CN1135892A - Application of earthworm extraction for curing female genital inflammation - Google Patents
Application of earthworm extraction for curing female genital inflammation Download PDFInfo
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- CN1135892A CN1135892A CN95110774A CN95110774A CN1135892A CN 1135892 A CN1135892 A CN 1135892A CN 95110774 A CN95110774 A CN 95110774A CN 95110774 A CN95110774 A CN 95110774A CN 1135892 A CN1135892 A CN 1135892A
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- extract
- female genital
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- earth
- lumbricus
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Abstract
The earthworm extractive (extracted by water or alcohol) in the form of suppository, membrane, tablet, effervesce, or drop can be used to cure the inflammation of woman's genetic tract, such as cervical erosion and vaginitis, with unique curative effect and less toxic side-effect.
Description
Technical field
The present invention relates to earth-worm extractive as raw material, promptly Lumbricus water extract or Lumbricus alcohol extract are in the new purposes of treatment female genital inflammation.
Background technology
Lumbricus is medicinal, is listed in the low-grades medicine in Shennong's Herbal, is a suppressing the hyperactive liver to relieve the wind syndrome Chinese medicine.It can heat clearing away, suppressing the hyperactive liver, Zhichuan, collateral dredging.It is fanatical dry to cure mainly height, diseases such as convulsion with spasms, headache due to pathogenic wind-heat.Use the history in existing more than 2,000 year.
There is Lumbricus kind more than 2400 in the known whole world, kind surplus China has 140 approximately.Wherein medicinal Lumbricus has 9 kinds, is subordinate to 2 kinds (huge earthworm section and Lumbricidaes) 3 and belongs to.The medicinal Lumbricus of China mostly is the dry body of huge earthworm section (Megascolecidae) animal Pheretima aspergillum (Pheretgimaaspergillum EPerrier 1872) or the dark different lip earthworm of Lumbricidae (Lumoricidae) animal back (Allolobophora caliginosa trapezoides) (Allolobophora Caliginosa (Savigny) trapezoides Ant, Duges, 1828).Pheretima aspergillum has another name called " LUMBRICUS " (Lumbricus Kwang Tangensis), mainly is distributed in Guangdong, Guangxi, Fujian and the Taiwan of China.Allolobophora caliginosa trapezoides claims " Pheretima " again, almost spreads all over all parts of the country.
The chemical constituent of Lumbricus, the research report is more detailed.According to the literature, Lumbricus chemical constituent alcohol extract contains compositions such as lumbrifebrine, lumbricin, terrestro-lumbrolysin, purine, choline, hypoxanthine, succinic acid, aminoacid, plurality of enzymes, guanidine.The water extract main component is the acid protein of streptokinase, water solublity, PAF, mostly is oligopeptide etc. after the hydrolysis.
The main pharmacological of Lumbricus, modern age, pharmacological evaluation and clinical observation all confirmed:
1, hypotensive effect: the Lumbricus alcohol extract does not have the discovery harmful effect to the heart, brain, liver, kidney, hemopoietic system, endocrine dysfunction.
2, antiasthmatic effect: compositions such as hypoxanthine, succinum alkali, several amino acids to expansion bronchus and antihistaminic allergy, have calmness, antiasthmatic effect.The property of medicine is lasting gently, and curative effect is more than 73%.
3, refrigeration function: lumbrifebrine (derivant of cruel propylhomoserin tyrosine), arachidonic acid etc. act on thermotaxic centre.
4, calm anticonvulsant action: succinic acid etc. have effects such as spasmolytic, epilepsy.
5, diuresis: succinic acid has diuresis.
6, collateral dredging effect: the successive dynasties book on Chinese herbal medicine is all on the books, the medicine commonly used of treatment arthromyodynia (arthritis).
7, kill smart effect: earth-worm extractive as raw material has sterilization functions to white mice and people's sperm.
8, excited uterus effect: earth-worm extractive as raw material can cause the hysterospasm contraction, so can be used as odinagogue.
9, antibiotic and antitumaous effect: earth-worm extractive as raw material has stronger antibacterial action to tubercule bacillus, and mice-transplanted tumor is had the obvious suppression effect.
