CN113599352A - 一种红曲草本膏剂的制备方法及设备 - Google Patents
一种红曲草本膏剂的制备方法及设备 Download PDFInfo
- Publication number
- CN113599352A CN113599352A CN202110919659.7A CN202110919659A CN113599352A CN 113599352 A CN113599352 A CN 113599352A CN 202110919659 A CN202110919659 A CN 202110919659A CN 113599352 A CN113599352 A CN 113599352A
- Authority
- CN
- China
- Prior art keywords
- parts
- red yeast
- yeast rice
- paste
- rice
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229940026314 red yeast rice Drugs 0.000 title claims abstract description 71
- 238000002360 preparation method Methods 0.000 title claims abstract description 31
- 239000002994 raw material Substances 0.000 claims abstract description 51
- 239000003814 drug Substances 0.000 claims abstract description 46
- 241000218176 Corydalis Species 0.000 claims abstract description 19
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 19
- 241001489978 Eupolyphaga Species 0.000 claims abstract description 17
- 229920002545 silicone oil Polymers 0.000 claims abstract description 17
- 244000035851 Chrysanthemum leucanthemum Species 0.000 claims abstract description 16
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 claims abstract description 16
- 229940057059 monascus purpureus Drugs 0.000 claims abstract description 16
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims abstract description 14
- 244000020518 Carthamus tinctorius Species 0.000 claims abstract description 14
- 235000003255 Carthamus tinctorius Nutrition 0.000 claims abstract description 14
- 244000018716 Impatiens biflora Species 0.000 claims abstract description 14
- 235000015912 Impatiens biflora Nutrition 0.000 claims abstract description 14
- 235000005155 Tanacetum balsamita Nutrition 0.000 claims abstract description 14
- 235000007212 Verbena X moechina Moldenke Nutrition 0.000 claims abstract description 14
- 240000001519 Verbena officinalis Species 0.000 claims abstract description 14
- 235000001594 Verbena polystachya Kunth Nutrition 0.000 claims abstract description 14
- 235000007200 Verbena x perriana Moldenke Nutrition 0.000 claims abstract description 14
- 235000002270 Verbena x stuprosa Moldenke Nutrition 0.000 claims abstract description 14
- 229940041616 menthol Drugs 0.000 claims abstract description 14
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 66
- 239000000284 extract Substances 0.000 claims description 48
- 238000010438 heat treatment Methods 0.000 claims description 28
- 239000000463 material Substances 0.000 claims description 27
- 235000007189 Oryza longistaminata Nutrition 0.000 claims description 26
- 240000007594 Oryza sativa Species 0.000 claims description 26
- 235000007164 Oryza sativa Nutrition 0.000 claims description 26
- 238000001914 filtration Methods 0.000 claims description 25
