the visual stratification process.

(5) When the emulsion is left standing for 10-12 hours, or even for 24-26 hours, the height of the emulsion phase decreases only slightly during this period, which is basically unobservable by consumers in daily use. When the standing time is extended from 24-26 hours, the height of the emulsion phase remains unchanged, indicating that after standing for 24-26 hours, the double-layer lotion reaches a final stable state.

It can be seen that the process of the double-layer lotion restoring stratification after being shaken is a dynamic process. Visible stratification can be observed after standing for 5 minutes, which not only satisfies the fun of the consumer experience, but also satisfies the convenience of use of consumers. That is, when consumers shake the lotion to apply it on the face, the whole process takes about ten seconds to one minute, so 5 minutes is enough, and 5 minutes also ensures that the product poured out after each shaking is uniform; after standing for 5 minutes to 1.5 hours, consumers can observe that the double-layer lotion has initially completed the first stratification; continue to stand for 4 hours, it can be observed that the height of the emulsion layer is still slowly changing, completing the phase balance process; continue to stand for 7-8 hours, and a complete visual stratification process can be completed. Such a stratification time is very consistent with consumers' usage habits, not only It can ensure that consumers can observe the re-stratification process of the double-layer lotion when using the product in the morning and evening every day. It can also meet the needs of a small number of consumers who use the product three times a day, morning, noon and evening. In about 4 hours, it can be observed that the phase separation process of the double-layer lotion has basically reached an equilibrium state.

Therefore, the visual stratification time of the double-layer lotion of the present invention is between 5 minutes and 4 hours.

Application Example 1

Based on Example 21, other ingredients such as active ingredients, fragrances, and preservatives such as phenoxyethanol were added to prepare samples for consumer use test evaluation.

82.25 parts by mass of deionized water, 2 parts by mass of glycerin, 3 parts by mass of butylene glycol, and 0.5 parts by mass of PEG-40 hydrogenated castor oil are mixed uniformly at 75-80° C. as the first phase, 3 parts by mass of sunflower seed oil, 2 parts by mass of caprylic/capric triglyceride, 4 parts by mass of squalane, and 2 parts by mass of polydimethylsiloxane are heated to 75-80° C. as the second phase, the second phase is added to the first phase at 75-80° C., homogenized at 4000 rpm, maintained for 12 minutes, cooled to room temperature to 45° C., 0.15 parts by mass of dipotassium glycyrrhizate, 0.5 parts by mass of bifid yeast fermentation product lysate, 0.1 parts by mass of bisabolol, 0.1 parts by mass of essence, and 0.4 parts by mass of phenoxyethanol are added, homogenized at 4000 rpm, maintained for 5 minutes, and a uniform milky white liquid is obtained; after the preparation is completed, it is allowed to stand until a double-layer lotion is used.

The oil-soluble bisabolol and essence are emulsified in the upper emulsion phase of the double-layer lotion, while the water-soluble dipotassium glycyrrhizinate and bifid yeast fermentation product lysate are in the lower water phase of the double-layer lotion; since the preservative phenoxyethanol has a certain distribution coefficient in the oil-water phase, part of it is in the emulsion phase and part in the water phase. When the double-layer lotion is shaken again, it will become a uniform milky white liquid again. These ingredients are evenly mixed in the milky white lotion. When consumers use the double-layer lotion, it can help soothe and repair the skin, giving them a pleasant experience.

Test Case 4: Consumer Usage Evaluation

Test population: Female consumers aged 25 to 35

Sample size: 10 people

Test samples: Toner 1# - Application Example 1 Double-layer Toner; Toner 2# - Commercially available L'Oreal Revitalizing Hyaluronic Acid Double Brightening Essence Water (referred to as "L'Oreal Essence Water")

How to use the product: According to your usual habit of using lotion, use lotion 1# and 2# on the left and right halves of the face respectively, and compare and score them; use at least 2 times a day, once in the morning and once in the evening; use each product for 3 days, for a total of 6 days.

assessment method:

Table 3: Consumer test evaluation methods

Table 4: Consumer use evaluation test results

From the results in Table 4, it can be seen that the double-layer lotion of the present invention is superior to the commercially available L'Oreal essence water in terms of the degree of liking the application feeling, the overall degree of liking the skin feeling, the skin comfort, the skin softness and the skin moisturizing effect. It can be seen that the double-layer lotion of the present invention has a better skin feel than the L'Oreal essence water and is more popular with consumers.

