CN113598345A - Functional food containing linseed powder and capable of interfering with hyperglycemia by combining with metformin - Google Patents

Functional food containing linseed powder and capable of interfering with hyperglycemia by combining with metformin Download PDF

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Publication number
CN113598345A
CN113598345A CN202110901671.5A CN202110901671A CN113598345A CN 113598345 A CN113598345 A CN 113598345A CN 202110901671 A CN202110901671 A CN 202110901671A CN 113598345 A CN113598345 A CN 113598345A
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parts
oligosaccharide
food
powder
metformin
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邹爱标
王青鹏
曾涛
王华林
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Wuhan Inuling Biotechnology Co ltd
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Wuhan Inuling Biotechnology Co ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L25/00—Food consisting mainly of nutmeat or seeds; Preparation or treatment thereof
    • A23L25/30—Mashed or comminuted products, e.g. pulp, pastes, meal, powders; Products made therefrom, e.g. blocks, flakes, snacks; Liquid or semi-liquid products
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
    • A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention discloses a functional food containing linseed powder for interfering hyperglycemia with metformin in a combined manner, which comprises the following components in parts by weight: 0-60 parts of flaxseed powder, 40-60 parts of beta-glucan, 15-20 parts of galacto-oligosaccharide, 15-20 parts of chitosan, 30-50 parts of Plantago ovata forsk powder, 15-20 parts of xylo-oligosaccharide, 15-20 parts of fructo-oligosaccharide and 10 parts of raffinose. The functional food of the invention can intervene in improving the blood sugar level of the diabetic; the components are all soluble dietary fibers extracted from plants, so that the health-care food has high safety, no side effect, easy taking and drinking and convenient carrying; when entering the body, the food is easy to absorb water and swell, occupies the space in the gastrointestinal tract, increases satiety and further reduces the intake of food; at the same time, gel is formed to wrap the food, which prevents the food from being rapidly digested and absorbed by the gastrointestinal tract. The reduction of food intake and the slowing of digestion can uniformly control the concentration level of sugar in blood, and is beneficial to the blood sugar control of diabetics.

Description

Functional food containing linseed powder and capable of interfering with hyperglycemia by combining with metformin
Technical Field
The present invention relates to synergistic compositions effective in the treatment of diabetes. Specifically, the invention mainly relates to a novel scheme for the joint intervention of the metformin and the functional food containing the linseed powder on the hyperglycemia.
Background
With changes in lifestyle and dietary structure, diabetes has been one of the most common and serious lifestyle-related diseases. Two types of diabetes are known, i.e., type I diabetes caused by insufficient insulin secretion and type II diabetes caused by decreased sensitivity to insulin. Most patients are type ii diabetes, often caused by inappropriate lifestyle habits.
Since diabetes is a slow process, many people with diabetes are unaware of their condition and only know that some obvious symptoms are present are they confirmed by hospital examination. In the diabetic population, about 80% of them are type II diabetes. In addition to drugs, it is now also desirable to control the effects of blood glucose levels through dietary and exercise intervention.
The diabetes treatment method is to stimulate islet beta cells by hypoglycemic drugs to produce more insulin, so as to achieve the purpose of controlling blood sugar. However, the side effects of this method are also obvious, which stimulates the damaged beta cells of the pancreatic islets for a long time, increases the secretion amount, only aggravates the damage of the beta cells of the pancreatic islets, and forms a vicious circle.
Disclosure of Invention
The invention aims to solve the technical problem of overcoming the defect that the insulin beta cells are easy to aggravate the damage of the insulin beta cells when the blood sugar is controlled by stimulating the insulin beta cells through hypoglycemic drugs in the prior art, and provides a functional food of flaxseed powder and metformin which jointly act to reduce the influence of uncomfortable side effects on gastrointestinal tracts caused by taking metformin while achieving the hypoglycemic effect.