- 238000002156 mixing Methods 0.000 claims description 22
- 239000000706 filtrate Substances 0.000 claims description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
- 238000004806 packaging method and process Methods 0.000 claims description 16
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 15
- 238000003756 stirring Methods 0.000 claims description 15
- 241000628997 Flos Species 0.000 claims description 10
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 10
- 238000010992 reflux Methods 0.000 claims description 10
- 238000007789 sealing Methods 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 8
- 238000000605 extraction Methods 0.000 claims description 6
- 241000228347 Monascus <ascomycete fungus> Species 0.000 claims description 5
- 230000001804 emulsifying effect Effects 0.000 claims description 5
- 238000001704 evaporation Methods 0.000 claims description 5
- 238000002844 melting Methods 0.000 claims description 5
- 230000008018 melting Effects 0.000 claims description 5
- 239000000843 powder Substances 0.000 claims description 5
- 238000004321 preservation Methods 0.000 claims description 5
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 5
- 238000010298 pulverizing process Methods 0.000 claims description 5
- 239000008213 purified water Substances 0.000 claims description 5
- 239000007787 solid Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 238000005303 weighing Methods 0.000 claims description 5
- 238000005485 electric heating Methods 0.000 claims description 4
- NEZONWMXZKDMKF-JTQLQIEISA-N Alkannin Chemical compound C1=CC(O)=C2C(=O)C([C@@H](O)CC=C(C)C)=CC(=O)C2=C1O NEZONWMXZKDMKF-JTQLQIEISA-N 0.000 claims description 3
- UNNKKUDWEASWDN-UHFFFAOYSA-N alkannin Natural products CC(=CCC(O)c1cc(O)c2C(=O)C=CC(=O)c2c1O)C UNNKKUDWEASWDN-UHFFFAOYSA-N 0.000 claims description 3
- 239000004229 Alkannin Substances 0.000 claims description 2
- 230000006978 adaptation Effects 0.000 claims description 2
- 235000019232 alkannin Nutrition 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 17
- 231100000331 toxic Toxicity 0.000 abstract description 8
- 230000002588 toxic effect Effects 0.000 abstract description 8
- 239000004480 active ingredient Substances 0.000 abstract description 3
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 3
- 230000003385 bacteriostatic effect Effects 0.000 abstract description 3
- 230000006378 damage Effects 0.000 abstract description 3
- 235000008216 herbs Nutrition 0.000 abstract description 3
- 231100000252 nontoxic Toxicity 0.000 abstract description 3
- 230000003000 nontoxic effect Effects 0.000 abstract description 3
- 238000004659 sterilization and disinfection Methods 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 description 14
- 230000036407 pain Effects 0.000 description 14
