CN113599420A - Medicine composition for deep cleaning of uterus and preparation method and application thereof - Google Patents
Medicine composition for deep cleaning of uterus and preparation method and application thereof Download PDFInfo
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
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- A61K2236/30—Extraction of the material
- A61K2236/35—Extraction with lipophilic solvents, e.g. Hexane or petrol ether
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
The invention provides a medicinal composition for deep cleaning of uterus, belonging to the technical field of traditional Chinese medicines, and the medicinal composition comprises the following raw materials in parts by weight: 1 to 5 parts of peach kernel, 0.3 to 0.8 part of leech, 0.5 to 1.5 parts of litsea cubeba, O30.01 to 0.04 portion of oil, the invention is prepared by mixing the traditional Chinese medicine and O3Oil composition, O3Decomposed O ions have strong penetrability, promote the penetration of traditional Chinese medicines, play the roles of activating blood circulation, removing blood stasis, sterilizing and diminishing inflammation, and have quick response and deep uterusThe cleaning efficiency is high, and the effects of maintaining beauty and keeping young and improving pregnancy rate are achieved. Compared with the traditional medicine, the total effective rate of deeply cleaning the uterus of the medicine composition is 97%, and the total effective rate of cleaning the uterus of the traditional medicine is 36%. The pharmaceutical composition provided by the invention has the advantages that the effect of cleaning the uterus is obviously improved, and the pharmaceutical composition has the effect of deeply cleaning the uterus.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a composition for deeply cleaning a uterine and a preparation method and application thereof.
Background
Gynecological diseases are one of four major subjects of clinical medicine, and are common diseases and frequently encountered diseases of women, such as menstrual blood and endometrium which are not completely discharged during menstrual period, postpartum lochiorrhea, blood stasis remained after parturition and the like, a large amount of germs are bred if the gynecological diseases are remained in uterine cavities for a long time, and thrombus blood crust blood stasis formed by the blood stasis blocks uterine blood vessels, so that female endometrium inflammation polyp, pelvic inflammation, unclean menstruation dragging, menstrual blood blackening, insufficient menstruation amount even amenorrhea, salpingemphraxis, uterine cavity adhesion infertility, uterine nodule tumor, skin yellow and long spots and other diseases are easily caused. Meanwhile, the old women are difficult to be pregnant due to fallopian tube blockage, intrauterine adhesion and poor uterine environment, and are easy to face risks of abortion, premature delivery and high fetal teratogenesis rate even after pregnancy. However, due to the lack of due knowledge and health care of the body of many people on gynecological diseases, the gynecological diseases are entangled and not cured for a long time, and great troubles are brought to normal life and work.
At present, conventional methods for cleaning the uterus comprise western medicine treatment, traditional Chinese medicine treatment, uterine curettage and the like, although a certain effect is achieved by adopting broad-spectrum antibiotics, germs are not thoroughly cleaned by the antibiotics, and mycoplasma, chlamydia and the like are infected by overuse of the antibiotics, so that the recurrence rate is high and the treatment difficulty is increased. The traditional Chinese medicine has low cure rate and unsatisfactory whole effect. When carrying out the curettage treatment for patient clinically, the apparatus of use need reciprocal business turn over patient's uterus, increases the infection risk, and medical personnel operate the degree of difficulty big, inefficiency, aggravates patient's misery simultaneously, consequently, it is the problem that current medical research and clinical needs to be solved to look for novel drug therapy method and carry out degree of depth clearance to the uterus.
Disclosure of Invention
The invention aims to provide a medicinal composition for deep cleaning of uterine cavity.
In order to achieve the above object, the present invention provides the following technical solutions:
the invention provides a medicinal composition for deep cleaning of uterus, which comprises the following raw materials in parts by weight:
1 to 5 parts of peach kernel, 0.3 to 0.8 part of leech, 0.5 to 1.5 parts of litsea cubeba, O30.01-0.04 part of oil.
