CN113678835A - Bactericidal composition and application thereof - Google Patents
Bactericidal composition and application thereof Download PDFInfo
- Publication number
- CN113678835A CN113678835A CN202110998734.3A CN202110998734A CN113678835A CN 113678835 A CN113678835 A CN 113678835A CN 202110998734 A CN202110998734 A CN 202110998734A CN 113678835 A CN113678835 A CN 113678835A
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- CN
- China
- Prior art keywords
- parts
- sophorolipid
- powder
- epoxiconazole
- agent
- Prior art date
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- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 77
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 47
- ZTOKUMPYMPKCFX-CZNUEWPDSA-N (E)-17-[(2R,3R,4S,5S,6R)-6-(acetyloxymethyl)-3-[(2S,3R,4S,5S,6R)-6-(acetyloxymethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-4,5-dihydroxyoxan-2-yl]oxyoctadec-9-enoic acid Chemical compound OC(=O)CCCCCCC/C=C/CCCCCCC(C)O[C@@H]1O[C@H](COC(C)=O)[C@@H](O)[C@H](O)[C@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](COC(C)=O)O1 ZTOKUMPYMPKCFX-CZNUEWPDSA-N 0.000 claims abstract description 37
- ZMYFCFLJBGAQRS-IRXDYDNUSA-N (2R,3S)-epoxiconazole Chemical compound C1=CC(F)=CC=C1[C@@]1(CN2N=CN=C2)[C@H](C=2C(=CC=CC=2)Cl)O1 ZMYFCFLJBGAQRS-IRXDYDNUSA-N 0.000 claims abstract description 32
- 239000005767 Epoxiconazole Substances 0.000 claims abstract description 32
- 238000000034 method Methods 0.000 claims abstract description 19
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 10
- 239000012752 auxiliary agent Substances 0.000 claims abstract description 4
- 239000000843 powder Substances 0.000 claims description 79
- 240000002234 Allium sativum Species 0.000 claims description 41
- 235000004611 garlic Nutrition 0.000 claims description 41
- 241000196324 Embryophyta Species 0.000 claims description 40
- 239000000419 plant extract Substances 0.000 claims description 38
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 27
- 241000205585 Aquilegia canadensis Species 0.000 claims description 19
- 241000124033 Salix Species 0.000 claims description 19
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- 238000003756 stirring Methods 0.000 claims description 18
- 238000001035 drying Methods 0.000 claims description 16
- 244000178993 Brassica juncea Species 0.000 claims description 14
- 235000005855 Brassica juncea var. subintegrifolia Nutrition 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
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- 239000002552 dosage form Substances 0.000 claims description 3
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- 239000000375 suspending agent Substances 0.000 claims description 3
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- 239000000080 wetting agent Substances 0.000 claims description 3
- 230000002538 fungal effect Effects 0.000 claims description 2
- 230000000855 fungicidal effect Effects 0.000 claims description 2
- 230000002070 germicidal effect Effects 0.000 claims 8
- 230000000694 effects Effects 0.000 abstract description 22
- 238000002360 preparation method Methods 0.000 abstract description 11
- 230000001954 sterilising effect Effects 0.000 abstract description 7
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 7
- 230000002265 prevention Effects 0.000 abstract description 6
- 230000002195 synergetic effect Effects 0.000 abstract description 6
- 230000008569 process Effects 0.000 abstract description 4
- 230000000052 comparative effect Effects 0.000 description 32
- 239000003153 chemical reaction reagent Substances 0.000 description 13
- 238000003672 processing method Methods 0.000 description 10
- 241000209094 Oryza Species 0.000 description 9
- 235000007164 Oryza sativa Nutrition 0.000 description 9
- 235000009566 rice Nutrition 0.000 description 9
- 244000052616 bacterial pathogen Species 0.000 description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 239000003899 bactericide agent Substances 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 241000219198 Brassica Species 0.000 description 5
- 235000003351 Brassica cretica Nutrition 0.000 description 5
- 235000003343 Brassica rupestris Nutrition 0.000 description 5
- QKSKPIVNLNLAAV-UHFFFAOYSA-N bis(2-chloroethyl) sulfide Chemical compound ClCCSCCCl QKSKPIVNLNLAAV-UHFFFAOYSA-N 0.000 description 5
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- 235000010460 mustard Nutrition 0.000 description 5
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- 239000002994 raw material Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- 229920001732 Lignosulfonate Polymers 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- -1 calcium alkyl sulfonate Chemical class 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 231100000252 nontoxic Toxicity 0.000 description 3
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- 238000001179 sorption measurement Methods 0.000 description 3
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- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 2
- 241000255789 Bombyx mori Species 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 231100000674 Phytotoxicity Toxicity 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 2