- 239000008280 blood Substances 0.000 description 13
- 210000004369 blood Anatomy 0.000 description 13
- 206010042674 Swelling Diseases 0.000 description 11
- 230000008961 swelling Effects 0.000 description 11
- 230000001737 promoting effect Effects 0.000 description 10
- 230000017531 blood circulation Effects 0.000 description 9
- 208000003251 Pruritus Diseases 0.000 description 8
- 229940079593 drug Drugs 0.000 description 8
- 230000007803 itching Effects 0.000 description 6
- 201000000736 Amenorrhea Diseases 0.000 description 5
- 206010001928 Amenorrhoea Diseases 0.000 description 5
- 231100000540 amenorrhea Toxicity 0.000 description 5
- 208000014674 injury Diseases 0.000 description 5
- 239000011505 plaster Substances 0.000 description 5
- 230000008736 traumatic injury Effects 0.000 description 5
- 206010000077 Abdominal mass Diseases 0.000 description 4
- 206010007247 Carbuncle Diseases 0.000 description 4
- 241000255925 Diptera Species 0.000 description 4
- 208000001848 dysentery Diseases 0.000 description 4
- 206010017553 Furuncle Diseases 0.000 description 3
- 238000009413 insulation Methods 0.000 description 3
- 239000012138 yeast extract Substances 0.000 description 3
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 2
- 208000005171 Dysmenorrhea Diseases 0.000 description 2
- 206010013935 Dysmenorrhoea Diseases 0.000 description 2
- 206010055690 Foetal death Diseases 0.000 description 2
- 244000303040 Glycyrrhiza glabra Species 0.000 description 2
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 description 2
- 206010019233 Headaches Diseases 0.000 description 2
- 206010049077 Hernia pain Diseases 0.000 description 2
- 206010020772 Hypertension Diseases 0.000 description 2
- 244000062730 Melissa officinalis Species 0.000 description 2
- 235000010654 Melissa officinalis Nutrition 0.000 description 2
- 201000009906 Meningitis Diseases 0.000 description 2
- 206010068319 Oropharyngeal pain Diseases 0.000 description 2
- 201000007100 Pharyngitis Diseases 0.000 description 2
- 241000972672 Phellodendron Species 0.000 description 2
- 208000004880 Polyuria Diseases 0.000 description 2
- 244000299790 Rheum rhabarbarum Species 0.000 description 2
- 235000009411 Rheum rhabarbarum Nutrition 0.000 description 2
- 241000246044 Sophora flavescens Species 0.000 description 2
- 230000036772 blood pressure Effects 0.000 description 2
- 208000021735 chronic enteritis Diseases 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 230000000249 desinfective effect Effects 0.000 description 2
- 230000029087 digestion Effects 0.000 description 2
- 238000007599 discharging Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000035619 diuresis Effects 0.000 description 2
- 208000010515 dystocia Diseases 0.000 description 2
- 230000004438 eyesight Effects 0.000 description 2
