CN113632977B - Dietary composition suitable for pregnant women with pregnancy-associated hepatitis and preparation method thereof - Google Patents

Dietary composition suitable for pregnant women with pregnancy-associated hepatitis and preparation method thereof Download PDF

Info

Publication number
CN113632977B
CN113632977B CN202111011329.4A CN202111011329A CN113632977B CN 113632977 B CN113632977 B CN 113632977B CN 202111011329 A CN202111011329 A CN 202111011329A CN 113632977 B CN113632977 B CN 113632977B
Authority
CN
China
Prior art keywords
parts
vitamin
hepatitis
pregnant women
pregnancy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN202111011329.4A
Other languages
Chinese (zh)
Other versions
CN113632977A (en
Inventor
刘昌�
姚青
廖侠
贾庆安
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
First Affiliated Hospital of Medical College of Xian Jiaotong University
Original Assignee
First Affiliated Hospital of Medical College of Xian Jiaotong University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by First Affiliated Hospital of Medical College of Xian Jiaotong University filed Critical First Affiliated Hospital of Medical College of Xian Jiaotong University
Priority to CN202111011329.4A priority Critical patent/CN113632977B/en
Publication of CN113632977A publication Critical patent/CN113632977A/en
Application granted granted Critical
Publication of CN113632977B publication Critical patent/CN113632977B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12—Fatty acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A23L33/155—Vitamins A or D
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/185—Vegetable proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/19—Dairy proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Pediatric Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

The invention discloses a dietary composition suitable for pregnant women with pregnancy-associated hepatitis and a preparation method thereof, wherein the composition comprises the following components: maltodextrin, resistant starch, concentrated whey protein, isolated soy protein, glutamic acid, ademetionine, vegetable oil powder, MCT oil powder, soybean phospholipid powder, omega-3 fatty acid, vitamin A, vitamin D 3 Vitamin E and vitamin K 1 Vitamin B 1 Vitamin B 2 Vitamin B 6 Vitamin B 12 Folic acid, nicotinic acid, vitamin C, sodium, potassium, iron, calcium, magnesium, chlorine, phosphorus, zinc, iodine, selenium and pectin. The special full-nutrition special medical food for pregnant women with the combined hepatitis has reasonable nutrition component collocation, synergistic action, meets the special nutrition requirements of the pregnant women with the hepatitis, and has remarkable effects of improving the nutrition state of the pregnant women with the hepatitis, guaranteeing the nutrition supply basis of the fetus, reducing the liver burden in gestation period and improving the liver inflammation state.

