CN113616709A

CN113616709A - A Chinese medicinal composition for treating male infertility, and its preparation method

Info

Publication number: CN113616709A
Application number: CN202111027289.2A
Authority: CN
Inventors: 吕向东
Original assignee: Yanghe Disabled People's Home Shili Town Qujiang District Quzhou City
Current assignee: Yanghe Disabled People's Home Shili Town Qujiang District Quzhou City
Priority date: 2021-09-02
Filing date: 2021-09-02
Publication date: 2021-11-09

Abstract

The invention provides a traditional Chinese medicine composition for treating male infertility and a preparation process thereof, and relates to the technical field of traditional Chinese medicines. A traditional Chinese medicine composition for treating male infertility comprises the following raw materials in parts by weight: 12-22 parts of spermatogenesis promoting component, 6-12 parts of alpha receptor retarder component, 10-20 parts of sperm active component, 6-12 parts of semen cuscutae, 5-12 parts of cistanche, 6-20 parts of medlar, 6-12 parts of dogwood, 1-5 parts of pilose antler and 5-10 parts of cynomorium songaricum. The traditional Chinese medicine composition for treating male infertility has excellent treatment effect on infertility caused by male oligospermia and asthenospermia and has extremely small side effect. In addition, the invention also provides a preparation process of the traditional Chinese medicine composition for treating male infertility, and the effective substances of the components of the traditional Chinese medicine composition for treating male infertility are extracted by the process, so that the effective components are reserved and the treatment effect is improved.

Description

A Chinese medicinal composition for treating male infertility, and its preparation method

Technical Field

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating male infertility and a preparation process thereof.

Background

In recent years, the incidence of male infertility tends to increase due to the fact that male reproductive health is affected by increasing environmental pollution, spreading of sexually transmitted diseases, occupational contact of harmful substances, poor living habits, and the like, and the quality of male semen tends to decrease (Huangping, li yonghai male infertility [ M ]. beijing: scientific and technical literature publisher, 1990.5.). A foreign survey (combining 101 reports on sperm counts from 1934 to 1996 in europe, america and north america) has shown that the number of male sperm has decreased by around 50% over the past half century. The analysis of causes of 880 cases of male infertility in China shows that oligospermia accounts for 18.0%; asthenospermia accounts for 59.0%, and oligospermia and asthenospermia become common types of male infertility. Oligospermia and asthenospermia are common diseases in andrology and are one of the most common causes of male infertility. The etiology of oligospermia and asthenospermia is complex, western medicine generally thinks that the aspermia and asthenospermia is mainly caused by hereditary diseases, congenital dysplasia, endocrine factors, vas deferens obstruction, varicose veins, genital tract infection, immune factors, metabolic nutritional factors, drug factors, diet, environmental factors, bad living habits and the like, the western medicine does not have specific methods and drug treatments with strong pertinence, at present, various hormone treatments are mainly adopted aiming at the etiology, although the certain curative effect is achieved, side effects of different degrees exist, the clinical curative effect is not good, and patients are often difficult to accept. The existing traditional Chinese medicine has poor and unobvious treatment effect on the infertility caused by male oligospermia and asthenospermia.

Disclosure of Invention

The invention aims to provide the traditional Chinese medicine composition for treating male infertility, which has excellent treatment effect on infertility caused by male oligospermia and asthenospermia and has little side effect.

The invention also aims to provide a preparation process of the traditional Chinese medicine composition for treating male infertility, which is used for extracting effective substances of each component of the traditional Chinese medicine composition for treating male infertility, and keeping effective components to improve the treatment effect.

The technical problem to be solved by the invention is realized by adopting the following technical scheme.

On one hand, the embodiment of the application provides a traditional Chinese medicine composition for treating male infertility, which comprises the following raw materials in parts by weight: 12-22 parts of spermatogenesis promoting component, 6-12 parts of alpha receptor retarder component, 10-20 parts of sperm active component, 6-12 parts of semen cuscutae, 5-12 parts of cistanche, 6-20 parts of medlar, 6-12 parts of dogwood, 1-5 parts of pilose antler and 5-10 parts of cynomorium songaricum.

In some embodiments of the present invention, the spermatogenesis promoting component comprises the following raw materials in parts by weight: 1-5 parts of Eurycoma longifolia, 1-2 parts of maca and 10-15 parts of herba epimedii.

In some embodiments of the present invention, the α receptor blocker comprises the following raw materials in parts by weight: 1-2 parts of carbendazim bark and 5-10 parts of nasturtium.

In some embodiments of the present invention, the sperm cell active component comprises the following raw materials in parts by weight: 10-20 parts of lithocarpus crassipes.

In some embodiments of the invention, the health-care food further comprises 40-50 parts of Chinese yam, 9-15 parts of rhizoma polygonati and 50-60 parts of honey.

In another aspect, the present application provides a process for preparing a traditional Chinese medicine composition for treating male infertility, which comprises the following steps:

weighing the spermatogenesis promoting component and the alpha receptor retarder component according to the weight part, crushing into coarse powder, adding an ethanol solution according to 4-9 times of the total weight of the coarse powder, performing reflux extraction for three times, filtering the extracted ethanol solution, recovering ethanol from filtrate, cooling, filtering, washing, and drying to obtain an extract;

pulverizing the rest components to obtain powder, and mixing the powder uniformly to obtain a mixture; adding water into the obtained mixture, extracting at high temperature and high pressure to obtain an extracting solution, concentrating the extracting solution under reduced pressure to 15% of the original volume, and filtering by a 400-mesh sieve to obtain a mixed solution; adding honey into the mixed solution according to the parts by weight; concentrating the mixed solution under reduced pressure, and spray drying to obtain powder;

weighing Chinese yam according to parts by weight, cooking the Chinese yam, mixing the powder, the extract and the cooked Chinese yam, adding water and stirring to form turbid liquid, weighing the forming agent according to parts by weight, adding the forming agent into the turbid liquid, and heating and stirring until the turbid liquid is formed into paste.

In some embodiments of the present invention, after the rest of the components are pulverized to obtain powder, the powder is sieved with a 40-80 mesh sieve before being uniformly mixed.

In some embodiments of the present invention, the reflux time of the reflux extraction is 2-5 h.

In some embodiments of the present invention, the volume concentration of the ethanol solution is 40% to 95%.

In some embodiments of the present invention, the above-mentioned forming agent comprises, by weight: starch, pectin, agar and alginic acid, and the balance of water.