Preferably, the pharmaceutical composition comprises the following raw materials in parts by weight:
2 to 4 parts of peach kernel, 0.4 to 0.6 part of leech, 0.8 to 1.2 parts of litsea cubeba, O30.02-0.03 part of oil.
The invention also provides a preparation method of the pharmaceutical composition, which comprises the following steps:
(1) soaking semen Persicae, Hirudo and fructus Litseae in oil, and filtering to obtain soaking solution;
(2) mixing the soaking solution with the O3Mixing the oils to obtain the medicinal composition.
Preferably, the peach kernels, the leeches and the litsea cubeba are crushed before being soaked, and the crushed particle size is 150-200 meshes.
Preferably, the volume ratio of the total mass of the peach kernels, the leeches and the litsea cubeba to the oil is (1.8-7.3): 10.
Preferably, the grease is olive oil.
Preferably, the soaking time is 12-36 hours; the soaking temperature is 12-30 ℃; the soaking times are 2-4 times.
The invention also provides application of the pharmaceutical composition or the pharmaceutical composition obtained by the preparation method in preparation of a medicine for deep cleaning of uterus.
Compared with the prior art, the invention has the beneficial effects that:
(1) the medicine composition of the present invention is prepared with Chinese medicine and O3Oil composition, O3The decomposed O ions have strong penetrability, promote the penetration of the traditional Chinese medicine, play the roles of activating blood circulation, removing blood stasis, sterilizing and diminishing inflammation, have quick response and high efficiency of deep cleaning of uterus, have the total effective rate of 97 percent, and simultaneously have the efficacies of maintaining beauty and keeping young and improving pregnancy rate.
(2) The preparation method of the pharmaceutical composition is simple and easy to operate, has low preparation cost, and is added with O3The oil promotes the penetration of the traditional Chinese medicine, and achieves the purpose of deep cleaning of the uterus.
Detailed Description
The invention provides a medicinal composition for deep cleaning of uterus, which comprises the following raw materials in parts by weight:
1 to 5 parts of peach kernel, 0.3 to 0.8 part of leech, 0.5 to 1.5 parts of litsea cubeba, O30.01-0.04 part of oil.
In the raw materials of the invention, peach kernel has the functions of activating blood circulation, removing stasis, softening hard masses, resolving masses, and softening adhesive strips, scars and calcified focuses in uterine cavity. The preferable weight part is 2 to 4 parts, and the more preferable weight part is 3 parts. The source of the peach kernel is not specially limited, and the peach kernel can be prepared by adopting a conventional commercial product.
In the raw materials, the leech has the effects of removing blood stasis and dissolving microthrombus and old blood scab on the inner wall of the uterus, the preferable weight part is 0.4-0.6 part, and the more preferable weight part is 0.5 part.
In the raw materials, the litsea cubeba can promote qi circulation, activate blood circulation, relieve pain, promote dissolved and fallen old tissues to be discharged outside the uterus and relieve discomfort of patients in the treatment process. The preferable weight part is 0.8-1.2 parts, more preferably 1 part, the source of the litsea cubeba is not particularly limited, and the litsea cubeba can be obtained by adopting a conventional commercial product.
Among the above raw materials of the present invention, O3The oil can harmonize the medicines, assist the medicines to be delivered to the focus, and can sterilize and diminish inflammation. The preferable weight part is 0.02-0.03 part, more preferably 0.02 part, and the invention is directed to O3The source of the oil is not particularly limited, and a conventional commercially available product may be used.
In the invention, peach kernel is a monarch drug; leeches are used as ministerial drugs; fructus Litseae as adjuvant drug; o is3Oil is a guiding drug. The medicines are combined, and the whole formula has the effects of promoting blood circulation, removing blood stasis, relieving pain, sterilizing and diminishing inflammation, thereby achieving the purpose of deeply cleaning the uterus.