- 239000000908 ammonium hydroxide Substances 0.000 description 2
- 229960000892 attapulgite Drugs 0.000 description 2
- 239000000440 bentonite Substances 0.000 description 2
- 229910000278 bentonite Inorganic materials 0.000 description 2
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 2
- 239000004202 carbamide Substances 0.000 description 2
- 238000013329 compounding Methods 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 238000001647 drug administration Methods 0.000 description 2
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- 239000000194 fatty acid Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
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- 238000009472 formulation Methods 0.000 description 2
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- 229920000609 methyl cellulose Polymers 0.000 description 2
- 239000001923 methylcellulose Substances 0.000 description 2
- 235000010981 methylcellulose Nutrition 0.000 description 2
- 229910052625 palygorskite Inorganic materials 0.000 description 2
- 230000000361 pesticidal effect Effects 0.000 description 2
- 229940051841 polyoxyethylene ether Drugs 0.000 description 2
- 229920000056 polyoxyethylene ether Polymers 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 230000001018 virulence Effects 0.000 description 2
- HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical compound O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 1
- 241001530056 Athelia rolfsii Species 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 102000012286 Chitinases Human genes 0.000 description 1
- 108010022172 Chitinases Proteins 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 241000221785 Erysiphales Species 0.000 description 1
- 229930186217 Glycolipid Natural products 0.000 description 1
- 239000005909 Kieselgur Substances 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 241000918585 Pythium aphanidermatum Species 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- SNAAJJQQZSMGQD-UHFFFAOYSA-N aluminum magnesium Chemical compound [Mg].[Al] SNAAJJQQZSMGQD-UHFFFAOYSA-N 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 239000007798 antifreeze agent Substances 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- OOCMUZJPDXYRFD-UHFFFAOYSA-L calcium;2-dodecylbenzenesulfonate Chemical compound [Ca+2].CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O.CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O OOCMUZJPDXYRFD-UHFFFAOYSA-L 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 229920003064 carboxyethyl cellulose Polymers 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 230000008686 ergosterol biosynthesis Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
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- 230000006872 improvement Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 238000004898 kneading Methods 0.000 description 1
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- 231100000957 no side effect Toxicity 0.000 description 1
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- 239000003002 pH adjusting agent Substances 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 244000000003 plant pathogen Species 0.000 description 1
- 229920005646 polycarboxylate Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- PYODKQIVQIVELM-UHFFFAOYSA-M sodium;2,3-bis(2-methylpropyl)naphthalene-1-sulfonate Chemical compound [Na+].C1=CC=C2C(S([O-])(=O)=O)=C(CC(C)C)C(CC(C)C)=CC2=C1 PYODKQIVQIVELM-UHFFFAOYSA-M 0.000 description 1
- HLPHHOLZSKWDAK-UHFFFAOYSA-M sodium;formaldehyde;naphthalene-1-sulfonate Chemical compound [Na+].O=C.C1=CC=C2C(S(=O)(=O)[O-])=CC=CC2=C1 HLPHHOLZSKWDAK-UHFFFAOYSA-M 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
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- 238000010998 test method Methods 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
- A01N43/16—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/40—Liliopsida [monocotyledons]
- A01N65/42—Aloeaceae [Aloe family] or Liliaceae [Lily family], e.g. aloe, veratrum, onion, garlic or chives
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Agronomy & Crop Science (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Environmental Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Pest Control & Pesticides (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention belongs to the technical field of sterilization compositions, and discloses a sterilization composition and application thereof. The bactericidal composition provided by the invention comprises a main agent and an auxiliary agent, wherein the main agent comprises sophorolipid and epoxiconazole, and the mass ratio of the sophorolipid to the epoxiconazole is 1: 0.025 to 40. The sophorolipid and the epoxiconazole are compounded for use, and the mass ratio of the sophorolipid to the epoxiconazole is controlled to be 1: 0.025-40, the preparation process is simple, the obvious synergistic effect can be achieved, and the prepared bactericidal composition is low in dosage, good in prevention effect, safe, efficient, environment-friendly, and capable of greatly reducing the negative effects on the environment in the using process.