Compared with the prior art, the embodiment of the invention has at least the following advantages or beneficial effects:

the invention provides a traditional Chinese medicine composition for treating male infertility, which comprises the following raw materials in parts by weight: 12-24 parts of spermatogenesis promoting component, 5-16 parts of alpha receptor retarder component, 10-20 parts of sperm active component, 6-12 parts of semen cuscutae, 5-12 parts of cistanche, 6-20 parts of medlar, 6-12 parts of dogwood, 1-5 parts of pilose antler and 5-10 parts of cynomorium songaricum. Said spermatogenic component is capable of promoting the production of spermatozoa in the testes of a patient; the alpha receptor blocker component can be used as an ED resisting substance to promote male erection and ejaculation of a patient; the sperm activity component is used for increasing the quality of sperms of patients, increasing the quality of the sperms in the process that the spermatogenesis promoting component promotes sperms produced by testes of the patients, providing a composition for the sperms to produce sperms for the testes, and promoting the testes to produce the sperms in large quantities. The dodder, the cistanche, the medlar, the dogwood, the pilose antler and the cynomorium songaricum have the functions of tonifying liver and kidney, securing essence and reducing urination, impotence caused by deficiency of essence and blood, tonifying kidney yang and benefiting essence and blood, and the dodder, the cistanche, the medlar, the dogwood, the pilose antler and the cynomorium songaricum are matched with the spermatogenesis promoting component, the alpha receptor blocker component and the sperm activity component, so that the treatment effect on male oligospermia can be improved, and side effects can be reduced. The oligospermia symptoms of oligospermia patients caused by various reasons generally show that the spermatogenic function is low and the spermogenic ability of the testis is reduced. The spermatogenic component, the alpha receptor blocker component and the sperm active component are compatible, the spermatogenic component can improve the effect of testosterone, and the mechanism for promoting spermatogenesis is adjusted through the hypothalamus pituitary gonadal axis, so that the capability of sperms generated by testis is promoted. The alpha receptor blocker component is an alpha adrenergic receptor blocker, can selectively block alpha 2 adrenergic receptors before synapse of ganglia, can protect blood vessel smooth muscle, can increase peripheral parasympathetic nerve tension, can reduce sympathetic nerve tension, can expand pulsation of penis, and can increase blood flow of cavernous sinus of penis to make penis fully erect; meanwhile, alkaloid substances in the alpha receptor blocker have beneficial effects on erectile function through central action, and free 3-methoxy-4-hydroxy-phenylethanediol in plasma is increased by blocking increased secretion of alpha 2 adrenaline and cell excitation in noradrenergic nucleus, so that central sensory nerves are excited and stimulated, the sexual desire is increased, and the excitability of sterile men is improved through the alpha receptor blocker. The compatibility of the alpha receptor blocker and the spermatogenesis promoting component can improve the treatment effect. The sperm active component contains a large amount of vitamins and protein substances, is easy to be absorbed by a human body, and the vitamins and the protein substances can promote the spermatogenesis of the testis, provide a base substance for sperm synthesis, improve the spermatogenic function of the testis and improve the quality of produced sperms. The sperm active component is matched with the spermatogenesis promoting component and the alpha receptor blocker component, so that the treatment effect on male infertility can be greatly improved.

Therefore, the traditional Chinese medicine composition for treating male infertility has excellent treatment effect on infertility caused by male oligospermia and asthenospermia and has little side effect.

The invention also provides a preparation process of the traditional Chinese medicine composition for treating male infertility, which comprises the following steps: weighing the spermatogenesis promoting component and the alpha receptor retarder component according to the weight part, crushing into coarse powder, adding an ethanol solution according to 4-9 times of the total weight of the coarse powder, performing reflux extraction for three times, filtering the extracted ethanol solution, recovering ethanol from filtrate, cooling, filtering, washing, and drying to obtain an extract; pulverizing the rest components to obtain powder, and mixing the powder uniformly to obtain a mixture; adding water into the obtained mixture, extracting at high temperature and high pressure to obtain an extracting solution, concentrating the extracting solution under reduced pressure to 15% of the original volume, and filtering by a 400-mesh sieve to obtain a mixed solution; adding honey into the mixed solution according to the parts by weight; concentrating the mixed solution under reduced pressure, and spray drying to obtain powder; weighing Chinese yam according to parts by weight, cooking the Chinese yam, mixing the powder, the extract and the cooked Chinese yam, adding water and stirring to form turbid liquid, weighing the forming agent according to parts by weight, adding the forming agent into the turbid liquid, and heating and stirring until the turbid liquid is formed into paste. The process effectively extracts effective substances in the spermatogenesis promoting component and the alpha receptor blocker component by an ethanol extraction method, simultaneously extracts the effective substances of the other components by high temperature and high pressure, and forms paste bodies by Chinese yam and a forming agent, so that patients can use the paste bodies conveniently. The method extracts effective substances of the components of the Chinese medicinal composition for treating male infertility, retains the effective components, and improves treatment effect.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.

It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present invention will be described in detail below with reference to specific examples.

The invention provides a traditional Chinese medicine composition for treating male infertility, which comprises the following raw materials in parts by weight: 12-24 parts of spermatogenesis promoting component, 5-16 parts of alpha receptor retarder component, 10-20 parts of sperm active component, 6-12 parts of semen cuscutae, 5-12 parts of cistanche, 6-20 parts of medlar, 6-12 parts of dogwood, 1-5 parts of pilose antler and 5-10 parts of cynomorium songaricum.

Said spermatogenic component is capable of promoting the production of spermatozoa in the testes of a patient; the alpha receptor blocker component can be used as an ED resisting substance to promote male erection and ejaculation of a patient; the sperm activity component is used for increasing the quality of sperms of patients, increasing the quality of the sperms in the process that the spermatogenesis promoting component promotes sperms produced by testes of the patients, providing a composition for the sperms to produce sperms for the testes, and promoting the testes to produce the sperms in large quantities.

The dodder, the cistanche, the medlar, the dogwood, the pilose antler and the cynomorium songaricum have the functions of tonifying liver and kidney, securing essence and reducing urination, impotence caused by deficiency of essence and blood, tonifying kidney yang and benefiting essence and blood, and the dodder, the cistanche, the medlar, the dogwood, the pilose antler and the cynomorium songaricum are matched with the spermatogenesis promoting component, the alpha receptor blocker component and the sperm activity component, so that the treatment effect on male oligospermia can be improved, and side effects can be reduced.