The invention also provides a preparation method of the pharmaceutical composition, which comprises the following steps:
(1) soaking semen Persicae, Hirudo and fructus Litseae in oil, and filtering to obtain soaking solution;
(2) mixing the soaking solution with the O3Mixing the oils to obtain the medicinal composition.
In the invention, the peach kernels, the leeches and the litsea cubeba are crushed before soaking, the crushed particle size is 150-200 meshes, preferably 180-190 meshes, and more preferably 185 meshes, the release of active ingredients is accelerated after the raw materials are crushed, and the crushing step not only can reduce the consumption of the raw materials, but also can shorten the soaking time.
In the invention, the volume ratio of the total mass of the peach kernels, the leeches and the litsea cubeba to the oil is (1.8-7.3): 10, preferably (3-6): 10, more preferably 4.5: 10.
in the invention, the grease is olive oil, and the grease soaking method can promote the dissolution of the effective components of peach kernels, leeches and litsea cubeba, and improve the effects of activating blood circulation, removing blood stasis and relieving pain. The source of the olive oil is not particularly limited in the invention, and the olive oil can be obtained by adopting a conventional commercial product.
In the invention, the soaking time is 12-36 hours, preferably 20-30 hours, and more preferably 24 hours; the soaking temperature is 12-30 ℃, preferably 20-25 ℃, and more preferably 22 ℃; the soaking times are 2-4 times, preferably 3 times, so that the soaking efficiency is improved, the soaking time is shortened, the dissolution of ineffective components is reduced, and the exertion of the drug effect is ensured.
The invention also provides application of the pharmaceutical composition or the pharmaceutical composition obtained by the preparation method in preparation of a medicine for deep cleaning of uterus. In the invention, the medicament for deep cleaning of the uterus comprises the pharmaceutical composition as an active ingredient; the medicine for deeply cleaning the uterus further comprises pharmaceutically acceptable auxiliary materials.
In the present invention, the method of use of the above pharmaceutical composition: the medicine composition is directly infused into the uterine cavity once a day, 3-5 mL of the medicine composition is infused every day, and 5 days are a treatment course. The medicine composition of the present invention is directly poured into the uterine cavity, so that the medicine concentration in the uterine cavity is high, the curative effect is good, and the medicine composition can not enter a gastrointestinal system and can not be absorbed to enter a blood system, and the burden and the damage to the body are avoided.
The pharmaceutical composition provided by the invention can obviously improve menstrual function after being used for 4-6 days, has the effects of smoothing oviduct, treating cervical adhesion, endometrial polyp and endometritis, maintaining beauty and keeping young and the like after being further used, and therefore, the effect of the pharmaceutical composition in the aspect of deep cleaning of uterus is obviously improved.
The technical solution of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. It is to be understood that the described embodiments are merely exemplary of the invention, and not restrictive of the full scope of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
Respectively weighing 3g of peach kernel, 0.5g of leech and 1g of litsea cubeba, then crushing to 185 meshes, uniformly mixing with 10mL of olive oil, soaking for 24 hours at 22 ℃, soaking for 3 times, merging and filtering to obtain a soaking solution, and finally mixing the soaking solution with 0.02g of O3Mixing the oil uniformly to obtain the medicinal composition.
Example 2
Respectively weighing 1g of peach kernel, 0.3g of leech and 0.5g of litsea cubeba, then crushing to 180 meshes, uniformly mixing with 10mL of olive oil, soaking for 12 hours at the temperature of 12 ℃, merging and filtering to obtain a soaking solution after 2 times of soaking, and finally mixing the soaking solution with 0.01g of O3Mixing the oil uniformly to obtain the medicinal composition.
Example 3
Respectively weighing 5g of peach kernel, 0.8g of leech and 1.5g of litsea cubeba, then crushing to 150 meshes, uniformly mixing with 10mL of olive oil, soaking for 36 hours at the temperature of 30 ℃, soaking for 4 times, merging and filtering to obtain a soaking solution, and finally mixing the soaking solution with 0.04g of O3Mixing the oil uniformly to obtain the medicinal composition.