Description
Technical Field
The invention relates to the technical field of bactericides, and in particular relates to a bactericidal composition and application thereof.
Background
Plants are organisms on the earth, have edible value, medicinal value, raw material value, ornamental value and cultural value, and can keep ecological balance, and plants are damaged by germs in the planting process, so that the germs of the plants need to be prevented and controlled by spraying a bactericide to the plants, the germs can be directly removed, the plants are prevented and controlled from being continuously damaged by the germs, the existing bactericide is diversified in variety, and can be correspondingly selected according to different germs for preventing and controlling the germs of the plants.
However, as the environment is damaged, the environmental pressure is increased, and higher requirements are also put forward on the environmental protection performance of the bactericide, but the difficulty of preventing and controlling plant pathogens is increased, on one hand, the occurrence degree and the occurrence quantity of diseases are improved, and on the other hand, the drug resistance of the pathogens is increased year by year under the continuous medicament selection pressure, so that the prevention and control effect of the bactericide is greatly reduced, and therefore, a high-efficiency and environment-friendly bactericide composition needs to be researched.
Disclosure of Invention
Based on this, there is a need for a bactericidal composition and its use.
In order to achieve the purpose, the invention adopts the following technical scheme:
the bactericidal composition comprises a main agent and an auxiliary agent, wherein the main agent comprises sophorolipid and epoxiconazole, and the mass ratio of the sophorolipid to the epoxiconazole is 1: 0.025 to 40.
In one embodiment, the sophorolipid and epoxiconazole are in a mass ratio of 1: 0.05 to 20.
In one embodiment, the sophorolipid and epoxiconazole are in a mass ratio of 1: 0.1 to 10.
In one embodiment, the dosage form of the bactericidal composition is one of a suspending agent and a water dispersible granule.
In one embodiment, the bactericidal composition comprises, by mass, 1 to 40 parts of sophorolipid, 1 to 40 parts of epoxiconazole, 5 to 20 parts of a dispersing agent, 1 to 5 parts of an antifreezing agent, 0.2 to 2 parts of a thickening agent, 0.5 to 0.8 part of an antifoaming agent, 0.3 to 0.5 part of a pH value regulator, and 30 to 70 parts of water.
In one embodiment, the bactericidal composition comprises 1-40 parts of sophorolipid, 1-40 parts of epoxiconazole, 6-8 parts of dispersing agent, 2-8 parts of wetting agent, 3-7 parts of disintegrating agent and 1-8 parts of filler by mass.
In one embodiment, the plant extract powder further comprises 8-25 parts by mass of modified plant extract powder.
In one embodiment, the modified plant extract powder is processed by the following steps: providing leaf mustard, willow leaves and honeysuckle, drying to enable the leaf mustard, the willow leaves and the honeysuckle to be crisp, then crushing to obtain plant powder, providing sawdust powder, stirring and mixing the sawdust powder and the plant powder to obtain premix, providing garlic, beating the garlic into garlic juice through a wall breaking machine, adding the premix into the garlic juice, adding activated carbon and water, stirring and mixing to obtain mixture, and then performing evaporation drying operation on the mixture to obtain the modified plant extraction powder.
