CN113694154A - 一种用于治疗肠炎的中药组合物 - Google Patents
一种用于治疗肠炎的中药组合物 Download PDFInfo
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- CN113694154A CN113694154A CN202111121241.8A CN202111121241A CN113694154A CN 113694154 A CN113694154 A CN 113694154A CN 202111121241 A CN202111121241 A CN 202111121241A CN 113694154 A CN113694154 A CN 113694154A
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Abstract
本发明涉及中药领域，具体涉及一种用于治疗肠炎的中药组合物。所述组合物的制备原料，包括以下成分，蒲公英、杜仲、马齿笕、鱼腥草、黄芪、车前子、野菊花、小茴香、贯众、当归、麦芽、白术、甘草、大青叶、山楂、麦芽、红枣、甘草、阿胶和叶酸。本发明提供的中药组合物兼顾肠炎治疗和营养补充两个方面，防止肠炎带来的营养流失造成的营养不良。本发明的组合物可以直接磨粉得到成品，也可以通过合适提取方法得到更好的治疗效果。
Description
技术领域
本发明涉及中药领域，具体涉及一种用于治疗肠炎的中药组合物。
背景技术
溃疡性结肠炎(Ulcerative colitis，UC)是一种病因尚不十分清楚的结肠和直肠慢性非特异性炎症性疾病，病变局限于大肠黏膜及黏膜下层，呈连续性分布，并缓慢反复发作。溃疡性结肠炎最早于1875年由Wilk和Moxon描述症状，1903年由Boas和Wilks定义，1920年由WHO正式认定为一种非特异性临床病症，临床主要表现为腹痛、腹泻和脓血便等。
溃疡性肠炎的治疗方案主要采用抗炎、抗菌、抑制免疫反应等方法，常用的药物有氨基水杨酸类、皮质类固醇类、免疫抑制剂、抗感染药等。
中医认为肠炎主要与脾胃相关，因此可归属于脾胃系诸证的＂痴疾＂、＂腹痛＂、＂泄泻＂等范畴。病因上与感受外邪、饮食所伤、情志失调、内伤劳倦、久病体虚、禀赋不足等密切相关；病理性质主要分为冷、热、虚、实四端；其病位在肠，所主病之脏与脾、肾等关系密切。
中国专利申请CN101439150A公开了一种治疗肠炎的中药组合物，包括按重量份数比的下述组份：吴茱萸10～30份，升麻6～12份，附子6～12份，乌药10～20份，小茴香10～30份，茯苓5～15份，葛根10～20份，白芍20～40份，补骨脂20～40份，黄芪20～40份，党参20～40份，陈皮20～40份，白术20～40份，艾叶10～20份，五味子6～12份。本发明的中药组合物具有清热解毒、消肿止痛、健脾益气、温补脾肾、化瘀通络、和营止血的功效。
中国专利申请CN105722521A公开了一种治疗溃疡性结肠炎的中药组合物，所述组合物的原料药组成为：黄连7-11重量份、炮姜7-11重量份、苦参7-11重量份、三七4-8重量份、青黛4-11重量份、木香4-8重量份、地榆炭7-11重量份和炙甘草1-5重量份。所述中药组合物治疗溃疡性结肠炎效果好，且复发率低，副作用不明显，同时具有清利肠道，温中健脾，平调寒热，化瘀止血的效果，减轻疾病痛苦，提高生活质量，延长生存时间。