The herba cistanches has the effects of invigorating kidney yang; replenishing essence and blood; moistening intestinal tract. Deficiency of both the major and kidney yang; impotence due to deficiency of essence and blood; and (5) spermatorrhea. The cistanche salsa contains the following components: cistanche deserticola essence, 8-epiloganic acid, 6-deoxycatalpol, Mussaenosidic acid, geniposide, leonurine, 8-epideoxymahonia acid, Gluroside, Bartsioside, terpene ether terpene, liriodenine, (+) -syringaresinol-Q-beta-D glucoside, lignan essence, cistanoside A, B, C, D, E, F, Acteoside, Echinacoside, 2' -Acetyl-acetate Ormanthoduride B. Also contains mannitol, sitosterol, succinic acid, sitosterol-beta-D-glucoside. Wherein, the cistanche salsa has the function of adjusting the decrease and increase of the content of the nucleic acid in the liver and spleen of the animals with yang deficiency and yin deficiency; has the effects of activating adrenal gland and releasing corticoids. The mechanism of action may be to enhance the hypothalamic-pituitary-ovarian luteinizing function not because they directly stimulate the secretion of pituitary luteinizing hormone, but rather to increase the reactivity of the pituitary to LRH and the reactivity of the ovary to LH. The main significance of tonifying the kidney by the traditional Chinese medicine is to improve the regulation mechanism in the organism and play an active treatment role by the restoration of the intrinsic function of the organism. Through research on the effect of cistanche on the DNA synthesis rate of 'yang deficiency' animals, the research discovers that the DNA synthesis rate is reduced due to the fact that hydroxyurea inhibits the reduction reaction of nucleotide at the diphosphorylation level, and 'yang deficiency' is caused by disturbance of protein and energy metabolism; the cistanche deserticola probably contains a bioactive factor for activating nucleotide reductase, so that the DNA synthesis rate of the animal with yang deficiency can be obviously improved, and the RNA synthesis is promoted; increasing the nucleic acid metabolism of the protein. Thus, cistanche deserticola has the effect of promoting sexual function.

The medlar has the main functions of nourishing kidney, moistening lung, tonifying liver and improving eyesight. It is indicated for liver and kidney yin deficiency, soreness and weakness of waist and knees, dizziness, blurred vision, hyperdacryosis, cough due to asthenia, diabetes, and spermatorrhea. The fructus Lycii has high content of total flavonoids, and has the same effect as semen Cuscutae.

The Corni fructus has effects of nourishing liver and kidney, astringing essence, and consolidating deficiency, and can be used for treating sexual impotence and spermatorrhea.

The oligospermia symptoms of oligospermia patients caused by various reasons generally show that the spermatogenic function is low and the spermogenic ability of the testis is reduced. The spermatogenic component, the alpha receptor blocker component and the sperm active component are compatible, the spermatogenic component can improve the effect of testosterone, and the mechanism for promoting spermatogenesis is adjusted through the hypothalamus pituitary gonadal axis, so that the capability of sperms generated by testis is promoted. The alpha receptor blocker component is an alpha adrenergic receptor blocker, and can selectively block alpha 2 adrenergic receptor before synapse of ganglia, protect blood vessel smooth muscle, increase peripheral parasympathetic nerve tension, and reduce sympathetic nerve tension, thereby expanding pulsation of penis, increasing blood flow of cavernous sinus of penis, and making penis fully erect.

Meanwhile, alkaloid substances in the alpha receptor blocker have beneficial effects on erectile function through central action, and free 3-methoxy-4-hydroxy-phenylethanediol in plasma is increased by blocking increased secretion of alpha 2 adrenaline and cell excitation in noradrenergic nucleus, so that central sensory nerves are excited and stimulated, the sexual desire is increased, and the excitability of sterile men is improved through the alpha receptor blocker. The compatibility of the alpha receptor blocker and the spermatogenesis promoting component can improve the treatment effect.

The sperm active component contains a large amount of vitamins and protein substances, is easy to be absorbed by a human body, and the vitamins and the protein substances can promote the spermatogenesis of the testis, provide a base substance for sperm synthesis, improve the spermatogenic function of the testis and improve the quality of produced sperms. The sperm active component is matched with the spermatogenesis promoting component and the alpha receptor blocker component, so that the treatment effect on male infertility can be greatly improved.

The dodder is a good medicine for tonifying kidney, liver and spleen, and is mainly clinically applied to kidney yin-yang deficiency syndromes such as lumbago due to kidney deficiency, impotence, spermatorrhea, frequent micturition, infertility due to cold womb, dark eyes and loose stool. The semen Cuscutae mainly contains flavonoids, phenolic acids, sterols, polysaccharides, alkaloids, microelements and amino acids. Semen Cuscutae total flavonoids have various effects on endocrine function of hypothalamus-pituitary-gonad axis, and can protect male sperm, inhibit division and proliferation of cancer cell in vitro, reduce blood sugar and blood lipid, and prevent and treat osteoporosis. Therefore, the flavonoid component in the dodder can play a role in treating impotence and spermatorrhea

Wherein the spermatogenesis promoting component comprises the following raw materials in parts by weight: 1-5 parts of Eurycoma longifolia, 1-2 parts of maca and 10-15 parts of herba epimedii. The Eurycoma longifolia contains alkaloid components, and the alkaloid components which are separated and identified from the Eurycoma longifolia currently comprise: 9, 10-dimethoxy-Canadian aster ketone, 10-hydroxy-9-methoxy-Canadian aster ketone, 11-hydroxy-10-methoxy-Canadian aster ketone, 5, 9-dimethoxy-Canadian aster ketone, 9-methoxy-3-methylcar-oline-5, 6-diketone and B-carboline alkaloid, etc., wherein the alkaloid components are mainly Canadian aster ketone structures from the chemical structure viewpoint. Eurycoma longifolia has the effects of inducing libido and improving libido; meanwhile, the Eurycoma longifolia can reduce the release of basic testosterone, but can induce the male interstitial cells to secrete the testosterone to be increased by the human chorionic gonadotropin, can promote the generation of sperms, improve the level of serum testosterone, and have the obvious effect of increasing the number, kinetic energy and activity of sperms synthesized by the testes. In addition, the active ingredient eurycomanone in the eurycomane roots is extracted, the testosterone activity of the eurycomanone is promoted, the eurycomanone can be converted into estradiol by inhibiting aromatase in leydig cells, so that the generation of testosterone steroid is promoted, and the male infertility caused by congenital testosterone deficiency can be treated.

The maca has the effects of enhancing physical strength, improving sexual function, resisting fatigue, resisting aging, enhancing immunity, regulating endocrine, relieving joint and neuropathic pain and the like. In the maca: the protein content is more than 10%, and at the same time, the protein also contains 59% of carbohydrate; 8.5% of fiber, it also contains abundant mineral substances such as zinc, calcium, iron, titanium, rubidium, potassium, sodium, copper, manganese, magnesium, strontium, phosphorus, iodine, etc., and contains vitamins C, B1, B2, B6, A, E, B12, B5, the fat content is not high but mostly unsaturated fatty acid, the content of linoleic acid and linolenic acid is more than 53%, the natural active ingredients include alkaloid, glucosinolate and its decomposition product benzyl isothiocyanate, sterol, polyphenol, etc. The maca contains two new plant active ingredients and several special maca alkaloids, wherein the two new plant active ingredients are maca amide and maca diluent, and the two substances have obvious effects on balancing the secretion of hormones in a human body, so the maca is also called as natural hormone starting. The maca not only can play a role in enhancing male sexual function, but also can play a role in increasing male sexual behavior, increasing the number of sperms, increasing physical strength, eliminating anxiety, effectively improving sexual performance, and avoiding the problem of decreased sexual performance caused by long-term administration of the cabond bark. The composition is compatible with the carbidopa bark in the following alpha receptor blocker, and can effectively eliminate side effects of palpitation and restlessness caused by the carbidopa bark. Meanwhile, the compatibility of maca and Eurycoma longifolia can greatly enhance the quantity and quality of sperms produced by the testis.

