CN113577364A - 一种用于晒后修复的医用敷料 - Google Patents

一种用于晒后修复的医用敷料 Download PDF

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CN113577364A
CN113577364A CN202110932062.6A CN202110932062A CN113577364A CN 113577364 A CN113577364 A CN 113577364A CN 202110932062 A CN202110932062 A CN 202110932062A CN 113577364 A CN113577364 A CN 113577364A
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parts
gel layer
medical dressing
vitamin
dressing
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钱陈
甘毅
潘健
王会
杨新元
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Changzhou Anmei Biotechnology Co ltd
Zhejiang A&F University ZAFU
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Changzhou Anmei Biotechnology Co ltd
Zhejiang A&F University ZAFU
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Abstract

一种用于晒后修复的医用敷料，其特征在于，包括凝胶层和无纺布层，其中凝胶层配方如下：溶剂40‑95份，甘草酸二钾0.01‑1份，二裂酵母发酵产物溶胞物1‑12份，二裂酵母发酵产物滤液1‑18份，维生素B30.1‑5份，维生素B50.1‑5份，维生素B120.01‑0.5份，维生素C或者其衍生物0.1‑4份，维生素E衍生物0.1‑2份，传明酸0.1‑3份，增稠剂0.1‑3份，pH调节剂0.1‑3份，防腐抑菌剂0.1‑4份；本发明通过益生菌提取物，搭配维生素，植物提取物等不仅可以预防或者减轻损伤发生，并且对已经形成的损伤提供了一套完整的修复方案。

