CN113663037A - Traditional Chinese medicine composition for inhibiting gastric cancer cell metastasis and preparation method thereof - Google Patents
Traditional Chinese medicine composition for inhibiting gastric cancer cell metastasis and preparation method thereof Download PDFInfo
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- CN113663037A CN113663037A CN202111074230.9A CN202111074230A CN113663037A CN 113663037 A CN113663037 A CN 113663037A CN 202111074230 A CN202111074230 A CN 202111074230A CN 113663037 A CN113663037 A CN 113663037A
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Abstract
The invention belongs to the technical field of biological medicines, and discloses a traditional Chinese medicine composition for inhibiting gastric cancer cell metastasis and a preparation method thereof, wherein the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 20-40 parts of dandelion, 20-40 parts of astragalus membranaceus, 20-30 parts of dried orange peel, 10-20 parts of liquorice, 10-20 parts of radix ophiopogonis, 10-15 parts of frankincense, 10-15 parts of myrrh, 10-15 parts of arisaema cum bile, 10-15 parts of leech, 10-15 parts of rhizoma paridis, 8-12 parts of endothelium corneum gigeriae galli, 8-12 parts of astragalus membranaceus, 8-12 parts of edible tulip, 5-10 parts of rhizoma sparganii, 5-10 parts of salvia miltiorrhiza and 5-10 parts of bighead atractylodes rhizome. The traditional Chinese medicine composition disclosed by the invention has the advantages that the medicines are mutually assisted and have synergistic effect, so that the effects of inducing diuresis to alleviate edema, softening and resolving hard mass, eliminating phlegm and descending qi, cooling blood and stopping bleeding, strengthening spleen and stomach, eliminating phlegm and relieving cough, killing parasites and removing food retention, and relieving exterior and interior syndromes and the like are achieved, and the traditional Chinese medicine composition has good effects of inhibiting the growth of gastric cancer cells and promoting the apoptosis of tumor cells; the traditional Chinese medicine composition for treating gastric cancer has the effects of improving the immune function, obviously reducing the pain of a tumor patient, prolonging the life cycle and improving the life quality of the patient, and long-term experimental research shows that the traditional Chinese medicine composition for treating gastric cancer has high safety and low toxic and side effects.
Description
Technical Field
The invention belongs to the technical field of biological medicines, and relates to a traditional Chinese medicine composition for inhibiting gastric cancer cell metastasis and a preparation method thereof.
Background
Due to environmental pollution, the change of living environment and living habits, the incidence of cancers is increasing, such as gastric cancer, liposarcoma and the like, wherein gastric cancer is one of ten malignant tumors worldwide, and the incidence and the death rate of the cancers are in front of various malignant tumors, thereby causing great threat to the life and the health of human beings. The morbidity and mortality of the gastric cancer in China are in the first five places, and in nearly 20 years, the morbidity and mortality of the gastric cancer in China have a trend of rising year by year, and the morbidity and mortality of the gastric cancer in several years in future are expected to continuously rise.
The traditional medicines for treating the gastric cancer mainly comprise chemical medicines, but because chemotherapy medicines have high toxicity, the chemotherapy medicines can kill tumor cells and also can kill human autoimmune cells such as leucocytes, lymphocytes and the like without selectivity, so that patients often have high adverse reaction after using, long treatment course and high cost due to low autoimmune capability and infection caused by the patients.
The traditional Chinese medicine is always one of the main ways of treating malignant tumors in China, and particularly has obvious advantages on the adjuvant therapy (the cooperation of radiotherapy, chemotherapy and other means) and palliative therapy of advanced tumors. The traditional Chinese medicine has unique advantages and wide application prospect in the aspects of tumor attenuation and synergism, not only improves the curative effect of treating middle and late gastric cancer and treating non-small cell gastric cancer, but also has small side effect, and can enhance the anti-cancer effect, reduce the side effect, improve the life quality and prolong the life cycle by combining with the schemes of operation, radiotherapy, chemotherapy and the like, so the traditional Chinese medicine plays more and more important roles in the aspects of tumor prevention and treatment.
Therefore, the development of a traditional Chinese medicine composition capable of effectively relieving the symptoms of gastric cancer patients and avoiding the anti-gastric cancer metastasis is a problem to be solved by those skilled in the art.