The Xianling spleen is pungent, sweet and warm in flavor and can move along the liver and kidney meridians. It is a key herb for tonifying the vital gate, replenishing essence and qi, strengthening tendons and bones, tonifying kidney and strengthening yang, and is clinically used for treating impotence, spermatorrhea and premature ejaculation in men. The herba Epimedii comprises flavone, lignanoid, phenol glycoside, alkaloid, polysaccharide, volatile oil, etc. Wherein the flavone is the main component, icariin is the key component of herba Epimedii for invigorating kidney and tonifying yang, and icariin can be used for treating erectile dysfunction. Icariin can act on hypothalamus-pituitary-gonad axis system, improve the expression of dopamine receptor in hypothalamus, and promote the pituitary to release gonadotropin, thereby improving the concentration of serum testosterone and improving male reproductive function. The mechanism of promoting spermatogenesis by the extract rich in the lignin in the eurycoma longifolia is also regulated by the hypothalamus-pituitary-gonad axis, and the effect of treating male infertility can be further improved by matching the extract with the epimedium herb.

Wherein, the alpha receptor retarder comprises the following raw materials in parts by weight: 1-2 parts of carbendazim bark and 5-10 parts of nasturtium. The cabarba bark mainly comprises the following components: corynanthine (I), corynanthine (II), amacrine (III), yohimbine (IV), corynanthine (V), beta-yohimbine (VI), alpha-yohimbine (VII), ursolic acid (IX) and the like. The corynanthine (I), corynanthine (II), amacrine (III), yohimbine (IV), corynanthine (V), beta-yohimbine (VI), alpha-yohimbine (VII) and ursolic acid (IX) all have the function of promoting male sexual function. The yohimbine in the carbine tree bark is used as an alpha adrenergic receptor blocker, can selectively block alpha 2 adrenergic receptors before synapse of ganglia, can protect vascular smooth muscle, can increase peripheral parasympathetic nerve tension, can reduce sympathetic nerve tension, can expand the pulsation of penis, and can increase blood flow of cavernous sinus of penis to make the penis fully erect; meanwhile, alkaloid substances in the bark of the carbindas have beneficial effects on the erectile function through central action, and free 3-methoxy-4-hydroxy-phenylethanediol in plasma is increased by blocking the increase of alpha 2 adrenergic secretion and the cell excitation in a noradrenergic nucleus, so that central sensory nerves are stimulated, and the sexual desire is increased.

The above-mentioned nasturtium also effectively prevents the decrease in the effect of hormone caused by alpha-adrenaline, thereby causing vasoconstriction in penile tissue and expanding the production of noradrenaline. Meanwhile, the male rhizomes contain a special procyanidin named procyanidin B-3, which has the effects of anti-inflammation and antioxidation. More importantly, it has the efficacy of correcting erectile dysfunction and infertility. The male rhizomes also contain a special procyanidin named procyanidin B-3, which has anti-inflammatory and antioxidant effects. More importantly, it has the efficacy of correcting erectile dysfunction and infertility. The male rhizomes have obvious stimulation effect on the smooth muscle of the penis, and the congestion can be generated by proper dosage. Meanwhile, the male rhizomes also have the function of blocking alpha-adrenergic receptors to reduce the congestion of penile tissues, so that the noradrenaline is increased, and the erection is easier and more durable. The inherent proanthocyanidin is a powerful antioxidant and can well keep physical strength. In addition, the male rhizomes also have strong function of enhancing testosterone secretion.

Wherein the sperm active component comprises the following raw materials in parts by weight: 10-20 parts of lithocarpus crassipes. The lithocarpus crassifolius is rich in vitamin A, vitamin B, vitamin C, calcium, ferrum, potassium, zinc and other trace elements. The protein content of the protein-containing rice milk is up to 15-26%, the carbohydrate content is 6.4%, the fat content is 2%, and the cellulose content is 1%. Sperm are produced in testis, but other organs also have promoting effects, and the vitamins have effects of providing raw materials for sperm, promoting sperm production, and keeping sexual organs from being damaged. Wherein vitamin E has the most close relationship with reproductive system, and has effects of preventing sexual organ aging, regenerating empty seminiferous tubule, and enhancing sperm motility. Meanwhile, human testis, prostate and semen contain zinc with high concentration, and the long-term intake of zinc is insufficient, which can cause sperm rarity and testis atrophy. Therefore, the mineral trace elements, especially calcium, iron, potassium and zinc elements have good effect of improving the production quality of sperms. The protein, fat and the like can be absorbed by human bodies, so that the protein, the fat and the like can be supplemented for sterile men, and the high-quality protein raw material is provided for forming semen.

Wherein the traditional Chinese medicine composition for treating male infertility also comprises 40-50 parts of Chinese yam, 9-15 parts of rhizoma polygonati and 50-60 parts of honey. The yam is the dried rhizome of the dioscorea opposita of the dioscoreaceae family, is one of the traditional medicine and food homologous foods, and has better medicinal health-care efficacy and glutinous and delicious flavor and quality. The Chinese yam has the effects of tonifying spleen and nourishing stomach, promoting the production of body fluid and benefiting lung, and tonifying kidney and arresting seminal emission, so the Chinese yam can play a certain role in improving male performance. Meanwhile, the traditional Chinese medicine composition has the effects of tonifying spleen and nourishing stomach, and can counteract the damage to the stomach caused by other components by being matched with other components in the traditional Chinese medicine composition. The yam has good mouthfeel and sweet taste, can effectively improve the uncomfortable mouthfeel of the components, and is easier to accept by patients. The sealwort is sweet and tasty in nature and is also a main material of a plurality of traditional Chinese medicine formulas. Rhizoma Polygonati can be used for treating weakness of spleen and stomach, asthenia, xerostomia, dry cough, essence and blood deficiency, internal heat, and diabetes. Therefore, the sealwort can further offset the damage to the stomach caused by other components. The honey is used for further improving the taste and improving the taste quality, and in addition, the sealwort is matched with the ginseng, the medlar, the herba epimedii, the semen cuscutae and the cistanche, has the effects of tonifying middle-jiao and Qi, is used as a stasis removing medicine, is mainly used for treating deficiency of both qi and yin and deficiency of heart and kidney, can be used for treating male kidney deficiency and sperm deficiency with damp-heat type asthenospermia and oligospermia, and further improves the treatment effect on male infertility.

