CN113710688A - 用于治疗血液癌症和实体瘤癌症的嵌合抗原受体修饰的t细胞(car-t) - Google Patents

用于治疗血液癌症和实体瘤癌症的嵌合抗原受体修饰的t细胞(car-t) Download PDF

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Publication number
CN113710688A
CN113710688A CN202080028702.4A CN202080028702A CN113710688A CN 113710688 A CN113710688 A CN 113710688A CN 202080028702 A CN202080028702 A CN 202080028702A CN 113710688 A CN113710688 A CN 113710688A
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chimeric antigen
antigen receptor
cancer
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Chinese (zh)
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C·E·普鲁萨克
T·J·基普斯
G·F·维德霍普夫
C·S·吴
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University of California San Diego UCSD
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University of California San Diego UCSD
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CN202080028702.4A 2019-03-26 2020-03-26 用于治疗血液癌症和实体瘤癌症的嵌合抗原受体修饰的t细胞(car-t) Pending CN113710688A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962824080P 2019-03-26 2019-03-26
US62/824,080 2019-03-26
US201962931103P 2019-11-05 2019-11-05
US62/931,103 2019-11-05
US202062969569P 2020-02-03 2020-02-03
US62/969,569 2020-02-03
PCT/US2020/025069 WO2020198531A2 (en) 2019-03-26 2020-03-26 Chimeric antigen receptor modified t-cells (car-t) for the treatment of hematological and solid tumor cancers

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CN113710688A true CN113710688A (zh) 2021-11-26

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CN202080028702.4A Pending CN113710688A (zh) 2019-03-26 2020-03-26 用于治疗血液癌症和实体瘤癌症的嵌合抗原受体修饰的t细胞(car-t)

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US (1) US20230312708A1 (https=)
EP (1) EP3953372A4 (https=)
JP (2) JP2022527081A (https=)
KR (1) KR20210143804A (https=)
CN (1) CN113710688A (https=)
AU (1) AU2020248448B2 (https=)
CA (1) CA3134465A1 (https=)
IL (1) IL286618A (https=)
MX (1) MX2021011494A (https=)
SG (1) SG11202110131SA (https=)
WO (1) WO2020198531A2 (https=)

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US20240415883A1 (en) * 2021-02-01 2024-12-19 The Regents Of The University Of California Treatment of neuroendocrine cancers
AU2022227686A1 (en) 2021-02-25 2023-07-27 Lyell Immunopharma, Inc. Ror1 targeting chimeric antigen receptor
WO2023217227A1 (zh) 2022-05-12 2023-11-16 先声再明医药有限公司 喜树碱类衍生物及配体-药物偶联物
US12600801B2 (en) * 2022-07-11 2026-04-14 Fred Hutchinson Cancer Center Single-domain antibodies that bind ROR1
WO2025076113A1 (en) 2023-10-05 2025-04-10 Capstan Therapeutics, Inc. Ionizable cationic lipids with conserved spacing and lipid nanoparticles
WO2025076127A1 (en) 2023-10-05 2025-04-10 Capstan Therapeutics, Inc. Constrained ionizable cationic lipids and lipid nanoparticles
KR20250052305A (ko) * 2023-10-10 2025-04-18 서울대학교산학협력단 키메라 항원 수용체를 발현하는 자연 살해 세포를 이용한 종양 미세환경의 주피세포를 표적하는 항암 세포 치료 기법 및 치료 효능 평가를 위한 종양 미세환경 오가노이드 모델 제작 기술
WO2025217454A2 (en) 2024-04-11 2025-10-16 Capstan Therapeutics, Inc. Ionizable cationic lipids and lipid nanoparticles
WO2025217452A1 (en) 2024-04-11 2025-10-16 Capstan Therapeutics, Inc. Constrained ionizable cationic lipids and lipid nanoparticles

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US20160208018A1 (en) * 2015-01-16 2016-07-21 Juno Therapeutics, Inc. Antibodies and chimeric antigen receptors specific for ror1
CN108424458A (zh) * 2017-02-13 2018-08-21 上海恒润达生生物科技有限公司 靶向ny-eso-1的嵌合抗原受体及其用途
CN108884164A (zh) * 2016-02-25 2018-11-23 细胞医学瑞士公司 用于免疫疗法的经修饰细胞
US20180369406A1 (en) * 2017-06-23 2018-12-27 VelosBio Inc. ROR1 Antibody Immunoconjugates

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US20130266551A1 (en) * 2003-11-05 2013-10-10 St. Jude Children's Research Hospital, Inc. Chimeric receptors with 4-1bb stimulatory signaling domain
PL3489261T3 (pl) * 2012-08-24 2021-08-16 The Regents Of The University Of California Przeciwciała i szczepionki do stosowania w leczeniu nowotworów z ekspresją ROR1 i w hamowaniu przerzutu
KR102048855B1 (ko) * 2014-07-29 2019-11-26 셀렉티스 암 면역요법을 위한 ror1(ntrkr1) 특이적 키메라 항원 수용체
AU2015343013B2 (en) * 2014-11-05 2020-07-16 Board Of Regents, The University Of Texas System Gene modified immune effector cells and engineered cells for expansion of immune effector cells
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US20180265593A1 (en) * 2015-01-16 2018-09-20 Juno Therapeutics, Inc. Antibodies and chimeric antigen receptors specific for ror1
CN108884164A (zh) * 2016-02-25 2018-11-23 细胞医学瑞士公司 用于免疫疗法的经修饰细胞
CN108424458A (zh) * 2017-02-13 2018-08-21 上海恒润达生生物科技有限公司 靶向ny-eso-1的嵌合抗原受体及其用途
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WO2020198531A3 (en) 2020-11-05
SG11202110131SA (en) 2021-10-28
IL286618A (en) 2021-12-01
MX2021011494A (es) 2021-12-15
AU2020248448A1 (en) 2021-10-14
AU2020248448B2 (en) 2026-01-29
EP3953372A4 (en) 2022-11-02
US20230312708A1 (en) 2023-10-05
JP2025081512A (ja) 2025-05-27
WO2020198531A2 (en) 2020-10-01
JP2022527081A (ja) 2022-05-30
EP3953372A2 (en) 2022-02-16
CA3134465A1 (en) 2020-10-01
KR20210143804A (ko) 2021-11-29

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