Among them, the full ingredients of the commercially available L'Oreal essence water include the following: water, hydrogenated polydecene, caprylic/capric triglyceride, squalane, safflower seed oil, 1,2-hexanediol, PEG-6 caprylic/capric glycerides, tromethamine, adenosine, capryloyl salicylic acid, sodium hyaluronate, PEG-40 glyceryl cocoate, ethylhexylglycerin, sodium cocoether sulfate, tocopherol (vitamin E), caprylyl glycol, phenoxyethanol, and fragrance.

Although the oil components in the formula of L'Oreal essence water partially overlap with the double-layer lotion of the present invention, the emulsifiers PEG-40 hydrogenated castor oil, PEG-20 methyl glucose sesquistearate, polysorbate 20, etc. used in the double-layer lotion of the present invention are not the formula technologies implemented by commercially available products. Therefore, the technical implementation methods of the present invention and the commercially available L'Oreal essence water are different.

Claims

A stable double-layer lotion comprising:

5-20% by weight of fat;

0.1-1 wt% of an emulsifier, wherein the emulsifier is an oil-in-water emulsifier having an HLB value between 13 and 17 and containing or not containing ethoxylated or propoxylated structurally modified esters or ethers;

1-10 wt % of a humectant; and

water;

Wherein, the weight ratio of the emulsifier to the oil is 1:15 to 1:33;

Wherein, the upper layer of the double-layer lotion is the emulsion phase, and the lower layer is the water phase;

Wherein, the visual stratification time of the double-layer lotion is 5 minutes to 4 hours.
The two-layer lotion according to claim 1, wherein the emulsifier comprises an ethoxylate of hydrogenated castor oil.
The double-layer lotion according to claim 1, wherein the emulsifier is selected from: PEG-40 hydrogenated castor oil, PEG-60 hydrogenated castor oil, PEG-20 methyl glucose sesquistearate, PEG-6 caprylic/capric glycerides, polysorbate-20, sucrose laurate, or a combination thereof.
The double-layer lotion according to claim 1, wherein the oil is a plant oil, liquid ester, synthetic oil, silicone oil, mineral oil or a combination thereof that is liquid at room temperature.
The double-layer lotion as claimed in claim 4, wherein the oil is selected from: sunflower seed oil, isopropyl palmitate, isopropyl myristate, isononyl isononanoate, C12-C15 alkyl benzoate, dicaprylyl carbonate, caprylic/capric triglyceride, silicone oil (such as polydimethylsiloxane and cyclopentasiloxane), squalane, pentaerythritol tetraoctanoate, mineral oil or a combination thereof.
The double-layer lotion according to claim 1, wherein the humectant is a polyol selected from the group consisting of glycerol, 1,3-propylene glycol, butylene glycol, dipropylene glycol, methyl propanediol, pentanediol, hexanediol, Caprylyl glycol, ethylhexylglycerin, or a combination thereof.
The double-layer lotion as claimed in claim 1, further comprising one or a combination of two or more water-soluble, fat-soluble, or amphiphilic cosmetic active substances.
The double-layer lotion according to claim 7, wherein the cosmetic active substance is selected from: vitamins, vitamin A or its derivatives, vitamin B or its derivatives, vitamin C or its derivatives, folic acid or its derivatives, vitamin D or its derivatives, vitamin E or its derivatives, carotenoids or carotene, proteins, amino acids, polypeptides, carnosine and decarboxylated carnosine, collagen and hydrolyzed collagen, ferulic acid, astaxanthin, ergothioneine, coenzymes, hyaluronic acid, ceramides, sugar or polysaccharide biomacromolecules, salicylic acid and its derivatives, tranexamic acid, tetrahydromethylpyrimidine carboxylic acid, bisabolol, lactobacillus and yeast fermentation broth, licorice-derived extracts, dipotassium glycyrrhizinate, glycyrrhetinic acid stearate, peony glycosides, asiaticoside, natural product extracts, or a combination of two or more thereof.
The method for preparing a double-layer lotion according to any one of claims 1 to 8, comprising the following steps:

(a) mixing a moisturizer, an emulsifier and water at room temperature to 90° C. to form a first phase;

(b) keeping the oil at room temperature to 90°C as the second phase;

(c) adding the second phase to the first phase at room temperature to 90° C. and homogenizing to a uniform milky white liquid;

(d) Cooling to room temperature to 45° C., adding other optional ingredients, and mixing well to obtain a double-layer lotion.
The preparation method according to claim 9, wherein steps (a), (b) and (c) are carried out at 70-90°C.