- 231100000869 headache Toxicity 0.000 description 2
- 208000006454 hepatitis Diseases 0.000 description 2
- 231100000283 hepatitis Toxicity 0.000 description 2
- 241000411851 herbal medicine Species 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 206010022000 influenza Diseases 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
- 239000000865 liniment Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 210000004877 mucosa Anatomy 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 201000009240 nasopharyngitis Diseases 0.000 description 2
- 231100000956 nontoxicity Toxicity 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 230000002040 relaxant effect Effects 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 210000002435 tendon Anatomy 0.000 description 2
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 1
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 241000131329 Carabidae Species 0.000 description 1
- 241000723346 Cinnamomum camphora Species 0.000 description 1
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 description 1
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 description 1
- 206010019345 Heat stroke Diseases 0.000 description 1
- 241001071917 Lithospermum Species 0.000 description 1
- 244000113306 Monascus purpureus Species 0.000 description 1
- 235000002322 Monascus purpureus Nutrition 0.000 description 1
- 239000010775 animal oil Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229960000846 camphor Drugs 0.000 description 1
- 229930008380 camphor Natural products 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 229940010454 licorice Drugs 0.000 description 1
- 235000011477 liquorice Nutrition 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000006748 scratching Methods 0.000 description 1
- 230000002393 scratching effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000010415 tropism Effects 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/04—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of ointments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/85—Verbenaceae (Verbena family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Insects & Arthropods (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Husbandry (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开了一种红曲草本膏剂的制备方法及设备,包括以下原料:红曲原料、野菊花、硅油、薄荷脑、红花、马鞭草、透骨草、元胡、土元和药物提取剂。本发明原料配方科学、合理且按合理的比例调配,使不同原料的有效成分充分融合互补,具有较高的经济效益和社会效益和推广价值,以天然草本配制而成,疗效好,以具有消肿止痒的中草药为主要有效成分,天然安全,适合各种人群使用,具有较好的抗菌、抑菌、消毒效果,且无毒性,不会对皮肤造成损伤,治疗时,涂抹适量本红曲草本膏剂于患处,一日一次或两次,1‑3天基本治愈,治愈后不易复发,无毒副作用。
Description
技术领域
本发明涉及药品生产技术领域,具体为一种红曲草本膏剂的制备方法及设备。
背景技术
膏药是中药外用的一种,由不同药物加基质调制而成,古称薄贴,用植物油或动物油加药熬成胶状物质,涂在布、纸或皮的一面,可以较长时间地贴在患处,主要用来治疗疮疖、消肿痛等。早在久远的年代,我国医学家就有言曰:"膏药能治病,无殊汤药,用之得法,其响立应。"膏药经皮肤发挥作用贴膏药疗法是中医临床常用的外治方法之一,它遵循中医辨证论治及中药的功效、主治与归经的原则,充分调动药物互相协调为用的效能,组成多味药物的复方,以发挥药物的良好效果。