Wherein, after the rest components are crushed to obtain powder, the powder needs to pass through a screen mesh which is 40-80 meshes before being uniformly mixed. The powder can be screened to obtain finer particles, which facilitates the extraction in the following extraction steps. Meanwhile, the larger particles which are not sieved can be continuously used for being sieved after being crushed by crushing equipment.

Wherein the reflux time of the reflux extraction is 2-5 h. The reflux extraction time is controlled to be 2-5 h, so that the extraction effect of effective substances can be effectively enhanced.

Wherein the volume concentration of the ethanol solution is 40-95%. The volume concentration of the ethanol solution is controlled to be between 40% and 95%, so that the extraction effect of effective substances can be improved.

Wherein, the forming agent comprises the following components in percentage by weight: 40% of starch, 10% of pectin, 8% of agar and 2% of alginic acid, and the balance of water. The forming agent is used for forming the turbid liquid, and the turbid liquid can be formed into a paste body through the forming agent for convenient use.

The features and properties of the present invention are described in further detail below with reference to examples.

Example 1

The embodiment provides a traditional Chinese medicine composition for treating male infertility, which comprises the following raw materials by weight: 1g of eurycoma longifolia, 1g of maca, 10g of herba epimedii, 1g of carbine bark, 5g of male rhizomes, 10g of lithocarpus pachychizus, 6g of semen cuscutae, 5g of cistanche, 6g of medlar, 6g of dogwood, 1g of cornu cervi pantotrichum, 5g of cynomorium songaricum, 40g of Chinese yam, 9g of rhizoma polygonati and 50g of honey.

In the embodiment, the preparation process of the traditional Chinese medicine composition for treating male infertility comprises the following steps:

weighing Eurycoma longifolia, maca, herba epimedii, cabond bark and male root fruits according to parts by weight, crushing into coarse powder, adding 40% ethanol solution according to 4 times of the total weight of the coarse powder, performing reflux extraction for three times for 2 hours, filtering the extracted ethanol solution, recovering ethanol from filtrate, cooling, filtering, washing and drying to obtain extract;

pulverizing the rest components to obtain powder, sieving with a 40-mesh sieve, and mixing the sieved powder to obtain mixture; adding water into the obtained mixture, extracting at high temperature and high pressure to obtain an extracting solution, concentrating the extracting solution under reduced pressure to 15% of the original volume, and filtering by a 400-mesh sieve to obtain a mixed solution; adding honey into the mixed solution according to the parts by weight; concentrating the mixed solution under reduced pressure, and spray drying to obtain powder;

Example 2

A traditional Chinese medicine composition for treating male infertility comprises the following raw materials by weight: 1.4g of Eurycoma longifolia Jack, 1.1g of maca, 10.5g of herba epimedii, 1.1g of caboda bark, 5.5g of male rhizomes, 11g of lithocarpus pachyrhizus, 6.6g of semen cuscutae, 5.7g of cistanche, 7.4g of medlar, 6.6g of dogwood, 1.4g of pilose antler, 5.5g of cynomorium songaricum, 41g of Chinese yam, 9.6g of rhizoma polygonati and 51g of honey.

weighing Eurycoma longifolia, maca, herba epimedii, cabond bark and male root fruits according to parts by weight, crushing into coarse powder, adding a 45% ethanol solution according to 4.5 times of the total weight of the coarse powder, performing reflux extraction for three times, wherein the reflux time is 2.3 hours, filtering the extracted ethanol solution, recovering ethanol from filtrate, cooling, filtering, washing and drying to obtain an extract;

pulverizing the rest components to obtain powder, sieving with 44 mesh sieve, and mixing the sieved powder to obtain mixture; adding water into the obtained mixture, extracting at high temperature and high pressure to obtain an extracting solution, concentrating the extracting solution under reduced pressure to 15% of the original volume, and filtering by a 400-mesh sieve to obtain a mixed solution; adding honey into the mixed solution according to the parts by weight; concentrating the mixed solution under reduced pressure, and spray drying to obtain powder;

Example 3

A traditional Chinese medicine composition for treating male infertility comprises the following raw materials by weight: 1.8g of Eurycoma longifolia Jack, 1.2g of maca, 11g of herba epimedii, 1.2g of caboda bark, 6g of male rhizomes, 12g of lithocarpus crassipes, 7.2g of semen cuscutae, 6.4g of cistanche, 8.8g of medlar, 7.2g of dogwood, 1.8g of pilose antler, 6g of cynomorium songaricum, 42g of Chinese yam, 10.2g of rhizoma polygonati and 52g of honey.

weighing Eurycoma longifolia, maca, herba epimedii, cabond bark and male root fruits according to parts by weight, crushing into coarse powder, adding 50% ethanol solution according to 5 times of the total weight of the coarse powder, performing reflux extraction for three times for 2.6 hours, filtering the extracted ethanol solution, recovering ethanol from filtrate, cooling, filtering, washing and drying to obtain extract;

pulverizing the rest components to obtain powder, sieving with 48 mesh sieve, and mixing the sieved powder to obtain mixture; adding water into the obtained mixture, extracting at high temperature and high pressure to obtain an extracting solution, concentrating the extracting solution under reduced pressure to 15% of the original volume, and filtering by a 400-mesh sieve to obtain a mixed solution; adding honey into the mixed solution according to the parts by weight; concentrating the mixed solution under reduced pressure, and spray drying to obtain powder;

Example 4

A traditional Chinese medicine composition for treating male infertility comprises the following raw materials by weight: 2.2g of Eurycoma longifolia Jack, 1.3g of maca, 11.5g of herba epimedii, 1.3g of caboda bark, 6.5g of male rhizomes, 13g of lithocarpus pachyrhizus, 7.8g of semen cuscutae, 7.1g of cistanche, 10.2g of medlar, 7.8g of dogwood, 2.2g of pilose antler, 6.5g of cynomorium songaricum, 43g of Chinese yam, 10.8g of rhizoma polygonati and 53g of honey.