中国专利申请CN106540019A公开了一种新的用于治疗溃疡性结肠炎的中药组合物及其制备方法。所述组合物主要由以下重量份的原料制成：党参5份～15份、苦参1份～10份、木香1份～10份、诃子肉3份～9份、盐泽泻1份～8份。制备所述中药组合物的方法包括下列步骤：按重量份取各原料，加水煎煮或使用乙醇水溶液提取，得到煎煮液或提取液，将得到的煎煮液或提取液滤过以得到滤液，并将滤液浓缩以得到清膏。本发明还提供了所述的中药组合物在制备用于治疗炎症的药物中的用途。本发明的中药组合物能对抗三硝基苯磺酸导致的大鼠结肠组织病理损伤，能增强整体炎性免疫反应，明显改善动物便血、腹泻、少动等外观体征，疗效明显。
虽然肠炎的治疗方案较多，但是肠炎的病程往往时间较长，尤其病程延续到妇女怀孕期间时，则会对母婴的营养吸收产生较大的干扰，影响母婴的营养吸收，针对这种特殊人群开发对身体负担小，药效平稳的中药组合物是必要的。
发明内容
本发明的目的是针对现有技术的不足，本发明提供一种可以补充营养同时兼顾药效的治疗肠炎的中药组合物
本发明的目的通过以下技术方案实现。
一种用于治疗肠炎的中药组合物，按重量份数计，制备原料包括以下组分：
蒲公英5～15重量份、杜仲5～10重量份、马齿笕5～10重量份、鱼腥草5～7重量份、黄芪10～20重量份、车前子5～10重量份、野菊花5～10重量份、小茴香5～10重量份、贯众10～30重量份、当归10～20重量份、麦芽5～10重量份、白术5～10重量份、甘草5～10重量份、大青叶5～10重量份、山楂5～20重量份、麦芽5～10重量份、红枣5～10重量份、甘草5～10重量份、阿胶2～6重量份和叶酸0.1～1重量份。
进一步地，所述中药组合物，按重量份数计，制备原料包括以下组分：
蒲公英10重量份、杜仲7重量份、马齿笕8重量份、鱼腥草6重量份、黄芪15重量份、车前子7重量份、野菊花7重量份、小茴香8重量份、贯众20重量份、当归15重量份、麦芽7重量份、白术7重量份、甘草8重量份、大青叶8重量份、山楂12重量份、麦芽7重量份、红枣7重量份、甘草8重量份、阿胶4重量份和叶酸0.5重量份。
本发明的中药组合物的制备方法，可以将所述份数的原料直接混合磨粉即得。
一种所述中药组合物的制备方法，将所述重量份数的原料混合，研磨成粉即得。
进一步地，所述研磨是研磨至20-40目的粉料。
本发明的中药组合物也可以将所述重量份的原料通过合适的提取方法得到。
一种所述中药组合物的制备方法，包括以下步骤：
S1：将所述重量份的蒲公英、杜仲、马齿笕、鱼腥草、黄芪、车前子、野菊花、小茴香和贯众混合磨粉后，经过水提、过滤、浓缩和干燥得提取物A；
S2：将所述重量份的当归、麦芽、白术、甘草、大青叶、山楂、麦芽、红枣、甘草和阿胶混合磨粉后，经过水-醇共提、过滤、浓缩和干燥得提取物B；
S3：将提取物A、提取物B和叶酸混合，研磨即得所述中药组合物。
进一步地，S1中，所述磨粉是将混合物磨成60-100目粉。
进一步地，S1中，所述水提是水用量为所述S1原料总重量份的10-15倍，温度为60-80℃提取10-15小时；
进一步地，S2中，所述磨粉是将混合物磨成60-100目粉。
进一步地，所述水-醇共提是在水和乙醇体积比为1:1-2，水-醇用量为所述S2原料总重量份的15-20倍，温度为40-60℃提取8-10小时。
进一步地，S3中，所述研磨为研磨至150-200目粉末。
本发明的优势在于：
1.本发明提供的中药组合物兼顾肠炎治疗和营养补充两个方面，防止肠炎带来的营养流失造成的营养不良。
2.本发明的组合物可以直接磨粉得到成品，也可以通过合适提取方法得到更好的治疗效果，猜测可能是由于中药成分复杂，不同药物组合之后，通过合适的方法提取可以祛除一些抑制药效的物质。
具体实施方式
本发明以下实施例所使用的组合物原料均为市售来源的，干燥制品，含水量为5-10％。
实施例1
一种用于治疗肠炎的中药组合物，按重量份数计，
蒲公英5重量份、杜仲10重量份、马齿笕10重量份、鱼腥草6重量份、黄芪10重量份、车前子10重量份、野菊花5重量份、小茴香10重量份、贯众10重量份、当归20重量份、麦芽10重量份、白术5重量份、甘草5重量份、大青叶10重量份、山楂20重量份、麦芽2重量份、红枣2重量份、甘草10重量份、阿胶6重量份和叶酸1重量份。
将各组分原料混合，一起磨至30目粉末，即得所述中药组合物。
实施例2
一种用于治疗肠炎的中药组合物，按重量份数计，
蒲公英10重量份、杜仲5重量份、马齿笕5重量份、鱼腥草6重量份、黄芪20重量份、车前子5重量份、野菊花10重量份、小茴香5重量份、贯众30重量份、当归10重量份、麦芽5重量份、白术10重量份、甘草10重量份、大青叶5重量份、山楂5重量份、麦芽10重量份、红枣5重量份、甘草5重量份、阿胶2重量份和叶酸0.1重量份。
将各组分原料混合，一起磨至30目粉末，即得所述中药组合物。
实施例3
一种用于治疗肠炎的中药组合物，按重量份数计，
蒲公英10重量份、杜仲7重量份、马齿笕8重量份、鱼腥草6重量份、黄芪15重量份、车前子7重量份、野菊花7重量份、小茴香8重量份、贯众20重量份、当归15重量份、麦芽7重量份、白术7重量份、甘草8重量份、大青叶8重量份、山楂12重量份、麦芽7重量份、红枣7重量份、甘草8重量份、阿胶4重量份和叶酸0.5重量份。
将各组分原料混合，一起磨至30目粉末，即得所述中药组合物。
实施例4
一种用于治疗肠炎的中药组合物，按重量份数计，
蒲公英10重量份、杜仲7重量份、马齿笕8重量份、鱼腥草6重量份、黄芪15重量份、车前子7重量份、野菊花7重量份、小茴香8重量份、贯众20重量份、当归15重量份、麦芽7重量份、白术7重量份、甘草8重量份、大青叶8重量份、山楂12重量份、麦芽7重量份、红枣7重量份、甘草8重量份、阿胶4重量份和叶酸0.5重量份。
所述组合物通过以下方法之别得到，
S1：将所述重量份的蒲公英、杜仲、马齿笕、鱼腥草、黄芪、车前子、野菊花、小茴香和贯众混合磨至80目粉末，加入此步骤原料总份数10倍重量份的水，升温至80℃，提取12小时，趁热过滤，回收滤液，浓缩，干燥得提取物A；
S2：将所述重量份的当归、麦芽、白术、甘草、大青叶、山楂、麦芽、红枣、甘草和阿胶混合磨至80目粉末，加入此步骤原料总份数20倍重量份的水-乙醇混合(水：乙醇＝1:1(V/V))液，升温至40℃，提取10小时、趁热过滤、回收滤液，浓缩和干燥得提取物B；
S3：将提取物A、提取物B和叶酸混合，研磨至150目粉即得所述中药组合物，总量42份。
实施例5
一种用于治疗肠炎的中药组合物，按重量份数计，
蒲公英10重量份、杜仲7重量份、马齿笕8重量份、鱼腥草6重量份、黄芪15重量份、车前子7重量份、野菊花7重量份、小茴香8重量份、贯众20重量份、当归15重量份、麦芽7重量份、白术7重量份、甘草8重量份、大青叶8重量份、山楂12重量份、麦芽7重量份、红枣7重量份、甘草8重量份、阿胶4重量份和叶酸0.5重量份。
所述组合物通过以下方法之别得到，
S1：将所述重量份的蒲公英、杜仲、马齿笕、鱼腥草、黄芪、车前子、野菊花、小茴香和贯众混合磨至80目粉末，加入此步骤原料总份数15倍重量份的水，升温至60℃，提取15小时，趁热过滤，回收滤液，浓缩，干燥得提取物A；
S2：将所述重量份的当归、麦芽、白术、甘草、大青叶、山楂、麦芽、红枣、甘草和阿胶混合磨至80目粉末，加入此步骤原料总份数15倍重量份的水-乙醇混合(水：乙醇＝1:2(V/V))液，升温至60℃，提取8小时、趁热过滤、回收滤液，浓缩和干燥得提取物B；
S3：将提取物A、提取物B和叶酸混合，研磨至150目粉即得所述中药组合物，总量48份。。
对比例1
和实施例3相比，鱼腥草、黄芪和车前子用量较多，不含贯众和白术。
一种用于治疗肠炎的中药组合物，按重量份数计，
蒲公英10重量份、杜仲7重量份、马齿笕8重量份、鱼腥草12重量份、黄芪30重量份、车前子14重量份、野菊花7重量份、小茴香8重量份、当归15重量份、麦芽7重量份、甘草8重量份、大青叶8重量份、山楂12重量份、麦芽7重量份、红枣7重量份、甘草8重量份、阿胶4重量份和叶酸0.5重量份。
将各组分原料混合，一起磨至30目粉末，即得所述中药组合物。
对比例2
和实施例3相比，鱼腥草、黄芪和车前子、贯众和白术的用量不同。
一种用于治疗肠炎的中药组合物，按重量份数计，
蒲公英10重量份、杜仲7重量份、马齿笕8重量份、鱼腥草2重量份、黄芪5重量份、车前子21重量份、野菊花7重量份、小茴香8重量份、贯众10重量份、当归15重量份、麦芽7重量份、白术17重量份、甘草8重量份、大青叶8重量份、山楂12重量份、麦芽7重量份、红枣7重量份、甘草8重量份、阿胶4重量份和叶酸0.5重量份。
将各组分原料混合，一起磨至30目粉末，即得所述中药组合物。
对比例3
和实施例4相比，所有原料使用水提取。
一种用于治疗肠炎的中药组合物，按重量份数计，
蒲公英10重量份、杜仲7重量份、马齿笕8重量份、鱼腥草6重量份、黄芪15重量份、车前子7重量份、野菊花7重量份、小茴香8重量份、贯众20重量份、当归15重量份、麦芽7重量份、白术7重量份、甘草8重量份、大青叶8重量份、山楂12重量份、麦芽7重量份、红枣7重量份、甘草8重量份、阿胶4重量份和叶酸0.5重量份。
所述组合物通过以下方法之别得到，
S1：将除叶酸外的原料按所述的重量份混合，磨至80目粉末，加入原料总份数10倍重量份的水，升温至80℃，提取12小时，趁热过滤，回收滤液，浓缩，干燥得提取物A；
S2，将提取物A和叶酸混合，研磨至150目粉即得所述中药组合物，总量50份。
效果验证
实验动物准备与分组：
相同3月龄SPF级SD大鼠，雌性，适应性饲养一周。
造模方法：将需要造模的大鼠禁食24小时，后腹腔注射20％乌拉坦溶液(6ml/kg)麻醉，将一直径约2mm长约12cm的橡胶输液管由肛门轻缓插人，深度为8cm，推入2％TNBS溶液100mg/kg，让动物保持平躺自然清醒。造模后第2天，观察实验大鼠出现便血、腹泻情况，大多数动物出现厌食、懒动现象，说明造模成功。
将造模后的大鼠按照体重随机分组，每组6只。每组分别给予实施例3、实施例4、对比例1、对比例2或对比例3，每天固定时间灌胃给药一次。
实施例3，实施例4、对比例1-3五个实验组，按生药量计算剂量给药，按生药量计，给药剂量为600mg/kg.BW；
另设正常组、模型组，每组6只大鼠。
检测指标
肠重系数：每只迅速剖取结肠，自距离肛门2cm处，向上取结肠8cm，沿着肠系膜纵向剪开肠腔，用生理盐水冲洗干净，肉眼观察炎症及溃疡发生情况，随后称重，以结肠重(g)/大鼠体重(kg)作为肠重系数。
髓过氧化物酶(MPO)活性：按试剂盒(Biovision，型号：K747)说明书处理样本，并测定各组样本MPO活性。
实验结果
表1各组实验肠重系数结果(％)
和空白组相比：**P＜0.01，*P＜0.05。
表2各组实验MPO活性数据
和空白组相比：**P＜0.01，*P＜0.05。
可以看出，对比例1和对比例2的组分含量不合适，结果较差，而对比例3由于采用了了不合适的提取方法，也无法得到好的效果。
最后应当说明的是，以上内容仅用以说明本发明的技术方案，而非对本发明保护范围的限制，本领域的普通技术人员对本发明的技术方案进行的简单修改或者等同替换，均不脱离本发明技术方案的实质和范围。
Claims (10)
1.一种用于治疗肠炎的中药组合物，按重量份数计，制备原料包括以下组分：
蒲公英5～15重量份、杜仲5～10重量份、马齿笕5～10重量份、鱼腥草5～7重量份、黄芪10～20重量份、车前子5～10重量份、野菊花5～10重量份、小茴香5～10重量份、贯众10～30重量份、当归10～20重量份、麦芽5～10重量份、白术5～10重量份、甘草5～10重量份、大青叶5～10重量份、山楂5～20重量份、麦芽5～10重量份、红枣5～10重量份、甘草5～10重量份、阿胶2～6重量份和叶酸0.1～1重量份。
2.根据权利要求1所述的中药组合物，其特征在于，按重量份数计，制备原料包括以下组分：
蒲公英10重量份、杜仲7重量份、马齿笕8重量份、鱼腥草6重量份、黄芪15重量份、车前子7重量份、野菊花7重量份、小茴香8重量份、贯众20重量份、当归15重量份、麦芽7重量份、白术7重量份、甘草8重量份、大青叶8重量份、山楂12重量份、麦芽7重量份、红枣7重量份、甘草8重量份、阿胶4重量份和叶酸0.5重量份。
3.一种如权利要求1-2任一项所述中药组合物的制备方法，将所述重量份数的原料混合，研磨成粉即得。
4.根据权利要求3所述的制备方法，其特征在于，所述研磨是研磨至20-40目的粉料。
5.一种如权利要求1-2任一项所述的中药组合物的制备方法，包括以下步骤：
S1：将所述重量份的蒲公英、杜仲、马齿笕、鱼腥草、黄芪、车前子、野菊花、小茴香和贯众混合磨粉后，经过水提、过滤、浓缩和干燥得提取物A；
S2：将所述重量份的当归、麦芽、白术、甘草、大青叶、山楂、麦芽、红枣、甘草和阿胶混合磨粉后，经过水-醇共提、过滤、浓缩和干燥得提取物B；
S3：将提取物A、提取物B和叶酸混合，研磨即得所述中药组合物。
6.根据权利要求5所述的制备方法，其特征在于，S1中，所述磨粉是将混合物磨成60-100目粉。
7.根据权利要求5所述的制备方法，其特征在于，S1中，所述水提是水用量为所述S1原料总重量份的10-15倍，温度为60-80℃提取10-15小时。
8.根据权利要求5所述的制备方法，其特征在于，S2中，所述磨粉是将混合物磨成60-100目粉。
9.根据权利要求5所述的制备方法，其特征在于，S2中，所述水-醇共提是在水和乙醇体积比为1:1-2，水-醇用量为所述S2原料总重量份的15-20倍，温度为40-60℃提取8-10小时。
10.根据权利要求5所述的制备方法，其特征在于，S3中，所述研磨为研磨至150-200目粉末。
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