Description

Dietary composition suitable for pregnant women with pregnancy-associated hepatitis and preparation method thereof
Technical Field
The invention belongs to the technical field of special medical foods, and particularly relates to a dietary composition suitable for pregnant women with pregnancy complicated with hepatitis and a preparation method thereof.
Background
Women in gestation are very sensitive to nutritional status. The people and the carriers of hepatitis B are many, the existing hepatitis B virus carriers are 8600 thousands of people in China, and about 2800 thousands of people are slow hepatitis B patients needing treatment. The pregnant woman carrying hepatitis B virus can increase liver burden and affect body metabolism and nutrition condition. The method comprises the following steps: firstly, the heat required by pregnant women is increased, the metabolism rate is increased, the nutrition consumption is increased, the glycogen storage in the liver is reduced, and the burden of the liver is increased; second, the level of estrogen in pregnant women increases, and estrogen needs to be inactivated in the liver, and prevents the liver from transporting fat and draining bile; thirdly, the mother must provide various nutrients to the fetus, which often results in deficiency of nutrition, vitamins and inorganic salts, and nausea, inappetence and constipation during pregnancy, which prevent nutrient intake. And hepatitis virus affects the metabolism of maternal hormone: first, estrogen metabolism in the liver can be hindered, resulting in uterine contractions, and the incidence of premature labor is greatly increased; second, hepatitis virus results in a decrease in the inactivating capacity of hepatic aldosterone, resulting in an increase in the incidence of pregnancy-induced hypertension syndrome. Therefore, the probability of early vaginal bleeding, pregnancy hypertension syndrome, diabetes, premature delivery, postpartum hemorrhage and the like is higher in the pregnancy period of the pregnant woman infected with hepatitis virus than in the normal pregnant woman. Most of clinical hepatitis treatment medicines are forbidden or cautious for pregnant women at present. In addition, the load of the liver during pregnancy is large, and the recovery of the hepatitis during pregnancy is often not ideal.
Due to lack of professional and scientific nutrition guidance, a part of pregnant women carrying hepatitis viruses still have the problems of unbalanced dietary structure during pregnancy and the like, and liver injury of the pregnant women infected by the hepatitis viruses is easily aggravated, and adverse events and poor pregnancy ending during pregnancy are induced. For example, an excessively high protein, high fat dietary structure may further burden the liver, with a high caloric, high carbohydrate, protein rich, relatively low fat energy supply structure. In addition, the nutrient elements can not meet the special requirements of pregnant women with pregnancy and hepatitis. For example, hepatitis viruses can disrupt folate metabolism, pregnant women with hepatitis are often more prone to folate deficiency than normal pregnant women, and folate deficiency can lead to fetal neurological deficits, with particular emphasis on folate supplementation and dosage; when the pregnant woman suffers from hepatitis, the vitamin C in the mother is more likely to be insufficient to influence the absorption of folic acid and iron, so that the standard of daily vitamin C supply for the pregnant woman with hepatitis is higher than that of a normal pregnant woman.
Thus, the nutritional problems that pregnant women with pregnancy and hepatitis are prone to have are: firstly, the three large energy substances have imperfect structure, poor nutrition state or heavy liver burden; secondly, the vitamin and mineral intake necessary for the growth and development of the fetus is insufficient; third, there is a lack of nutrients effective in alleviating liver inflammation.
Currently, there are no full nutritional formulas specially designed for pregnant women with pregnancy complicated with hepatitis, and several special medical foods designed for liver diseases have more or less disadvantages in some aspects. For example: first, in the selection of protein species, the instant Kang Zhilian amino acid type liver disease total nutrient powder selects hydrolyzed collagen, but studies clearly show that: collagen and hydrolyzed collagen have chemotactic stimulation function on fibroblasts in vivo, can remarkably increase the density of the fibroblasts, can cause remarkable increase of the diameter of collagen fibers, and can have adverse effects on liver injury and liver fibrosis patients; in addition, the protein composition is almost completely mainly animal protein, such as the complete nutrition powder of the only-cascadable branched-chain amino acid type liver diseases, etc., but the ammonia production of the animal protein after being decomposed in the intestinal tract is very high, which is not beneficial to the illness state and metabolism of the pregnant women with hepatitis. Secondly, the lack of other non-aromatic amino acids such as glutamic acid, arginine, aspartic acid, methionine and the like besides branched-chain amino acids, such as the forced storage branched-chain amino acid type total nutrient powder, has important functions for improving liver diseases, and can increase the utilization efficiency of the branched-chain amino acids, so that the lack of the amino acids makes the product value greatly reduced. Third, the vitamin and mineral content such as folic acid, vitamin C, iron, calcium, etc. cannot meet the metabolic demands of pregnant women with pregnancy complicated with hepatitis.
Therefore, it is necessary to provide a full-nutrition special medical food suitable for pregnant women with pregnancy complicated with hepatitis.
Disclosure of Invention
In view of the above, the present invention provides a dietary composition suitable for pregnant women with pregnancy complicated with hepatitis and a preparation method thereof, wherein the composition can meet the special energy requirements of the pregnant women with hepatitis, ensure sufficient energy of energy supply materials, optimize structure, facilitate digestion and absorption, and greatly reduce liver burden; according to the special micronutrient requirements of the pregnant women with hepatitis, vitamins and minerals which are necessary for strengthening the growth and development of the fetus of the pregnant women with hepatitis; meanwhile, the safe and effective antioxidant substances are particularly added to relieve liver inflammation states, so that the burden of the liver in gestation period is reduced to the greatest extent on the basis of improving the nutrition state of the pregnant women with hepatitis and guaranteeing the nutrition supply of fetuses, the liver inflammation states are improved, the occurrence of pregnancy complications is reduced, and the pregnancy safety of the pregnant women with hepatitis is guaranteed.
In order to solve the technical problems, the invention discloses a dietary composition suitable for pregnant women with pregnancy complicated with hepatitis, which comprises the following components in parts by mass: 48-60 parts of maltodextrin, 3-6 parts of resistant starch, 13-18 parts of concentrated whey protein, 6-10 parts of soy protein isolate, 0.4-0.8 part of glutamic acid, 0.4-1.0 part of ademetionine, 8-11 parts of vegetable oil powder, 5-7 parts of MCT oil powder, 1.5-3 parts of soybean phospholipid powder, 1.5-3 parts of omega-3 fatty acid and 2X 10 of vitamin A -4 -3×10 -4 Parts, vitamin D 3 5×10 -6 -10×10 -6 0.01-0.04 part of vitamin E and vitamin K 1 2×10 -5 -2.5×10 -5 Parts, vitamin B 1 3.5×10 -4 -7×10 -4 Parts, vitamin B 2 3.5×10 -4 -7×10 -4 Parts, vitamin B 6 3.5×10 -4 -7×10 -4 Parts, vitamin B 12 0.6×10 -6 -2×10 -6 Parts, folic acid 7×10 -4 -11×10 -4 Parts, nicotinic acid 5X 10 -3 -10×10 -3 0.08-0.1 part of vitamin C, 0.4-0.5 part of sodium, 0.5-0.6 part of potassium and 6X 10 iron -3 -10×10 -3 0.4 to 0.7 part of calcium, 0.1 to 0.2 part of magnesium, 0.2 to 0.3 part of chlorine, 0.2 to 0.3 part of phosphorus, 0.008 to 0.016 part of zinc and 3.3 multiplied by 10 of iodine -6 -10×10 -6 Parts of selenium 0.3 x 10 -4 -0.5×10 -4 2-4 parts of pectin.