In one embodiment, the modified plant extract powder has a particle size of 500 to 800 mesh.
In one embodiment, the dispersant comprises at least one of a polycarboxylate, a lignosulfonate, a calcium alkyl sulfonate, a sodium naphthalene sulfonate formaldehyde condensate, an alkylphenol ethoxylate, a fatty acid polyoxyethylene ester, a fatty amine polyoxyethylene ether, and a glycerol polyoxyethylene ether fatty acid ester.
In one embodiment, the anti-freeze agent comprises at least one of ethylene glycol, propylene glycol, and glycerol.
In one embodiment, the thickener comprises at least one of xanthan gum, carboxymethyl cellulose, carboxyethyl cellulose, methyl cellulose, magnesium aluminum silicate, polyvinyl alcohol.
In one embodiment, the defoaming agent comprises at least one of silicone oil, silicone compound and C8-10 fatty alcohol.
In one embodiment, the wetting agent comprises at least one of sodium lauryl sulfate, calcium dodecylbenzenesulfonate, nekal BX, powdered saponin, and silkworm excrement.
In one embodiment, the disintegrant comprises at least one of bentonite, urea, ammonium sulfate, aluminum chloride, citric acid, succinic acid, and sodium bicarbonate.
In one embodiment, the filler comprises at least one of kaolin, diatomaceous earth, bentonite, attapulgite, and starch.
In one embodiment, the pH adjusting agent comprises at least one of ammonium hydroxide, potassium hydroxide, sodium hydroxide, hydrochloric acid, acetic acid, citric acid, and phosphoric acid.
The invention also provides application of the bactericidal composition in preventing and treating plant fungal diseases. Specifically, the bactericidal composition can be used for preventing and treating rice blast, powdery mildew, rot, damping off, banded sclerotial blight, gibberellic disease, late blight and anthracnose.
Compared with the prior art, the invention has the following advantages and technical effects:
(1) the bactericidal composition provided by the invention is prepared into a specific dosage form by compounding the sophorolipid and the epoxiconazole and using an auxiliary agent, wherein the sophorolipid is a glycolipid natural surfactant, the sophorolipid is generated by microbial fermentation or enzyme catalysis, the raw materials are nontoxic and have no side effect and have small influence on the environment, the sophorolipid is also a nontoxic and harmless reagent and is nontoxic, odorless and free of any stimulation to the human body, the sophorolipid can be degraded, namely, the sophorolipid can not remain after being used, the influence on the environment is avoided, the environment is more green and environment-friendly, the epoxiconazole can be used as an inhibitor, can inhibit the synthesis of ergosterol of pathogenic bacteria, inhibit the formation of cell walls, influence the normal growth of the pathogenic bacteria, and improve the activity of chitinase of plants to cause the contraction of fungal haustor, therefore, the compound sophorolipid and epoxiconazole are compounded for use, and the mass ratio of the sophorolipid to the epoxiconazole is controlled to be 1: 0.025-40, the preparation process is simple, the obvious synergistic effect can be achieved, and the prepared bactericidal composition is low in dosage, good in prevention effect, safe, efficient, environment-friendly, and capable of greatly reducing the negative effects on the environment in the using process.
(2) The sterilization composition provided by the invention has good sterilization effect by adding the modified plant extract powder which contains mustard, willow leaves, honeysuckle and garlic, can be used for further improving the control effect of the sterilization composition by being compounded with sophorolipid and epoxiconazole, and meanwhile, the sawdust powder is also added, can play a certain warm-keeping effect on plants and has a protection effect on the plants so as to be beneficial to ensuring the normal growth of the plants, so that the antibacterial property of the plants is improved, in addition, the activated carbon has good adsorption performance by adding the activated carbon, particularly, the activated carbon also has good adsorption performance on gas, and the garlic has pungent smell, and the smell of the garlic can be adsorbed by adding the activated carbon so as to avoid the influence of the smell generated by the garlic on workers in the preparation process of the sterilization composition, moreover, the prepared bactericidal composition can be prevented from having garlic smell, the quality of the prepared bactericidal composition is prevented from being influenced, the wood chip powder and the activated carbon have adsorption performance, and mustard, willow leaves, honeysuckle and garlic can be adsorbed, so that the mustard, the willow leaves, the honeysuckle and the garlic are better and more stably stored in the bactericidal composition system, the stability of the prepared bactericidal composition is improved, and the control efficacy and the efficacy durability of the bactericidal composition are improved.