Description

一种用于晒后修复的医用敷料
技术领域
本发明涉及医用敷料领域，具体涉及一种用于晒后修复的医用敷料。
背景技术
日光中的紫外线(UVR)与皮肤老化有着密切的关系，是“光老化”中的最重要因素。
一般紫外线根据波长范围分为三段：长波紫外线(UVA)波长320nm～400n；中波紫外线UVB波长280nm～320nm；短波紫外线UVC波180nm～280nm。长波穿透能力强，短波能量密度高，由于臭氧层的存在，到达地球表面，对人产生影响的主要是长波UVA和中波UVB，UVB主要导致皮肤诱发炎症，发红发热，而UVA则是使皮肤细胞DNA发生损伤，并且不断累积，导致皮肤的老化。
紫外线对人体的直接伤害是导致DNA的损伤：损伤较轻的，会发生单链的断链，一般会形成环丁烷嘧啶二聚体(CPDs)，最主要为胸腺嘧啶二聚体。如果损伤较为严重，则会发生整条双链的断裂，从而形成核小体，前者损伤较轻，但会不断通过传代累积损伤，从而导致衰老或者癌症的发生。而后者则会引发细胞凋亡，从而引发蜕皮等现象。紫外线还能通过氧自由基导致过氧化损伤，如导致胶原蛋白的糖基化等。紫外线还可以影响免疫系统，导致免疫紊乱，从而引发问题肌肤。
如发明专利CN111840130A，其提出了CBD(大麻二酚)的解决方案，其具有修复和抗氧化功效，然后针对免疫调节以及DNA损伤却未有方案，而且现在国内已经把CBD成为列为化妆品违禁成分。如发明CN105213271A提出了防晒修复霜，然而其针对晒后的皮肤发红，以及晒后黑色素等形成没有多大效果。因此晒后修复是一个综合工程，因此需要一个较为全面的解决方案。
发明内容
本发明要解决的技术问题是：提供一种用于晒后皮肤护理，也可以用于皮肤激光微整之后，起到修复作用的医用敷料。
本发明解决上述技术问题的技术方案如下：
一种用于晒后修复的医用敷料，包括凝胶层和无纺布层，
其中凝胶层配方如下：
Figure BDA0003211386190000011
Figure BDA0003211386190000021
优选的，所述溶剂选自水。
优选的，所述增稠剂选自卡波姆或透明质酸钠。
优选的，所述pH调节剂选自TEA。
优选的，所述防腐抑菌剂选自羟基苯乙酮和己二醇。
优选的，所述凝胶层配方如下：
Figure BDA0003211386190000022
优选的，所述凝胶层配方如下：
Figure BDA0003211386190000023
优选的，所述敷料可以采用喷剂敷料，所述喷剂敷料除不含增稠剂，其余成分与凝胶层相同。
本发明中化合物的中文命名与结构式有冲突的，以结构式为准；结构式有明显错误的除外。
(1)本发明调节免疫，抵御紫外线导致的炎症，迅速去红。
(2)本发明通过抗氧化，消除氧自由基，抵御氧化损伤以及蛋白糖基化。
(3)本发明提升DNA修复酶活性，降低累积的损伤导致的皮肤老化。
(4)本发明减少黑色素形成，降低黑色素沉着，提亮肤色。
附图说明
图1为用户使用本发明实施例1制备得到的医用敷料使用前后对比图；
图2为用户使用本发明实施例1制备得到的医用敷料使用前后Visia对比图。
具体实施方式
以下结合实例说明本发明，但不限制本发明。在本领域内，技术人员对本发明所做的简单替换或改进均属于本发明所保护的技术方案内。
实施例1：
本发明所述医用冷敷贴有凝胶层和无纺布等基质组成，其中凝胶层制备工艺如下：
称取90.4kg纯化水置于水相锅中，加入卡波姆0.12kg，分散均匀，升温至85℃后，搅拌保温半个小时；待卡波姆充分溶解后降温至65℃，加入TEA约0.12kg调节pH至6；降温至45℃以下，后加入甘草酸二钾0.01kg，二裂酵母发酵产物溶胞物2kg，二裂酵母发酵产物滤液5kg，维生素B3 0.2kg，维生素B5 0.2kg，维生素B12 0.01kg，维生素C 0.1kg，维生素E醋酸酯0.5kg，传明酸0.5kg；加入对羟基苯乙酮0.5kg，己二醇0.5kg，搅拌0.5h后过滤出锅，灌装医用冷敷贴成品。
实施例2：
用户在军训晒后，使用实施例1的医用冷敷贴，贴敷半小时以上，而后揭下清洗，使用前后对比如图1所示，用户在使用前后进行拍照，并使用Visia进行监测前后对比如图2所示。
在Visia图中，颜色越红，越深，表明晒伤越严重，因此通过两个对比结果可以看出本例在使用本医用冷敷贴可以缓解晒伤导致的炎症。
实施例3：
参考实施例1，配制凝胶层，其中二裂酵母溶胞物添加量为1kg，其余成分不变。
实施例4
参考实施例1，配置凝胶层，其中二裂酵母溶胞物添加量为5kg，其余成分不变。
实施例5
参考实施例1，配置凝胶层，其中二裂酵母溶胞物添加量为10kg，其余成分不变。
对比例1
按照CN111840130A专利实施例1方案制备得到敷料。
对比例2
按照CN105213271A专利实施例1方案制备得到防晒霜。
实施例6
给不同的晒后客户使用实施例1，实施例4，实施例5，实施例6的医用冷敷贴，对炎症缓解，祛红效果调查如下：
项目 一级晒伤 二级晒伤 三级晒伤 四级晒伤
实施例1 缓解 缓解 基本缓解 部分缓解
实施例3 缓解 基本缓解 部分缓解 无明显效果
实施例4 缓解 缓解 部分缓解 部分缓解
实施例5 缓解 基本缓解 部分缓解 无明显效果
对比例1 缓解 基本缓解 无明显效果 无明显效果
对比例2 缓解 无明显效果 无明显效果 无明显效果
根据晒伤等级划分，一般可以分为四级：1、一级晒伤(轻度晒伤)：皮肤发红，并有微微发热；2、二级晒伤(中度晒伤)：皮肤红肿，干燥发痒，皮肤紧绷，伴有疼痛感；3、三级晒伤(重度晒伤)：皮肤灼热，疼痛，肉眼可见的红肿和蜕皮；4、四级晒伤(严重晒伤)：蜕皮严重，甚至出现红斑、水肿、水疱或者成片的红疹。
二裂酵母发酵产物溶胞物在本方案中起到舒缓炎症以及修复屏障作用，并具有修复DNA损伤功能，从调查结果看，并非添加量越高越好，在2％添加量时，效果较好。
以上所述的仅是本发明的优选实施方式，应当指出，对于本领域的普通技术人员来说，在不脱离本发明创造构思的前提下，还可以做出若干变形和改进，这些都属于本发明的保护范围。

Claims (8)

1.一种用于晒后修复的医用敷料，其特征在于，包括凝胶层和无纺布层，其中凝胶层配方如下：
Figure FDA0003211386180000011
2.一种用于晒后修复的医用敷料，其特征在于，包括凝胶层和无纺布层，其中凝胶层配方如下：
Figure FDA0003211386180000012
3.一种用于晒后修复的医用敷料，其特征在于，包括凝胶层和无纺布层，其中凝胶层配方如下：
Figure FDA0003211386180000013
Figure FDA0003211386180000021
4.根据权利要求1～3任一项所述的用于晒后修复的医用敷料，其特征在于，所述溶剂选自水。
5.根据权利要求1～3任一项所述的用于晒后修复的医用敷料，其特征在于，所述增稠剂选自卡波姆或透明质酸钠。
6.根据权利要求1～3任一项所述的用于晒后修复的医用敷料，其特征在于，所述pH调节剂选自TEA。
7.根据权利要求1～3任一项所述的用于晒后修复的医用敷料，其特征在于，所述防腐抑菌剂选自羟基苯乙酮和己二醇。
8.根据权利要求1～3任一项所述的用于晒后修复的医用敷料，其特征在于，所述敷料可以采用喷剂敷料，所述喷剂敷料除不含增稠剂，其余成分与凝胶层相同。
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