Disclosure of Invention
The invention aims to research the compatibility of a traditional Chinese medicine compound, provides a traditional Chinese medicine composition for inhibiting gastric cancer cell metastasis and a preparation method thereof, can inhibit gastric cancer cell proliferation and metastasis, induces cancer cell apoptosis, obviously improves the curative effect of treating gastric cancer, and has small side effect.
In order to solve the technical problems, the technical scheme of the invention is as follows:
a traditional Chinese medicine composition for inhibiting gastric cancer cell metastasis comprises the following raw materials in parts by weight: 20-40 parts of dandelion, 20-40 parts of rhizoma sparganii, 20-30 parts of dried orange peel, 10-20 parts of liquorice, 10-20 parts of radix ophiopogonis, 10-15 parts of frankincense, 10-15 parts of myrrh, 10-15 parts of arisaema cum bile, 10-15 parts of leech, 10-15 parts of rhizoma paridis, 8-12 parts of endothelium corneum gigeriae galli, 8-12 parts of astragalus membranaceus, 8-12 parts of edible tulip, 5-10 parts of cinnamon, 5-10 parts of salvia miltiorrhiza and 5-10 parts of bighead atractylodes rhizome.
Preferably, the traditional Chinese medicine composition for inhibiting gastric cancer cell metastasis comprises the following raw materials in parts by weight: the feed comprises the following raw materials in parts by weight: 40 parts of dandelion, 30 parts of rhizoma sparganii, 30 parts of dried orange peel, 20 parts of liquorice, 18 parts of radix ophiopogonis, 15 parts of frankincense, 15 parts of myrrh, 12 parts of arisaema cum bile, 12 parts of leech, 10 parts of rhizoma paridis, 10 parts of endothelium corneum gigeriae galli, 10 parts of astragalus membranaceus, 8 parts of edible tulip, 8 parts of cinnamon, 8 parts of salvia miltiorrhiza and 8 parts of bighead atractylodes rhizome.
Preferably, the composition is prepared into oral liquid, pills, granules, tablets and capsules by different preparation means and pharmaceutically acceptable carriers.
The invention also aims to provide a preparation method of the traditional Chinese medicine composition for inhibiting gastric cancer cell metastasis, which comprises the following steps:
(1) weighing the raw materials according to the parts by weight of the traditional Chinese medicine composition in the claim 1 for later use;
(2) mixing the raw materials, soaking in water, decocting with middle fire, and filtering to obtain a first medicinal mixture and a first medicinal preparation;
(3) and adding water into the first medicine mixture, decocting for the second time with medium fire to obtain a second medicine, and mixing with the first medicine to obtain the traditional Chinese medicine composition.
Preferably, the soaking time in the step (2) is 100-150min, and the soaking temperature is 8-15 ℃.
Preferably, the first decoction in the step (2) is carried out at the temperature of 80-95 ℃ for 60-80 min.
Preferably, the second decoction in the step (3) is carried out at the temperature of 80-95 ℃ for 40-60 min.
The invention also provides the medical application of the traditional Chinese medicine composition. The taking method of the traditional Chinese medicine composition comprises the following steps: decocting with water, 1 dose per day, and taking twice in the morning and evening, with 30 days as a treatment course. Clinical and pharmacological experimental results show that the traditional Chinese medicine composition has an obvious effect of treating the gastric cancer, has no toxic or side effect, can particularly and remarkably improve side effects such as hot flashes caused by endocrine therapy, and has an effective rate of over 70 percent. Opens up a new way for the clinical treatment of the gastric cancer and has important social value.
The pharmacological actions of the various raw materials adopted by the invention are as follows:
dandelion: bitter and sweet in property and cold in nature, entering liver and stomach meridians, are indicated for furuncle, swelling and toxicity, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, pulmonary abscess, intestinal abscess, jaundice due to damp-heat pathogen, stranguria with astringency and pain due to heat.
Three-edge: pungent, bitter and mild; entering liver and spleen channels, breaking blood and promoting qi circulation, removing food retention and relieving pain; can be used for treating abdominal mass, dysmenorrhea, blood stasis, amenorrhea, thoracic obstruction, heart pain, and pain due to food stagnation.
Dried orange peel: bitter and pungent taste, warm in nature; entering lung and spleen meridians; regulating qi-flowing, invigorating spleen, eliminating dampness and phlegm, and can be used for treating abdominal distention, anorexia, vomiting and diarrhea, cough and excessive phlegm.
Licorice root: bitter and pungent taste, slight sweet back, entering liver and gallbladder meridians, and is mainly used for promoting qi circulation, relieving depression, dispelling wind and dampness, promoting blood circulation and relieving pain. It is indicated for wind-cold headache, dizziness, hypochondriac pain, abdominal pain, cold arthralgia, spasm of tendons, amenorrhea, dystocia, postpartum pain due to blood stasis, carbuncle, cellulitis, sore and ulcer. Can be used for treating menoxenia, amenorrhea, dysmenorrhea, abdominal pain, pricking pain in chest and hypochondrium, traumatic injury, swelling and pain, headache, and rheumatalgia.
Radix ophiopogonis: sweet, slightly cold and slightly bitter in nature and taste; it has effects in nourishing yin, promoting salivation, moistening lung, and clearing away heart-fire, and can be used for treating dry cough due to lung dryness, cough due to asthenia, thirst due to body fluid consumption, insomnia, diabetes due to internal heat, constipation, and diphtheria.
Frankincense: pungent, bitter and warm in nature. Heart, liver and spleen meridians entered; the efficacy is as follows: promoting blood circulation, activating qi-flowing, relieving pain, subsiding swelling, promoting granulation, and can be used for treating thoracic obstruction, cardialgia, gastralgia, dysmenorrhea, amenorrhea, puerperal blood stasis, abdominal pain, rheumatalgia, spasm of tendons and vessels, traumatic injury, carbuncle, swelling, and pyocutaneous disease.
Myrrh: pungent, bitter and neutral in flavor; it enters heart, liver and spleen meridians. Removing blood stasis, relieving pain, eliminating swelling, and promoting granulation; the main treatment is as follows: can be used for treating thoracic obstruction, cardialgia, gastralgia, dysmenorrhea, amenorrhea, puerperal blood stasis, abdominal mass, rheumatic arthralgia, traumatic injury, carbuncle, swelling, and pyocutaneous disease.
Bile star: bitter taste and cool nature. Enter heart, liver and lung meridians. Clear fire and resolve phlegm, and calm the aeipathia. It is indicated for wind-phlegm obstruction, convulsion, epilepsy, phlegm-fire, dyspnea, cough, dizziness and vertigo.
Leech: salty, bitter and neutral; has little toxicity. Entering liver meridian; break blood and dredge channels, dispel stasis and eliminate disease. Can be used for treating amenorrhea due to blood stasis, abdominal mass, apoplexy, hemiplegia, traumatic injury.
Rhizoma paridis: bitter and cold in nature and with little toxicity; has effects in clearing away heat and toxic materials, relieving swelling and pain, cooling liver, and arresting convulsion. Can be used for treating sore, carbuncle, swelling, sore throat, venomous snake bite, traumatic injury, convulsion, infantile convulsion, and epilepsy.
Endothelium corneum gigeriae galli: sweet and neutral, entering spleen, stomach, small intestine and bladder meridians; invigorating stomach, promoting digestion, arresting seminal emission, relieving stranguria, and removing calculus, and can be used for treating dyspepsia, emesis, dysentery, infantile malnutrition, enuresis, nocturnal emission, stranguria with stone, odynuria, gallbladder distention, and hypochondriac pain.
Astragalus root: sweet taste and mild nature, has the effects of invigorating qi, consolidating exterior, promoting urination, tonifying heart, lowering blood pressure, resisting bacteria, expelling toxin, expelling pus, promoting granulation, enhancing capillary resistance, arresting sweating and sex hormone, and can be used for treating exterior deficiency, spontaneous perspiration, internal injury due to qi deficiency, spleen deficiency, diarrhea, edema, carbuncle, cellulitis, etc.
And (3) edible tulip: is bitter in taste and warm in nature, has toxic effect, has the effects of relieving asthma, relieving cough, relieving pain and resisting cancer, and can be used for treating tracheitis and asthma.
Cinnamon: pungent and warm in flavor, mainly treats all diseases, nourishes spirit, harmonizes color, benefits joints, and tonifies middle-jiao and Qi. The medicines are engaged for relieving the bowels firstly, and the spirit is relieved after long-term administration, so that the body is light and not old. The face is bright and beautiful, and the eyebrows are as good as children.
Red sage root: bitter and slightly cold in nature; it has effects in dispelling blood stasis, relieving pain, promoting blood circulation, dredging channels, clearing heart fire, and relieving restlessness, and can be used for treating menoxenia, amenorrhea, dysmenorrhea, thoracico-abdominal pain, pyretic arthralgia, pyocutaneous disease, vexation, insomnia, hepatosplenomegaly, and angina pectoris.
White atractylodes rhizome: bitter, sweet and warm. Invigorate spleen, replenish qi, dry dampness, induce diuresis, stop sweating, prevent abortion. Can be used for treating spleen deficiency, anorexia, dyspepsia, diarrhea, edema, spontaneous perspiration, threatened abortion, and spontaneous perspiration.
Compared with the prior art, the invention has the beneficial effects that:
the traditional Chinese medicine composition disclosed by the invention has the advantages that the medicines are mutually assisted and have synergistic effect, so that the effects of inducing diuresis to alleviate edema, softening and resolving hard mass, eliminating phlegm and descending qi, cooling blood and stopping bleeding, strengthening spleen and stomach, eliminating phlegm and relieving cough, killing parasites and removing food retention, and relieving exterior and interior syndromes and the like are achieved, and the traditional Chinese medicine composition has good effects of inhibiting the growth of gastric cancer cells and promoting the apoptosis of tumor cells; the traditional Chinese medicine composition for treating gastric cancer has the effects of improving the immune function, obviously reducing the pain of a tumor patient, prolonging the life cycle and improving the life quality of the patient, and long-term experimental research shows that the traditional Chinese medicine composition for treating gastric cancer has high safety and low toxic and side effects.
Detailed Description
The following further describes the embodiments of the present invention. It should be noted that the description of the embodiments is provided to help understanding of the present invention, but the present invention is not limited thereto. In addition, the technical features involved in the embodiments of the present invention described below may be combined with each other as long as they do not conflict with each other.
Example 1
A traditional Chinese medicine composition for inhibiting gastric cancer cell metastasis comprises the following raw materials in parts by weight: 20 parts of dandelion, 20 parts of rhizoma sparganii, 20 parts of dried orange peel, 10 parts of liquorice, 10 parts of radix ophiopogonis, 10 parts of frankincense, 10 parts of myrrh, 10 parts of arisaema cum bile, 10 parts of leech, 10 parts of rhizoma paridis, 8 parts of endothelium corneum gigeriae galli, 8 parts of astragalus membranaceus, 8 parts of edible tulip, 5 parts of cinnamon, 5 parts of salvia miltiorrhiza and 5 parts of bighead atractylodes rhizome.
A preparation method of a traditional Chinese medicine composition for inhibiting gastric cancer cell metastasis comprises the following steps:
(1) weighing the raw materials according to the parts by weight of the traditional Chinese medicine composition in the claim 1 for later use;
(2) mixing the raw materials, soaking in water at 8 deg.C for 150min, decocting at 80 deg.C for 80min, and filtering to obtain first medicinal mixture and first medicinal preparation;
(3) decocting the first medicinal materials in water at 80 deg.C for 60min to obtain second medicinal preparation, and mixing with the first medicinal preparation to obtain the final product.
Example 2
A traditional Chinese medicine composition for inhibiting gastric cancer cell metastasis comprises the following raw materials in parts by weight: 40 parts of dandelion, 30 parts of rhizoma sparganii, 30 parts of dried orange peel, 20 parts of liquorice, 18 parts of radix ophiopogonis, 15 parts of frankincense, 15 parts of myrrh, 12 parts of arisaema cum bile, 12 parts of leech, 10 parts of rhizoma paridis, 10 parts of endothelium corneum gigeriae galli, 10 parts of astragalus membranaceus, 8 parts of edible tulip, 8 parts of cinnamon, 8 parts of salvia miltiorrhiza and 8 parts of bighead atractylodes rhizome.
A preparation method of a traditional Chinese medicine composition for inhibiting gastric cancer cell metastasis comprises the following steps:
(1) weighing the raw materials according to the parts by weight of the traditional Chinese medicine composition in the claim 1 for later use;
(2) mixing the raw materials, soaking in water at 10 deg.C for 120min, decocting at 85 deg.C for 70min, and filtering to obtain first medicinal mixture and first medicinal preparation;
(3) decocting the first medicinal materials in water at 85 deg.C for 50min to obtain second medicinal preparation, and mixing with the first medicinal preparation to obtain the final product.
Example 3
A traditional Chinese medicine composition for inhibiting gastric cancer cell metastasis comprises the following raw materials in parts by weight: 30 parts of dandelion, 30 parts of rhizoma sparganii, 25 parts of dried orange peel, 18 parts of liquorice, 15 parts of radix ophiopogonis, 12 parts of frankincense, 12 parts of myrrh, 12 parts of arisaema cum bile, 10 parts of leech, 10 parts of rhizoma paridis, 10 parts of endothelium corneum gigeriae galli, 10 parts of astragalus membranaceus, 10 parts of edible tulip, 8 parts of cinnamon, 8 parts of salvia miltiorrhiza and 8 parts of bighead atractylodes rhizome.
A preparation method of a traditional Chinese medicine composition for inhibiting gastric cancer cell metastasis comprises the following steps:
(1) weighing the raw materials according to the parts by weight of the traditional Chinese medicine composition in the claim 1 for later use;
(2) mixing the raw materials, soaking in water at 12 deg.C for 120min, decocting at 90 deg.C for 65min, and filtering to obtain first medicinal mixture and first medicinal preparation;
(3) adding water into the first mixture, decocting at 90 deg.C for 45min to obtain second medicinal preparation, and mixing with the first medicinal preparation to obtain the final product.
Example 4
A traditional Chinese medicine composition for inhibiting gastric cancer cell metastasis comprises the following raw materials in parts by weight: 40 parts of dandelion, 40 parts of rhizoma sparganii, 30 parts of dried orange peel, 20 parts of liquorice, 20 parts of radix ophiopogonis, 15 parts of frankincense, 15 parts of myrrh, 15 parts of arisaema cum bile, 15 parts of leech, 15 parts of rhizoma paridis, 12 parts of endothelium corneum gigeriae galli, 12 parts of astragalus mongholicus, 12 parts of edible tulip, 10 parts of cinnamon, 10 parts of salvia miltiorrhiza and 10 parts of bighead atractylodes rhizome.
A preparation method of a traditional Chinese medicine composition for inhibiting gastric cancer cell metastasis comprises the following steps:
(1) weighing the raw materials according to the parts by weight of the traditional Chinese medicine composition in the claim 1 for later use;
(2) mixing the raw materials, soaking in water at 15 deg.C for 100min, decocting at 95 deg.C for 60min, and filtering to obtain first medicinal mixture and first medicinal preparation;
(3) decocting the first medicinal materials in water at 95 deg.C for 40min to obtain second medicinal preparation, and mixing with the first medicinal preparation to obtain the final product.
Clinical trial
In order to further investigate the curative effect of the medicament, clinical trial study is carried out on patients suffering from gastric cancer, all patients voluntarily receive treatment, the reaction is good, no obvious toxic or side effect exists, patients with confirmed gastric cancer are study test objects, and the following description is given by taking a plurality of typical cases:
case 1: wangzhi, male, 60 years old, patient had a history of gastric cancer operation before 10 years, and there was no recurrence after operation; the patient in 6 months in 2019 goes to a hospital for gastroscopy due to feeling of 'epigastric discomfort', the recurrence of the gastric cancer is pathologically displayed, and then the patient goes to the hospital for chemotherapy treatment and comes to one place for treatment. After the patient takes the medicine (the traditional Chinese medicine composition prepared according to the method in the embodiment 3) for 7 days, the patient feels mild symptoms and the fullness is relieved, so the syndrome differentiation treatment is continuously carried out. The patient takes the medicine for 2 courses of treatment, the chemotherapy treatment is smoothly completed in the period, no chemotherapy toxic or side reaction is seen at present, no obvious discomfort exists, the life is self-care, no special diet exists, the condition of an illness is stable, and the clinic follow-up is carried out till now.
Case 2: sunzhi, female, age 53, visited the hospital for "feeling stomach pain and discomfort" in 2019 for 4 months, and was diagnosed with stomach cancer and lymphoma under the gastroscope. After the diagnosis is confirmed, the chemotherapy treatment is carried out. Patients generally have poor conditions after chemotherapy treatment, the symptoms of the digestive system are not obviously improved, and the patients cannot tolerate further chemotherapy treatment, so the patients have treatment. After the patient takes the traditional Chinese medicine composition (prepared according to the method in the embodiment 3) for 7 days, the subjective stomach symptoms are slightly improved compared with the former symptoms, the patient can think of food and mainly speak, and the spirit is obviously improved compared with the former symptoms, so the syndrome differentiation treatment is continued. After a course of treatment, the symptoms of the epigastric fullness and pain are obviously improved, no obvious vomiting is caused after eating the food, the strength is gradually recovered, the patient can basically and automatically take care of life and movement, and the tongue is light red and greasy. After the medicine is taken for 3 courses, the diet and the life of the patient are not greatly different from those of the common people, and the chemotherapy treatment is completed in the period without obvious discomfort and toxic and side effects. The patients have the usual condition at present, the disease condition is stable, and the follow-up visit of the outpatient clinic is up to now
Case 3: li Shi, male, 51 years old, patient confirmed gastric cancer in 2017, and improved after surgical resection. The recurrence of gastric cancer is checked in 7 months in 2020, and chemotherapy is carried out. The patient is named as a poor-quality patient who is ill after chemotherapy in 2013 and 8 months. After the patient takes the traditional Chinese medicine composition prepared according to the method in the example 3 for 7 days, the patient can make a double-diagnosis, and the symptoms of dry mouth and hypodynamia are improved to a certain extent, so the stomach-benefiting decoction is continuously treated based on syndrome differentiation. After the patient takes the medicine for 1 course of treatment, the patient obviously relieves the self-complaint of the feeling of fullness in the gastric cavity, generally improves the condition, and continues the follow-up visit of the clinic.
The foregoing is considered as illustrative of the preferred embodiments of the invention, but is made merely for the purpose of providing an understanding of the principles of the embodiments; meanwhile, for a person skilled in the art, according to the present embodiment, there may be a change in the specific implementation and application scope, and in summary, the present disclosure should not be construed as a limitation to the present invention.
Claims (7)
1. A traditional Chinese medicine composition for inhibiting gastric cancer cell metastasis is characterized in that: the feed comprises the following raw materials in parts by weight: 20-40 parts of dandelion, 20-40 parts of rhizoma sparganii, 20-30 parts of dried orange peel, 10-20 parts of liquorice, 10-20 parts of radix ophiopogonis, 10-15 parts of frankincense, 10-15 parts of myrrh, 10-15 parts of arisaema cum bile, 10-15 parts of leech, 10-15 parts of rhizoma paridis, 8-12 parts of endothelium corneum gigeriae galli, 8-12 parts of astragalus membranaceus, 8-12 parts of edible tulip, 5-10 parts of cinnamon, 5-10 parts of salvia miltiorrhiza and 5-10 parts of bighead atractylodes rhizome.
2. The traditional Chinese medicine composition for inhibiting gastric cancer cell metastasis according to claim 1, which is characterized in that: the feed comprises the following raw materials in parts by weight: 40 parts of dandelion, 30 parts of rhizoma sparganii, 30 parts of dried orange peel, 20 parts of liquorice, 18 parts of radix ophiopogonis, 15 parts of frankincense, 15 parts of myrrh, 12 parts of arisaema cum bile, 12 parts of leech, 10 parts of rhizoma paridis, 10 parts of endothelium corneum gigeriae galli, 10 parts of astragalus membranaceus, 8 parts of edible tulip, 8 parts of cinnamon, 8 parts of salvia miltiorrhiza and 8 parts of bighead atractylodes rhizome.
3. The traditional Chinese medicine composition for inhibiting gastric cancer cell metastasis according to claim 1, which is characterized in that: the composition is prepared into oral liquid, pills, granules, tablets and capsules by different preparation methods and pharmaceutically acceptable carriers.
4. A method for preparing the traditional Chinese medicine composition for inhibiting gastric cancer cell metastasis according to claims 1 to 3, which is characterized in that: the method comprises the following steps:
(1) weighing the raw materials according to the parts by weight of the traditional Chinese medicine composition in the claim 1 for later use;
(2) mixing the raw materials, soaking in water, decocting with middle fire, and filtering to obtain first medicinal mixture and first medicinal preparation;
(3) and adding water into the first medicine mixture, decocting for the second time with medium fire to obtain a second medicine, and mixing with the first medicine to obtain the traditional Chinese medicine composition.
5. The preparation method of the traditional Chinese medicine composition for inhibiting gastric cancer cell metastasis according to claim 4, characterized in that: the soaking time in the step (2) is 100-150min, and the soaking temperature is 8-15 ℃.
6. The preparation method of the traditional Chinese medicine composition for inhibiting gastric cancer cell metastasis according to claim 4, characterized in that: in the step (2), the first decoction temperature is 80-95 ℃ and the time is 60-80 min.
7. The preparation method of the traditional Chinese medicine composition for inhibiting gastric cancer cell metastasis according to claim 4, characterized in that: and (3) decocting for the second time at 80-95 ℃ for 40-60 min.
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