In order to solve the technical problems, the invention provides the following technical scheme:
a functional food containing flaxseed powder for interfering with hyperglycemia by combining with metformin comprises the following components in parts by weight:
0-60 parts of flaxseed powder, 40-60 parts of beta-glucan, 15-20 parts of galacto-oligosaccharide, 15-20 parts of chitosan, 30-50 parts of Plantago ovata forsk powder, 15-20 parts of xylo-oligosaccharide, 15-20 parts of fructo-oligosaccharide and 10 parts of raffinose.
Beta-glucan: can reduce cholesterol content, reduce low density lipoprotein content, and increase high density lipoprotein content. Effectively improve the feeling of peripheral tissues to insulin, reduce the requirement on insulin, promote the recovery of glucose and have obvious inhibition and prevention effects on diabetes.
Galacto-oligosaccharide: regulating intestinal flora balance, and improving immunity; increasing the activity and content of superoxide dismutase (SOD), and resisting aging; a large amount of short-chain fatty acid is generated, so that intestinal peristalsis is stimulated, the humidity of excrement is increased, and constipation is prevented; improving lactose intolerance; reducing the blood pressure of the human body; reduces the production of toxic fermentation products such as indole and formic acid and harmful enzymes, and simultaneously generates B vitamins, nicotinic acid and folic acid, thereby being beneficial to health.
And (3) chitosan:chitosanHas effects in enhancing immunity, activating cell, preventing cancer, reducing blood lipid,Blood pressure loweringHas the functions of resisting aging, regulating the environment of the organism and the like.
Plantago ovata powder: plantago ovata forsk fiber can be used for preventing/treating constipation or diarrhea. It can sufficiently absorb water, increase volume to mass which can be excreted, increase intestinal peristalsis, reduce the time of transporting feces in the intestine, and gradually become regular. Plantago ovata forsk fiber helps control postprandial blood glucose elevation. Meanwhile, through intervention in diabetes, plantain herb helps to reduce the insulin demand of diabetics.
And (3) xylo-oligosaccharide: inhibiting pathogenic bacteria and diarrhea; preventing constipation (Bifidobacterium uses xylooligosaccharide to produce a large amount of short chain fatty acid, which can stimulate intestinal tract peristalsis, increase feces wetness, and maintain certain osmotic pressure, thereby preventing constipation); lowering serum cholesterol; lowering blood pressure; has immunity enhancing and anticancer effects.
Fructo-oligosaccharide: proliferation of beneficial intestinal bacteria; can reduce the content of cholesterol and triglyceride in serum; promoting absorption of nutrients, especially calcium; can be used for preventing and treating diarrhea and constipation.
And (3) linseed powder: linseed supplement can improve intestinal mobility, slightly lower LDL cholesterol, and increase blood levels of polyunsaturated substances in healthy adultsFatty acids。
Cotton seed candy: the raffinose is bifidobacterium in human intestinal tract,Lactobacillus acidophilusExcellent nutrient source and effective proliferation of beneficial bacteriaFactor(s)The raffinose has the functions of regulating the intestines and improving defecation, and can improve the digestion function of a human body and promote the absorption of the calcium by the human body. Thereby enhancing the immunity of human body. Has obvious effects of preventing diseases and resisting aging.
Preferably, the composition comprises the following components in parts by weight:
20-60 parts of flaxseed powder, 40-50 parts of beta-glucan, 15-20 parts of galacto-oligosaccharide, 15-20 parts of chitosan, 30-40 parts of Plantago ovata forsk powder, 15-20 parts of xylo-oligosaccharide, 15-20 parts of fructo-oligosaccharide and 10 parts of raffinose.
Furthermore, the glycosylated hemoglobin is normally used by 6-8% of people, and is taken 2 times a day, 15g once, half an hour before breakfast and lunch; the metformin is normally used by people with glycosylated hemoglobin more than 8 percent, and is taken 3 times a day, 15g once and half an hour before meals.
The invention has the following beneficial effects: the functional food of the invention can intervene in improving the blood sugar level of the diabetic; soluble dietary fibers are extracted from plants, are new resource food, have high safety and no side effect, are easy to take and drink with water and are convenient to carry; when entering the body, the food is easy to absorb water and swell, occupies the space in the gastrointestinal tract, increases satiety and further reduces the intake of food; at the same time, gel is formed to wrap the food, which prevents the food from being rapidly digested and absorbed by the gastrointestinal tract. The concentration level of sugar in blood can be uniformly controlled due to the reduction of food intake and the reduction of digestion. Is beneficial to the blood sugar control of the diabetics, and achieves the aim of balancing the blood sugar.
Detailed Description
The following description of the preferred embodiments of the present invention is provided for the purpose of illustration and description, and is in no way intended to limit the invention.
Examples
Implementing group one: 0 part of flaxseed, 60 parts of beta-glucan, 20 parts of galacto-oligosaccharide, 20 parts of chitosan, 50 parts of psyllium powder, 20 parts of xylo-oligosaccharide, 20 parts of fructo-oligosaccharide and 10 parts of raffinose.
And (2) implementing a group two: 20 parts of flaxseed, 50 parts of beta-glucan, 20 parts of galacto-oligosaccharide, 20 parts of chitosan, 40 parts of psyllium powder, 20 parts of xylo-oligosaccharide, 20 parts of fructo-oligosaccharide and 10 parts of raffinose.
And (3) implementing group III: 40 parts of flaxseed, 40 parts of beta-glucan, 20 parts of galacto-oligosaccharide, 20 parts of chitosan, 30 parts of psyllium powder, 20 parts of xylo-oligosaccharide, 20 parts of fructo-oligosaccharide and 10 parts of raffinose.
And the implementation group IV: 60 parts of flaxseed, 40 parts of beta-glucan, 15 parts of galacto-oligosaccharide, 15 parts of chitosan, 30 parts of psyllium powder, 15 parts of xylo-oligosaccharide, 15 parts of fructo-oligosaccharide and 10 parts of raffinose.
Control group: 15g of starch.
The mixture is prepared into 15g per bag of samples according to the proportion.
The community medical institution in central China screened 160 diabetic patients (within 1 year) who used metformin (oral administration after meal, 0.5 g/time, 2 times/d) in total.
The first intervention scheme is as follows: one bag of 15g is eaten half an hour before breakfast, and the metformin is normally used. Two stages (metformin on the first week, functional food on weeks 2 to 4) (50 people in total, 10 per group)
Figure BDA0003200119220000041
Figure BDA0003200119220000051
And (2) intervention scheme II: one bag of 15g is eaten after half an hour of breakfast, and metformin is normally used. Two stages (metformin on the first week, functional food on weeks 2 to 4) (50 people in total, 10 per group)
Figure BDA0003200119220000052
The intervention scheme I and the scheme II find that the pre-meal eating effect is better than the post-meal eating effect, and particularly the blood sugar control is carried out after 2 hours. Wherein the proportional product of group three performed the best in intervention program one.
And (3) intervention scheme III: and (5) continuously optimizing the intervention scheme by taking the proportion of the three formulations of the implementation group as the optimal formulation. Two phases (metformin on the first week, functional food added on weeks 2 to 4) were performed (60 people were involved, 15 people per group).
Test group one: the product can be used 2 times a day and one bag at a time, and is half an hour before meal (breakfast and lunch)
Test group two: the product can be used 2 times a day and one bag at a time, and is half an hour before meal (breakfast and supper)
Test group three: the product is used 2 times a day and once bag, and is half an hour before meal (lunch and dinner)
Test group four: the product is used 3 times a day and one bag at a time, and is half an hour before meal (breakfast, lunch, dinner)
Figure BDA0003200119220000061
The data of the intervention scheme III can be analyzed, and the intervention effect of the test group I and the test group IV is better. In view of patient medical expense issues, the test group-intervention program (2 times a day, one bag at a time, half an hour before breakfast and lunch) is recommended for people with better diabetes control (6-8% glycated hemoglobin); people with severe diabetes (glycated hemoglobin > 8%) recommended four intervention programs in the test group (3 times a day, one bag at a time, half an hour before a meal).
In addition, in the later visit, it was found that the patients who participated in the study group had very few side effects due to metformin, such as nausea, vomiting, gastrointestinal discomfort, constipation and diarrhea. The number of metformin side reactions was greater in the two control groups.
Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that changes may be made in the embodiments and/or equivalents thereof without departing from the spirit and scope of the invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims (4)

1. A functional food containing flaxseed powder for interfering with hyperglycemia by combining with metformin is characterized by comprising the following components in parts by weight:
0-60 parts of flaxseed powder, 40-60 parts of beta-glucan, 15-20 parts of galacto-oligosaccharide, 15-20 parts of chitosan, 30-50 parts of Plantago ovata forsk powder, 15-20 parts of xylo-oligosaccharide, 15-20 parts of fructo-oligosaccharide and 10 parts of raffinose.
2. The functional food containing linseed powder for intervening in hyperglycemia in combination with metformin according to claim 1, which comprises the following components in parts by weight:
20-60 parts of flaxseed powder, 40-50 parts of beta-glucan, 15-20 parts of galacto-oligosaccharide, 15-20 parts of chitosan, 30-40 parts of Plantago ovata forsk powder, 15-20 parts of xylo-oligosaccharide, 15-20 parts of fructo-oligosaccharide and 10 parts of raffinose.
3. The functional food containing linseed meal for intervening in hyperglycemia in combination with metformin according to claim 1, wherein:
the glycosylated hemoglobin is normally used by 6-8% of people, and is taken 2 times a day, 15g once, half an hour before breakfast and lunch;
the metformin is normally used by people with glycosylated hemoglobin more than 8 percent, and is taken 3 times a day, 15g once and half an hour before meals.
4. The functional food containing flaxseed meal for interventions in hyperglycemia in combination with metformin according to claim 1, characterized in that it is prepared by mixing the components using a three-dimensional mixer.
CN202110901671.5A 2021-08-06 2021-08-06 Functional food containing linseed powder and capable of interfering with hyperglycemia by combining with metformin Pending CN113598345A (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102119931A (en) * 2011-02-21 2011-07-13 寿光富康制药有限公司 Novel metformin hydrochloride slow-releasing tablet and preparation method thereof
CN104664370A (en) * 2015-01-15 2015-06-03 杭州益智健康食品有限公司 Chewable flax tablet
CN110432500A (en) * 2019-08-07 2019-11-12 武汉英纽林生物科技有限公司 A kind of prebiotic compositions and preparation method and purposes containing inulin
CN112617212A (en) * 2020-12-14 2021-04-09 扬州方广食品有限公司 Blood sugar reducing meal replacement powder and preparation method thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102119931A (en) * 2011-02-21 2011-07-13 寿光富康制药有限公司 Novel metformin hydrochloride slow-releasing tablet and preparation method thereof
CN104664370A (en) * 2015-01-15 2015-06-03 杭州益智健康食品有限公司 Chewable flax tablet
CN110432500A (en) * 2019-08-07 2019-11-12 武汉英纽林生物科技有限公司 A kind of prebiotic compositions and preparation method and purposes containing inulin
CN112617212A (en) * 2020-12-14 2021-04-09 扬州方广食品有限公司 Blood sugar reducing meal replacement powder and preparation method thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
刘冰;秦贞奎;林祥梅;梅琳;刘万顺;韩宝芹;: "壳寡糖对试验性糖尿病大鼠餐后血糖及肝肌糖原含量的影响", 安徽农业科学, vol. 37, no. 03, pages 1113 - 1116 *
赵利;党占海;李毅;张建平;谢小龙;王溪森;胡延萍;: "亚麻籽的保健功能和开发利用", 中国油脂, vol. 31, no. 03, pages 71 - 74 *

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Application publication date: 20211105