Detailed Description
The present invention will be described in further detail with reference to specific examples, but the embodiments of the present invention are not limited thereto. All the raw materials and reagents used in the present invention are commercially available raw materials and reagents, unless otherwise specified. In the examples, the components are used in g and mL in parts by mass.
Examples 1 to 12
The bactericidal compositions of examples 1-12, wherein the bactericidal composition includes the components shown in table 1 in parts by mass.
TABLE 1 table of fungicidal composition of examples 1-12
The formulations of examples 1-9 in table 1 were prepared according to the following procedure:
(1) adding lignosulfonate, propylene glycol, methylcellulose, silicone compounds, ammonium hydroxide and water into a stirrer in proportion, and uniformly mixing by high-speed shearing to obtain a premix;
(2) and adding the sophorolipid, the epoxiconazole, the modified plant extract powder and the premix into a ball mill according to the proportion, and milling the balls for 2-3 hours to ensure that the particle diameters are all below 5mm, thereby obtaining the bactericidal composition of the examples 1-9, wherein the bactericidal composition is in the form of a suspending agent.
The treatment method of the modified plant extract powder comprises the following steps: providing leaf mustard, willow leaves and honeysuckle, drying at 50 ℃, crushing to obtain plant powder, providing sawdust powder, stirring and mixing the sawdust powder and the plant powder to obtain premix, providing garlic, beating the garlic into garlic juice through a wall breaking machine, adding the premix into the garlic juice, adding activated carbon and water, stirring and mixing to obtain a mixture, and evaporating and drying the mixture to obtain the modified plant extract powder. The particle size of the modified plant extract powder is 600 meshes.
The formulations of examples 10-12 in Table 1 were prepared according to the following procedure:
(1) adding sophorolipid, epoxiconazole, lignosulfonate, silkworm excrement, urea, attapulgite and modified plant extract powder into a stirrer according to a certain proportion, and uniformly stirring and mixing to obtain a mixed material;
(2) adding the mixed material into an ultramicro jet mill, carrying out crushing operation, adding the mixed material into a kneader, carrying out kneading operation, then adding the kneaded material into a fluidized bed granulation dryer, and carrying out granulation and drying to obtain the bactericidal composition of examples 10-12, wherein the bactericidal composition is in the form of water dispersible granules.
The treatment method of the modified plant extract powder comprises the following steps: providing leaf mustard, willow leaves and honeysuckle, drying at 50 ℃, crushing to obtain plant powder, providing sawdust powder, stirring and mixing the sawdust powder and the plant powder to obtain premix, providing garlic, beating the garlic into garlic juice through a wall breaking machine, adding the premix into the garlic juice, adding activated carbon and water, stirring and mixing to obtain a mixture, and evaporating and drying the mixture to obtain the modified plant extract powder. The particle size of the modified plant extract powder is 600 meshes.
Comparative example 1
The difference between the comparative example 1 and the example 2 is that the bactericidal composition of the comparative example 1 does not contain epoxiconazole, the dosage of sophorolipid is 40 parts by mass, and the other reagent dosage and preparation method are the same as the example 2.
Comparative example 2
The difference between the comparative example 2 and the example 2 is that the bactericidal composition of the comparative example 2 does not contain sophorolipid, and the amount of epoxiconazole is 40 parts by mass, and the amounts of other reagents and the preparation method are the same as those of the example 2.
Comparative example 3
The difference between the comparative example 3 and the example 2 is that the sterilization composition of the comparative example 3 does not contain the modified plant extract powder, and the amounts of other reagents and the preparation method are the same as those of the example 2.