现如今蚊虫叮咬皮肤后,夏季天气炎热,蚊虫肆虐,即使再小心防护,也很难避免不被叮咬,一般人被蚊子叮咬后,都会出现红肿、痒、痛等症状。叮咬后要注意避免过分挠抓,否则特别容易发生感染。通常为了止痒,大多数人会在红肿部分皮肤上涂抹花露水、风油精等。但是花露水含有酒精成分,涂抹在身上,随着酒精的挥发会带走身体的热量,产生凉爽感,但长期大量使用,会导致体表排汗功能障碍,排汗不畅,体内热量排泄不畅,容易引起中暑。花露水刺激性成分含量较高,而儿童皮肤娇嫩,如果直接涂抹在皮肤上,会给儿童皮肤带来一些刺激,引起不适。风油精的主要成分之一樟脑具有一定的毒性,孕妇和儿童都不适宜使用。
发明内容
本发明的目的在于提供一种红曲草本膏剂的制备方法及设备,以解决上述背景技术中提出的问题。
为实现上述目的,本发明提供如下技术方案:一种红曲草本膏剂的制备方法,包括以下重量份的原料:红曲原料30-50份、野菊花10-15份、硅油10-15份、薄荷脑1-3份、红花3-6份、马鞭草2-5份、透骨草3-6份、元胡2-4份、土元1-3份和药物提取剂5-10份;
所述红曲草本膏剂的制备方法包括如下步骤:
S11:按照上述重量份数称取各原料;
S12:通过红曲原料制备红曲提取物;
S13:将野菊花、硅油、薄荷脑、红花、马鞭草、透骨草、元胡、土元用粉碎机粉碎成细粉,加入药材总重量10-30倍量的纯净水放入煎煮机中煎煮2-4小时,过滤,收集滤液;再在药渣中加入药材重量8-15倍量的水煎煮1-2小时;过滤,收集滤液,将两次滤液合并,浓缩至半固态浸膏;
S14:将半固态浸膏加入至调膏机,加热至80-90℃后保温搅拌,边搅拌边缓慢加入红曲提取物和药物提取剂,熔化,待充分乳化后,继续搅拌20-50min后静置50-70min,得到红曲草本膏剂;
S15:将红曲草本膏剂加入包装机进行打包即可。
作为优选,包括以下重量份的原料:红曲原料40份、野菊花12份、硅油12份、薄荷脑2份、红花5份、马鞭草4份、透骨草5份、元胡3份、土元2份和药物提取剂8份。
作为优选,包括以下重量份的原料:红曲原料30份、野菊花10份、硅油10份、薄荷脑1份、红花3份、马鞭草2份、透骨草3份、元胡2份、土元1份和药物提取剂5份。
作为优选,包括以下重量份的原料:红曲原料50份、野菊花15份、硅油15份、薄荷脑3份、红花6份、马鞭草5份、透骨草6份、元胡4份、土元3份和药物提取剂10份。
作为优选,所述药物提取剂包括紫草素、甘草、大黄、黄柏、苦参提取液的一种或多种。
作为优选,所述红曲提取物的制备方法具体包括如下步骤:
S21:在红曲原料中,加入浓度为60-100%的乙醇,加入乙醇量为红曲原料量的4-12倍,加热回流2-5小时,滤过;滤渣加入浓度60-100%的乙醇,加入量按质量分溶剂量为红曲原料量的4-8倍,加热回流1-4小时,滤过;
S22:合并滤液,在50-90℃下浓缩成25℃温度下相对密度达1.1-1.4的浸膏;
S23:在浸膏中按红曲原料质量分加入1-4倍、浓度60-100%的乙醇,溶解,过滤,回收乙醇至稠膏,在稠膏中按红曲原料质量分加入0.5-1倍的浓度为80-95%乙醇,60-95℃蒸干,并保温1-5小时,得红曲提取物。
作为优选,所述乙醇也可以采用甲醇、丙醇或异丙醇。
另一方面,本发明还提供一种红曲草本膏剂的制备设备,用于制备上述任一所述的红曲草本膏剂,包括输料机、粉碎机、煎煮机、调膏机和包装机;
所述煎煮机包括机箱和设置于机箱内用于盛放药剂的药剂盛放网,所述机箱内底部安装有加热底座,所述加热底座内安装有电加热板,所述机箱的顶部开设有凹槽,所述药剂盛放网的顶部边缘安装有与所述凹槽截面尺寸相适配的限位环,所述药剂盛放网的顶部设置有密封盖,所述密封盖上安装有提环,所述机箱的外壁上安装有隔热手柄。
作为优选,所述限位环与密封盖的厚度之和与所述凹槽的深度相同。
与现有技术相比,本发明的有益效果是:
1、本发明的红曲草本膏剂的制备方法及设备,原料配方科学、合理且按合理的比例调配,使不同原料的有效成分充分融合互补,具有较高的经济效益和社会效益和推广价值,以天然草本配制而成,疗效好,以具有消肿止痒的中草药为主要有效成分,天然安全,适合各种人群使用,具有较好的抗菌、抑菌、消毒效果,且无毒性,不会对皮肤造成损伤,治疗时,涂抹适量本红曲草本膏剂于患处,一日一次或两次,1-3天基本治愈,治愈后不易复发,无毒副作用。
2、本发明中,添加的红曲有消食祛肿、活血通络、和胃健脾之功效,从红曲中提取红曲霉素对治疗慢性肠炎、痢疾有效。
3、本发明中,添加的野菊花味苦、辛、凉,清热解毒,疏风散热,散瘀,明目,降血压。防治流行性脑脊髓膜炎,预防流行性感冒、感冒,治疗高血压、肝炎、痢疾、痈疖疗疮都有明显效果。野菊花的浸液对杀灭孑孓及蝇蛆也非常有效。
4、本发明中,添加的薄荷脑用于皮肤或粘膜,有清凉止痒作用,疏风;清热。主风热感冒;头痛;目赤;咽喉肿痛;齿痛;皮肤瘙痒。
5、本发明中,添加的红花性辛,温;活血通经,去瘀止痛。对经闭,症瘕,难产,死胎,产后恶露不行、瘀血作痛,痈肿,跌扑损伤有特殊功效。
6、本发明中,添加的马鞭草清热解毒,活血散瘀,利水消肿。
7、本发明中,添加的透骨草性味辛、温、无毒,功用:祛风、除湿、舒筋活血、止痛。
8、本发明中,添加的元胡用于全身各部气滞血瘀之痛,痛经,经闭,症瘕,产后瘀阻,跌扑损伤,疝气作痛。
附图说明
图1为本发明红曲草本膏剂制备设备的组成图;
图2为本发明煎煮机的剖视结构示意图。
图中各标号的含义:
10、机箱;11、加热底座;12、电加热板;13、凹槽;14、出口嘴;15、隔热手柄;
20、药剂盛放网;21、限位环;22、密封盖;23、提环。
具体实施方式
下面将结合本发明实施例,对本发明实施例中的技术方案进行清楚、完整地描述,显然,所描述的实施例仅仅是本发明一部分实施例,而不是全部的实施例。基于本发明中的实施例和附图,本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例,都属于本发明保护的范围。
本发明提供以下技术方案:
实施例1
一种红曲草本膏剂的制备方法,包括以下重量份的原料:红曲原料40份、野菊花12份、硅油12份、薄荷脑2份、红花5份、马鞭草4份、透骨草5份、元胡3份、土元2份和药物提取剂8份。
本实施例中,红曲草本膏剂的制备方法包括如下步骤:
S11:按照上述重量份数称取各原料;
S12:通过红曲原料制备红曲提取物;
S13:将野菊花、硅油、薄荷脑、红花、马鞭草、透骨草、元胡、土元用粉碎机粉碎成细粉,加入药材总重量20倍量的纯净水放入煎煮机中煎煮3小时,过滤,收集滤液;再在药渣中加入药材重量10倍量的水煎煮1.5小时;过滤,收集滤液,将两次滤液合并,浓缩至半固态浸膏;
S14:将半固态浸膏加入至调膏机,加热至85℃后保温搅拌,边搅拌边缓慢加入红曲提取物和药物提取剂,熔化,待充分乳化后,继续搅拌30min后静置60min,得到红曲草本膏剂;
S15:将红曲草本膏剂加入包装机进行打包即可。
值得说明的是,药物提取剂采用大黄、黄柏、苦参混合提取液。
本实施例中,红曲提取物的制备方法具体包括如下步骤:
S21:在红曲原料中,加入浓度为70%的乙醇,加入乙醇量为红曲原料量的10倍,加热回流3小时,滤过;滤渣加入浓度70%的乙醇,加入量按质量分溶剂量为红曲原料量的5倍,加热回流3小时,滤过;
S22:合并滤液,在80℃下浓缩成25℃温度下相对密度达1.3的浸膏;
S23:在浸膏中按红曲原料质量分加入3倍、浓度70%的乙醇,溶解,过滤,回收乙醇至稠膏,在稠膏中按红曲原料质量分加入1倍的浓度为70%乙醇,80℃蒸干,并保温4小时,得红曲提取物。
进一步的,乙醇也可以采用甲醇、丙醇或异丙醇。
另一方面,如图1和图2所示,本发明还提供一种红曲草本膏剂的制备设备,包括上述的红曲草本膏剂的制备方法,包括输料机、粉碎机、煎煮机、调膏机和包装机,煎煮机包括机箱10和设置于机箱10内用于盛放药剂的药剂盛放网20,机箱10内底部安装有加热底座11,加热底座11内安装有电加热板12,机箱10的顶部开设有凹槽13,药剂盛放网20的顶部边缘安装有与凹槽13截面尺寸相适配的限位环21,药剂盛放网20的顶部设置有密封盖22,密封盖22上安装有提环23,机箱10的外壁上安装有隔热手柄15。
此外,限位环21与密封盖22的厚度之和与凹槽13的深度相同。
实施例2
一种红曲草本膏剂的制备方法,包括以下重量份的原料:红曲原料30份、野菊花10份、硅油10份、薄荷脑1份、红花3份、马鞭草2份、透骨草3份、元胡2份、土元1份和药物提取剂5份。
本实施例中,红曲草本膏剂的制备方法包括如下步骤:
S11:按照上述重量份数称取各原料;
S12:通过红曲原料制备红曲提取物;
S13:将野菊花、硅油、薄荷脑、红花、马鞭草、透骨草、元胡、土元用粉碎机粉碎成细粉,加入药材总重量10倍量的纯净水放入煎煮机中煎煮2小时,过滤,收集滤液;再在药渣中加入药材重量8倍量的水煎煮1小时;过滤,收集滤液,将两次滤液合并,浓缩至半固态浸膏;
S14:将半固态浸膏加入至调膏机,加热至80℃后保温搅拌,边搅拌边缓慢加入红曲提取物和药物提取剂,熔化,待充分乳化后,继续搅拌20min后静置50min,得到红曲草本膏剂;
S15:将红曲草本膏剂加入包装机进行打包即可。
值得说明的是,药物提取剂采用苦参提取液。
本实施例中,红曲提取物的制备方法具体包括如下步骤:
S21:在红曲原料中,加入浓度为60%的乙醇,加入乙醇量为红曲原料量的4倍,加热回流2小时,滤过;滤渣加入浓度60%的乙醇,加入量按质量分溶剂量为红曲原料量的4倍,加热回流1小时,滤过;
S22:合并滤液,在50℃下浓缩成25℃温度下相对密度达1.1的浸膏;
S23:在浸膏中按红曲原料质量分加入1倍、浓度60%的乙醇,溶解,过滤,回收乙醇至稠膏,在稠膏中按红曲原料质量分加入0.5倍的浓度为80%乙醇,60℃蒸干,并保温2小时,得红曲提取物。
进一步的,乙醇也可以采用甲醇、丙醇或异丙醇。
另一方面,如图1所示,本发明还提供一种红曲草本膏剂的制备设备,包括上述的红曲草本膏剂的制备方法,包括输料机、粉碎机、煎煮机、调膏机和包装机。
另一方面,如图1和图2所示,本发明还提供一种红曲草本膏剂的制备设备,包括上述的红曲草本膏剂的制备方法,包括输料机、粉碎机、煎煮机、调膏机和包装机,煎煮机包括机箱10和设置于机箱10内用于盛放药剂的药剂盛放网20,机箱10内底部安装有加热底座11,加热底座11内安装有电加热板12,机箱10的顶部开设有凹槽13,药剂盛放网20的顶部边缘安装有与凹槽13截面尺寸相适配的限位环21,药剂盛放网20的顶部设置有密封盖22,密封盖22上安装有提环23,机箱10的外壁上安装有隔热手柄15。
此外,限位环21与密封盖22的厚度之和与凹槽13的深度相同。
实施例3
一种红曲草本膏剂的制备方法,包括以下重量份的原料:红曲原料50份、野菊花15份、硅油15份、薄荷脑3份、红花6份、马鞭草5份、透骨草6份、元胡4份、土元3份和药物提取剂10份。
本实施例中,红曲草本膏剂的制备方法包括如下步骤:
S11:按照上述重量份数称取各原料;
S12:通过红曲原料制备红曲提取物;
S13:将野菊花、硅油、薄荷脑、红花、马鞭草、透骨草、元胡、土元用粉碎机粉碎成细粉,加入药材总重量30倍量的纯净水放入煎煮机中煎煮4小时,过滤,收集滤液;再在药渣中加入药材重量15倍量的水煎煮2小时;过滤,收集滤液,将两次滤液合并,浓缩至半固态浸膏;
S14:将半固态浸膏加入至调膏机,加热至90℃后保温搅拌,边搅拌边缓慢加入红曲提取物和药物提取剂,熔化,待充分乳化后,继续搅拌50min后静置70min,得到红曲草本膏剂;
S15:将红曲草本膏剂加入包装机进行打包即可。
值得说明的是,本实施例中药物提取剂采用紫草素和甘草的混合药剂。
本实施例中,红曲提取物的制备方法具体包括如下步骤:
S21:在红曲原料中,加入浓度为70%的乙醇,加入乙醇量为红曲原料量的8倍,加热回流5小时,滤过;滤渣加入浓度70%的乙醇,加入量按质量分溶剂量为红曲原料量的8倍,加热回流4小时,滤过;
S22:合并滤液,在60℃下浓缩成25℃温度下相对密度达1.4的浸膏;
S23:在浸膏中按红曲原料质量分加入3倍、浓度80%的乙醇,溶解,过滤,回收乙醇至稠膏,在稠膏中按红曲原料质量分加入1倍的浓度为80%乙醇,90℃蒸干,并保温3小时,得红曲提取物。
进一步的,乙醇也可以采用甲醇、丙醇或异丙醇。
另一方面,如图1和图2所示,本发明还提供一种红曲草本膏剂的制备设备,包括上述的红曲草本膏剂的制备方法,包括输料机、粉碎机、煎煮机、调膏机和包装机,煎煮机包括机箱10和设置于机箱10内用于盛放药剂的药剂盛放网20,机箱10内底部安装有加热底座11,加热底座11内安装有电加热板12,机箱10的顶部开设有凹槽13,药剂盛放网20的顶部边缘安装有与凹槽13截面尺寸相适配的限位环21,药剂盛放网20的顶部设置有密封盖22,密封盖22上安装有提环23,机箱10的外壁上安装有隔热手柄15。
此外,限位环21与密封盖22的厚度之和与凹槽13的深度相同。
本发明中红曲草本膏剂的制备方法胶囊具体治疗时,涂抹适量本红曲草本膏剂于患处,一日一次或两次,1-3天基本治愈,治愈后不易复发,无毒副作用。
