CN113663044B - Changqing pill for nourishing liver and preparation method thereof - Google Patents
Changqing pill for nourishing liver and preparation method thereof Download PDFInfo
- Publication number
- CN113663044B CN113663044B CN202110981185.9A CN202110981185A CN113663044B CN 113663044 B CN113663044 B CN 113663044B CN 202110981185 A CN202110981185 A CN 202110981185A CN 113663044 B CN113663044 B CN 113663044B
- Authority
- CN
- China
- Prior art keywords
- parts
- thick paste
- weight
- following components
- prepared
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/424—Gynostemma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Insects & Arthropods (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Dermatology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Ophthalmology & Optometry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to the technical field of traditional Chinese medicine pills, and particularly relates to a Changqing pill for protecting liver and a preparation method thereof. The Changqing pill is prepared from thick paste A and medicinal powder B according to the mass ratio of 1: 1-3, mixing uniformly and making into pills; wherein the thick paste A comprises the following components in parts by weight: 50-100 parts of white peony root; 20-100 parts of liquorice; 20-100 parts of dried orange peel; 50-150 parts of honeysuckle; 10-50 parts of medlar; 5-20 parts of gynostemma pentaphylla; the medicinal powder B comprises the following components in parts by weight: 10-50 parts of poria cocos; 20-100 parts of rhizoma atractylodis; 20-100 parts of turmeric; 30-100 parts of kudzu root; 10-80 parts of astragalus; 100-200 parts of honey powder. The Changqing pill has the functions of protecting liver and resisting fatigue, is suitable for people with dry eyes, acerbity, yellowing, red silky eyes, no luster, dark face and the like, and has good effect on diseases caused by liver and gall, such as fatty liver, jaundice and the like.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicine pills, and particularly relates to a Changqing pill for nourishing liver and a preparation method thereof.
Background
The liver is the largest detoxifying organ of human body and has important effect on human body. At present, the police bell is sounded to our health because of liver injury caused by excessive drinking and excessive fatigue, and even acute and chronic alcoholism, mild and moderate fatty liver, mental depression and other problems occur.
At present, a plurality of health care products for relieving alcoholism and protecting liver are available on the market, and although the health care products have certain corresponding functions, the effects are single. In addition, although a certain amount of the health-care product for dispelling the effects of alcohol and protecting the liver is not greatly damaged by eating, the liver and the kidney can be damaged by taking the health-care product for a long time, and the effect of protecting the liver cannot be achieved.
Patent application 201611241985.2 discloses a liver nourishing and sobering-up health tea, a preparation method and application thereof, the liver nourishing and sobering-up health tea has more functions, not only can play roles in protecting the liver and sobering up for drinkers, but also can play roles in protecting the gastrointestinal tract, reducing blood fat and improving sleep quality, is also suitable for common health-care crowds, but the health tea is only suitable for daily health preservation and care, and has a limited effect on liver maintenance.
Patent application 201610712454.0 discloses a liver protecting traditional Chinese medicine pill and a preparation method thereof, wherein the liver protecting traditional Chinese medicine pill comprises the following raw materials: 37. the traditional Chinese medicine pill for protecting liver is prepared by simply and uniformly mixing the raw materials of sedum sarmentosum, lucid ganoderma, rheum officinale, ligusticum wallichii and honey, and then carrying out pill rolling after mould pressing, but the patent does not disclose any specific curative effect of the medicine.
The invention designs the Changqing pill for protecting liver based on the characteristics of mild action, diverse drug effects and small side effect of traditional Chinese medicines or natural medicines.
Disclosure of Invention
In view of the technical problems in the background art, the invention aims to provide a Changqing pill for liver maintenance, which is suitable for the liver maintenance of sub-health-state people.
The invention also aims to provide a preparation method of the Changqing pills for protecting liver, which can greatly improve the utilization efficiency of medicinal materials and is easy to realize industrial production.
In order to achieve the above object, the present invention provides the following technical solutions: the Changqing pill for nourishing the liver is prepared from thick paste A and medicinal powder B according to a mass ratio of 1: 1-3, mixing uniformly and making into pills; wherein the thick paste A comprises the following components in parts by weight:
50-100 parts of white peony root;
20-100 parts of liquorice;
20-100 parts of dried orange peel;
50-150 parts of honeysuckle;
10-50 parts of medlar;
5-20 parts of gynostemma pentaphylla;
the medicinal powder B comprises the following components in parts by weight:
10-50 parts of poria cocos;
20-100 parts of rhizoma atractylodis;
20-100 parts of turmeric;
30-100 parts of kudzu root;
10-80 parts of astragalus;
100-200 parts of honey powder.