Example 4
General data
60 abnormal uterine bleeding patients are selected, wherein 3 cases of irregular menstruation, 5 cases of endometrial polyps, 4 cases of oviduct obstruction, 16 cases of functional bleeding, 13 cases of pelvic inflammation, 6 cases of intrauterine adhesion, 3 cases of uterine fibroids and 10 cases of endometritis, wherein 28 cases of the control group have the age of 18-55 years, the average age of 36 years, the course of disease of 3-10 years, 32 cases of the test group have the age of 20-52 years, the average age of 38 years and the course of disease of 3-12 years. The general data of two groups of patients are compared, and the difference is not statistically significant (P is more than 0.05).
Method of treatment
Control group: injecting cefoperazone sodium and sulbactam sodium into the injection by intravenous injection for 2-4 g/day; the cassia twig and poria cocos capsules are orally taken for 3 granules/time, three times a day and are used for combined treatment for 5-7 days.
Test groups: 3.5mL of the pharmaceutical composition is directly infused into the uterine cavity once a day, 5 days is a treatment course, and the treatment lasts for 5 days.
The therapeutic effect judgment standard is as follows:
and (3) healing: after treatment, the vaginal bleeding stops in 3-5 days, the menstrual cycle, menstrual flow and menstrual period are recovered to be normal (the total amount of menstrual flow is less than 80mL), the symptoms such as lower abdominal pain, fever, lumbosacral distending pain and the like disappear, general examination, gynecological examination and physical and chemical examination are normal, and the disease does not relapse within 1 month after the medicine is stopped.
The effect is shown: the vaginal bleeding stops within 5-10 days after treatment, the menstrual period returns to normal, the menstrual cycle and menstrual amount are basically normal (the menstrual amount is reduced by 1/3 or less than 100mL compared with that before treatment), the symptoms such as lower abdominal pain, fever, lumbosacral distending pain and the like disappear or are obviously relieved, and general examination, gynecological examination and physical and chemical examination are obviously improved.
The method has the following advantages: the vaginal bleeding stops after more than 10 days of treatment, the menstrual period is shortened, the menstrual cycle and the menstrual amount are improved, the lower abdominal pain, fever, lumbosacral distending pain and other symptoms are relieved, and general examination, gynecological examination and physical and chemical examination are improved.
And (4) invalidation: the vaginal bleeding does not stop after treatment, the menstrual period, the period and the menstrual amount are not changed, the symptoms such as lower abdominal pain, fever, lumbosacral distending pain and the like are not reduced or aggravated, and the general examination, the gynecological examination and the physical and chemical examination are not improved or aggravated before the treatment.
The total effective rate is (recovery + significant effect + effective)/the number of patients in the group is multiplied by 100%.
The treatment results are as follows:
the therapeutic effect of the patients in the control group and the test group is shown in table 1:
TABLE 1 treatment results of patients in control and test groups
Success case
For the adult women, the female is 41 years old, the menstrual flow is little in the last 6 years, the color is dark, and the menstrual period lasts for 2 days, and the traditional Chinese medicines, western medicines and even nutriments are taken in the menstrual period, so that the effects are not obviously improved. The medicine composition is infused for cleaning uterus in 3-month and 2-month 2020, the menstrual volume is increased after one course of treatment, the color of menstrual blood is red, and the menstrual period is also increased from 2 days to 3 days.
The Hu lady, 33 years old, had suffered from fallopian tube obstruction, had been had uterine laparoscopic surgery in 2014, had been no pregnancy, was examined again in 2019 for fallopian tube obstruction in 1 month, after adopting the pharmaceutical composition of the invention to treat 3 months, the examined fallopian tube is unobstructed again, and succeed in conception.
Bear women, 37 years old, infertility 12 years old, have not abandoned treatment all the time, the hysteroscope separates the intrauterine adhesion many times, the uterine curettage operation treats the endometrial polyp, the endometrial polyp and the intrauterine adhesion are also recurrent attacks, have not been pregnant all the time. After the medicine composition is adopted to deeply clean the uterus for 2 courses of treatment, the pregnancy is successful.
The Yang woman is 29 years old, the menstrual volume is small, the menstrual period is 8 days, the menstrual blood is black, the B-ultrasonic examination shows a strong echo light spot in the uterus, and the inflammatory calcification is diagnosed.
Zhao women, 28 years old, have suffered from the disease for 3 years, factor endometrium polyp is combined with endometritis, the menstruation is irregular, the menstrual period and the period are long, B ultrasonic examination shows that the endometrium is thickened, the long-acting contraceptive is taken once to improve, after 2 courses of treatment by adopting the pharmaceutical composition of the invention, the menstrual period and the menstrual volume are recovered to be normal. No recurrence was observed in 3 months of follow-up.
The plum female is 29 years old, and the liquid passing examination shows that the left fallopian tube is unobstructed, the right side is painful and not smooth, and the menoxenia is found, and the menstrual flow and the color of menstrual blood are improved after 1 treatment course by adopting the pharmaceutical composition.
The female aged 26 years old has uterine cavity adhesion combined polycystic ovary syndrome, has small menstrual flow, delays even does not have menstruation, and has normal menstrual cycle, increased menstrual flow and improved menstrual blood color after 1 treatment course by adopting the pharmaceutical composition.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.
Claims (8)
1. The medicine composition for deep cleaning of the uterine cavity is characterized by comprising the following raw materials in parts by weight:
1 to 5 parts of peach kernel, 0.3 to 0.8 part of leech, 0.5 to 1.5 parts of litsea cubeba, O30.01-0.04 part of oil.
2. The pharmaceutical composition of claim 1, wherein the pharmaceutical composition comprises the following raw materials in parts by weight:
2 to 4 parts of peach kernel, 0.4 to 0.6 part of leech, 0.8 to 1.2 parts of litsea cubeba, O30.02-0.03 part of oil.
3. A process for the preparation of a pharmaceutical composition according to claim 1 or 2, comprising the steps of:
(1) soaking semen Persicae, Hirudo and fructus Litseae in oil, and filtering to obtain soaking solution;
(2) mixing the soaking solution with the O3Mixing the oils to obtain the medicinal composition.
4. The preparation method according to claim 3, wherein the peach kernel, the leech and the litsea cubeba are crushed before being soaked, and the crushed particle size is 150-200 meshes.
5. The preparation method according to claim 3, wherein the volume ratio of the total mass of the peach kernel, the leech and the litsea cubeba to the oil is (1.8-7.3): 10.
6. The method according to claim 4 or 5, wherein the oil or fat is olive oil.
7. The preparation method according to claim 3, wherein the soaking time is 12 to 36 hours; the soaking temperature is 12-30 ℃; the soaking times are 2-4 times.
8. The pharmaceutical composition according to claim 1 or 2 or the pharmaceutical composition obtained by the preparation method according to any one of claims 3 to 7, for use in preparing a medicament for deep cleaning of uterus.
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Citations (1)
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CN106177452A (en) * | 2016-07-04 | 2016-12-07 | 陈永如 | Compound recipe Radix Arnebiae (Radix Lithospermi) ozone oil preparation and application |
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CN106177452A (en) * | 2016-07-04 | 2016-12-07 | 陈永如 | Compound recipe Radix Arnebiae (Radix Lithospermi) ozone oil preparation and application |
Non-Patent Citations (2)
Title |
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彭湘莲;等: "山苍子精油的提取及其抑菌研究现状", 《林产研究》 * |
王珍;等: "抵挡汤加味治疗子宫内膜异位症80例", 《广西中医药》 * |
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