本发明的红曲草本膏剂的制备方法及设备,原料配方科学、合理且按合理的比例调配,使不同原料的有效成分充分融合互补,具有较高的经济效益和社会效益和推广价值,以天然草本配制而成,疗效好,以具有消肿止痒的中草药为主要有效成分,天然安全,适合各种人群使用,具有较好的抗菌、抑菌、消毒效果,且无毒性,不会对皮肤造成损伤,治疗时,涂抹适量本红曲草本膏剂于患处,一日一次或两次,1-3天基本治愈,治愈后不易复发,无毒副作用。
本发明中,添加的红曲有消食祛肿、活血通络、和胃健脾之功效。"从红曲中提取"红曲霉素"对治疗慢性肠炎、痢疾有效。
本发明中,添加的野菊花味苦、辛、凉,清热解毒,疏风散热,散瘀,明目,降血压。防治流行性脑脊髓膜炎,预防流行性感冒、感冒,治疗高血压、肝炎、痢疾、痈疖疗疮都有明显效果。野菊花的浸液对杀灭孑孓及蝇蛆也非常有效。
本发明中,添加的薄荷脑用于皮肤或粘膜,有清凉止痒作用,疏风;清热。主风热感冒;头痛;目赤;咽喉肿痛;齿痛;皮肤瘙痒。
本发明中,添加的红花性辛,温;活血通经,去瘀止痛。对经闭,症瘕,难产,死胎,产后恶露不行、瘀血作痛,痈肿,跌扑损伤有特殊功效。
本发明中,添加的马鞭草清热解毒,活血散瘀,利水消肿。
本发明中,添加的透骨草性味辛、温、无毒,功用:祛风、除湿、舒筋活血、止痛。
本发明中,添加的元胡用于全身各部气滞血瘀之痛,痛经,经闭,症瘕,产后瘀阻,跌扑损伤,疝气作痛。
本发明中,添加的土元活血散瘀,通经止痛。主治:跌打损伤,淤血肿痛,闭经,产后瘀血腹痛。
以上显示和描述了本发明的基本原理、主要特征和本发明的优点。本行业的技术人员应该了解,本发明不受上述实施例的限制,上述实施例和说明书中描述的仅为本发明的优选例,并不用来限制本发明,在不脱离本发明精神和范围的前提下,本发明还会有各种变化和改进,这些变化和改进都落入要求保护的本发明范围内。本发明要求保护范围由所附的权利要求书及其等效物界定。
Claims (9)
1.一种红曲草本膏剂的制备方法,其特征在于:包括以下重量份的原料:红曲原料30-50份、野菊花10-15份、硅油10-15份、薄荷脑1-3份、红花3-6份、马鞭草2-5份、透骨草3-6份、元胡2-4份、土元1-3份和药物提取剂5-10份;
所述红曲草本膏剂的制备方法包括如下步骤:
S11:按照上述重量份数称取各原料;
S12:通过红曲原料制备红曲提取物;
S13:将野菊花、硅油、薄荷脑、红花、马鞭草、透骨草、元胡、土元用粉碎机粉碎成细粉,加入药材总重量10-30倍量的纯净水放入煎煮机中煎煮2-4小时,过滤,收集滤液;再在药渣中加入药材重量8-15倍量的水煎煮1-2小时;过滤,收集滤液,将两次滤液合并,浓缩至半固态浸膏;
S14:将半固态浸膏加入至调膏机,加热至80-90℃后保温搅拌,边搅拌边缓慢加入红曲提取物和药物提取剂,熔化,待充分乳化后,继续搅拌20-50min后静置50-70min,得到红曲草本膏剂;
S15:将红曲草本膏剂加入包装机进行打包即可。
2.根据权利要求1所述的红曲草本膏剂的制备方法,其特征在于:包括以下重量份的原料:红曲原料40份、野菊花12份、硅油12份、薄荷脑2份、红花5份、马鞭草4份、透骨草5份、元胡3份、土元2份和药物提取剂8份。
3.根据权利要求2所述的红曲草本膏剂的制备方法,其特征在于:包括以下重量份的原料:红曲原料30份、野菊花10份、硅油10份、薄荷脑1份、红花3份、马鞭草2份、透骨草3份、元胡2份、土元1份和药物提取剂5份。
4.根据权利要求3所述的红曲草本膏剂的制备方法,其特征在于:包括以下重量份的原料:红曲原料50份、野菊花15份、硅油15份、薄荷脑3份、红花6份、马鞭草5份、透骨草6份、元胡4份、土元3份和药物提取剂10份。
5.根据权利要求4所述的红曲草本膏剂的制备方法,其特征在于:所述药物提取剂包括紫草素、甘草、大黄、黄柏、苦参提取液的一种或多种。
6.根据权利要求5所述的红曲草本膏剂的制备方法,其特征在于:所述红曲提取物的制备方法具体包括如下步骤:
S21:在红曲原料中,加入浓度为60-100%的乙醇,加入乙醇量为红曲原料量的4-12倍,加热回流2-5小时,滤过;滤渣加入浓度60-100%的乙醇,加入量按质量分溶剂量为红曲原料量的4-8倍,加热回流1-4小时,滤过;
S22:合并滤液,在50-90℃下浓缩成25℃温度下相对密度达1.1-1.4的浸膏;
S23:在浸膏中按红曲原料质量分加入1-4倍、浓度60-100%的乙醇,溶解,过滤,回收乙醇至稠膏,在稠膏中按红曲原料质量分加入0.5-1倍的浓度为80-95%乙醇,60-95℃蒸干,并保温1-5小时,得红曲提取物。
7.根据权利要求6所述的红曲草本膏剂的制备方法,其特征在于:所述乙醇也可以采用甲醇、丙醇或异丙醇。
8.一种红曲草本膏剂的制备设备,用于制备权利要求1-7中任一所述的红曲草本膏剂,其特征在于:包括输料机、粉碎机、煎煮机、调膏机和包装机;
所述煎煮机包括机箱(10)和设置于机箱(10)内用于盛放药剂的药剂盛放网(20),所述机箱(10)内底部安装有加热底座(11),所述加热底座(11)内安装有电加热板(12),所述机箱(10)的顶部开设有凹槽(13),所述药剂盛放网(20)的顶部边缘安装有与所述凹槽(13)截面尺寸相适配的限位环(21),所述药剂盛放网(20)的顶部设置有密封盖(22),所述密封盖(22)上安装有提环(23),所述机箱(10)的外壁上安装有隔热手柄(15),机箱(10)外壁顶部还安装有出口嘴(14)。
9.根据权利要求8所述的红曲草本膏剂的制备设备,其特征在于:所述限位环(21)与密封盖(22)的厚度之和与所述凹槽(13)的深度相同。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202110919659.7A CN113599352A (zh) | 2021-08-11 | 2021-08-11 | 一种红曲草本膏剂的制备方法及设备 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202110919659.7A CN113599352A (zh) | 2021-08-11 | 2021-08-11 | 一种红曲草本膏剂的制备方法及设备 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN113599352A true CN113599352A (zh) | 2021-11-05 |
Family
ID=78308223