Comparative example 4
The difference between the comparative example 4 and the example 2 is that the processing method of the modified plant extract powder is different, and the processing method of the modified carrier of the comparative example 4 is as follows: the treatment method of the modified plant extract powder comprises the following steps: providing willow leaves and honeysuckle, performing drying operation, controlling the drying temperature to be 50 ℃ so that the willow leaves and the honeysuckle are crisp, performing crushing operation to obtain plant powder, providing sawdust powder, performing stirring and mixing operation on the sawdust powder and the plant powder to obtain premix, providing garlic, beating the garlic into garlic juice through a wall breaking machine, adding the premix into the garlic juice, adding activated carbon and water, performing stirring and mixing operation to obtain mixture, and performing evaporation drying operation on the mixture to obtain the modified plant extract powder. The particle size of the modified plant extract powder is 600 meshes. Other amounts of reagents and preparation method were the same as in example 2.
Comparative example 5
The difference between the comparative example 5 and the example 2 is that the processing method of the modified plant extract powder is different, and the processing method of the modified carrier of the comparative example 5 is as follows: the treatment method of the modified plant extract powder comprises the following steps: providing leaf mustard and honeysuckle, performing drying operation, controlling the drying temperature to be 50 ℃ so that the leaf mustard and the honeysuckle are crisp, performing crushing operation to obtain plant powder, providing sawdust powder, performing stirring and mixing operation on the sawdust powder and the plant powder to obtain premix, providing garlic, beating the garlic into garlic juice through a wall breaking machine, adding the premix into the garlic juice, adding activated carbon and water, performing stirring and mixing operation to obtain mixture, and performing evaporation drying operation on the mixture to obtain the modified plant extract powder. The particle size of the modified plant extract powder is 600 meshes. Other amounts of reagents and preparation method were the same as in example 2.
Comparative example 6
The difference between the comparative example 6 and the example 2 is that the processing method of the modified plant extract powder is different, and the processing method of the modified carrier of the comparative example 6 is as follows: the treatment method of the modified plant extract powder comprises the following steps: providing leaf mustard and willow leaves, drying, controlling the drying temperature to be 50 ℃ so that the leaf mustard and the willow leaves are crisp, then crushing to obtain plant powder, providing sawdust powder, stirring and mixing the sawdust powder and the plant powder to obtain premix, providing garlic, beating the garlic into garlic juice through a wall breaking machine, adding the premix into the garlic juice, adding activated carbon and water, stirring and mixing to obtain a mixture, and then performing evaporation drying on the mixture to obtain the modified plant extract powder. The particle size of the modified plant extract powder is 600 meshes. Other amounts of reagents and preparation method were the same as in example 2.
Comparative example 7
The difference between the comparative example 7 and the example 2 is that the processing method of the modified plant extract powder is different, and the processing method of the modified carrier of the comparative example 7 is as follows: the treatment method of the modified plant extract powder comprises the following steps: providing leaf mustard, willow leaves and honeysuckle, drying at 50 ℃ so that the leaf mustard, the willow leaves and the honeysuckle become crisp, crushing to obtain plant powder, providing wood chip powder, stirring and mixing the wood chip powder and the plant powder to obtain premix, adding activated carbon and water into the premix, stirring and mixing to obtain mixture, and evaporating and drying the mixture to obtain the modified plant extract powder. The particle size of the modified plant extract powder is 600 meshes. Other amounts of reagents and preparation method were the same as in example 2.
Comparative example 8
The difference between the comparative example 8 and the example 2 is that the processing method of the modified plant extract powder is different, and the processing method of the modified carrier of the comparative example 8 is as follows: the treatment method of the modified plant extract powder comprises the following steps: providing leaf mustard, willow leaves and honeysuckle, drying at 50 ℃ so that the leaf mustard, the willow leaves and the honeysuckle are crisp, crushing to obtain plant powder, providing garlic, beating the garlic into garlic juice through a wall breaking machine, adding the plant powder into the garlic juice, adding water, stirring and mixing to obtain a mixture, and evaporating and drying the mixture to obtain the modified plant extract powder. The particle size of the modified plant extract powder is 600 meshes. Other amounts of reagents and preparation method were the same as in example 2.
Comprehensive virulence determination
Comprehensive toxicity measurement was performed using the bactericidal compositions prepared in examples 2, 4 to 9, and 1 to 8 as examples.
The determination method comprises the following steps: referring to the test criterion NY/T1156.2-2006 for indoor bioassay of pesticides, a plate method is adopted.
Carrying out statistical analysis by using DPS statistical analysis software, calculating EC50 of each medicament, and calculating the co-toxicity coefficient (CTC value) of the mixture according to a Sun Yunpei method, wherein a single dose of sophorolipid is used as a standard reagent, namely the bactericidal composition in the comparative example 1 is used as the standard reagent, and specifically, the co-toxicity coefficient (CTC) is more than or equal to 120, which shows a synergistic effect; the co-toxicity coefficient (CTC) is less than or equal to 80, and the antagonism is shown; 80 < co-toxicity coefficient (CTC) < 120 showed additive effects.
TABLE 2 comprehensive virulence determination results
As can be seen from the data in table 2, the sophorolipid and epoxiconazole are compounded to serve as the effective components of the bactericidal composition, so that the bactericidal composition with higher safety and a cotoxicity coefficient greater than 120 can be obtained, and the sophorolipid and the epoxiconazole are mixed according to the mass ratio of 1: the compound shows obvious synergistic effect within the range of 0.025-40, wherein when the mass ratio of the sophorolipid to the epoxiconazole is 1: 1, the synergistic effect is most obvious.
Field test
The test method comprises the following steps: taking the bactericidal compositions prepared in the examples 2, 4 to 9 and 1 to 8 as examples, a field pesticide application test is carried out, a blank control group is set, the pesticide application treatment is not carried out, 5 points are randomly sampled in each test treatment area, 2 plants are surveyed at each point, 5 leaves at the middle part and the lower part of each plant are surveyed, and 50 leaves are sampled and surveyed.
The degree of rice blast attack is recorded by a classification method, and the classification standard is as follows:
level 0: no disease spots;
level 1: brown spot disease is appeared;
and 3, level: the area of the lesion spots accounts for less than 5% of the area of the whole leaf;
and 5, stage: the area of the lesion spots accounts for less than 6-25% of the area of the whole leaf;
and 7, stage: the area of the lesion spots accounts for less than 26-50% of the area of the whole leaf;
and 9, stage: the lesion area accounts for more than 50% of the whole leaf area.
Investigation time and number of times: the test was conducted 3 times, and the number of the predose bases, 7 days after the administration, and 14 days after the administration were examined.
Drug effect calculation method
Phytotoxicity investigation method
After the application, the chemical is continuously 14d to visually determine whether the chemical damages the crops.
TABLE 3 index of illness before taking medicine
TABLE 4 index of disease index questionnaire 7 days after drug administration
TABLE 5 index of disease index questionnaire 14 days after drug administration
TABLE 6 field test results of efficacy
As can be seen from tables 3 to 6, the prevention and control effect on rice blast is remarkably improved after the sophorolipid and epoxiconazole are compounded, wherein, as can be seen by comparing examples 2 and 4 to 9 with comparative examples 1 to 2, the pesticide effect improvement after the sophorolipid and epoxiconazole are compounded is remarkable, the prevention and control effect on rice blast is remarkably improved, the safety is good, rice grows normally in the growth process, and no phytotoxicity phenomenon occurs, which indicates that the compound is safe to rice, wherein, the prevention and control effect of the example 2 is best, that is, when the mass ratio of the sophorolipid to the epoxiconazole is 1: 1, the control effect on the rice blast is best, specifically, the control effect is as high as 89.44% after 14 days of pesticide application, as can be seen by comparing the example 2 with the comparative example 3, under the same dosage and mass ratio of sophorolipid and epoxiconazole, the control effect can be further improved by adding modified plant extract powder, as can be seen by comparing the example 2 with the comparative example 4, the comparative example 5, the comparative example 6 and the comparative example 7, the best control effect on the rice blast can be achieved by compounding mustard, willow leaves and honeysuckle with garlic juice, as can be seen by comparing the example 2 with the comparative example 8, the active effective components such as the mustard, the willow leaves, the honeysuckle and the garlic juice can be better adsorbed and stored by adding the sawdust powder and the active carbon, so that the pesticide effect of the bactericidal composition and the control effect on the rice blast can be greatly improved, and the sawdust powder can play a certain warm-keeping effect on plants, plays a role in protecting plants, is favorable for ensuring the normal growth of the plants, and is favorable for improving the antibacterial property of the plants. In conclusion, the bactericidal composition disclosed by the invention can achieve an obvious synergistic effect, and the prepared bactericidal composition is low in dosage, good in control effect, safe and efficient in use, greatly reduced in negative effect on the environment, green and environment-friendly.