10, anti-allergic effects: the Lumbricus nitrogen containing component has the irritated effect of antihistaminic.
11, functions of detoxifying and promoting tissue regeneration: no matter take orally and external, mucosa and skin ulcer are all had the healing of promotion effect.
12, thrombolytic, fibrinolytic and blood coagulation resisting function, Lumbrukinase, solubilized fibrin and activator of plasminogen effect.
13, other effect: the Lumbricus water extract has the effect of paralysis consciousness.Lumbricus also has the jaundice eliminating effect.
As can be seen above-mentioned, Lumbricus has wide biological activity, and developing Lumbricus medicinal is purpose of the present invention.
Summary of the invention
The object of the present invention is to provide the application of earth-worm extractive as raw material in preparation treatment female genital diseases medicine.
Another object of the present invention is to provide and contain above-mentioned earth-worm extractive as raw material at the pharmaceutical composition for the treatment of female genital inflammation.
A further object of the present invention is to extract the method that above-mentioned earth-worm extractive as raw material is used for the treatment of female genital inflammation.
The present invention relates to the application of earth-worm extractive as raw material at preparation treatment female genital inflammation, its Lumbricus is mainly the dry polypide of Pheretima aspergillum (Pheretgima aspergillum EPerrier1872) and the dark different lip earthworm of the back of the body (Allolobophora Caliginosa (Savigny) Trapezoides Aut, Duges, 1828).
Above-mentioned earth-worm extractive as raw material comprises compositions such as streptokinase, the acid protein of water solublity, aminoacid, PAF, oligopeptide, lumbricin, hypoxanthine, succinic acid, guanidine.
Through pharmacology and clinical confirmation, mucosa and skin ulcer all there is the healing of promotion effect.Antitumor action is arranged.To the urogenital tract infection patient, patients of cervical ruin especially, determined curative effect has functions of detoxifying and promoting tissue regeneration.Satisfactory effect.
The invention further relates to a kind of pharmaceutical composition for the treatment of female genital inflammation, the above-mentioned earth-worm extractive as raw material that wherein contains effective dose, earth-worm extractive as raw material of the present invention can be made various dosage forms according to prior art, wherein can contain acceptable carrier on the materia medica, excipient or other additives.As make suppository, effervescent, tablet, membrane, drop etc., but folk prescription or be made into compound recipe and use.
Above-mentioned earth-worm extractive as raw material, in the application of treatment female genital inflammation, when the outer time spent, effective dose is 0.1～5% of this extract.
The above-mentioned earth-worm extractive as raw material that the present invention relates in the treatment female genital inflammation is used, is mainly used in treatment cervical erosion, trichomonal vaginitis etc.
Adopt earth-worm extractive as raw material of the present invention, in treatment during female genital inflammation, curative effect is fast, curative effect is reliable, toxic and side effects is little, the cure rate height.
The invention still further relates to a kind of method of female genital inflammation, effective dose of the above-mentioned earth-worm extractive as raw material of external for the treatment of.
Best mode for carrying out the invention
Embodiment 1
1 part of earth-worm extractive as raw material is dissolved in 400 parts of 2% glycerites and Azone0.1～2%, makes solution become to contain 0.25% earth-worm extractive as raw material.
Embodiment 2
1 routine earth-worm extractive as raw material is dissolved in 200 parts of 2% glycerites and Azone0.1～2%, makes solution become to contain 0.5% earth-worm extractive as raw material.
Embodiment 3
1 part of earth-worm extractive as raw material is dissolved in 100 parts of 1%-2% glycerites and Azone0.1～2%, makes solution become to contain 1% earth-worm extractive as raw material.
Embodiment 4
1 part of earth-worm extractive as raw material is dissolved in 50 parts of 1%～2% glycerites and Azone0.1～2%, makes solution become to contain 2% earth-worm extractive as raw material.
Experimental example
Case 1-10:
Case 1-10 is the 24-35 women in year.10 examples are patients of cervical ruin.Year do not wait sick time half a year to 8, the treatment natural law did not wait in 3-12 days, and the treatment number of times does not wait for 3-10 time.Administering mode is external, and subjective symptoms and objective sign shape disappear.Details sees Table 1.
Model case one:
26 years old patients, the course of disease is suffered from slight cervical erosion more than a year.Behind the external secondary, recovery from illness.Once a day, use the next day.
Two of model case:
28 years old patients, the course of disease two and half is suffered from moderate cervical erosion.After the external five times, recovery from illness.Once a day, first three time logotype is used the next day of back twice.
Industrial applicability
The present invention to the invention of the new purposes of earth-worm extractive as raw material can with such extract for the preparation of Medicine and the pharmaceutical composition for the treatment of female genital inflammation.
Table 1 earth-worm extractive as raw material treatment cervical erosion
| Case number | Age | The course of disease | Rotten to the corn calibration | The treatment number of times | The treatment fate | Curative effect |
| 1 2 3 4 5 6 7 8 9 10 | 24 24 26 27 27 28 30 32 32 35 | 1y 1.3y 6y 3y 4.4y 2y 4y 3y 6y 8y | I I I II + II + II II + II II + II + | 2 2 3 6 6 5 6 6 8 10 | 3 3 5 10 10 9 10 10 12 12 | Recovery from illness recovery from illness recovery from illness recovery from illness recovery from illness recovery from illness recovery from illness recovery from illness recovery from illness recovery from illness |
Claims (6)
1, the pharmaceutical composition of earth-worm extractive as raw material preparation is in the purposes of treatment female genital inflammation.
2, application according to claim 1, it is characterized by this extract is water extract and ethanol extract.
3, water extract according to claim 2 is characterized in that Lumbricus water extract Main Ingredients and Appearance is the acid protein of streptokinase, water solublity, mostly is oligopeptide etc. after the hydrolysis.
4, alcohol extract according to claim 2, the main component that it is characterized in that the Lumbricus alcohol extract is lumbricin, terrestro-lumbrolysin, hypoxanthine, succinic acid, aminoacid, plurality of enzymes etc.
5, application according to claim 1 is characterized in that the method that the pharmaceutical composition of this water extract and alcohol extract preparation is used for the treatment of female genital inflammation is external.
6, application according to claim 1, base are characterised in that the pharmaceutical composition effective dose of this water extract and alcohol extract treatment female genital inflammation is 0.25%～5% of an extract.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN95110774A CN1135892A (en) | 1995-05-18 | 1995-05-18 | Application of earthworm extraction for curing female genital inflammation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN95110774A CN1135892A (en) | 1995-05-18 | 1995-05-18 | Application of earthworm extraction for curing female genital inflammation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1135892A true CN1135892A (en) | 1996-11-20 |
Family
ID=5078120
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN95110774A Pending CN1135892A (en) | 1995-05-18 | 1995-05-18 | Application of earthworm extraction for curing female genital inflammation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1135892A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106890321A (en) * | 2015-12-18 | 2017-06-27 | 深圳瑞健生命科学研究院有限公司 | A kind of method for preventing and treating cervical erosion |
| CN109331044A (en) * | 2018-11-20 | 2019-02-15 | 成都市农林科学院 | A kind of earth-worm extractive as raw material and preparation method thereof |
| US10874721B2 (en) | 2015-12-18 | 2020-12-29 | Talengen International Limited | Method for preventing and treating cervical erosion |
| US11007253B2 (en) | 2015-12-18 | 2021-05-18 | Talengen International Limited | Method for preventing or treating radiation and chemical damage |
-
1995
- 1995-05-18 CN CN95110774A patent/CN1135892A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106890321A (en) * | 2015-12-18 | 2017-06-27 | 深圳瑞健生命科学研究院有限公司 | A kind of method for preventing and treating cervical erosion |
| US10874721B2 (en) | 2015-12-18 | 2020-12-29 | Talengen International Limited | Method for preventing and treating cervical erosion |
| US11007253B2 (en) | 2015-12-18 | 2021-05-18 | Talengen International Limited | Method for preventing or treating radiation and chemical damage |
| CN109331044A (en) * | 2018-11-20 | 2019-02-15 | 成都市农林科学院 | A kind of earth-worm extractive as raw material and preparation method thereof |
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| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |