CN113598801A - Head fixing device for PET-CT scanning anesthesia rat of small animal - Google Patents

Head fixing device for PET-CT scanning anesthesia rat of small animal Download PDF

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Publication number
CN113598801A
CN113598801A CN202110927064.6A CN202110927064A CN113598801A CN 113598801 A CN113598801 A CN 113598801A CN 202110927064 A CN202110927064 A CN 202110927064A CN 113598801 A CN113598801 A CN 113598801A
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scanning
pet
fixing device
head fixing
fixed
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CN113598801B (en
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王德广
徐垚
唐广胜
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Xuzhou Medical University
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Xuzhou Medical University
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/02Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
    • A61B6/03Computed tomography [CT]
    • A61B6/037Emission tomography
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/04Positioning of patients; Tiltable beds or the like
    • A61B6/0407Supports, e.g. tables or beds, for the body or parts of the body
    • A61B6/0421Supports, e.g. tables or beds, for the body or parts of the body with immobilising means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/50Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
    • A61B6/508Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for non-human patients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61DVETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D7/00Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
    • A61D7/04Devices for anaesthetising animals by gases or vapours; Inhaling devices

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biophysics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Anesthesiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Dentistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Apparatus For Radiation Diagnosis (AREA)

Abstract

The invention discloses a head fixing device for a PET-CT scanning anesthetized rat of a small animal, which relates to the technical field of scanning anesthetized rats, and particularly relates to a head fixing device for a PET-CT scanning anesthetized rat of a small animal. The invention can effectively provide a visual channel for the housing through the transparent partition plate, thereby being convenient for observing the state of the laboratory mouse in the housing; the rotation range that the direction inside groove in the housing can effectual restriction ring frid to can effectual assurance ring frid pivoted stability, the cooperation between servo motor accessible adjusting gear and the tooth impels the ring frid to rotate in the inside of housing, thereby can effectually change the turned angle of ring frid, and adjust the ring frid to suitable position, and can overturn the laboratory mouse, be used for the scanning experiment.

Description

Head fixing device for PET-CT scanning anesthesia rat of small animal
Technical Field
The invention relates to the technical field of scanning anesthetized rats, in particular to a head fixing device for a PET-CT scanning anesthetized rat of a small animal.
Background
PET is called positron emission computed tomography imaging, and is an imaging device reflecting the gene, molecule, metabolism and functional states of pathological changes. It uses positron nuclide to mark glucose and other human metabolites as an imaging agent, and reflects the metabolic change of the imaging agent through the uptake of the imaging agent by a focus, thereby providing biological metabolic information of diseases for clinic. Is a new milestone for the development of life science and medical imaging technology at present.
When anesthesia rat is scanned to traditional toy PET-CT, the whole head of rat is lying prone on the plane of scanning the bed body, the image rat that scans out like this is different with the shown image of rat brain atlas, and the rat of scan state can be observed, the whole posture that leans forward that is of rat brain, the image that scans out like this and the anatomical image of rat brain anatomical atlas mismatch, the rat brain side view that rat brain anatomical atlas shows is for upwards and the uppermost is the level, if carry out some structures that the posture adjustment will influence the scanned image through the image that software will scan out, cause the scanning result distortion easily, and the shortcoming of corresponding rat brain structure is difficult to observe.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides a head fixing device for a PET-CT scanning anesthesia rat of a small animal, which solves the problems in the background technology.
In order to achieve the purpose, the invention is realized by the following technical scheme: the utility model provides a head fixing device for toy PET-CT scans anesthesia rat, includes supplementary centre gripping stop gear and plastics lid shell, be equipped with unable adjustment base in the plastics lid shell, still wear to be equipped with locking screw in the plastics lid shell, locking screw's end connection has the acting as go-between, the cover is equipped with the lantern ring on acting as go-between, be equipped with the anesthetic gas pipe on the plastics lid shell.
Optionally, supplementary centre gripping stop gear includes frid, housing, fixed slider, transparent baffle, spacing base, direction inside groove, ring frid, tooth, cavity, gasbag, connection trachea, flexible clamp plate, rubber spacer, notes pneumatic valve, adjusting gear and servo motor, be equipped with spacing base on the frid, be equipped with the housing fixed with spacing base on the spacing base, the junction of frid and spacing base be equipped with the fixed slider of frid size complex, fixed slider integral type is fixed on spacing base.
Optionally, the groove plate is fixedly connected with the fixed base.
Optionally, a transparent partition plate is arranged on the groove plate, and the transparent partition plate is bonded and fixed on the groove plate.
Optionally, a guide inner groove is formed in the housing, a circular groove plate matched with the guide inner groove in size is arranged in the guide inner groove, teeth are arranged in the circular groove plate, the teeth are integrally fixed on the circular groove plate, the circular groove plate is meshed with the servo motor through the matching between the teeth and the adjusting gear, and the servo motor is fixed on the limiting base through bolts.
Optionally, a plurality of cavities are further formed in the annular groove plate, air bags are arranged in the cavities, connecting air pipes are connected between the air bags, and air injection valves are arranged on the connecting air pipes.
Optionally, a C-shaped flexible pressing plate is arranged in the cavity, a rubber spacer is arranged on the flexible pressing plate, and the rubber spacer is bonded and fixed on the flexible pressing plate.
Optionally, the plastic cover shell is communicated with the anesthetic gas tube.
Optionally, the pull wire is of a circular ring structure, the pull wire is inserted into the lantern ring, and the tail end of the pull wire is fixed on the lantern ring.
Optionally, the fixed base is in an inclined triangle structure.
The invention provides a head fixing device for PET-CT scanning anesthetized rats of small animals, which has the following beneficial effects:
1. the head fixing device for the PET-CT scanning anesthesia rat of the small animal is provided with an auxiliary clamping limiting mechanism, and the housing can move on the groove plate through a fixing slide block on a limiting base, so that the position of the housing can be effectively changed, and the position of the laboratory rat can be synchronously changed; the auxiliary clamping and limiting mechanism can be connected with the plastic cover shell by fixing the groove plate and the fixing base, so that the overall convenience of the device for anaesthetizing the experimental mouse is improved; the transparent partition plate can effectively provide a visual channel for the housing, so that the state of the laboratory mouse in the housing can be observed conveniently; the guide inner groove in the housing can effectively limit the rotation range of the ring groove plate, can effectively ensure the rotation stability of the ring groove plate and can avoid the ring groove plate from deflecting, and the servo motor can push the ring groove plate to rotate in the housing through the matching between the adjusting gear and the teeth, so that the rotation angle of the ring groove plate can be effectively changed, the ring groove plate can be adjusted to a proper position, and a laboratory mouse can be overturned for a scanning experiment; the tracheal inside of connecting is introduced into inert gas to the accessible gas injection valve, and connects trachea and gasbag intercommunication, can be with the inside of gaseous leading-in gasbag for the gasbag expands gradually, and with external force action flexible pressing plate, can extrude flexible pressing plate into the cavity, apply pressure in the laboratory mouse until flexible pressing plate, thereby can effectual restriction laboratory mouse's position, provide the flexibility for the laboratory mouse and compress tightly, and cooperate the uncomfortable sense that rubber shock insulator can effectual alleviate the laboratory mouse.
2. The head fixing device for the PET-CT scanning anesthesia rat of the small animal can introduce anesthetic gas into the plastic cover shell through the anesthetic gas pipe, so that the anesthetic gas can provide anesthetic treatment for the experimental rat; the incisors of the experimental mouse can be inserted into the lantern ring, and the pull wire can be pulled, so that the lantern ring is matched with the pull wire to fasten the incisors; the fixed base is an inclined triangular structure and can provide a placing position for the laboratory mouse.
Drawings
FIG. 1 is a schematic front view of the present invention;
FIG. 2 is a schematic side view of the auxiliary clamping and limiting mechanism of the present invention;
FIG. 3 is an enlarged view of a portion A of FIG. 2 according to the present invention.
In the figure: 1. an auxiliary clamping limiting mechanism; 101. a groove plate; 102. a housing; 103. fixing the sliding block; 104. a transparent partition; 105. a limiting base; 106. guiding the inner groove; 107. a ring groove plate; 108. teeth; 109. a cavity; 110. an air bag; 111. connecting an air pipe; 112. a flexible platen; 113. a rubber spacer; 114. an air injection valve; 115. an adjusting gear; 116. a servo motor; 2. a plastic cover shell; 3. a fixed base; 4. a pull wire; 5. a collar; 6. locking the screw rod; 7. an anesthetic gas tube.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments.
In the description of the present invention, "a plurality" means two or more unless otherwise specified; the terms "upper", "lower", "left", "right", "inner", "outer", "front", "rear", "head", "tail", and the like, indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, are only for convenience in describing and simplifying the description, and do not indicate or imply that the device or element referred to must have a particular orientation, be constructed in a particular orientation, and be operated, and thus, should not be construed as limiting the invention. Furthermore, the terms "first," "second," "third," and the like are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
In the description of the present invention, it is to be noted that, unless otherwise explicitly specified or limited, the terms "connected" and "connected" are to be interpreted broadly, e.g., as being fixed or detachable or integrally connected; can be mechanically or electrically connected; may be directly connected or indirectly connected through an intermediate. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.
Example one
As shown in fig. 1, the embodiment provides a head fixing device for PET-CT scanning of anesthetized rat for small animal, which comprises an auxiliary clamping and limiting mechanism 1 and a plastic cover shell 2, wherein the plastic cover shell 2 is communicated with an anesthetic gas pipe 7, the anesthetic gas pipe 7 can guide anesthetic gas into the plastic cover shell 2, so that anesthetic gas can provide anesthetic treatment for the laboratory rat, a fixing base 3 is arranged in the plastic cover shell 2, the fixing base 3 is in an inclined triangular structure and can provide a placing position for the laboratory rat, a locking screw 6 is further arranged in the plastic cover shell 2 in a penetrating manner, the end of the locking screw 6 is connected with a pull wire 4, the pull wire 4 is in a circular ring structure, the pull wire 4 is inserted into a lantern ring 5, the tail end of the pull wire 4 is fixed on the lantern ring 5, a door tooth of the laboratory rat can be inserted into the lantern ring 5, the pull wire 4 can be pulled, so that the lantern ring 5 is matched with the pull wire 4 to fasten the door tooth, the pull wire 4 is sleeved with a lantern ring 5, and the plastic cover shell 2 is provided with an anesthetic gas pipe 7.
Example two
The scheme in the first embodiment is further described in the following with reference to specific working modes, which are described in detail in the following:
as shown in fig. 1, 2 and 3, as a preferred embodiment, in addition to the above-mentioned manner, the auxiliary clamping and limiting mechanism 1 includes a slot plate 101, a housing 102, a fixed slide block 103, a transparent partition plate 104, a limiting base 105, an inner guide slot 106, a slot plate 107, teeth 108, a cavity 109, an air bag 110, a connecting air tube 111, a flexible pressing plate 112, a rubber spacer 113, an air injection valve 114, an adjusting gear 115 and a servo motor 116, the slot plate 101 is fixedly connected with the fixed base 3, the auxiliary clamping and limiting mechanism 1 can be connected with the plastic cover housing 2 by fixing the slot plate 101 and the fixed base 3, so as to improve the convenience of the whole anesthetizing mouse of the device, the transparent partition plate 104 is arranged on the slot plate 101, the transparent partition plate 104 is adhesively fixed on the slot plate 101, the transparent partition plate 104 can effectively provide a visual channel for the housing 102, so as to facilitate observing the state of the anesthetizing mouse in the housing 102, the groove plate 101 is provided with a limit base 105, the limit base 105 is provided with a cover 102 fixed with the limit base 105, the cover 102 is internally provided with a guide inner groove 106, the guide inner groove 106 is internally provided with a groove plate 107 with matched size, the groove plate 107 is also provided with a plurality of cavities 109, the cavities 109 are internally provided with C-shaped flexible press plates 112, the flexible press plates 112 are provided with rubber spacers 113, the rubber spacers 113 are adhered and fixed on the flexible press plates 112, the cavities 109 are internally provided with air bags 110, connecting air pipes 111 are connected between the air bags 110, the connecting air pipes 111 are provided with air injection valves 114, inert gas can be introduced into the connecting air pipes 111 through the air injection valves 114, the connecting air pipes 111 are communicated with the air bags 110, the gas can be introduced into the air bags 110, the air bags 110 are gradually expanded, external force is acted on the flexible press plates 112, the flexible press plates 112 can be extruded out of the cavities 109 until the flexible press plates 112 apply pressure to experimental mice, thereby effectively limiting the position of the laboratory mouse, providing flexible compression for the laboratory mouse, and being matched with the rubber spacer 113 to effectively reduce the uncomfortable feeling of the laboratory mouse, the ring slot plate 107 is internally provided with the teeth 108, the teeth 108 are integrally fixed on the ring slot plate 107, the ring slot plate 107 is meshed with the servo motor 116 through the matching between the teeth 108 and the adjusting gear 115, the servo motor 116 is fixed on the limiting base 105 through bolts, the guiding inner slot 106 in the housing 102 can effectively limit the rotating range of the ring slot plate 107, can effectively ensure the rotating stability of the ring slot plate 107, and avoid the ring slot plate 107 from deflecting, at the moment, the servo motor 116 can push the ring slot plate 107 to rotate in the housing 102 through the matching between the adjusting gear 115 and the teeth 108, thereby effectively changing the rotating angle of the ring slot plate 107, and adjusting the ring slot plate 107 to a proper position, and can overturn the laboratory mouse for the scanning experiment, the junction of frid 101 and spacing base 105 is equipped with the fixed slider 103 with frid 101 size complex, and fixed slider 103 integral type is fixed on spacing base 105, and the fixed slider 103 on the spacing base 105 of housing 102 accessible moves on frid 101, can effectual change housing 102's position to and can change laboratory mouse's position in step.
To sum up, when the head fixing device for PET-CT scanning anesthesia rat of the small animal is used, firstly, the laboratory mouse is placed inside the housing 102, then, the inert gas can be introduced into the connecting air pipe 111 through the gas injection valve 114, the connecting air pipe 111 is communicated with the air bag 110, the gas can be introduced into the air bag 110, the air bag 110 is gradually expanded, the external force is applied to the flexible pressing plate 112, the flexible pressing plate 112 can be extruded out of the cavity 109 until the flexible pressing plate 112 applies the pressure to the laboratory mouse, thereby the position of the laboratory mouse can be effectively limited, secondly, the housing 102 can move on the groove plate 101 through the fixed slide block 103 on the limit base 105, the housing 102 can be moved to a proper position, then, the servo motor 116 can push the ring groove plate 107 to rotate inside the housing 102 through the matching between the adjusting gear 115 and the teeth 108 to turn over the laboratory mouse, for scanning experiments;
finally, the housing 102 is a semi-closed plastic space, the head of the laboratory rat brain is just accommodated in the plastic space, only one side of the plastic space is not closed, a channel for placing the laboratory rat brain into the plastic space is provided after anesthesia during experiments, a small hole for passing in and out through the gas anesthesia gas pipe 7 is arranged right above the device and close to the front center, a small hole for passing in and out of a thin line is arranged in the upper third part right in front of the device, the stay wire 4 in the hole is buckled with the door tooth of the laboratory rat in the device and can draw the laboratory rat, the stay wire 4 is buckled with the locking screw 6 fixed right in front outside the device, the locking screw 6 can rotate, the stay wire 4 can be tensioned while rotating, the effect of drawing the fixed door tooth is achieved, the rotating locking screw 6 is connected with the right in front of the device, and the rotating locking screw 6 can be fixed after rotating
Two side surfaces of the housing 102 are vertical to the ground, the upper surface is parallel to the ground, the lower surface is provided with an inclined fixed base 3, and the fixed base 3 is gradually lifted from front to back and just adapts to the shape below the brain of the experimental rat.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be able to cover the technical scope of the present invention and the equivalent alternatives or modifications according to the technical solution and the inventive concept of the present invention within the technical scope of the present invention.

Claims (10)

1. The utility model provides a head fixing device that is used for PET-CT scanning anesthesia rat of toy, includes supplementary centre gripping stop gear (1) and plastics lid shell (2), its characterized in that: be equipped with unable adjustment base (3) in plastics lid shell (2), still wear to be equipped with locking screw (6) in plastics lid shell (2), the end connection of locking screw (6) has acting as go-between (4), the cover is equipped with lantern ring (5) on acting as go-between (4), be equipped with anesthetic gas pipe (7) on plastics lid shell (2).
2. The head fixing device for PET-CT scanning anesthetized rat of small animal as claimed in claim 1, characterized in that: supplementary centre gripping stop gear (1) is including frid (101), housing (102), fixed slider (103), transparent baffle (104), spacing base (105), direction inside groove (106), frid (107), tooth (108), cavity (109), gasbag (110), connecting pipe (111), flexible clamp plate (112), rubber spacer (113), gas injection valve (114), adjusting gear (115) and servo motor (116), be equipped with spacing base (105) on frid (101), be equipped with housing (102) fixed with spacing base (105) on spacing base (105), frid (101) are equipped with fixed slider (103) with frid (101) size complex with the junction of spacing base (105), fixed slider (103) integral type is fixed on spacing base (105).
3. The head fixing device for PET-CT scanning anesthetized rat of small animal as claimed in claim 2, wherein: the groove plate (101) is fixedly connected with the fixed base (3).
4. The head fixing device for PET-CT scanning anesthetized rat of small animal as claimed in claim 2, wherein: and a transparent partition plate (104) is arranged on the groove plate (101), and the transparent partition plate (104) is adhered and fixed on the groove plate (101).
5. The head fixing device for PET-CT scanning anesthetized rat of small animal as claimed in claim 2, wherein: a guide inner groove (106) is formed in the housing (102), a ring groove plate (107) with matched size is arranged in the guide inner groove (106), teeth (108) are arranged in the ring groove plate (107), the teeth (108) are integrally fixed on the ring groove plate (107), the ring groove plate (107) is meshed with a servo motor (116) through matching between the teeth (108) and an adjusting gear (115), and the servo motor (116) is fixed on the limiting base (105) through bolts.
6. The head fixing device for the PET-CT scanning anesthesia rat of the small animal according to claim 5, characterized in that: the annular groove plate (107) is further provided with a plurality of cavities (109), air bags (110) are arranged in the cavities (109), connecting air pipes (111) are connected between the air bags (110), and air injection valves (114) are arranged on the connecting air pipes (111).
7. The head fixing device for the PET-CT scanning anesthesia rat of the small animal according to claim 6, characterized in that: the flexible pressing plate (112) is arranged in the cavity (109) and is C-shaped, a rubber spacer (113) is arranged on the flexible pressing plate (112), and the rubber spacer (113) is fixedly bonded on the flexible pressing plate (112).
8. The head fixing device for PET-CT scanning anesthetized rat of small animal as claimed in claim 1, characterized in that: the plastic cover shell (2) is communicated with the anesthetic gas pipe (7).
9. The head fixing device for PET-CT scanning anesthetized rat of small animal as claimed in claim 1, characterized in that: the pull wire (4) is of a circular ring-shaped structure, the pull wire (4) is inserted into the lantern ring (5), and the tail end of the pull wire (4) is fixed on the lantern ring (5).
10. The head fixing device for PET-CT scanning anesthetized rat of small animal as claimed in claim 1, characterized in that: the fixed base (3) is of an inclined triangular structure.
CN202110927064.6A 2021-08-12 2021-08-12 Head fixing device for PET-CT scanning anesthetized rats of small animals Active CN113598801B (en)

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Cited By (1)

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CN117598718A (en) * 2024-01-17 2024-02-27 南京瑞德医疗科技有限公司 Camera movement detection device for CBCT and control method thereof

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CN212592552U (en) * 2020-09-30 2021-02-26 中国人民解放军空军军医大学 Mouse fixing device for experiments

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CN204072135U (en) * 2014-09-18 2015-01-07 中国人民解放军第二军医大学 Air-pressure type experimental mouse CT scan fixture
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Publication number Priority date Publication date Assignee Title
CN117598718A (en) * 2024-01-17 2024-02-27 南京瑞德医疗科技有限公司 Camera movement detection device for CBCT and control method thereof
CN117598718B (en) * 2024-01-17 2024-04-12 南京瑞德医疗科技有限公司 Camera movement detection device for CBCT and control method thereof

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