Optionally, the composition comprises the following components in parts by mass: 54-60 parts of maltodextrin, 3-4 parts of resistant starch, 13-14 parts of concentrated whey protein, 8.5-10 parts of soybean protein isolate, 0.6-0.8 part of glutamic acid, 0.7-1.0 part of ademetionine, 8-10.4 parts of vegetable oil powder, 5-6 parts of MCT oil powder, 1.5-2.5 parts of soybean phospholipid powder and omega-3 fatty acid 1.5-2 parts, vitamin A2.5X10 -4 -3×10 -4 Parts, vitamin D 3 8×10 -6 -10×10 -6 0.03-0.04 parts of vitamin E and vitamin K 1 2.3×10 -5 -2.5×10 -5 Parts, vitamin B 1 5×10 -4 -7×10 -4 Parts, vitamin B 2 5×10 -4 -7×10 -4 Parts, vitamin B 6 5×10 -4 -7×10 -4 Parts, vitamin B 12 1.2×10 -6 -2×10 -6 Parts, folic acid 9×10 -4 -11×10 -4 Parts, nicotinic acid 8×10 -3 -10×10 -3 0.09-0.1 part of vitamin C, 0.45-0.5 part of sodium, 0.55-0.6 part of potassium and 8X 10 parts of iron -3 -10×10 -3 0.4-0.7 part of calcium, 0.15-0.2 part of magnesium, 0.25-0.3 part of chlorine, 0.25-0.3 part of phosphorus, 0.01-0.016 part of zinc and 6X 10 part of iodine -6 -10×10 -6 Parts of selenium 0.4 x 10 -4 -0.5×10 -4 3-4 parts of pectin.
The invention also discloses a preparation method of the dietary composition suitable for pregnant women with pregnancy-associated hepatitis, which comprises the following steps:
step 1, weighing: the components are weighed according to the following mass parts: 48-60 parts of maltodextrin, 3-6 parts of resistant starch, 13-18 parts of concentrated whey protein, 6-10 parts of soy protein isolate, 0.4-0.8 part of glutamic acid, 0.4-1.0 part of ademetionine, 8-11 parts of vegetable oil powder, 5-7 parts of MCT oil powder, 1.5-3 parts of soybean phospholipid powder, 1.5-3 parts of omega-3 fatty acid and 2X 10 of vitamin A -4 -3×10 -4 Parts, vitamin D 3 5×10 -6 -10×10 -6 0.01-0.04 part of vitamin E and vitamin K 1 2×10 -5 -2.5×10 -5 Parts, vitamin B 1 3.5×10 -4 -7×10 -4 Parts, vitamin B 2 3.5×10 -4 -7×10 -4 Parts, vitamin B 6 3.5×10 -4 -7×10 -4 Parts, vitamin B 12 0.6×10 -6 -2×10 -6 Parts, folic acid 7×10 -4 -11×10 -4 Parts, nicotinic acid 5X 10 -3 -10×10 -3 0.08-0.1 part of vitamin C, 0.4-0.5 part of sodium, 0.5-0.6 part of potassium and iron6×10 -3 -10×10 -3 0.4 to 0.7 part of calcium, 0.1 to 0.2 part of magnesium, 0.2 to 0.3 part of chlorine, 0.2 to 0.3 part of phosphorus, 0.008 to 0.016 part of zinc and 3.3 multiplied by 10 of iodine -6 -10×10 -6 Parts of selenium 0.3 x 10 -4 -0.5×10 -4 2-4 parts of pectin;
step 2, homogenizing and sterilizing: mixing the weighed materials in a dry mixer, and homogenizing for 2-4 times; sterilizing;
and step 3, packaging and sterilizing: placing the sterilized dry powder into an aluminum foil composite bag, filling nitrogen, sealing, and sterilizing after sealing; the dietary composition suitable for pregnant women with pregnancy complicated with hepatitis is prepared.
Optionally, the mixing speed in the step 2 is 1500-2000 r/min, and the time is 10-20 minutes.
Optionally, the sterilization time in the step 2 is 10 seconds, and the sterilization temperature is 110-125 ℃.
Optionally, the sterilization temperature in the step 3 is 110-125 ℃ and the time is 5-25 minutes.
Compared with the prior art, the invention can obtain the following technical effects:
1) The composition can meet the energy metabolism requirement of pregnancy combined hepatitis: the full-nutrition formula food with high calories, high carbohydrates, sufficient high-quality protein and low fat is designed for the pregnant women with hepatitis. The protein fraction is specifically formulated with soy protein in combination with whey protein. The soybean plant protein contains more branched chain amino acids, less aromatic amino acids, does not contain cholesterol, is matched with whey protein, has high absorption and utilization efficiency, and provides sufficient protein to support liver functions; the soybean plant protein contains a certain amount of dietary fiber, can promote intestinal peristalsis, can reduce pH value of colon after being decomposed by bacteria, accelerates detoxification, reduces ammonia absorption, and keeps stool smooth. The proportion of medium-chain fatty acids (MCT) in the fat fraction is about 35%, MCT provides sufficient energy for rapid metabolic oxidation after entry into the body and is less burdened on the liver than long-chain triacylglycerols (LCT). Therefore, the energy ratio of the invention has the following advantages: (1) the energy is sufficient, the proportion is proper, the components are high in quality, and the feed additive is easy to digest and absorb; (2) the liver burden is small; (3) can be used for improving malnutrition caused by nausea, inappetence, constipation, etc.
2) The invention can strengthen folic acid, calcium, iron, vitamin C and vitamin B 12 Nutrient substances required by pregnant women: (1) folic acid: folic acid is involved in the synthesis of deoxyribonucleic acid (IDNA) and ribonucleic acid (RNA). The metabolic disorder of folic acid is caused by the increase of estrogen and progesterone secretion in gestation and the damage of hepatitis virus, so that the patient is easy to produce megaloblastic anemia. Furthermore, it has been reported that: if the liver patient with pregnancy complicated with hepatitis lacks folic acid, the fetus has increased risk of nervous system defect, such as no nerve tube malformation of brain, rachium, etc. Therefore, the folic acid requirement of pregnant women with pregnancy complicated with hepatitis is increased by one time compared with that of normal pregnant women. (2) Dimension C: the fetus growth and development need a large amount of vitamin C, and when the fetus is suffering from hepatitis, the vitamin C of the mother body is more likely to be insufficient, so that the standard of daily vitamin C supply of pregnant and hepatitis-combined patients is 80-100 milligrams. In addition, when hepatitis or liver cell function is abnormal, it can affect the metabolism of multiple vitamins and minerals and exert active effects, such as calcium, iron, and vitamin D hydroxylation at C25, vitamin B1 synthesis thiamine pyrophosphate (TPP), etc. The invention reasonably strengthens the nutrient substances for pregnant women with the hepatitis.
3) The invention can improve liver inflammation state and promote liver function recovery of pregnant women: most of clinical hepatitis treatment medicines are forbidden or cautious for pregnant women at present. In addition, the load of the liver during pregnancy is large, and the recovery of the hepatitis during pregnancy is often not ideal. Therefore, improvement of liver inflammatory states in pregnant women is a very viable and necessary way from a nutritional point of view. The nutrition substances which are specially added to the invention and are helpful for improving liver inflammation state mainly comprise the following 4 kinds: firstly, the soybean lecithin not only can repair damaged liver cell membranes, promote liver cell regeneration and prevent fatty liver; can also reduce serum cholesterol content, and is helpful for liver function recovery. Second, n-3 unsaturated fatty acids (omega-3 PUFAs) not only contain DHA and EPA necessary for fetal growth, but also exert anti-inflammatory (down-regulating inflammatory cytokines, lowering IL-1, IL-10, TNF-alpha levels), regulating immune function, lowering lipid, anticoagulation, etc. Thirdly, the L-methionine can a) resist liver cirrhosis, fatty liver and various acute, chronic, viral and icteric hepatitis, and the membrane fluidity is enhanced by promoting phospholipid methylation of liver cell membranes, and the Na+ -K+ -ATPase pumping effect is strong; enhancing the transthio function, thereby enhancing the synthesis of cysteine, glutathione and taurine in liver cells, enhancing the detoxification function, being beneficial to the recovery of normal physiological functions of liver cells, promoting the regression of jaundice and the recovery of liver functions. b) Against intrahepatic cholestasis caused by various causes: viral infection, pregnancy and long-term parenteral nutrition are all possible to cause intrahepatic cholestasis, methionine is covalently bound to bile acid by taurine formation, acid solubility is enhanced, extrahepatic cells are easily excreted, and Na+ -K+ -ATPase activity is enhanced by methylation of phospholipid of hepatic cell membranes to promote bile excretion. Methionine can be used to significantly reduce jaundice, skin itching and liver function abnormalities caused by cholestasis. Fourth, glutamic acid: enhancing the function of the immune system; the synthesis of glutathione can be participated, so that the oxidation resistance of organisms can be improved; protecting gastrointestinal mucosa epithelial cells and reducing intestinal bacteria shift; improving the nitrogen balance of organism metabolism, etc.
The special full-nutrition special medical food for pregnant women with the pregnancy-induced hepatitis, which is prepared by the invention, has reasonable nutrition component collocation and proper processing technology, and can keep the product state, taste and nutrition component uniform and stable for a long time.