The above embodiments are the best mode for carrying out the present invention, but the embodiments of the present invention are not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be regarded as equivalent substitutions and are included in the scope of the present invention.
Claims (10)
1. The bactericidal composition is characterized by comprising a main agent and an auxiliary agent, wherein the main agent comprises sophorolipid and epoxiconazole, and the mass ratio of the sophorolipid to the epoxiconazole is 1: 0.025 to 40.
2. The germicidal composition of claim 1, wherein: the weight ratio of the sophorolipid to the epoxiconazole is 1: 0.05 to 20.
3. The germicidal composition of claim 1, wherein: the weight ratio of the sophorolipid to the epoxiconazole is 1: 0.1 to 10.
4. The germicidal composition of claim 1, wherein: the dosage form of the bactericidal composition is one of a suspending agent and water dispersible granules.
5. The germicidal composition of claim 1, wherein: the bactericidal composition comprises, by mass, 1-40 parts of sophorolipid, 1-40 parts of epoxiconazole, 5-20 parts of a dispersing agent, 1-5 parts of an antifreezing agent, 0.2-2 parts of a thickening agent, 0.5-0.8 part of an antifoaming agent, 0.3-0.5 part of a pH value regulator and 30-70 parts of water.
6. The germicidal composition of claim 1, wherein: the bactericidal composition comprises, by mass, 1-40 parts of sophorolipid, 1-40 parts of epoxiconazole, 6-8 parts of a dispersing agent, 2-8 parts of a wetting agent, 3-7 parts of a disintegrating agent and 1-8 parts of a filler.
7. The germicidal composition as claimed in any one of claims 1-6, wherein: the plant extract powder comprises, by mass, 8-25 parts of modified plant extract powder.
8. The germicidal composition of claim 7, wherein: the treatment method of the modified plant extract powder comprises the following steps: providing leaf mustard, willow leaves and honeysuckle, drying to enable the leaf mustard, the willow leaves and the honeysuckle to be crisp, then crushing to obtain plant powder, providing sawdust powder, stirring and mixing the sawdust powder and the plant powder to obtain premix, providing garlic, beating the garlic into garlic juice through a wall breaking machine, adding the premix into the garlic juice, adding activated carbon and water, stirring and mixing to obtain mixture, and then performing evaporation drying operation on the mixture to obtain the modified plant extraction powder.
9. The germicidal composition of claim 8, wherein: the particle size of the modified plant extraction powder is 500-800 meshes.
10. Use of a fungicidal composition as claimed in any of claims 1 to 9 for the control of fungal plant diseases.
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| CN112616844A (en) * | 2020-11-27 | 2021-04-09 | 浙江威尔达化工有限公司 | Bactericide |
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| CN102548398A (en) * | 2009-09-29 | 2012-07-04 | 赢创高施米特有限公司 | Use of sophorolipids and derivatives thereof in combination with pesticides as adjuvant/additive for plant protection and the industrial non-crop field |
| CN112616844A (en) * | 2020-11-27 | 2021-04-09 | 浙江威尔达化工有限公司 | Bactericide |
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