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202110919659.7A Pending CN113599352A (zh) | 2021-08-11 | 2021-08-11 | 一种红曲草本膏剂的制备方法及设备 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN113599352A (zh) |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1411836A (zh) * | 2001-10-19 | 2003-04-23 | 郗继福 | 红花药酒液 |
CN2628039Y (zh) * | 2003-05-16 | 2004-07-28 | 刘宝华 | 新型中药粉碎煎煮机 |
CN101485719A (zh) * | 2008-01-16 | 2009-07-22 | 北京天科仁祥医药科技有限公司 | 一种用于预防和治疗皮肤疾病的中药组合物及其制备方法 |
CN101623342A (zh) * | 2008-07-08 | 2010-01-13 | 张殿明 | 一种中草药制剂 |
CN104784669A (zh) * | 2015-05-08 | 2015-07-22 | 李秀飞 | 一种治疗皮肤瘙痒肿痛的药剂及其制备方法 |
CN108721474A (zh) * | 2018-09-14 | 2018-11-02 | 中商国能孵化器集团有限公司 | 一种用于蚊虫叮咬后消肿止痒的药物组合物及其制备方法 |
CN113041947A (zh) * | 2021-03-31 | 2021-06-29 | 刘仲春 | 一种中医内科临床用药液搅拌装置及方法 |
-
2021
- 2021-08-11 CN CN202110919659.7A patent/CN113599352A/zh active Pending
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1411836A (zh) * | 2001-10-19 | 2003-04-23 | 郗继福 | 红花药酒液 |
CN2628039Y (zh) * | 2003-05-16 | 2004-07-28 | 刘宝华 | 新型中药粉碎煎煮机 |
CN101485719A (zh) * | 2008-01-16 | 2009-07-22 | 北京天科仁祥医药科技有限公司 | 一种用于预防和治疗皮肤疾病的中药组合物及其制备方法 |
CN101623342A (zh) * | 2008-07-08 | 2010-01-13 | 张殿明 | 一种中草药制剂 |
CN104784669A (zh) * | 2015-05-08 | 2015-07-22 | 李秀飞 | 一种治疗皮肤瘙痒肿痛的药剂及其制备方法 |
CN108721474A (zh) * | 2018-09-14 | 2018-11-02 | 中商国能孵化器集团有限公司 | 一种用于蚊虫叮咬后消肿止痒的药物组合物及其制备方法 |
CN113041947A (zh) * | 2021-03-31 | 2021-06-29 | 刘仲春 | 一种中医内科临床用药液搅拌装置及方法 |
Non-Patent Citations (2)
Title |
---|
胡献国;: "用野菊花治病的几则验方", 求医问药, no. 02 * |
谭建华;: "疏痛安涂膜剂简介", 中药新药与临床药理, no. 01, pages 200 * |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN103990081A (zh) | 一种中药组合物及其在制备治疗婴幼儿黄疸药物中的用途 | |
CN108653434A (zh) | 一种治疗脾虚痰湿型多囊卵巢综合征的药物组合物 | |
CN108653429B (zh) | 一种治疗麦粒肿疾病的中药组合物及其应用 | |
CN103599409B (zh) | 一种治疗三叉神经痛的中药组合物 | |
CN101940680A (zh) | 治疗急性腹泻的中草药 | |
CN101987135B (zh) | 一种治疗破伤风的药物及其制备方法 | |
CN113599352A (zh) | 一种红曲草本膏剂的制备方法及设备 | |
CN103656581A (zh) | 治疗冻疮的中药组合物及制备方法 | |
CN102872368A (zh) | 一种用于泻火解毒的中药贴敷制剂 | |
CN112957441A (zh) | 一种祛风除湿、温通经络、活血止痛的外用药膜涂膜剂及其制备方法 | |
CN106728347B (zh) | 一种风湿液及其制备方法 | |
CN1045893C (zh) | 一种治疗妇女子宫肌瘤的药物 | |
CN112691157A (zh) | 一种风湿类关节炎药材组合物的配方及制备方法 | |
CN112043805A (zh) | 一种外用健脾胃消食贴膏的制备方法 | |
CN105055737A (zh) | 一种消炎镇痛散 | |
CN1178682C (zh) | 治疗心血管疾病的中药 | |
CN102228567A (zh) | 一种治疗三叉神经痛的药物 | |
CN104189663A (zh) | 颈部淋巴结核疏肝解郁制剂及制备方法 | |
CN103948875A (zh) | 一种治疗乙肝的药品及其制备方法 | |
CN111388604B (zh) | 一种治疗偏头痛的中药组合物及其制备方法 | |
CN102327440A (zh) | 治疗流注的中草药 | |
CN111973692B (zh) | 一种红花逍遥制剂及其制备方法、抗抑郁中的应用 | |
CN114177266B (zh) | 一种预防及治疗hpv病毒感染的中药组合物 | |
CN1203804A (zh) | 肝病康复全方药 | |
CN101129997A (zh) | 郁金解表口服液 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
WD01 | Invention patent application deemed withdrawn after publication | ||
WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20211105 |