Of course, it is not necessary for any of the products embodying the invention to achieve all of the technical effects described above at the same time.
Detailed Description
The following will describe embodiments of the present invention in detail by referring to examples, so that the implementation process of how to apply the technical means to solve the technical problems and achieve the technical effects of the present invention can be fully understood and implemented.
The invention discloses a dietary composition suitable for pregnant women with pregnancy complicated with hepatitis, which comprises the following components in parts by mass: 48-60 parts of maltodextrin, 3-6 parts of resistant starch, 13-18 parts of concentrated whey protein, 6-10 parts of soy protein isolate, 0.4-0.8 part of glutamic acid, 0.4-1.0 part of adenosylmethionine, 8-11 parts of vegetable oil powder, 5-7 parts of MCT oil powder, 1.5-3 parts of soybean phospholipid powder, 1.5-3 parts of omega-3 fatty acid and vitaminsA 2×10 -4 -3×10 -4 Parts, vitamin D 3 5×10 -6 -10×10 -6 0.01-0.04 part of vitamin E and vitamin K 1 2×10 -5 -2.5×10 -5 Parts, vitamin B 1 3.5×10 -4 -7×10 -4 Parts, vitamin B 2 3.5×10 -4 -7×10 -4 Parts, vitamin B 6 3.5×10 -4 -7×10 -4 Parts, vitamin B 12 0.6×10 -6 -2×10 -6 Parts, folic acid 7×10 -4 -11×10 -4 Parts, nicotinic acid 5X 10 -3 -10×10 -3 0.08-0.1 part of vitamin C, 0.4-0.5 part of sodium, 0.5-0.6 part of potassium and 6X 10 iron -3 -10×10 -3 0.4 to 0.7 part of calcium, 0.1 to 0.2 part of magnesium, 0.2 to 0.3 part of chlorine, 0.2 to 0.3 part of phosphorus, 0.008 to 0.016 part of zinc and 3.3 multiplied by 10 of iodine -6 -10×10 -6 Parts of selenium 0.3 x 10 -4 -0.5×10 -4 2-4 parts of pectin.
The value ranges of the components are based on the energy nutrient substance requirements of the pregnant women with hepatitis, so that the optimal range and the optimal ratio are achieved, the basic nutrient requirements are ensured, the liver burden is reduced to the greatest extent, and the liver function recovery is promoted. If the ratio is less than the above range, the basic nutritional requirements of the pregnant women with hepatitis cannot be met, and the inflammatory state of the liver cannot be effectively improved; if the ratio is larger than the above range, the liver burden of the pregnant woman with hepatitis is increased, which is unfavorable for liver function recovery.
The invention also discloses a preparation method of the dietary composition suitable for pregnant women with pregnancy-associated hepatitis, which comprises the following steps:
step 1, weighing: the components are weighed according to the following mass parts: 48-60 parts of maltodextrin, 3-6 parts of resistant starch, 13-18 parts of concentrated whey protein, 6-10 parts of soy protein isolate, 0.4-0.8 part of glutamic acid, 0.4-1.0 part of ademetionine, 8-11 parts of vegetable oil powder, 5-7 parts of MCT oil powder, 1.5-3 parts of soybean phospholipid powder, 1.5-3 parts of omega-3 fatty acid and 2X 10 of vitamin A -4 -3×10 -4 Parts, vitamin D 3 5×10 -6 -10×10 -6 0.01-0.04 part of vitamin E and vitamin K 1 2×10 -5 -2.5×10 -5 Parts and vitaminB 1 3.5×10 -4 -7×10 -4 Parts, vitamin B 2 3.5×10 -4 -7×10 -4 Parts, vitamin B 6 3.5×10 -4 -7×10 -4 Parts, vitamin B 12 0.6×10 -6 -2×10 -6 Parts, folic acid 7×10 -4 -11×10 -4 Parts, nicotinic acid 5X 10 -3 -10×10 -3 0.08-0.1 part of vitamin C, 0.4-0.5 part of sodium, 0.5-0.6 part of potassium and 6X 10 iron -3 -10×10 -3 0.4 to 0.7 part of calcium, 0.1 to 0.2 part of magnesium, 0.2 to 0.3 part of chlorine, 0.2 to 0.3 part of phosphorus, 0.008 to 0.016 part of zinc and 3.3 multiplied by 10 of iodine -6 -10×10 -6 Parts of selenium 0.3 x 10 -4 -0.5×10 -4 2-4 parts of pectin.
Step 2, homogenizing and sterilizing: mixing the weighed materials in a dry mixer, wherein the rotating speed of the dry mixer is 1500-2000 r/min, the time is 10-20 minutes, and the materials are homogenized for 2-4 times; sterilizing the homogenized mixture at 110-125deg.C for 10-20 seconds.
Under the conditions of homogenization and sterilization, the components can be effectively homogenized and sterilized, and the components and the activity of the components are not destroyed. If the content is less than the above range, the components cannot be thoroughly and homogeneously mixed and effectively sterilized; while greater than the above range may deteriorate the nutritional value and active effects of the components.
And step 3, packaging and sterilizing: and placing the mixed dry powder into an aluminum foil composite bag, filling nitrogen and sealing. Sealing, and sterilizing at 110-125deg.C for 5-25 min.
Example 1
The dietary composition suitable for pregnant women with pregnancy complicated with hepatitis comprises the following components in parts by mass: 56 parts of maltodextrin, 4 parts of resistant starch, 14 parts of concentrated whey protein, 10 parts of soybean protein isolate, 0.6 part of glutamic acid, 0.7 part of adenosylmethionine, 10.4 parts of vegetable oil powder, 6 parts of MCT oil powder, 2 parts of soybean phospholipid powder, 2 parts of omega-3 fatty acid and 2.5 multiplied by 10 of vitamin A -4 Parts, vitamin D 3 8×10 -6 Parts, vitamin E0.03 parts, vitamin K 1 2.3×10 -5 Parts, vitamin B 1 5×10 -4 Parts, vitamin B 2 5×10 -4 Parts and vitaminB 6 5×10 -4 Parts, vitamin B 12 1.5×10 -6 Parts, folic acid 9×10 -4 Parts, nicotinic acid 8×10 -3 0.09 part of vitamin C, 0.45 part of sodium, 0.55 part of potassium and 8 multiplied by 10 parts of iron -3 0.45 part of calcium, 0.15 part of magnesium, 0.25 part of chlorine, 0.25 part of phosphorus, 0.012 part of zinc and 6 multiplied by 10 of iodine -6 Parts of selenium 0.4 x 10 -4 3 parts of pectin.
The preparation method of the dietary composition suitable for pregnant women with pregnancy-associated hepatitis comprises the following steps:
step 1, weighing all the materials according to the components;
step 2, homogenizing and sterilizing: mixing the weighed materials in a dry mixer, wherein the rotation speed of the dry mixer is 1800r/min, the time is 15 minutes, and the materials are homogenized for 3 times; the homogenized mixture was sterilized at 118℃for 10 seconds.
And step 3, packaging and sterilizing: and placing the mixed dry powder into an aluminum foil composite bag, filling nitrogen and sealing. After sealing, the mixture was sterilized at 118℃for 15 minutes.
Example 2
The dietary composition suitable for pregnant women with pregnancy complicated with hepatitis comprises the following components in parts by mass: 60 parts of maltodextrin, 6 parts of resistant starch, 18 parts of concentrated whey protein, 10 parts of soybean protein isolate, 0.8 part of glutamic acid, 1.0 part of adenosylmethionine, 8 parts of vegetable oil, 5 parts of MCT oil powder, 1.5 parts of soybean phospholipid powder, 1.5 parts of omega-3 fatty acid and 3 multiplied by 10 of vitamin A -4 Parts, vitamin D 3 10×10 -6 Parts, vitamin E0.04 parts, vitamin K 1 2.5×10 -5 Parts, vitamin B 1 7×10 -4 Parts, vitamin B 2 7×10 -4 Parts, vitamin B 6 7×10 -4 Parts, vitamin B 12 2×10 -6 Parts, folic acid 11×10 -4 Parts, nicotinic acid 10×10 -3 0.1 part of vitamin C, 0.5 part of sodium, 0.6 part of potassium and 10 multiplied by 10 of iron -3 0.7 part of calcium, 0.2 part of magnesium, 0.3 part of chlorine, 0.3 part of phosphorus, 0.016 part of zinc and 10 multiplied by 10 of iodine -6 Parts of selenium 0.5 x 10 -4 4 parts of pectin.
The preparation method of the dietary composition suitable for pregnant women with pregnancy-associated hepatitis comprises the following steps:
step 1, weighing all the materials according to the components;
step 2, homogenizing and sterilizing: mixing the weighed materials in a dry mixer, wherein the rotating speed of the dry mixer is 1500r/min, the time is 20 minutes, and homogenizing is carried out for 2 times; the homogenized mixture was sterilized at 125℃for 17 seconds.
And step 3, packaging and sterilizing: and placing the mixed dry powder into an aluminum foil composite bag, filling nitrogen and sealing. After sealing, the mixture was sterilized at 125℃for 5 minutes.
Example 3
The dietary composition suitable for pregnant women with pregnancy complicated with hepatitis comprises the following components in parts by mass: 48 parts of maltodextrin, 6 parts of resistant starch, 13 parts of concentrated whey protein, 6 parts of soy protein isolate, 0.4 part of glutamic acid, 0.4 part of adenosylmethionine, 11 parts of vegetable oil powder, 7 parts of MCT oil powder, 3 parts of soybean phospholipid powder, 3 parts of omega-3 fatty acid and 2 multiplied by 10 of vitamin A -4 Parts, vitamin D 3 5×10 -6 Parts, vitamin E0.01 parts, vitamin K 1 2×10 -5 Parts, vitamin B 1 3.5×10 -4 Parts, vitamin B 2 3.5×10 -4 Parts, vitamin B 6 3.5×10 -4 Parts, vitamin B 12 0.6×10 -6 Parts, folic acid 7×10 -4 Parts, nicotinic acid 5X 10 -3 0.08 part of vitamin C, 0.4 part of sodium, 0.5 part of potassium and 6 multiplied by 10 parts of iron -3 0.4 part of calcium, 0.1 part of magnesium, 0.2 part of chlorine, 0.2 part of phosphorus, 0.008 part of zinc and 3.3X10 part of iodine -6 Parts of selenium 0.3 x 10 -4 2 parts of pectin.