Preferably, the thick paste A is prepared by the following method:
1) Decocting: adding white paeony root, liquorice, dried orange peel, honeysuckle, medlar and gynostemma pentaphylla into a multifunctional extraction tank, adding 5-6 times of water, heating and decocting for 1-2 hours, and filtering to obtain filtrate I; decocting the dregs of a decoction with 2-3 times of water for 0.5-1.5 hours, filtering, combining with the filtrate I to obtain a filtrate II, and discarding the dregs of a decoction;
2) Concentration: controlling the temperature at 65-75 ℃ and the vacuum degree of-0.08 Mpa to-0.09 Mpa, heating and concentrating the filtrate II to the relative density of 1.20-1.25, and collecting thick paste;
3) Alcohol precipitation: putting the thick paste into an alcohol precipitation tank, adding ethanol until the alcohol content reaches 50-60%, fully stirring, and standing for more than 12 hours; taking supernatant, filtering, recovering ethanol from filtrate, and concentrating to obtain thick paste A with the relative density of 1.30-1.40;
preferably, the medicinal powder B is prepared by the following method: vacuum drying Poria, rhizoma Atractylodis, curcuma rhizome, radix Puerariae and radix astragali, pulverizing into mixture of less than 45 μm, leaching with anhydrous ethanol, collecting leaching solution, centrifuging the leaching solution, removing precipitate, vacuum concentrating clear liquid to dry, pulverizing, adding Mel powder, and stirring to obtain medicinal powder B.
As a preferred embodiment of the invention, the thick paste A comprises the following components in parts by weight:
50 parts of white peony root;
50 parts of liquorice;
50 parts of dried orange peel;
100 parts of honeysuckle;
10 parts of medlar;
5 parts of gynostemma pentaphylla;
the medicinal powder B comprises the following components in parts by weight:
10 parts of poria cocos;
50 parts of rhizoma atractylodis;
50 parts of turmeric;
50 parts of kudzu root;
80 parts of astragalus;
100 parts of honey powder.
As a preferred embodiment of the invention, the thick paste A comprises the following components in parts by weight:
80 parts of white peony root;
20 parts of liquorice;
100 parts of dried orange peel;
50 parts of honeysuckle;
50 parts of medlar;
20 parts of gynostemma pentaphylla;
the medicinal powder B comprises the following components in parts by weight:
20 parts of poria cocos;
80 parts of rhizoma atractylodis;
100 parts of turmeric;
30 parts of kudzu roots;
50 parts of astragalus;
150 parts of honey powder.
As a preferred embodiment of the invention, the thick paste A comprises the following components in parts by weight:
100 parts of white peony root;
100 parts of liquorice;
20 parts of dried orange peel;
150 parts of honeysuckle;
30 parts of medlar;
15 parts of gynostemma pentaphylla;
the medicinal powder B comprises the following components in parts by weight:
50 parts of poria cocos;
100 parts of rhizoma atractylodis;
100 parts of turmeric;
150 parts of kudzu roots;
80 parts of astragalus;
200 parts of honey powder.
The technical scheme adopted for realizing the other purpose of the invention is as follows: a preparation method of Changqing pills for nourishing liver comprises the following preparation steps:
1) Weighing the components of the medicine formula according to the parts by weight;
2) Preparation of thick paste a: decocting: adding white paeony root, liquorice, dried orange peel, honeysuckle, medlar and gynostemma pentaphylla into a multifunctional extraction tank, adding 5-6 times of water, heating and decocting for 1-2 hours, and filtering to obtain filtrate I; decocting the medicine dregs with 2-3 times of water for 0.5-1.5 hours, filtering, combining with the filtrate I to obtain a filtrate II, and discarding the medicine dregs; concentration: controlling the temperature at 65-75 ℃ and the vacuum degree of-0.08 Mpa to-0.09 Mpa, heating and concentrating the filtrate II to the relative density of 1.20-1.25, and collecting thick paste;
3) Alcohol precipitation: putting the thick paste into an alcohol precipitation tank, adding ethanol until the ethanol content is 50-60%, fully stirring, and standing for more than 12 hours; taking supernatant, filtering, recovering ethanol from filtrate, and concentrating to obtain thick paste A with the relative density of 1.30-1.40;
4) Vacuum drying Poria, rhizoma Atractylodis, curcuma rhizome, radix Puerariae and radix astragali, pulverizing into mixture of less than 45 μm, leaching with anhydrous ethanol, collecting leaching solution, centrifuging the leaching solution, removing precipitate, vacuum concentrating clear liquid to dry, pulverizing, adding Mel powder, and stirring to obtain medicinal powder B;
5) Mixing the thick paste A and the medicinal powder B according to a mass ratio of 1: 1-3, and making pills after uniformly mixing to obtain the liver-nourishing youth-keeping pills.
The invention has the technical advantages and beneficial effects that:
1. according to the preparation method, thick paste A and medicinal powder B are creatively prepared firstly, the white paeony root, the liquorice, the dried orange peel, the honeysuckle, the medlar and the gynostemma pentaphylla are prepared into the thick paste A, the poria cocos, the rhizoma atractylodis, the turmeric, the kudzuvine root, the astragalus and the honey powder are prepared into the medicinal powder B, and then pills are prepared according to a proportion to prepare the liver-nourishing youth-growing pills.
2. The honey powder is selected, so that the rich nutritional ingredients of honey are reserved, the contact with the outside air after the honey is selected traditionally is avoided, the storage performance of the Changqing pills is ensured, and meanwhile, the micronized medicine powder has the advantages that the medicine powder particles can be better dispersed and are easier to be absorbed by gastrointestinal tracts. The honey powder is selected to improve the taste of the Changqing pills to a certain extent.
3. The Changqing pill has the functions of protecting liver and resisting fatigue, is suitable for people with dry eyes, acerbity, yellowing, red silky eyes, no luster, dark face and the like, and has good effect on diseases caused by liver and gall, such as fatty liver, jaundice and the like.
Drawings
FIG. 1 is a graph showing the effect of groups on mouse liver glycogen content.
FIG. 2 is a graph showing the effect of groups on mouse SOD activity.
Fig. 3 is a schematic representation of the effect of groups on mouse GSH-Px activity.
FIG. 4 is a graph showing the effect of groups on CAT activity in mice.
Figure 5 is a schematic of the effect of groups on mouse MDA activity.
Detailed Description
The following description of the embodiments of the present invention will be made with reference to the accompanying drawings. The following examples are only for illustrating the technical solutions of the present invention more clearly, and the protection scope of the present invention is not limited thereby.
The invention relates to a Changqing pill for protecting liver, which is prepared from thick paste A and medicinal powder B in a mass ratio of 1: 1-3, mixing uniformly and making into pills; wherein the thick paste A comprises the following components in parts by weight:
50-100 parts of white peony root;
20-100 parts of liquorice;
20-100 parts of dried orange peel;
50-150 parts of honeysuckle;
10-50 parts of medlar;
5-20 parts of gynostemma pentaphylla;
the medicinal powder B comprises the following components in parts by weight:
10-50 parts of poria cocos;
20-100 parts of rhizoma atractylodis;
20-100 parts of turmeric;
30-100 parts of kudzu root;
10-80 parts of astragalus;
100-200 parts of honey powder.
The raw materials of the components of the invention are all commercial products.
Example 1
The invention relates to a Changqing pill for protecting liver, which is prepared from thick paste A and medicinal powder B in a mass ratio of 1:1, uniformly mixing and then making pills; wherein the thick paste A comprises the following components in parts by weight:
50 parts of white peony root;
50 parts of liquorice;
50 parts of dried orange peel;
100 parts of honeysuckle;
10 parts of medlar;
5 parts of gynostemma pentaphylla;
the medicinal powder B comprises the following components in parts by weight:
10 parts of poria cocos;
50 parts of rhizoma atractylodis;
50 parts of turmeric;
50 parts of kudzu root;
80 parts of astragalus;
100 parts of honey powder.
Example 2
The invention relates to a Changqing pill for nourishing liver, which is prepared from thick paste A and medicinal powder B according to a mass ratio of 1:2 mixing uniformly and making into pills; wherein the thick paste A comprises the following components in parts by weight:
80 parts of white peony root;
20 parts of liquorice;
100 parts of dried orange peel;
50 parts of honeysuckle;
50 parts of Chinese wolfberry;
20 parts of gynostemma pentaphylla;
the medicinal powder B comprises the following components in parts by weight:
20 parts of poria cocos;
80 parts of rhizoma atractylodis;
100 parts of turmeric;
30 parts of kudzu roots;
50 parts of astragalus;
150 parts of honey powder.