weighing Eurycoma longifolia, maca, herba epimedii, cabond bark and male root fruits according to parts by weight, crushing into coarse powder, adding 55% ethanol solution according to 5.5 times of the total weight of the coarse powder, performing reflux extraction for three times, performing reflux time for 2.9 hours, filtering the extracted ethanol solution, recovering ethanol from filtrate, cooling, filtering, washing and drying to obtain an extract;

pulverizing the rest components to obtain powder, sieving with a sieve of 52 meshes, and mixing the sieved powder to obtain a mixture; adding water into the obtained mixture, extracting at high temperature and high pressure to obtain an extracting solution, concentrating the extracting solution under reduced pressure to 15% of the original volume, and filtering by a 400-mesh sieve to obtain a mixed solution; adding honey into the mixed solution according to the parts by weight; concentrating the mixed solution under reduced pressure, and spray drying to obtain powder;

Example 5

A traditional Chinese medicine composition for treating male infertility comprises the following raw materials by weight: 2.6g of Eurycoma longifolia Jack, 1.4g of maca, 12g of herba epimedii, 1.4g of caboda bark, 7g of male root and fruit, 14g of lithocarpus crassipes, 8.4g of semen cuscutae, 7.8g of cistanche, 11.6g of medlar, 8.4g of dogwood, 2.6g of pilose antler, 7g of cynomorium songaricum, 44g of Chinese yam, 11.4g of rhizoma polygonati and 54g of honey.

weighing Eurycoma longifolia, maca, herba epimedii, cabond bark and male root fruits according to parts by weight, crushing into coarse powder, adding 60% ethanol solution according to 6 times of the total weight of the coarse powder, performing reflux extraction for three times for 3.2 hours, filtering the extracted ethanol solution, recovering ethanol from filtrate, cooling, filtering, washing and drying to obtain extract;

pulverizing the rest components to obtain powder, sieving with a 56-mesh sieve, and mixing the sieved powder to obtain mixture; adding water into the obtained mixture, extracting at high temperature and high pressure to obtain an extracting solution, concentrating the extracting solution under reduced pressure to 15% of the original volume, and filtering by a 400-mesh sieve to obtain a mixed solution; adding honey into the mixed solution according to the parts by weight; concentrating the mixed solution under reduced pressure, and spray drying to obtain powder;

Example 6

A traditional Chinese medicine composition for treating male infertility comprises the following raw materials by weight: 3g of eurycoma longifolia, 1.5g of maca, 12.5g of herba epimedii, 1.5g of cabenadine bark, 7.5g of male rhizomes, 15g of lithocarpus crassipes, 9g of semen cuscutae, 8.5g of cistanche, 13g of medlar, 9g of dogwood, 3g of pilose antler, 7.5g of cynomorium songaricum, 45g of Chinese yam, 12g of rhizoma polygonati and 55g of honey.

weighing Eurycoma longifolia, maca, herba epimedii, cabond bark and male root fruits according to parts by weight, crushing into coarse powder, adding 65% ethanol solution according to 6.5 times of the total weight of the coarse powder, performing reflux extraction for three times for 3.5 hours, filtering the extracted ethanol solution, recovering ethanol from filtrate, cooling, filtering, washing and drying to obtain extract;

pulverizing the rest components to obtain powder, sieving with a 60-mesh sieve, and mixing the sieved powder to obtain mixture; adding water into the obtained mixture, extracting at high temperature and high pressure to obtain an extracting solution, concentrating the extracting solution under reduced pressure to 15% of the original volume, and filtering by a 400-mesh sieve to obtain a mixed solution; adding honey into the mixed solution according to the parts by weight; concentrating the mixed solution under reduced pressure, and spray drying to obtain powder;

Example 7

A traditional Chinese medicine composition for treating male infertility comprises the following raw materials by weight: 3.4g of Eurycoma longifolia Jack, 1.6g of maca, 13g of herba epimedii, 1.6g of caboda bark, 8g of male root and fruit, 16g of lithocarpus crassipes, 9.6g of semen cuscutae, 9.2g of cistanche, 14.4g of medlar, 9.6g of dogwood, 3.4g of pilose antler, 8g of cynomorium songaricum, 46g of yam, 12.6g of rhizoma polygonati and 56g of honey.

weighing Eurycoma longifolia, maca, herba epimedii, cabond bark and male root fruits according to parts by weight, crushing into coarse powder, adding 65% ethanol solution according to 7 times of the total weight of the coarse powder, performing reflux extraction for three times for 3.8 hours, filtering the extracted ethanol solution, recovering ethanol from filtrate, cooling, filtering, washing and drying to obtain extract;

pulverizing the rest components to obtain powder, sieving with a 64-mesh sieve, and mixing the sieved powder to obtain a mixture; adding water into the obtained mixture, extracting at high temperature and high pressure to obtain an extracting solution, concentrating the extracting solution under reduced pressure to 15% of the original volume, and filtering by a 400-mesh sieve to obtain a mixed solution; adding honey into the mixed solution according to the parts by weight; concentrating the mixed solution under reduced pressure, and spray drying to obtain powder;

Example 8

A traditional Chinese medicine composition for treating male infertility comprises the following raw materials by weight: 3.8g of Eurycoma longifolia Jack, 1.7g of maca, 13.5g of herba epimedii, 1.7g of caboda bark, 8.5g of male rhizomes, 17g of lithocarpus pachyrhizus, 10.2g of semen cuscutae, 9.9g of cistanche, 15.8g of medlar, 10.2g of dogwood, 3.8g of pilose antler, 8.5g of cynomorium songaricum, 47g of Chinese yam, 13.2g of rhizoma polygonati and 57g of honey.

weighing Eurycoma longifolia, maca, herba epimedii, cabond bark and male root fruits according to parts by weight, crushing into coarse powder, adding 70% ethanol solution according to the weight of 7.5 times of the total weight of the coarse powder, performing reflux extraction for three times, performing reflux time for 4.2 hours, filtering the extracted ethanol solution, recovering ethanol from filtrate, cooling, filtering, washing and drying to obtain extract;

pulverizing the rest components to obtain powder, sieving with a 68-mesh sieve, and mixing the sieved powder to obtain mixture; adding water into the obtained mixture, extracting at high temperature and high pressure to obtain an extracting solution, concentrating the extracting solution under reduced pressure to 15% of the original volume, and filtering by a 400-mesh sieve to obtain a mixed solution; adding honey into the mixed solution according to the parts by weight; concentrating the mixed solution under reduced pressure, and spray drying to obtain powder;

Example 9

A traditional Chinese medicine composition for treating male infertility comprises the following raw materials by weight: 4.2g of Eurycoma longifolia Jack, 1.8g of maca, 14g of herba epimedii, 1.8g of cabenadine bark, 9g of male rhizomes, 18g of lithocarpus crassipes, 10.8g of semen cuscutae, 10.6g of cistanche, 17.2g of medlar, 10.8g of dogwood, 4.2g of pilose antler, 9g of cynomorium songaricum, 48g of Chinese yam, 13.8g of rhizoma polygonati and 58g of honey.

weighing Eurycoma longifolia, maca, herba epimedii, cabond bark and male root fruits according to parts by weight, crushing into coarse powder, adding 75% ethanol solution according to 8 times of the total weight of the coarse powder, performing reflux extraction for three times for 4.5 hours, filtering the extracted ethanol solution, recovering ethanol from filtrate, cooling, filtering, washing and drying to obtain extract;

pulverizing the rest components to obtain powder, sieving with 72 mesh sieve, and mixing the sieved powder to obtain mixture; adding water into the obtained mixture, extracting at high temperature and high pressure to obtain an extracting solution, concentrating the extracting solution under reduced pressure to 15% of the original volume, and filtering by a 400-mesh sieve to obtain a mixed solution; adding honey into the mixed solution according to the parts by weight; concentrating the mixed solution under reduced pressure, and spray drying to obtain powder;

Example 10

A traditional Chinese medicine composition for treating male infertility comprises the following raw materials by weight: 4.6g of Eurycoma longifolia Jack, 1.9g of maca, 14.5g of herba epimedii, 1.9g of caboda bark, 9.5g of male rhizomes, 19g of lithocarpus pachyrhizus, 11.4g of semen cuscutae, 11.3g of cistanche, 18.6g of medlar, 11.4g of dogwood, 4.6g of pilose antler, 9.5g of cynomorium songaricum, 49g of Chinese yam, 14.4g of rhizoma polygonati and 59g of honey.

weighing Eurycoma longifolia, maca, herba epimedii, cabond bark and male root fruits according to parts by weight, crushing into coarse powder, adding an 85% ethanol solution according to 8.5 times of the total weight of the coarse powder, performing reflux extraction for three times for 4.7 hours, filtering the extracted ethanol solution, recovering ethanol from the filtrate, cooling, filtering, washing and drying to obtain an extract;

pulverizing the rest components to obtain powder, sieving with 76 mesh sieve, and mixing the sieved powder to obtain mixture; adding water into the obtained mixture, extracting at high temperature and high pressure to obtain an extracting solution, concentrating the extracting solution under reduced pressure to 15% of the original volume, and filtering by a 400-mesh sieve to obtain a mixed solution; adding honey into the mixed solution according to the parts by weight; concentrating the mixed solution under reduced pressure, and spray drying to obtain powder;

Example 10

A traditional Chinese medicine composition for treating male infertility comprises the following raw materials by weight: 5g of eurycoma longifolia, 2g of maca, 15g of herba epimedii, 2g of carbine tree bark, 10g of male rhizomes, 20g of lithocarpus pachychizus, 12g of semen cuscutae, 12g of cistanche, 20g of medlar, 12g of dogwood, 5g of cornu cervi pantotrichum, 10g of cynomorium songaricum, 50g of Chinese yam, 15g of rhizoma polygonati and 60g of honey.

weighing Eurycoma longifolia, maca, herba epimedii, cabond bark and male root fruits according to parts by weight, crushing into coarse powder, adding 95% ethanol solution according to 9 times of the total weight of the coarse powder, performing reflux extraction for three times for 5 hours, filtering the extracted ethanol solution, recovering ethanol from filtrate, cooling, filtering, washing and drying to obtain extract;

pulverizing the rest components to obtain powder, sieving with 80 mesh sieve, and mixing the sieved powder to obtain mixture; adding water into the obtained mixture, extracting at high temperature and high pressure to obtain an extracting solution, concentrating the extracting solution under reduced pressure to 15% of the original volume, and filtering by a 400-mesh sieve to obtain a mixed solution; adding honey into the mixed solution according to the parts by weight; concentrating the mixed solution under reduced pressure, and spray drying to obtain powder;

Test example 1

240 adult male mice are selected, and each 20 adult male mice are divided into one group, and the groups are numbered from 1 to 12. The same amount of the Chinese medicinal composition for treating male infertility prepared according to the different parameters of examples 1 to 12 was fed to the male mice of groups 1 to 11 periodically daily. Finally, mice in group 12 were fed with the same amount of physiological saline as in groups 1 to 11, and were also fed regularly daily. Observing male mice fed with group 1-11 after 30 days by taking group 12 as a control group, and detecting the number of sperms of the male mice (collecting epididymis and directly observing the swimming state and counting by microscopic examination), the concentration of the sperms, the teratospermia rate, the pH value of the semen, the survival rate of the sperms and the activity of the sperms; simultaneously, detecting the testosterone level in the serum; organ indices of organs such as testis, epididymis and liver were also compared and recorded in the table.

TABLE 1 Male mouse sperm detection analysis table

TABLE 2 Male mouse serum testosterone level detection and analysis table

TABLE 3 viscera index detection and analysis table for male mice

	Liver factor (%)	Testis coefficient (%)	Epididymis coefficient (%)
				Group 1	6.73±1.46	0.93±0.11	0.13±0.03
Group 2	6.69±1.52	0.88±0.17	0.11±0.03
				Group 3	6.74±1.53	0.82±0.18	0.12±0.04
Group 4	6.71±1.51	0.87±0.15	0.12±0.04
				Group 5	6.77±1.56	0.85±0.12	0.13±0.05
Group 6	6.76±1.81	0.83±0.17	0.12±0.03
				Group 7	6.73±1.64	0.94±0.17	0.14±0.04
Group 8	6.68±1.54	0.93±0.17	0.13±0.04
				Group 9	6.72±1.73	0.88±0.16	0.13±0.03
Group 10	6.75±1.36	0.94±0.18	0.14±0.03
				Group 11	6.69±1.45	0.83±0.18	0.12±0.04
Group 12	6.72±1.56	0.53±0.17	0.08±0.03

As can be seen from the analysis of the above tables 1 to 3, the number of sperms, the concentration of sperms, the pH value of semen, the survival rate of sperms and the activity of sperms of the male mice fed with the compositions of the present examples 1 to 11 are significantly higher than those of the male mice of the group 12 of the control group, and the teratospermia rate is significantly reduced; meanwhile, the serum testosterone level of the male mice fed with the feed of the embodiment 1-11 is obviously higher than that of the male mice in the 12 th group of the control group; the organ index of organs such as testis, epididymis and liver fed to the male mice of the present examples 1-11 was significantly higher than that of the male mice of the group 12 of the control group. The characteristics show that the traditional Chinese medicine composition for treating male infertility fed in the embodiments 1-11 can obviously promote the generation of sperms in the testes of mice.

To sum up, the traditional Chinese medicine composition for treating male infertility provided by the embodiment of the invention comprises the following raw materials in parts by weight: 12-24 parts of spermatogenesis promoting component, 5-16 parts of alpha receptor retarder component, 10-20 parts of sperm active component, 6-12 parts of semen cuscutae, 5-12 parts of cistanche, 6-20 parts of medlar, 6-12 parts of dogwood, 1-5 parts of pilose antler and 5-10 parts of cynomorium songaricum. Said spermatogenic component is capable of promoting the production of spermatozoa in the testes of a patient; the alpha receptor blocker component can be used as an ED resisting substance to promote male erection and ejaculation of a patient; the sperm activity component is used for increasing the quality of sperms of patients, increasing the quality of the sperms in the process that the spermatogenesis promoting component promotes sperms produced by testes of the patients, providing a composition for the sperms to produce sperms for the testes, and promoting the testes to produce the sperms in large quantities. The dodder, the cistanche, the medlar, the dogwood, the pilose antler and the cynomorium songaricum have the functions of tonifying liver and kidney, securing essence and reducing urination, impotence caused by deficiency of essence and blood, tonifying kidney yang and benefiting essence and blood, and the dodder, the cistanche, the medlar, the dogwood, the pilose antler and the cynomorium songaricum are matched with the spermatogenesis promoting component, the alpha receptor blocker component and the sperm activity component, so that the treatment effect on male oligospermia can be improved, and side effects can be reduced. The oligospermia symptoms of oligospermia patients caused by various reasons generally show that the spermatogenic function is low and the spermogenic ability of the testis is reduced. The spermatogenic component, the alpha receptor blocker component and the sperm active component are compatible, the spermatogenic component can improve the effect of testosterone, and the mechanism for promoting spermatogenesis is adjusted through the hypothalamus pituitary gonadal axis, so that the capability of sperms generated by testis is promoted. The alpha receptor blocker component is an alpha adrenergic receptor blocker, can selectively block alpha 2 adrenergic receptors before synapse of ganglia, can protect blood vessel smooth muscle, can increase peripheral parasympathetic nerve tension, can reduce sympathetic nerve tension, can expand pulsation of penis, and can increase blood flow of cavernous sinus of penis to make penis fully erect; meanwhile, alkaloid substances in the alpha receptor blocker have beneficial effects on erectile function through central action, and free 3-methoxy-4-hydroxy-phenylethanediol in plasma is increased by blocking increased secretion of alpha 2 adrenaline and cell excitation in noradrenergic nucleus, so that central sensory nerves are excited and stimulated, the sexual desire is increased, and the excitability of sterile men is improved through the alpha receptor blocker. The compatibility of the alpha receptor blocker and the spermatogenesis promoting component can improve the treatment effect. The sperm active component contains a large amount of vitamins and protein substances, is easy to be absorbed by a human body, and the vitamins and the protein substances can promote the spermatogenesis of the testis, provide a base substance for sperm synthesis, improve the spermatogenic function of the testis and improve the quality of produced sperms. The sperm active component is matched with the spermatogenesis promoting component and the alpha receptor blocker component, so that the treatment effect on male infertility can be greatly improved. Therefore, the traditional Chinese medicine composition for treating male infertility has excellent treatment effect on infertility caused by male oligospermia and asthenospermia and has little side effect. The invention also provides a preparation process of the traditional Chinese medicine composition for treating male infertility, which comprises the following steps: weighing the spermatogenesis promoting component and the alpha receptor retarder component according to the weight part, crushing into coarse powder, adding an ethanol solution according to 4-9 times of the total weight of the coarse powder, performing reflux extraction for three times, filtering the extracted ethanol solution, recovering ethanol from filtrate, cooling, filtering, washing, and drying to obtain an extract; pulverizing the rest components to obtain powder, and mixing the powder uniformly to obtain a mixture; adding water into the obtained mixture, extracting at high temperature and high pressure to obtain an extracting solution, concentrating the extracting solution under reduced pressure to 15% of the original volume, and filtering by a 400-mesh sieve to obtain a mixed solution; adding honey into the mixed solution according to the parts by weight; concentrating the mixed solution under reduced pressure, and spray drying to obtain powder; weighing Chinese yam according to parts by weight, cooking the Chinese yam, mixing the powder, the extract and the cooked Chinese yam, adding water and stirring to form turbid liquid, weighing the forming agent according to parts by weight, adding the forming agent into the turbid liquid, and heating and stirring until the turbid liquid is formed into paste. The process effectively extracts effective substances in the spermatogenesis promoting component and the alpha receptor blocker component by an ethanol extraction method, simultaneously extracts the effective substances of the other components by high temperature and high pressure, and forms paste bodies by Chinese yam and a forming agent, so that patients can use the paste bodies conveniently. The method can extract effective components of the Chinese medicinal composition for treating male infertility, retain effective components, and improve therapeutic effect

The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Claims

1. A traditional Chinese medicine composition for treating male infertility is characterized by comprising the following raw materials in parts by weight: 12-22 parts of spermatogenesis promoting component, 6-12 parts of alpha receptor retarder component, 10-20 parts of sperm active component, 6-12 parts of semen cuscutae, 5-12 parts of cistanche, 6-20 parts of medlar, 6-12 parts of dogwood, 1-5 parts of pilose antler and 5-10 parts of cynomorium songaricum.

2. The traditional Chinese medicine composition for treating male infertility according to claim 1, wherein the spermatogenesis promoting component comprises the following raw materials in parts by weight: 1-5 parts of Eurycoma longifolia, 1-2 parts of maca and 10-15 parts of herba epimedii.

3. The traditional Chinese medicine composition for treating male infertility according to claim 1, wherein the alpha receptor blocker comprises the following raw materials in parts by weight: 1-2 parts of carbendazim bark and 5-10 parts of nasturtium.

4. The traditional Chinese medicine composition for treating male infertility according to claim 1, wherein the sperm active component comprises the following raw materials in parts by weight: 10-20 parts of lithocarpus crassipes.

5. The traditional Chinese medicine composition for treating male infertility according to claim 1, further comprising 40-50 parts of Chinese yam, 9-15 parts of rhizoma polygonati and 50-60 parts of honey.

6. A preparation process of a traditional Chinese medicine composition for treating male infertility is characterized by comprising the following steps:

weighing Chinese yam according to parts by weight, cooking the Chinese yam, mixing the powder, the extract and the cooked Chinese yam, adding water and stirring to form a suspension, weighing a forming agent according to parts by weight, adding the forming agent into the suspension, and heating and stirring until the suspension is formed into an ointment.

7. The manufacturing process of claim 6, wherein after the rest of the components are pulverized to obtain powder, the powder needs to pass through a screen mesh which is 40-80 meshes before the powder is uniformly mixed.

8. The manufacturing process of claim 6, wherein the reflux time of the reflux extraction is 2-5 h.

9. The process according to claim 6, wherein the volume concentration of the ethanol solution is 40-95%.

10. The manufacturing process of claim 6, wherein the forming agent comprises the following components in percentage by weight: starch, pectin, agar and alginic acid, and the balance of water.