The preparation method of the dietary composition suitable for pregnant women with pregnancy-associated hepatitis comprises the following steps:
step 1, weighing all the materials according to the components;
step 2, homogenizing and sterilizing: mixing the weighed materials in a dry mixer, wherein the rotation speed of the dry mixer is 2000r/min, the time is 10 minutes, and the materials are homogenized for 4 times; the homogenized mixture was sterilized at 110℃for 20 seconds.
And step 3, packaging and sterilizing: and placing the mixed dry powder into an aluminum foil composite bag, filling nitrogen and sealing. After sealing, the mixture was sterilized at 110℃for 25 minutes.
Example 4
The dietary composition suitable for pregnant women with pregnancy complicated with hepatitis comprises the following components in parts by mass: 48 parts of maltodextrin, 6 parts of resistant starch, 13 parts of concentrated whey protein, 6 parts of soy protein isolate, 0.4 part of glutamic acid, 0.4 part of adenosylmethionine, 11 parts of vegetable oil powder, 7 parts of MCT oil powder, 3 parts of soybean phospholipid powder, 3 parts of omega-3 fatty acid and 2 multiplied by 10 of vitamin A -4 Parts, vitamin D 3 5×10 -6 Parts, vitamin E0.01 parts, vitamin K 1 2×10 -5 Parts, vitamin B 1 3.5×10 -4 Parts, vitamin B 2 3.5×10 -4 Parts, vitamin B 6 3.5×10 -4 Parts, vitamin B 12 0.6×10 -6 Parts, folic acid 7×10 -4 Parts, nicotinic acid 5X 10 -3 0.08 part of vitamin C, 0.4 part of sodium, 0.5 part of potassium and 6 multiplied by 10 parts of iron -3 0.4 part of calcium, 0.1 part of magnesium, 0.2 part of chlorine, 0.2 part of phosphorus, 0.008 part of zinc and 3.3X10 part of iodine -6 Parts of selenium 0.3 x 10 -4 2 parts of pectin.
The preparation method of the dietary composition suitable for pregnant women with pregnancy-associated hepatitis is the same as in example 1.
Example 5
The omega-3 fatty acid is a dietary composition suitable for pregnant women with pregnancy complicated with hepatitis, and comprises the following components in parts by mass: 52 parts of maltodextrin, 5 parts of resistant starch, 15 parts of concentrated whey protein, 7.5 parts of soy protein isolate, 0.5 part of glutamic acid, 0.6 part of adenosylmethionine, 10 parts of vegetable oil powder, 6.5 parts of MCT oil powder, 2 parts of soybean phospholipid powder, 2.5 parts of omega-3 fatty acid and 2.3 multiplied by 10 of vitamin A -4 Parts, vitamin D 3 7×10 -6 Parts, vitamin E0.02 parts, vitamin K 1 2.1×10 -5 Parts, vitamin B 1 4×10 -4 Parts, vitamin B 2 4×10 -4 Parts, vitamin B 6 4×10 -4 Parts, vitamin B 12 0.8×10 -6 8X 10 portions of folic acid -4 Parts, nicotinic acid 7X 10 -3 0.08 part of vitamin C and 0 part of sodium4 parts, 0.5 part of potassium and 7 multiplied by 10 of iron -3 0.6 part of calcium, 0.1 part of magnesium, 0.2 part of chlorine, 0.2 part of phosphorus, 0.01 part of zinc and 6 multiplied by 10 parts of iodine -6 Parts of selenium 0.4 x 10 -4 2 parts of pectin.
The preparation method of the dietary composition suitable for pregnant women with pregnancy-associated hepatitis is the same as in example 1.
Comparative example 1
The dietary composition suitable for pregnant women with pregnancy complicated with hepatitis comprises the following components in parts by mass: 56 parts of maltodextrin, 4 parts of resistant starch, 24 parts of collagen, 0.6 part of glutamic acid, 0.7 part of adenosyl methionine, 10.4 parts of vegetable oil powder, 6 parts of MCT oil powder, 2 parts of soybean lecithin powder, 2 parts of omega-3 fatty acid and 2.5 multiplied by 10 of vitamin A -4 Parts, vitamin D 3 8×10 -6 Parts, vitamin E0.03 parts, vitamin K 1 2.3×10 -5 Parts, vitamin B 1 5×10 -4 Parts, vitamin B 2 5×10 -4 Parts, vitamin B 6 5×10 -4 Parts, vitamin B 12 1.5×10 -6 Parts, folic acid 9×10 -4 Parts, nicotinic acid 8×10 -3 0.09 part of vitamin C, 0.45 part of sodium, 0.55 part of potassium and 8 multiplied by 10 parts of iron -3 0.45 part of calcium, 0.15 part of magnesium, 0.25 part of chlorine, 0.25 part of phosphorus, 0.012 part of zinc and 6 multiplied by 10 of iodine -6 Parts of selenium 0.4 x 10 -4 3 parts of pectin.
The preparation method of the dietary composition suitable for pregnant women with pregnancy-associated hepatitis is the same as in example 1.
Comparative example 2
The dietary composition suitable for pregnant women with pregnancy complicated with hepatitis comprises the following components in parts by mass: 56 parts of maltodextrin, 4 parts of resistant starch, 14 parts of concentrated whey protein, 10 parts of soybean protein isolate, 1.3 parts of alanine, 10.4 parts of vegetable oil powder, 6 parts of palm oil powder, 2 parts of soybean phospholipid powder, 2 parts of omega-3 fatty acid and 2.5 multiplied by 10 of vitamin A -4 Parts, vitamin D 3 8×10 -6 Parts, vitamin E0.03 parts, vitamin K 1 2.3×10 -5 Parts, vitamin B 1 5×10 -4 Parts, vitamin B 2 5×10 -4 Parts, vitamin B 6 5×10 -4 Parts, vitamin B 12 1.5×10 -6 Parts, folic acid 9×10 -4 Parts, nicotinic acid 8×10 -3 0.09 part of vitamin C, 0.45 part of sodium, 0.55 part of potassium and 8 multiplied by 10 parts of iron -3 0.45 part of calcium, 0.15 part of magnesium, 0.25 part of chlorine, 0.25 part of phosphorus, 0.012 part of zinc and 6 multiplied by 10 of iodine -6 Parts of selenium 0.4 x 10 -4 3 parts of pectin.
The preparation method of the dietary composition suitable for pregnant women with pregnancy-associated hepatitis is the same as in example 1.
Comparative example 3
56 parts of maltodextrin, 4 parts of resistant starch, 14 parts of concentrated whey protein, 10 parts of soybean protein isolate, 0.6 part of glutamic acid, 0.7 part of adenosylmethionine, 12.4 parts of vegetable oil powder, 6 parts of MCT oil powder, 0.1 part of omega-3 fatty acid and 2.5 multiplied by 10 of vitamin A -4 Parts, vitamin D 3 8×10 -6 Parts, vitamin E0.03 parts, vitamin K 1 2.3×10 -5 Parts, vitamin B 1 5×10 -4 Parts, vitamin B 2 5×10 -4 Parts, vitamin B 6 5×10 -4 Parts, vitamin B 12 1.5×10 -6 Parts, folic acid 9×10 -4 Parts, nicotinic acid 8×10 -3 0.09 part of vitamin C, 0.45 part of sodium, 0.55 part of potassium and 8 multiplied by 10 parts of iron -3 0.45 part of calcium, 0.15 part of magnesium, 0.25 part of chlorine, 0.25 part of phosphorus, 0.012 part of zinc and 6 multiplied by 10 of iodine -6 Parts of selenium 0.4 x 10 -4 3 parts of pectin.
The preparation method of the dietary composition suitable for pregnant women with pregnancy-associated hepatitis is the same as in example 1.
Comparative example 4
56 parts of maltodextrin, 4 parts of resistant starch, 14 parts of concentrated whey protein, 10 parts of soybean protein isolate, 10.4 parts of vegetable oil powder, 6 parts of MCT oil powder, 0.1 part of omega-3 fatty acid and 2.5 multiplied by 10 of vitamin A -4 Parts, vitamin D 3 8×10 -6 Parts, vitamin E0.03 parts, vitamin K 1 2.3×10 -5 Parts, vitamin B 1 5×10 -4 Parts, vitamin B 2 5×10 -4 Parts, vitamin B 6 5×10 -4 Parts, vitamin B 12 1.5×10 -6 Parts, folic acid 9×10 -4 Parts, nicotinic acid 8×10 -3 0.09 part of vitamin C, 0.45 part of sodium, 0.55 part of potassium and 8 multiplied by 10 parts of iron -3 0.45 part of calcium, 0.15 part of magnesium, 0.25 part of chlorine, 0.25 part of phosphorus, 0.012 part of zinc and 6 multiplied by 10 of iodine -6 Parts of selenium 0.4 x 10 -4 3 parts of pectin.
The preparation method of the dietary composition suitable for pregnant women with pregnancy-associated hepatitis is the same as in example 1.
TABLE 1 formulation tables for examples 1-5 and comparative examples 1-4
The effect of the invention on improving the nutritional status and liver function of pregnant women with gestational combined viral hepatitis b is described below in conjunction with specific experimental data:
1. design of experiment