Example 3
The invention relates to a Changqing pill for protecting liver, which is prepared from thick paste A and medicinal powder B in a mass ratio of 1:3 mixing uniformly and making into pills; wherein the thick paste A comprises the following components in parts by weight:
100 parts of white peony root;
100 parts of liquorice;
20 parts of dried orange peel;
150 parts of honeysuckle;
30 parts of medlar;
15 parts of gynostemma pentaphylla;
the medicinal powder B comprises the following components in parts by weight:
50 parts of poria cocos;
100 parts of rhizoma atractylodis;
100 parts of turmeric;
150 parts of kudzu roots;
80 parts of astragalus;
200 parts of honey powder.
The following tests were carried out on three groups of examples 1-3 above:
selecting: kunming mouse, male, 18-22 g; a breeding environment: the temperature is kept at 25 ℃, the relative humidity is 60 percent, and the illumination time is 12 hours.
The test method comprises the following steps: mice were divided into four groups, A/B/C/D groups, respectively.
Group A: administration of example 1; group B: administration example 2; group C: administration example 3; group D: equal amount of clear water is given.
Four groups of mice were dosed for 30 days, and after each day dosing, the mice were acclimatized in a running wheel with a diameter of 17cm and a speed of 150 cycles/min for 45min.
On day 31, three groups of mice were dosed normally, run for 120min in the running wheel, and sacrificed after resting for 30min, livers of the mice were harvested, washed and stored at low temperature for determination of glycogen, SOD, GSH-Px, CAT, and MDA contents in the livers.
The results are shown in figures 1-5, and it is concluded that group A/B/C has significant liver-protecting and anti-fatigue effects compared with group D. Among the three groups A/B/C, the group A has the best liver protection effect, but the effect is not obvious compared with the group B.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the technical principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.
Claims (4)
1. A preparation method of a Changqing pill for nourishing liver is characterized by comprising the following steps: the preparation steps are as follows:
1) Weighing the components of the medicine formula according to the parts by weight;
2) Preparation of thick paste A: decocting: adding white paeony root, liquorice, dried orange peel, honeysuckle, medlar and gynostemma pentaphylla into a multifunctional extraction tank, adding 5-6 times of water, heating and decocting for 1-2 hours, and filtering to obtain filtrate I; decocting the medicine dregs with 2-3 times of water for 0.5-1.5 hours, filtering, combining with the filtrate I to obtain a filtrate II, and discarding the medicine dregs; concentration: controlling the temperature at 65-75 ℃ and the vacuum degree of-0.08 Mpa to-0.09 Mpa, heating and concentrating the filtrate II to the relative density of 1.20-1.25, and collecting thick paste;
3) Alcohol precipitation: putting the thick paste into an alcohol precipitation tank, adding ethanol until the ethanol content is 50-60%, fully stirring, and standing for more than 12 hours; taking supernatant, filtering, recovering ethanol from filtrate, and concentrating to obtain thick paste A with the relative density of 1.30-1.40;
4) Vacuum drying Poria, rhizoma Atractylodis, curcuma rhizome, radix Puerariae and radix astragali, pulverizing into mixture of less than 45 μm, leaching with anhydrous ethanol, collecting leaching solution, centrifuging the leaching solution, removing precipitate, vacuum concentrating clear liquid to dry, pulverizing, adding Mel powder, and stirring to obtain medicinal powder B;
5) Mixing the thick paste A and the medicinal powder B according to a mass ratio of 1: 1-3, mixing uniformly and making pills to obtain the liver-nourishing youth-keeping pills;
the thick paste A is prepared from the following components in parts by weight:
50-100 parts of white peony root;
20-100 parts of liquorice;
20-100 parts of dried orange peel;
50-150 parts of honeysuckle;
10-50 parts of medlar;
5-20 parts of gynostemma pentaphylla;
the medicinal powder B is prepared from the following components in parts by weight:
10-50 parts of poria cocos;
20-100 parts of rhizoma atractylodis;
20-100 parts of turmeric;
30-100 parts of kudzu root;
10-80 parts of astragalus;
100-200 parts of honey powder.
2. The method of claim 1, wherein: the thick paste A is prepared from the following components in parts by weight:
50 parts of white peony root;
50 parts of liquorice;
50 parts of dried orange peel;
100 parts of honeysuckle;
10 parts of medlar;
5 parts of gynostemma pentaphylla;
the medicinal powder B is prepared from the following components in parts by weight:
10 parts of poria cocos;
50 parts of rhizoma atractylodis;
50 parts of turmeric;
50 parts of kudzu root;
80 parts of astragalus;
100 parts of honey powder.
3. The method of claim 1, wherein: the thick paste A is prepared from the following components in parts by weight:
80 parts of white peony root;
20 parts of liquorice;
100 parts of dried orange peel;
50 parts of honeysuckle;
50 parts of medlar;
20 parts of gynostemma pentaphylla;
the medicine powder B is prepared from the following components in parts by weight:
20 parts of poria cocos;
80 parts of rhizoma atractylodis;
100 parts of turmeric;
30 parts of kudzu roots;
50 parts of astragalus;
150 parts of honey powder.
4. A method according to claim 1, characterized by: the thick paste A is prepared from the following components in parts by weight:
100 parts of white peony root;
100 parts of liquorice;
20 parts of dried orange peel;
150 parts of honeysuckle;
30 parts of medlar;
15 parts of gynostemma pentaphylla;
the medicinal powder B is prepared from the following components in parts by weight:
50 parts of poria cocos;
100 parts of rhizoma atractylodis;
100 parts of turmeric;
150 parts of kudzu roots;
80 parts of astragalus;
200 parts of honey powder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110981185.9A CN113663044B (en) | 2021-08-25 | 2021-08-25 | Changqing pill for nourishing liver and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110981185.9A CN113663044B (en) | 2021-08-25 | 2021-08-25 | Changqing pill for nourishing liver and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN113663044A CN113663044A (en) | 2021-11-19 |
| CN113663044B true CN113663044B (en) | 2023-03-31 |
Family
ID=78546090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110981185.9A Active CN113663044B (en) | 2021-08-25 | 2021-08-25 | Changqing pill for nourishing liver and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113663044B (en) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107158152A (en) * | 2017-07-21 | 2017-09-15 | 四川省中医药科学院 | A kind of traditional Chinese medicine health care product composition |
-
2021
- 2021-08-25 CN CN202110981185.9A patent/CN113663044B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN113663044A (en) | 2021-11-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102058759B (en) | Medicinal tea prepared from Chinese medicinal materials by microbial fermentation | |
| CN103740566B (en) | Rosa roxbunghii medicinal liquor and preparation method thereof | |
| CN112057551A (en) | Composition with functions of nourishing yin and tonifying kidney and preparation method and application thereof | |
| CN105029605A (en) | Preparation method of jasmine health maintenance enzyme beverage | |
| CN103468558A (en) | Nutritional wild fern root vinegar and preparation method thereof | |
| CN101142976A (en) | American ginseng and honey composition and preparation method thereof | |
| CN103181435B (en) | Lung moistening health tea and preparation method thereof | |
| CN104904962A (en) | Complex fermented gynostemma pentaphylla type Chinese herbal medicine health tea | |
| CN100542584C (en) | Compound hippophae rhamnoides lozenge and preparation method thereof | |
| CN104367809A (en) | Nine-steamed-dried product as well as preparation method and application | |
| CN104351442A (en) | Longan leaf heat-clearing and detoxifying tea | |
| CN105360413A (en) | Health care tea paste capable of clearing away summer heat and fabrication method thereof | |
| CN107960508A (en) | A kind of kidney tonifying and dispelling fatigue, the pressed candy for improving sleep | |
| CN103141680B (en) | Composite cattle feed containing Chinese medicinal herbs | |
| CN110564570A (en) | agilawood-flavor liquor formula and method | |
| CN106235318A (en) | The method preparing ferment for primary raw material with Flos Lonicerae, Rhizoma Curcumae Longae | |
| CN109730315A (en) | A kind of rhizoma polygonati edible mushroom oral solution and preparation method thereof that is antifatigue, improving immunity | |
| CN113663044B (en) | Changqing pill for nourishing liver and preparation method thereof | |
| CN103749839A (en) | Lucid ganoderma-pawpaw tea | |
| CN107751980A (en) | A kind of preparation method of nourishment for vitality buccal tablet | |
| CN107495340A (en) | A kind of anti-trioxypurine diuretic compositions and preparation method thereof | |
| CN109730301A (en) | A kind of edible mushroom gomuti palm powder of strengthening spleen and nourishing stomach and preparation method thereof | |
| CN108815304A (en) | A kind of herbal mediciment of strengthen immunity and preparation method thereof | |
| CN103719851A (en) | Preparation method and application of medlar extract | |
| CN103893381A (en) | Composition with lead discharge function and preparation method and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |