CN1136867C - Antivirus compound medicine - Google Patents
Antivirus compound medicine Download PDFInfo
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- CN1136867C CN1136867C CNB001161245A CN00116124A CN1136867C CN 1136867 C CN1136867 C CN 1136867C CN B001161245 A CNB001161245 A CN B001161245A CN 00116124 A CN00116124 A CN 00116124A CN 1136867 C CN1136867 C CN 1136867C
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Abstract
The present invention relates to compound anti-respiratory tract influenza viruses and various kinds of virus medicine, which is the improvement of the component of Anti-virus and antipyretic oral liquid. The medicine uses earthworms as main medicine, is matched with traditional Chinese medicine antibacterials, such as houttuynia, scutellaria roots, honeysuckle flowers, and increases adjuvant orange peel to combine licorice roots. The present invention is mainly suitable for respiratory tract chronic diseases induced by virus infection, has broad-spectrum specific action for resisting respiratory tract influenza viruses and various viruses, breaks through the traditional treatment method that medicine for eliminating phlegm, stopping cough and relieving asthma must be used for treating chronic bronchitis, emphysema, pulmonary heart diseases, etc. Compared with the Anti-virus and antipyretic oral liquid, the treatment effect of the present invention is more evident. Besides, the present invention of which the cost is reduced to about 1 time is safe to admit.
Description
The present invention relates to preventing respiratory influenza virus and other multiple virus is main medicine, particularly relate to improvement to " anti-virus and antipyretic oral liquid " prescription, and mainly be applicable to due to illness poison to infect and the respiratory tract chronic disease of bringing out, such as the medicine of diseases such as chronic bronchitis, emphysema, pulmonary heart disease, chronic pharyngolaryngitis etc. and flu, influenza, herpes zoster.
As everyone knows, due to illness poison infect and the respiratory tract chronic disease of bringing out such as: chronic bronchitis, emphysema, pulmonary heart disease, chronic pharyngolaryngitis etc. are a kind of commonly encountered diseases, frequently-occurring disease, in case morbidity, obstinate, and outbreak repeatedly, serious harm health.At " high medical college teaching material " (internal medicine), People's Health Publisher's in October, 1991 third edition is pointed out for the 13rd page: " infection is that chronic bronchitis takes place, a key factor of development; be mainly virus and bacterial infection ..., virus or virus and mycoplasma mixed infection damage air flue mucosa bring out bacterial infection." should (internal medicine) the 9th page point out again: " acute upper respiratory tract infection have approximately 70～80% cause by virus ", secondary bacterial infection.
How is the clinical symptoms performance of chronic bronchitis? " the clinical research guideline of new Chinese medicine treatment chronic bronchitis " (hereinafter to be referred as " guideline ") page 1 record of health ministry promulgation in 1993: " be cardinal symptom to cough, to cough up phlegm clinically; or with panting; annual outbreak continues 3 months at least, and continuous more than 2 years.Primary disease belongs to cough, the cough with asthma category of the traditional Chinese medical science." traditional Chinese traditional treatment is coughed, expectorant, breathe heavily prescription, except that adopting heat clearing away or warming the lung cold-dispelling drug, must mend with Qinghua heat-phlegm, warming for resolving cold-phlegm, cough suppressing panting calming medicine.The patent of invention " anti-virus and antipyretic oral liquid " (patent No.: ZL 94111925,4) of in October, 1994 application, its prescription is: Pheretima, Herba Houttuyniae, Radix Scutellariae, Bulbus Fritillariae Thunbergii, Semen Armeniacae Amarum, the Rhizoma Pinelliae, Pericarpium Citri Reticulatae, Radix Glycyrrhizae, wherein Bulbus Fritillariae Thunbergii, the Rhizoma Pinelliae, Semen Armeniacae Amarum promptly are this type of expectorants, antitussives and anti-asthmatics medicine things.
Expectorant cough suppressant and anti-asthmatic is long-standing in the traditional Chinese medical herbal treatment respiratory tract disease.All have special chapters and sections example to go out at Chinese medicine and pharmacy commonly used to reduce phlegm, cough-relieving, suppressing panting calming medicine and argumentation.Above-mentioned " guideline " is middle to be claimed cough, cough up phlegm or with panting, showed effect every year lasting 3 months at least.As seen cough, expectorant, breathe heavily the disease refractory more.Also have adopt contain morphine, codeine and
Pavine
The foxtail millet shell suppresses the respiratory center cough-relieving, but curative effect is still very general.
The objective of the invention is in order to overcome the weak point of above existing prescription, subduction expectorants, antitussives and anti-asthmatics medicine thing Bulbus Fritillariae Thunbergii, the Rhizoma Pinelliae, Semen Armeniacae Amarum three components in existing prescription, and a kind of medicine that mainly is applicable to preventing respiratory influenza virus and other multiple viral effects is provided.This medicine has been broken through diseases such as traditional treatment chronic bronchitis must be with the method for treatment of expectorants, antitussives and anti-asthmatics medicine thing, make therapeutic effect better, take safer and medicine valency cost reduces about one times.
The objective of the invention is to realize with following measure:
The present invention is based on the preventing respiratory influenza virus of Pheretima and other multiple virus function and is principal agent with it, and it is combined and make to be equipped with antibacterials again.
Principal agent Pheretima of the present invention and Chinese medicine antibacterials Herba Houttuyniae, Radix Scutellariae, Flos Lonicerae combination; As pressing Chinese medicine prescription prescription, increase adjuvant drug Pericarpium Citri Reticulatae, messenger drug Radix Glycyrrhizae, Flos Lonicerae have the upper respiratory tract of enhancing heat clearing away antibiotic effect.
The present invention also can increase the antibiotic Chinese medicinal components of heat clearing away according to the state of an illness.As Fructus Forsythiae, Rhizoma Coptidis, Ilex purpurea Hassk.[I.chinensis Sims.
Pheretima of the present invention is the pure dried Pheretima of silt of dispelling, and also available fresh and alive Pheretima is used as medicine, and dried Pheretima and fresh and alive Pheretima ratio are 1: 5.The present invention all adopts the prior art pharmacy.For example Pheretima can adopt the saline solution hypertonic pressure that contains 1-8% of prior art to extract the antiviral composition earlier, adopts new technologies such as prior art with other heat clearing away antibacterials class formulas removes slag, purifies, concentrates, dehydration to make various dosage forms such as solid, oral liquid, injection again.
Component of the present invention and consumption are as follows: weight g
Pheretima (clean body) 3-35, Herba Houttuyniae 10-80, Radix Scutellariae 8-45, Flos Lonicerae 10-50, Pericarpium Citri Reticulatae 7-15, Radix Glycyrrhizae 3-8.
The antibiotic Chinese medicine of heat clearing away of the present invention can increase following component and consumption: weight g
Fructus Forsythiae 8-50, Rhizoma Coptidis 5-45, Ilex purpurea Hassk.[I.chinensis Sims 10-60.
Principal agent of the present invention: the Pheretima preparation was once tested through Sichuan Province health and epidemic prevention station resisiting influenza virus in JIUYUE, 1994, conclusion is: should " medicine adopts in the Embryo Gallus domesticus and experiment; when dilution in 1: 50 the anti-93-1 strain in 3 type grippe virus A3/ another name for Sichuan Province is had inhibitory action, this medicine has no side effect to the Embryo Gallus domesticus growth promoter.”
From the 13rd page of contained chronic bronchitis of above-mentioned (internal medicine) third edition because of as seen: viral repeated infection, secondary bacterial infection are the key factors that chronic bronchitis scorchingly takes place, development worsens.How is clinical efficacy so? therefore investigate thoroughly that the Pheretima preparation is used for clinical treatment whether antiviral wide spectrum specific action is arranged, extremely important.For this reason:
Medicine of the present invention once be applied to treat different year due to illness poison infect and the respiratory tract chronic disease of bringing out, for preventing due to illness the difference of therapeutic effect between poison variation or different virus, being close on 200 routine patients through tens, to take the clinical observation curative effect that does not add the expectorants, antitussives and anti-asthmatics medicine thing pretty good.For example:
1. the 32 routine patients that tried out by two doctors of unit of inventor place system from 1988 to 1992, have 16 examples to be the chronic bronchitis inflammation, symptom is: cough, cough up phlegm, abundant expectoration is white foam, normal easily expectoration.The 3 days curative effects of taking medicine are: face control 9 examples and account for 56%; Produce effects 7 examples account for 44%.
2.1994 year to 1996 by Hospital Affiliated To Chengdu Traditional Chinese Medicine Univ associate chief physician Zhang Fapin clinical observation 7 examples in inpatient, the sick kind and curative effect such as following table:
As seen treat that sympotoms caused by cold factors are coughed, expectorant, breathe heavily curative effect the best by this example.Medicament composing prescription is joined Herba Houttuyniae 15g, Radix Scutellariae 10g for the Pheretima preparation.
| The sick kind | Chronic bronchitis inflammation (4 example) | Flu (3 example) | ||
| The cold early stage pulmonary heart disease of type (2 people) 1 people | Pattern of fever (2 people) | Cold type (1 people) | Pattern of fever (2 people) | |
| Curative effect | Face control | Produce effects | Face control | Produce effects |
| Medicine time | 6 days | 5 days 1 people of 1 people 7 days | 6 days | 6 days |
| Age | 64 65 | 65 54 | 56 | 22 53 |
| Sex | The woman man | Woman woman | The woman | Woman woman |
3. radical cure is for example on probation
A, Chen Changtao, the man, 65 years old (live: Chengdu is military waits Spora Lygodii temple street, district No. 48) initially suffered from chronic pharyngitis the sixties when examination was treated, and still progressively increased the weight of through the integrative therapy state of an illness.The attached first hospital's department of otorhinolaryngology expert diagnosis of Nikkei West China medical university in 90 year November 26 is " pharynx trickle charge blood " (being pharyngeal chronic congestion).Symptom is mainly itching throat, pharyngalgia, coughs, coughs up phlegm, abundant expectoration is the white foam shape, examination clothes Pheretima anti-virus formulation unsatisfactory curative effect, change the Pheretima anti-virus formulation in conjunction with the antimicrobial Flos Lonicerae of heat clearing away, forsythia fruit for treating one month after researched and analysed on March 20th, 91, in Nikkei in the 91 year April 26 same expert diagnosis of same hospital department of otorhinolaryngology " pharyngeal congestion is not obvious; " continue to take Chinese medicine, the control of seizures treatment that continues was effected a radical cure more in 3 years.
B, Geng Junru, the man, 80 years old, (living in No. 20 1-1 in mouth loess slope, competiting place, Chongqing City) initially suffered from the chronic bronchitis inflammation fifties.Now be chronic bronchitis inflammation, emphysema, early stage pulmonary heart disease, symptom cough, is coughed up phlegm, the few little Huang of expectorant is thick, the heart consider pant, sputum streaked with blood sometimes.Take the Pheretima anti-virus formulation and be equipped with coptos bolus for clearing the upper heat.25, letter of 99 on Decembers claims: " cough is clearly better with spitting of blood, and a wheat harvesting period comes, and spitting of blood stops, spits and also changes light." on January 8th, 2000 letter key medicine claims again: " emphysema in 50 years and early stage pulmonary heart disease, and emphysema and chronic bronchitis inflammation after worsening have stopped developing to bad direction.”
C, He Yuepei (father that Chengdu Branch of the Chinese Academy of Sciences is wished in Helan), the man 70 years old, suffers from surplus the chronic bronchitis scorching 30 year.Now be chronic bronchitis inflammation, emphysema.On probation at the beginning of 92, single bacterial infection increases the weight of, and treats the bacterial infection basic controlling with the treatment of Pheretima anti-virus formulation, coughs, coughs up phlegm, expectorant is for sticking rare, and it is tight that the heart is considered gas, takes the Pheretima anti-virus formulation and is equipped with the Succus Bambusae medicine and took effect 8 days clinical cures in 3 days.Added antibiotic in Yin Zhiyadi 7-8 days, the curative effect in a winter of control treatment after this is excellent.Because of going back home, he stops examination.
More than each case relate to the antibiotic Chinese medicine of heat clearing away of doing the supporting role with the Pheretima anti-virus formulation.Herba Houttuyniae, Radix Scutellariae, Flos Lonicerae, Fructus Forsythiae, Succus Bambusae, coptos bolus for clearing the upper heat etc. are promptly arranged; And different medications metering.This is to make supporting role's clinical efficacy according to the state of an illness respectively in order to observe multiple antibiotic heat clearing away medicine, is beneficial to be familiar with better the antivirus action of Pheretima.For example treating chronic pharyngitis with Flos Lonicerae, Fructus Forsythiae as the supporting role, is to be convenient to make curative effect relatively with traditional remedies.Draw the antiviral curative effect of Pheretima whereby.
In a word, the present invention not with the Pheretima anti-virus compound Drug therapy of expectorants, antitussives and anti-asthmatics medicine thing due to illness malicious infection-induced the cough based on the respiratory tract chronic disease, cough up phlegm, pant, reach the instant effect good effect, sufficed to show that the antiviral wide spectrum specific action of Pheretima medicine.This invention is to break through the key that disease such as traditional prescription therapeutic chronic bronchitis must adopt the expectorants, antitussives and anti-asthmatics medicine thing.Wide, the sick kind of antivirus action therapeutic domain of the present invention is many, from catching a cold to pulmonary heart disease state of an illness great disparity; The old man in year from the child to 80-90, the difference of patient age is especially big; Individual body constitution, the outstanding difference of defense function immunity are greatly; The classification of virus, antibacterial that can infect respiratory tract morbidity is many, and gradient of infection is also different, therefore can utilize the different meterings of different antibacterials to set up into a plurality of compound recipes with Pheretima antiviral function.For example, due to illness poison its symptom of infection of bringing out is mainly cough, coughs up phlegm, expectorant is white mucus spume shape at the chronic bronchitis inflammation, the normal easily expectoration of expectorant or with panting, the best composition and the consumption of medicine for treatment are: pure land dragon 13g (being roughly equal to market top grade Pheretima 26g), Herba Houttuyniae 45g, Radix Scutellariae 15g, Flos Lonicerae 30g, Pericarpium Citri Reticulatae 8g, Radix Glycyrrhizae 3g.But be used for the treatment of patients with cor pulmonale, antibacterial action is obviously not enough.When severe bacterial infections occurring, expectorant uses the heat clearing away antibacterial action of this medicine not good when being mucus purulence, purulence.At this moment should select other antibacterials to this pathogenic bacterium sensitivity for use, for example the antibiotics control of bacterial infection adopts drug combination.Chinese medicine antibacterials that the present invention selects for use and Pheretima prescription are safer for taking, and also can adopt the Chinese medicine antibacterials in other antibacterials replacement prescription certainly.
Former prescription and novel composing prescription medical material price ratio of the present invention, prescription is used: the medical material valency is Chengdu retail price in 2000.
Former prescription: 1.56 yuan of Pheretima 26g, 0.27 yuan of Herba Houttuyniae 45g, 0.54 yuan of Radix Scutellariae 18g, 0.03 yuan of Pericarpium Citri Reticulatae 10g, 0.05 yuan of Radix Glycyrrhizae 5g, 2.45 yuan of subtotals.0.9 yuan of Bulbus Fritillariae Thunbergii 15g, 0.45 yuan of Semen Armeniacae Amarum 15g, 1.05 yuan of Rhizoma Pinelliae 15g, 2.40 yuan of subtotals.
Cancellation Bulbus Fritillariae Thunbergii, Semen Armeniacae Amarum, the Rhizoma Pinelliae, the medical material valency reduces by one times approximately.
Novel composing prescription: pure land dragon 13g (being roughly equal to market top grade Pheretima 26g) Herba Houttuyniae 45g, Flos Lonicerae 30g, Radix Scutellariae 15g, Pericarpium Citri Reticulatae 8g, Radix Glycyrrhizae 3g.
The present invention compares with " anti-virus and antipyretic oral liquid " has following characteristics:
This prescription broken through diseases such as traditional treatment chronic bronchitis must be with the method for treatment of expectorants, antitussives and anti-asthmatics medicine thing.
2. Flos Lonicerae strengthens the antibiotic function of treatment upper respiratory tract in this prescription, thereby further improves curative effect.
3. the present invention reduces about one times of medicine valency, alleviates state revenue and expenditure, society, individual burden.
4. the present invention takes safer.For example, Semen Armeniacae Amarum is slightly poisonous, and overdose can be poisoned.
Claims (4)
1. an antivirus compound medicine is characterized in that its active component mainly is prepared from by following materials of weight proportions: Pheretima 3-35, Herba Houttuyniae 10-80, Radix Scutellariae 8-45, Flos Lonicerae 10-50, Pericarpium Citri Reticulatae 7-15, Radix Glycyrrhizae 3-8.
2. the described antivirus compound medicine of claim 1 is characterized in that preparing the used raw material of its active component and is: Pheretima 13, Herba Houttuyniae 45, Radix Scutellariae 15, Flos Lonicerae 30, Pericarpium Citri Reticulatae 8, Radix Glycyrrhizae 3.
3. the described antivirus compound medicine of claim 1 is characterized in that can also adding in the raw material Rhizoma Coptidis 5-45, Fructus Forsythiae 8-50, Ilex purpurea Hassk.[I.chinensis Sims 10-60.
4. any described antivirus compound medicine among the claim 1-3 is characterized in that it can be solid dosage forms or liquid dosage form.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB001161245A CN1136867C (en) | 2000-09-26 | 2000-09-26 | Antivirus compound medicine |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB001161245A CN1136867C (en) | 2000-09-26 | 2000-09-26 | Antivirus compound medicine |
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| CN1293960A CN1293960A (en) | 2001-05-09 |
| CN1136867C true CN1136867C (en) | 2004-02-04 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2006093164A1 (en) * | 2005-02-28 | 2008-08-07 | 大阪府 | Viral infection and growth inhibitor containing earthworm-derived components |
| CN104107216A (en) * | 2014-05-16 | 2014-10-22 | 清远容大生物工程有限公司 | Traditional Chinese medicine compound preparation and its preparation method and use |
| CN105031199A (en) * | 2015-09-07 | 2015-11-11 | 王俊喜 | Traditional Chinese medicine for treating herpes zoster |
| CN108653574B (en) * | 2018-08-13 | 2021-07-20 | 三株福尔制药有限公司 | Probiotic fermented antiviral composition and preparation method and application thereof |
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