The invention and the comparative examples were tested by randomly selecting 45 pregnant women with mild abnormal liver function and viral hepatitis B, randomly dividing the pregnant women into 9 groups, 5 pregnant women in each group, and using the invention in each of the treatment groups 1 to 9 in each of the treatment groups 1, 2, 3, 4, 5, 1, 2, 3 and 4, and selecting 5 pregnant women as the control group according to the same standard. The eating method comprises the following steps: every 100g of the product is brewed by 400mL of warm boiled water to replace any meal or multiple meals for eating, and the eating is continuous for 2 months. Serum folic acid and vitamin B are detected by sampling venous blood of pregnant women in the morning on an empty stomach within 1 week before the use and within 1 week after the use of the product 12 And serum ferritin and liver function detection including glutamic-oxaloacetic transaminase ALT, glutamic-pyruvic transaminase AST, total bilirubin, direct bilirubin and total cholic acid TBA. Wherein, the measurement of serum folic acid, vitamin B12 and serum ferritin adopts a radioimmunoassay: 3ml of fasting venous blood was collected in the early morning and stored at room temperature for 20min using BY-160CCentrifuging for 10min at 3500r/min, separating, and freeze preserving (-20deg.C). Three indicators were checked using a MAGLUMI2000 fully automated luminescence tester, following strictly the relevant principles. The liver function detection method comprises the steps of extracting 5-10 ml of fasting venous blood, placing the fasting venous blood in an anticoagulation tube, centrifuging for 10min at the centrifugation speed of 3 000r/min, separating blood cells from serum, adopting the combination of the serum and a reagent, and checking the concentration of glutamic oxaloacetic transaminase ALT, glutamic pyruvic transaminase AST, total bilirubin, direct bilirubin and indirect bilirubin by using an instrument. The kit is developed by Zhongsheng North control biotechnology Co., ltd; reference is made to the liver function index test method in clinical biochemistry test of national higher school, medical test course, people health press, 2012, book, eighth chapter, which is mainly compiled by Feng Wenli and Fan Qishi.
2 detection index and result
2.1 serum folic acid and vitamin B of pregnant women 12 And serum ferritin assay
Serum folic acid and vitamin B of pregnant women before treatment 12 The difference was statistically not significant (P > 0.05) compared to serum ferritin. After treatment, serum folic acid and vitamin B of pregnant women in groups 1, 2, 3 and 4 are treated 12 And serum ferritin levels were significantly elevated on average compared to the pre-treatment levels of the same group, the differences were statistically significant (P < 0.05); and treating 5, 6, 7, 8, 9 groups of pregnant women with serum folic acid and vitamin B 12 The serum ferritin level was slightly higher than that of the same group treatment, and the difference was not statistically significant (P>0.05)。
Table 2 different treatments of serum folic acid and vitamin B of pregnant women with combined hepatitis 12 And serum ferritin changes
2.2 liver function detection of pregnant women: ALT, AST, total bilirubin, direct bilirubin and Total cholic acid TBA
Before treatment, ALT, AST, total bilirubin, direct bilirubin and total cholic acid TBA of pregnant women in each group were compared, and the difference was not statistically significant (P > 0.05). After treatment, the levels of ALT, AST, total bilirubin, direct bilirubin and total cholic acid TBA of pregnant women in groups 1, 2, 3 and 4 are obviously reduced compared with those of the pregnant women before the treatment in the same group, and the difference is statistically significant (P is less than 0.05); the serum folic acid, vitamin B12 and serum ferritin levels of the pregnant women in the groups 5, 6, 7, 8 and 9 are slightly reduced compared with those in the same group, and the difference has no statistical significance (P is more than 0.05)
TABLE 3 variation of ALT, AST, total bilirubin, direct bilirubin and Total cholic acid TBA in pregnant women with combined hepatitis from different treatments
The invention relates to a specific full-nutrition special medical food suitable for pregnant women with gestational complicated hepatitis or liver function abnormality. Firstly, the pregnant woman carrying hepatitis B virus can increase liver burden, influence organism metabolism and nutrition condition, and the pregnant woman has nausea, inappetence and constipation, and the deficiency of nutrition, vitamins and inorganic salts can occur. In addition, since hepatitis virus can disturb the metabolism of folic acid, pregnant women suffering from hepatitis often have deficiency of folic acid, vitamin C and the like more easily than normal pregnant women, and deficiency of folic acid causes deficiency of fetal nervous system, so that special attention is paid to supplementation of vitamins such as folic acid. In addition, some pregnant women carrying hepatitis B virus have the problem of unbalanced dietary structure during pregnancy, such as high-fat and high-protein diet, which is extremely easy to burden the liver, further damage the liver and pregnancy complications. Research at home and abroad shows that compared with normal people, HBV infected pregnant women have higher probability of early vaginal bleeding, pregnancy hypertension syndrome, diabetes, premature rupture of fetal membranes, neck winding of umbilical cords, premature delivery, postpartum hemorrhage and the like during pregnancy. Most of clinical hepatitis treatment medicines are forbidden or cautious for pregnant women at present. In addition, the load of the liver during pregnancy is large, and the recovery of the hepatitis during pregnancy is often not ideal.
The invention starts from the aspect 3 to improve the nutrition and liver function state of pregnant women with pregnancy and hepatitis: the energy supply proportion is optimally designed, the anti-hepatitis antioxidant substances are added, the vitamins and minerals necessary for fetal growth and development are enhanced, the three are mutually synergistic and mutually promoted, the burden of the liver is reduced as much as possible on the basis of ensuring sufficient nutrition of pregnant women and fetuses, the liver is facilitated to be repaired, the occurrence of pregnancy complications is reduced, and the pregnancy safety is ensured. The liver function indexes ALT and AST can reflect the liver injury degree, and the total bilirubin, the indirect bilirubin, the total cholic acid and the like can reflect the intrahepatic cholestasis degree. The formulation used in treatment group 6 replaced whey protein and soy protein isolate with collagen; alanine was used in place of glutamic acid and adenosylmethionine in the formulation used in treatment group 7; the formulation used in treatment group 8 replaced soybean lecithin and omega-3 unsaturated fatty acids with vegetable oil; treatment group 9 used a formulation with simultaneous removal of glutamic acid, adenosylmethionine, soy lecithin, and omega-3 unsaturated fatty acids. The results show that the reduction degree of ALT, AST, total bilirubin, indirect bilirubin and total cholic acid after pregnant women in treatment groups 5, 6, 7, 8 and 9 are not statistically different, and the treatment effect is obviously inferior to that of treatment groups 1, 2, 3 and 4; folic acid and vitamin B of serum simultaneously 12 The rise degree of serum iron is obviously inferior to that of treatment groups 1, 2, 3 and 4, which shows that high-quality protein, soybean lecithin, n-3 unsaturated fatty acid, L-methionine and glutamic acid are effective in improving liver inflammation state of pregnant women with hepatitis, promoting liver function recovery, folic acid and vitamin B 12 Normal metabolism has important synergistic effect; and none of them alone or replaced by other substances can achieve an effective therapeutic effect. In addition, sufficient folic acid and vitamin B are additionally supplemented 12 The trace elements can obviously improve serum folic acid and vitamin B of pregnant women with pregnancy complicated with hepatitis 12 Ferritin levels.
Therefore, the special full-nutrition formula special medical food designed for pregnant women with pregnancy combined with hepatitis can effectively improve the malnutrition state of the pregnant women, reduce the burden of livers and promote the repair of the livers, thereby ensuring the pregnancy safety and avoiding the occurrence of poor pregnancy ending.
While the foregoing description illustrates and describes several preferred embodiments of the invention, it is to be understood that the invention is not limited to the forms disclosed herein, but is not to be construed as limited to other embodiments, and is capable of use in various other combinations, modifications and environments and is capable of changes or modifications within the spirit of the invention described herein, either as a result of the foregoing teachings or as a result of the knowledge or skill of the relevant art. And that modifications and variations which do not depart from the spirit and scope of the invention are intended to be within the scope of the appended claims.

Claims (5)

1. A dietary composition suitable for pregnant women with pregnancy-associated hepatitis, which is characterized by comprising the following components in parts by mass: 54-60 parts of maltodextrin, 3-4 parts of resistant starch, 13-14 parts of concentrated whey protein, 8.5-10 parts of soy protein isolate, 0.6-0.8 part of glutamic acid, 0.7-1.0 part of adenosylmethionine, 8-10.4 parts of vegetable oil powder, 5-6 parts of MCT oil powder, 1.5-2.5 parts of soybean phospholipid powder, 1.5-2 parts of omega-3 fatty acid and 2.5 multiplied by 10 of vitamin A -4 -3×10 -4 Parts, vitamin D 3 8×10 -6 -10×10 -6 0.03-0.04 parts of vitamin E and vitamin K 1 2.3×10 -5 -2.5×10 -5 Parts, vitamin B 1 5×10 -4 -7×10 -4 Parts, vitamin B 2 5×10 -4 -7×10 -4 Parts, vitamin B 6 5×10 -4 -7×10 -4 Parts, vitamin B 12 1.2×10 -6 -2×10 -6 Parts, folic acid 9×10 -4 -11×10 -4 Parts, nicotinic acid 8×10 -3 -10×10 -3 0.09-0.1 part of vitamin C, 0.45-0.5 part of sodium, 0.55-0.6 part of potassium and 8X 10 parts of iron -3 -10×10 -3 0.4-0.7 part of calcium, 0.15-0.2 part of magnesium, 0.25-0.3 part of chlorine, 0.25-0.3 part of phosphorus, 0.01-0.016 part of zinc and 6X 10 part of iodine -6 -10×10 -6 Parts of selenium 0.4 x 10 -4 -0.5×10 -4 3-4 parts of pectin.
2. A method of preparing a dietary composition suitable for pregnant women with pregnancy associated with hepatitis, comprising the steps of:
step 1, weighing:the components are weighed according to the following mass parts: 54-60 parts of maltodextrin, 3-4 parts of resistant starch, 13-14 parts of concentrated whey protein, 8.5-10 parts of soy protein isolate, 0.6-0.8 part of glutamic acid, 0.7-1.0 part of adenosylmethionine, 8-10.4 parts of vegetable oil powder, 5-6 parts of MCT oil powder, 1.5-2.5 parts of soybean phospholipid powder, 1.5-2 parts of omega-3 fatty acid and 2.5 multiplied by 10 of vitamin A -4 -3×10 -4 Parts, vitamin D 3 8×10 -6 -10×10 -6 0.03-0.04 parts of vitamin E and vitamin K 1 2.3×10 -5 -2.5×10 -5 Parts, vitamin B 1 5×10 -4 -7×10 -4 Parts, vitamin B 2 5×10 -4 -7×10 -4 Parts, vitamin B 6 5×10 -4 -7×10 -4 Parts, vitamin B 12 1.2×10 -6 -2×10 -6 Parts, folic acid 9×10 -4 -11×10 -4 Parts, nicotinic acid 8×10 -3 -10×10 -3 0.09-0.1 part of vitamin C, 0.45-0.5 part of sodium, 0.55-0.6 part of potassium and 8X 10 parts of iron -3 -10×10 -3 0.4-0.7 part of calcium, 0.15-0.2 part of magnesium, 0.25-0.3 part of chlorine, 0.25-0.3 part of phosphorus, 0.01-0.016 part of zinc and 6X 10 part of iodine -6 -10×10 -6 Parts of selenium 0.4 x 10 -4 -0.5×10 -4 3-4 parts of pectin;
step 2, mixing and sterilizing: mixing the weighed materials in a dry mixer for 2-4 times; sterilizing;
and step 3, packaging and sterilizing: placing the sterilized dry powder into an aluminum foil composite bag, filling nitrogen, sealing, and sterilizing after sealing; the dietary composition suitable for pregnant women with pregnancy complicated with hepatitis is prepared.
3. The preparation method according to claim 2, wherein the mixing speed in the step 2 is 1500-2000 r/min for 10-20 minutes.
4. The method according to claim 2, wherein the sterilization time in the step 2 is 10 seconds and the sterilization temperature is 110 to 125 ℃.
5. The method according to claim 2, wherein the sterilization temperature in step 3 is 110 to 125 ℃ for 5 to 25 minutes.
CN202111011329.4A 2021-08-31 2021-08-31 Dietary composition suitable for pregnant women with pregnancy-associated hepatitis and preparation method thereof Active CN113632977B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202111011329.4A CN113632977B (en) 2021-08-31 2021-08-31 Dietary composition suitable for pregnant women with pregnancy-associated hepatitis and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202111011329.4A CN113632977B (en) 2021-08-31 2021-08-31 Dietary composition suitable for pregnant women with pregnancy-associated hepatitis and preparation method thereof

Publications (2)

Publication Number Publication Date
CN113632977A CN113632977A (en) 2021-11-12
CN113632977B true CN113632977B (en) 2023-09-19

Family

ID=78424573

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202111011329.4A Active CN113632977B (en) 2021-08-31 2021-08-31 Dietary composition suitable for pregnant women with pregnancy-associated hepatitis and preparation method thereof

Country Status (1)

Country Link
CN (1) CN113632977B (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104082656A (en) * 2014-06-12 2014-10-08 广东省农业科学院蚕业与农产品加工研究所 Nutrient meal suitable for patient with liver disease and manufacturing method thereof
CN105558046A (en) * 2016-01-12 2016-05-11 刘保惠 Formula food with special medicinal purpose and suitable for liver disease and preparation method thereof
CN110447892A (en) * 2019-07-24 2019-11-15 北京诺康达医药科技股份有限公司 A kind of special medicine purposes amino acid pattern hepatopathy full nutrition formula food
CN111227235A (en) * 2020-03-05 2020-06-05 北京诺康达医药科技股份有限公司 Total-nutrient formula food for liver diseases and preparation method and application thereof
CN112385844A (en) * 2019-08-16 2021-02-23 华润圣海健康科技有限公司 Nutritional powder with high protein absorption and utilization rate

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104082656A (en) * 2014-06-12 2014-10-08 广东省农业科学院蚕业与农产品加工研究所 Nutrient meal suitable for patient with liver disease and manufacturing method thereof
CN105558046A (en) * 2016-01-12 2016-05-11 刘保惠 Formula food with special medicinal purpose and suitable for liver disease and preparation method thereof
CN110447892A (en) * 2019-07-24 2019-11-15 北京诺康达医药科技股份有限公司 A kind of special medicine purposes amino acid pattern hepatopathy full nutrition formula food
CN112385844A (en) * 2019-08-16 2021-02-23 华润圣海健康科技有限公司 Nutritional powder with high protein absorption and utilization rate
CN111227235A (en) * 2020-03-05 2020-06-05 北京诺康达医药科技股份有限公司 Total-nutrient formula food for liver diseases and preparation method and application thereof

Also Published As

Publication number Publication date
CN113632977A (en) 2021-11-12

Similar Documents

Publication Publication Date Title
SandstroÈm Micronutrient interactions: effects on absorption and bioavailability
Ben Nutritional management of newborn infants: practical guidelines
Massironi et al. Nutritional deficiencies in inflammatory bowel disease: therapeutic approaches
CN102771797B (en) All-round enteral nutrition preparation and preparation method thereof
Chen et al. Type I glycogen storage disease: nine years of management with cornstarch
CN106473153A (en) Full nutrition formula food and preparation method thereof
CN103330215A (en) Nutrition formula food applicable to tumor patient
CN107440088A (en) Improve operation, the nutrients and preparation method thereof of chemicotherapy tumor patient immunity
CN110810845A (en) Total nutrient formula powder with ketogenesis, fat reduction and sugar resistance functions and application thereof
CN107951015A (en) Full nutrient formulation powder and preparation method thereof
CN106668835A (en) Enteral nutrient for oncotherapy and preparation method thereof
AU2020294253A1 (en) Nutritional Composition For Promoting Intestinal Health
EP2413718A1 (en) Reduction of risk of obesity
CN107048137A (en) It is a kind of suitable for low-phosphorus whey albumen powder of Patients with Chronic Renal Disease and preparation method thereof
JPH0394655A (en) Nutrient feeding composition
WO2007100435A2 (en) Use of dha and ara in the preparation of a composition for the prevention or treatment of anemia
CN113632977B (en) Dietary composition suitable for pregnant women with pregnancy-associated hepatitis and preparation method thereof
CN117481199A (en) Premature/low birth weight infant food for promoting growth and development, and preparation method and application thereof
CN108208798A (en) Full nutrient formulation liquid and preparation method thereof
CN111165802A (en) Medical nutrition powder for kidney disease non-dialysis patients and preparation method thereof
CN114025779A (en) Use of whey protein micelles to control postprandial glucose response
CN1893839A (en) Nutritional composition for wound healing
CN114831313A (en) Pregnant woman nutrition bag suitable for gestational diabetes mellitus and preparation method thereof
CN105166901B (en) A kind of dialysis patient alimentation composition
CN104982768B (en) A kind of jelly and preparation method thereof of suitable nephropathy patient&#39;s energy supplement

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant